Bioactive Diarylheptanoids from Alpinia coriandriodora
作者机构：Key Laboratory of Plant Resources Conservation and Sustainable UtilizationSouth China Botanical GardenChinese Academy of SciencesTianhe DistrictXingke Road 723Guangzhou 510650People’s Republic of China Guangdong Provincial Key Laboratory of Digital Botanical GardenSouth China Botanical GardenChinese Academy of SciencesXingke Road 723Tianhe DistrictGuangzhou 510650People’s Republic of China School of Life SciencesUniversity of Chinese Academy of SciencesYuquanlu 19ABeijing 100049People’s Republic of China
出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)
年 卷 期：2021年第11卷第1期
页 面：63-72页
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 070303[理学-有机化学] 0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0817[工学-化学工程与技术] 0703[理学-化学] 0901[农学-作物学] 0902[农学-园艺学]
基 金：supported by NSFC Grants(Nos.81172942 and 81872773)
主 题：Alpinia coriandriodora Diarylheptanoid Antioxidant Anti-inflammatory
摘 要：Eight new diarylheptanoids,coriandralpinins A-H(1-8),were isolated from the rhizomes of Alpinia coriandriodora,an edible plant of the ginger *** structures,including the absolute configurations,were established by extensive spectroscopic analysis and ECD *** 1-8 have a 1,5-O-bridged diarylheptanoid structure featuring polyoxygenated aryl *** evaluated for intracellular antioxidant activity using t-BHP stressed RAW264.7 mac-rophages,all these compounds scavenged reactive oxygen species(ROS)in a concentration-dependent *** 3 and 5 also showed inhibitory activity against NO release in LPS-induced RAW 264.7 *** known flavonols,7,4′-di-O-methylkaempferol,7-O-methylquercetin,7,4′-di-O-methylquercetin,7,3′,4′-tri-O-methylquercetin,kaempferol 3-O-β-d-(6-O-α-l-rhamnopyranosyl)glucopyranoside,and 3-O-β-d-glucopyranuronosylquercetin were also isolated and characterized from the rhizomes.
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