Structural,Functional,and Molecular Imaging of Autism Spectrum Disorder
作者机构：Department of Nuclear Medicine and Medical PET CenterThe Second Hospital of Zhejiang University School of MedicineHangzhou 310009China Key Laboratory of Medical Molecular Imaging of Zhejiang ProvinceHangzhou 310009China Key Laboratory for Biomedical Engineering of Ministry of EducationZhejiang UniversityHangzhou 310027China Laboratory for Pathophysiological and Health ScienceRIKEN Center for Biosystems Dynamics ResearchHyogo 650-0047Japan Department of Surgical OncologyThe Second Hospital of Zhejiang University School of MedicineHangzhou 310009China Institute of Nuclear Medicine and Molecular ImagingZhejiang UniversityHangzhou 310009China The College of Biomedical Engineering and Instrument Science of Zhejiang UniversityHangzhou 310027China
出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)
年 卷 期：2021年第37卷第7期
页 面：1051-1071页
核心收录：
学科分类：0710[理学-生物学] 050302[文学-传播学] 05[文学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0503[文学-新闻传播学]
基 金：the National Key Research and the Development Program of China(2016YFA0100900) the National Natural Science Foundation of China(81761148029,81725009,81425015,and 81900255)
主 题：Autism spectrum disorder Positron emission tomography Magnetic resonance imaging Molecular imaging Functional connectivity Serotonin Oxytocin
摘 要：Autism spectrum disorder(ASD)is a heterogeneous neurodevelopmental disorder associated with both genetic and environmental *** approaches have been widely employed to parse the neurophysiological mechanisms underlying ASD,and provide critical insights into the anatomical,functional,and neurochemical *** reviewed recent advances in neuroimaging studies that focused on ASD by using magnetic resonance imaging(MRI),positron emission tomography(PET),or single-positron emission tomography(SPECT).Longitudinal structural MRI has delineated an abnormal developmental trajectory of ASD that is associated with cascading neurobiological processes,and functional MRI has pointed to disrupted functional neural ***,PET and SPECT imaging have revealed that metabolic and neurotransmitter abnormalities may contribute to shaping the aberrant neural circuits of *** large-scale,multi-center,multimodal investigations are essential to elucidate the neurophysiological underpinnings of ASD,and facilitate the development of novel diagnostic biomarkers and better-targeted therapy.
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