检索结果-南通市图书馆

A new diarylheptanoid from the bark of Myrica rubra

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2008年第5期19卷 547-549页

作者： Ding Yong Wang En Gui Liu Yu Jing Feng College of Pharmacy Guangdong Pharmaceutical University Guangzhou Higher Education Mega Center Guangzhou 510006 China

A new diarylheptanoid, 3,5-dimethoxy1-17-hydroxyl-4, 11, 19-triketo-[7,0]meta-cyclophane, named as rubanone 1, was isolated from the bark of Myrica rubra along with four known compounds 2-5. Their structures were eluc... 详细信息

关键词： Myrica rubra diarylheptanoid Rubanone

Pterocarine, a New diarylheptanoid from Pterocarya tonkinesis, its Cell Cycle Inhibition at G_0/G_1 Phase and Induction of Apoptosis in HCT-15 and K562 Cells

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2005年第2期16卷 215-218页

作者： HongBingLIU ChengBinCUI BingCAI QianQunGU DongYunZHANG QingChunZHAO HuaShiGUAN TianjinInstituteforBiomedicinalResearch（TIBiR） Tanjin300384 KeyLaboratoryofMarineDrugs MinistryofEducationChina MarineDrugandFoodInstitute OceanUniversityofChinaQingdao266003／／BeijingInstituteofPharmacologyandToxicologyAMMSBeijing100850 KeyLaboratoryofMarineDrugs MinistryofEducationChina MarineDrugandFoodInstitute OceanUniversityofChinaQingdao266003

Pterocarine (1), a new diarylheptanoidal compound, was isolated from Pterocaryatonkinesis (Franch.) Dode. together with a known diarylheptanoid, myricatomentogenin (2), througha bioassay-guided fractionation procedure. The structure of 1 was elucidated as (+)-3', 4''-epoxy-1-(4'-hydroxyphenyl)-7-(3''-hydroxyphenyl)-heptane-3-one by the spectroscopic *** (1) inhibited the proliferation of tsFT210, HCT-15 and K562 cells with the inhibitionrates of 20.2±2.4, 23.8±2.4 and 50.5±1.2% at 100 μg/mL, respectively. Flow cytometric analysisindicated that 1 could inhibit the cell cycle of tsFT210, HCT-15 and K562 cells at the G0/G1 phaseand could also induce apoptosis in HCT-15 (19%) and K562 (11%) cells.

关键词： Pterocarine diarylheptanoid phenolic compound structure cell cycle inhibitor apop-tosis inducer Pterocarya tonkinesis Juglandaceae.

A new dimeric diarylheptanoid from the rhizomes of Alpinia officinarum

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2014年第2期12卷 139-141页

作者： LIU Dan QU Wei ZHAO Ling GUAN Fu-Qin LIANG Jing-Yu Department of Natural Medicinal Chemistry China Pharmaceutical University College of Biotechnology and Pharmaceutical Engineering Wuhan Polytechnic University Institute of Botany Jiangsu Province and Chinese Academy of Science

AIM: To study the chemical constituents of the rhizomes of Alpinia officinarum Hance. METHOD: Compounds were isolated by repeated column chromatography, and their structures were elucidated on the basis of spectral analysis. The cytotoxic activities of these compounds were evaluated with the T98G and B16F10 cell lines by the MTT assay. RESULTS: A dimeric diarylheptanoid, named alpinin B(1), along with three known diarylheptanoids were obtained, and their structures were identified as alpinin B(1), 1, 7-diphenyl-3,5-heptanedione(2),(4E)-1, 7-diphenylhept-4-en-3-one(3) and(4E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one(4). CONCLUSION: Compound 1 is a new dimeric diarylheptanoid. The biosynthetic pathway of 1 was speculated to originate from a Michael reaction between compounds 2 and 3. Compound 3 showed cytotoxicity against the human glioblastoma T98G cell line with IC50 of 27 μmol L 1.

关键词： Alpinia officinarum Hance diarylheptanoid alpinin B 1,7-diphenyl-3,5-heptanedione (4E)-l,7-diphenylhept-4-en -3-one

Molecular basis of the anti-inflammatory potential of a diarylheptanoid in murine macrophage RAW 264.7 cells

在线全文

学校读者我要写书评

暂无评论

Advances in Biological Chemistry 2013年第6期3卷 541-548页

作者： Bharathi Raja Rajaganapathy Karthikeyan Thirugnanam Muthusamy Velusamy Shanmuganathan Anand Singaravelu Lakshmi Baddireddi Subadhra Tissue Culture and Drug Discovery Lab Centre for Biotechnology Anna University Chennai India Tissue Culture and Drug Discovery Lab Centre for Biotechnology Anna University Chennai India 2National Institute of Nutrition (Indian Council of Medical Research) Hyderabad India National Institute of Nutrition (Indian Council of Medical Research) Hyderabad India

