Recent progress in the molecular imaging of therapeutic monoclonal antibodies

作     者：Kaifeng He Su Zeng Linghui Qian Kaifeng He;Su Zeng;Linghui Qian

作者机构：Institute of Drug Metabolism and Pharmaceutical AnalysisZhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2020年第10卷第5期

页      面：397-413页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0817[工学-化学工程与技术] 100102[医学-免疫学] 0703[理学-化学] 0702[理学-物理学] 10[医学] 

基　　金：We acknowledge financial support from the National Natural Science Foundation of China(81903574) the Fundamental Research Funds for the Central Universities(2019QNA7046,2020QNA7001) 

主　　题：Therapeutic monoclonal antibodies Molecular structure Biological function Molecular imaging 

摘      要：Therapeutic monoclonal antibodies have become one of the central components of the healthcare system and continuous efforts are made to bring innovative antibody therapeutics to patients in *** is equally critical to acquire sufficient knowledge of their molecular structure and biological functions to ensure the efficacy and safety by incorporating new detection approaches since new challenges like individual differences and resistance are *** techniques for determining antibody disposition including plasma drug concentration measurements using LC-MS or ELISA,and tissue distribution using immunohistochemistry and immunofluorescence are now complemented with molecular imaging modalities like positron emission tomography and near-infrared fluorescence imaging to obtain more dynamic information,while methods for characterization of antibody’s interaction with the target antigen as well as visualization of its cellular and intercellular behavior are still under *** progress in detecting therapeutic antibodies,in particular,the development of methods suitable for illustrating the molecular dynamics,is described here.