Chemical constituents from the aerial parts of Musella lasiocarpa
作者机构：State Key Laboratory of Phytochemistry and Plant Resources in West ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201China Graduate University of Chinese Academy of SciencesBeijing 100039China
出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)
年 卷 期：2011年第1卷第1期
页 面：41-47页
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：This work was financially supported by the National Basic Research Program of China(973 Program No.2009CB522303 and No.2011CB915503) the NSFC(No.U0932602) the National Natural Science Foundation of China(No.90813004) the State Key Laboratory of Phytochemistry and Plant Resources in West China(No.P2010-ZZ05)
主 题：monotypic diarylheptanoid phenylphenalenone acenaphtylene sucrose ester Musella lasiocarpa
摘 要：Phytochemical investigation of the aerial parts of the monotypic plant,Musella lasiocarpa,led to the isolation of four rare bicyclic diarylheptanoids,musellarins B-E(2-5),two new phenylphenalenones,2-methoxy-9-(3′,4′-dihydroxyphenyl)-1H-phenalen-1-one(9),2-methoxy-9-(3′-methoxy-4′-hydroxyphenyl)-1H-phenalen-1-one(10),a new acenaphtylene derivative,trans-(1S,2S)-3-(4′-methoxyphenyl)-acenaphthene-1,2-diol(13),and two new sucrose esters,1,2′,3′,4′,6′-O-pentaacetyl-3-O-trans-p-coumaroylsucrose(16),1,2′,3′,4′,6′-O-pentaacetyl-3-O-cis-p-coumaroylsucrose(17),together with nine known *** addition,(4E,6E)-1-(3′,4′-dihydroxyphenyl)-7-(4′′-hydroxyphenyl)-hepta-4,6-dien-3-one(15)was isolated for the first time from a natural *** structures of new compounds were elucidated by analysis of their spectroscopic *** 2,6,8-10,12,and 14 were cytotoxic toward several of the human tumor cell lines(HL-60,SMMC-7721,A-549,MCF-7,and SW480).Of these,the new compound 9 was the most potent one,with IC50 values of 5.8,10.3,6.3,3.3,and 2.3μM,respectively.
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