Natural products play a significant role in human health in relation to the prevention and treatment of inflammatory disorders. In this study, we examined the molecular basis of the anti-inflammatory potential of a diarylheptonoid (DAH) isolated from Alpinia officinarum hexane extract (AOHE) with special emphasis on their ability to modulate the nuclear factor-κB (NF-кB) signaling involved in the inflammatory response. Measurement of Nitrite by Griess reaction which revealed the effect of DAH in RAW 264.7 macrophages showed an inhibition in the nitric oxide production through the suppression of inducible nitric oxide synthase (iNOS) gene level expression. NF-кB reporter gene assay suggests inhibition of NF-кB transcriptional activity, thus inhibiting LPS-induced phosphorylation and degradation of IкBα and a downregulation of NF-кB protein expression confirms the immunomodulatory effect of DAH. Furthermore, downregulation in the gene level expression of NF-кB signaling markers such as IL-1β, TNF-α and COX-2 suggests the anti-inflammatory potential of DAH via inhibition of NF-кB activation.

关键词： diarylheptanoid NF-кB Lipopolysaccharide TNF-α COX-2 iNOS Cytokines

Two New diarylheptanoids from the Rhizomes of Zingiber officinale

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2004年第11期15卷 1306-1308页

作者： JianPingMA XiaoLingJIN LiYANG ZhongLiLIU NationalLaboratoryofAppliedOrganicChemistry LanzhouUniversityLanzhou730000

Two new diaryheptanoids, (5S)-5-acetoxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3- heptanone (1) and (3S,5S)-3,5-diacetoxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptane (2) were isolated from the rhizomes of Zingiber officina... 详细信息

关键词： Zingiber officinale diarylheptanoid (5S)-5-acetoxy-1,7-bis(4-hydroxy-3-methoxy- phenyl)-3-heptanone (3S,5S)-3,5-diacetoxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptane.

Antioxidant and Cytotoxic diarylheptanoids Isolated from Zingiber officinale Rhizomes

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2012年第6期30卷 1351-1355页

作者：李宁汪玲玉祖灵博王开金邸磊王志 Anhui Key Laboratory of Bioactivity of Natural Products School of PharmacyAnhui Medical UniversityHefeiAnhui 230032China Anhui Province Function Laboratory of Resource Use and Development of Traditional Chinese Medicine Materials School of Life SciencesAnhui UniversityHefeiAnhui 230039China

One new diarylheptanoid, namely （4E,6E）-7-（3,4-dihydroxy-5-methoxyphenyl）-1-（4-hydroxy-3-methoxyphenyl）- hepta-4,6-dien-3-one （1）, was isolated from the rhizomes of Zingiber officinale, along with ten known ones, tetra- hydrocurcumin （2）, curcumin （3）, 5-hydroxy-1,7-bis（4-hydroxy-3-methoxyphenyl）heptan-3-one （4）, gingerenone A （5）, 7-（3,4-dihydroxyphenyl）-5-hydroxy-1-（4-hydroxy-3-methoxyphenyl）heptan-3-one （6）, （E）-1,7-bis（4-hydroxy- 3-methoxyphenyl）hept-1-ene-3,5-dione （7）, （E）-7-（4-hydroxy-3-methoxyphenyl）-1-（4-hydroxyphenyl）-hept-l-ene- 3,5-dione （8）, shogasulfonic acid A （9）, 1,5-epoxy-3-hydroxy-1-（3,4-dihydroxy-5-methoxyphenyl）-7-（4-hydroxy-3- methoxyphenyl）heptane （10）, and （3S, SS）-3,5-diacetoxy-1,7-bis（3,4-dihydroxyphenyl）heptane （11）. Their structures were elucidated on the basis of spectral evidence and comparisons with literature data. The free radical scavenging activity of 1--11 was evaluated by the 1,l-diphenyl-2-picrylhydrazyl （DPPH） assay. Most of the isolated com- pounds were found to be better antioxidants than the positive control ascorbic acid. These compounds were also evaluated for their cytotoxicity against HeLa and MNK-45 cells using the MTT assay. Our results suggest that com- pounds 3 and 5-8 inhibited HeLa cells, and 3, 5, 7 and 8 inhibited MNK-45 cells. It was found that compound 5 was markedly cytotoxic against HeLa and MNK-45 cell lines with ICs0 values of 6.4 and 7.8 μmol/L, respectively.

