Molecular imaging:design mechanism and bioapplications

作     者：Lanlan Chen Yifan Lyu Xuan Zhang Liting Zheng Qingqing Li Ding Ding Fengming Chen Yihao Liu Wei Li Yutong Zhang Qiuling Huang Zhiqiang Wang Tiantian Xie Qiang Zhang Yingyu Sima Ke Li Shuai Xu Tianbing Ren Mengyi Xiong Ying Wu Jibin Song Lin Yuan Huanghao Yang Xiao-Bing Zhang Weihong Tan Lanlan Chen;Yifan Lyu;Xuan Zhang;Liting Zheng;Qingqing Li;Ding Ding;Fengming Chen;Yihao Liu;Wei Li;Yutong Zhang;Qiuling Huang;Zhiqiang Wang;Tiantian Xie;Qiang Zhang;Yingyu Sima;Ke Li;Shuai Xu;Tianbing Ren;Mengyi Xiong;Ying Wu;Jibin Song;Lin Yuan;Huanghao Yang;Xiao-Bing Zhang;Weihong Tan

作者机构：Molecular Science and Biomedicine Laboratory(MBL)State Key Laboratory of Chemo/Biosensing and Chemomet-ricsCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha 410082China Key Laboratory for Analytical Science of Food Safety and Biology(Ministry of Education)College of ChemistryFuzhou UniversityFuzhou 350108China College of ChemistryBeijing University of Chemical TechnologyBeijing 100029China The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Institute of Molecular Medicine(IMM)State Key Laboratory of Oncogenes and Related Genes Renji HospitalShanghai Jiao Tong University School of MedicineCollege of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2023年第66卷第5期

页      面：1336-1383页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

基　　金：supported by the National Key R&D Program of China (2020YFA0210800, 2020YFA0909000) the National Natural Science Foundation of China (22176035, U21A20377, 21874024, 21890744, 22107027, 22074036) Shenzhen Science and Technology Program (RCBS20200714114821377) 

主　　题：molecular imaging imaging probes multimodality biomedical applications diseases diagnosis 

摘      要：Molecular imaging is a non-invasive method to image and analyze the concentration and activity of functional biomolecules in cells or in vivo at molecular level,and plays an increasing role in deep understanding of biological processes,early and accurate diagnosis of diseases,and evaluation of ***,numerous novel molecular imaging probes have been developed,involving every biomedical imaging modality,such as optical imaging,photoacoustic imaging,magnetic resonance imaging,single-photon-emission computed tomography,and positron emission *** this review,we summarize the development of current state-of-the-art molecular imaging *** introduce the design strategies of molecular probes and detailed imaging modalities,and highlight the properties of probes and biomedical imaging applications in cells and in vivo,including disease diagnosis,drug tracking,and imaging-guided *** we discuss the perspectives and challenges in this emerging *** expect this review could inspire more effective molecular imaging probes to be developed,achieving the goal towards clinical practices.