关键词： Zingiber officinale diarylheptanoid NMR spectroscopy structure elucidation antioxidant and cyto-toxic activities

Bioactive diarylheptanoids from Alpinia coriandriodora

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2021年第1期11卷 63-72页

作者： Xiao-Li Cheng Han-Xiang Li Juan Chen Ping Wu Jing-Hua Xue Zhong-Yu Zhou Nia-He Xia Xiao-Yi Wei Key Laboratory of Plant Resources Conservation and Sustainable Utilization South China Botanical GardenChinese Academy of SciencesTianhe DistrictXingke Road 723Guangzhou 510650People’s Republic of China Guangdong Provincial Key Laboratory of Digital Botanical Garden South China Botanical GardenChinese Academy of SciencesXingke Road 723Tianhe DistrictGuangzhou 510650People’s Republic of China School of Life Sciences University of Chinese Academy of SciencesYuquanlu 19ABeijing 100049People’s Republic of China

Eight new diarylheptanoids,coriandralpinins A-H(1-8),were isolated from the rhizomes of Alpinia coriandriodora,an edible plant of the ginger *** structures,including the absolute configurations,were established by extensive spectroscopic analysis and ECD *** 1-8 have a 1,5-O-bridged diarylheptanoid structure featuring polyoxygenated aryl *** evaluated for intracellular antioxidant activity using t-BHP stressed RAW264.7 mac-rophages,all these compounds scavenged reactive oxygen species(ROS)in a concentration-dependent *** 3 and 5 also showed inhibitory activity against NO release in LPS-induced RAW 264.7 *** known flavonols,7,4′-di-O-methylkaempferol,7-O-methylquercetin,7,4′-di-O-methylquercetin,7,3′,4′-tri-O-methylquercetin,kaempferol 3-O-β-d-(6-O-α-l-rhamnopyranosyl)glucopyranoside,and 3-O-β-d-glucopyranuronosylquercetin were also isolated and characterized from the rhizomes.

关键词： Alpinia coriandriodora diarylheptanoid Antioxidant Anti-inflammatory

Two new compounds from Zingiber officinale

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2007年第10期18卷 1247-1249页

作者： Yu Zhao Qiao Feng Tao Rong Ping Zhang Chang Xin Zhou Hui Dou Shu Yun Shi Ye Cheng Xiao Lian Li Sun Su Zeng Ke Xin Huang Xiao Dong Zhang Xiao Kun Li Department of Traditional Chinese Medicine and Natural Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China College of Pharmacy Kunming College of Medicine Kunming 650031 China Pharmacy School of Wenzhou Medical College Wenzhou 325035 China

A new cyclic diarylheptanoid, 1,5-epoxy-3-hydroxy-1-（3-methoxy-4,5-dihydroxyphenyl）-7-（4-hydroxyphenyl）-heptane （1）, as well as a new monoterpene, 10-O-β-n-glucopyranosyl-hydroxy cineole （2） were isolated from the rhizomes of Zingiber officinale. The structures of compounds 1 and 2 were established based on their spectral data. In addition, the antioxidant activities of these compounds were also measured.

关键词： diarylheptanoid Monoterpene Zingiber officinale Antioxidant

Chemical constituents from the aerial parts of Musella lasiocarpa

在线全文

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2011年第1期1卷 41-47页

作者： Liao-Bin DONG Juan HE Xing-Yao LI Xing-De WU Xu DENG Gang XU Li-Yan PENG Yu ZHAO Yan LI Xun GONG Qin-Shi ZHAO State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Graduate University of Chinese Academy of Sciences Beijing 100039China

Phytochemical investigation of the aerial parts of the monotypic plant,Musella lasiocarpa,led to the isolation of four rare bicyclic diarylheptanoids,musellarins B-E(2-5),two new phenylphenalenones,2-methoxy-9-(3′,4′-dihydroxyphenyl)-1H-phenalen-1-one(9),2-methoxy-9-(3′-methoxy-4′-hydroxyphenyl)-1H-phenalen-1-one(10),a new acenaphtylene derivative,trans-(1S,2S)-3-(4′-methoxyphenyl)-acenaphthene-1,2-diol(13),and two new sucrose esters,1,2′,3′,4′,6′-O-pentaacetyl-3-O-trans-p-coumaroylsucrose(16),1,2′,3′,4′,6′-O-pentaacetyl-3-O-cis-p-coumaroylsucrose(17),together with nine known *** addition,(4E,6E)-1-(3′,4′-dihydroxyphenyl)-7-(4′′-hydroxyphenyl)-hepta-4,6-dien-3-one(15)was isolated for the first time from a natural *** structures of new compounds were elucidated by analysis of their spectroscopic *** 2,6,8-10,12,and 14 were cytotoxic toward several of the human tumor cell lines(HL-60,SMMC-7721,A-549,MCF-7,and SW480).Of these,the new compound 9 was the most potent one,with IC50 values of 5.8,10.3,6.3,3.3,and 2.3μM,respectively.

关键词： monotypic diarylheptanoid phenylphenalenone acenaphtylene sucrose ester Musella lasiocarpa