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Pterocarine, a New Diarylheptanoid from Pterocarya tonkinesis, its Cell Cycle Inhibition at G_0/G_1 Phase and Induction of Apoptosis in HCT-15 and K562 Cells

Pterocarine, a New Diarylheptanoid from Pterocarya tonkinesis, its Cell Cycle Inhibition at G_0/G_1 Phase and Induction of Apoptosis in HCT-15 and K562 Cells

作     者:HongBingLIU ChengBinCUI BingCAI QianQunGU DongYunZHANG QingChunZHAO HuaShiGUAN 

作者机构:TianjinInstituteforBiomedicinalResearch(TIBiR)Tanjin300384 KeyLaboratoryofMarineDrugsMinistryofEducationChina MarineDrugandFoodInstituteOceanUniversityofChinaQingdao266003//BeijingInstituteofPharmacologyandToxicologyAMMSBeijing100850 KeyLaboratoryofMarineDrugsMinistryofEducationChina MarineDrugandFoodInstituteOceanUniversityofChinaQingdao266003 

出 版 物:《Chinese Chemical Letters》 (中国化学快报(英文版))

年 卷 期:2005年第16卷第2期

页      面:215-218页

核心收录:

学科分类:1008[医学-中药学(可授医学、理学学位)] 100703[医学-生药学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基  金:This work was supported by the Fund from the National Natural Science Foundation of China(C.-B.CUI,No.39825126) the Fund for the 973-project from Ministry of Science and Technology(C.-B.CUI,No.1998051113),China the Fund for Cheung Kong Scholar(C.B.CUI)from Cheung Kong Scholars Program,Ministry of Education of China 

主  题:Pterocarine diarylheptanoid phenolic compound structure cell cycle inhibitor apop-tosis inducer Pterocarya tonkinesis Juglandaceae. 

摘      要:Pterocarine (1), a new diarylheptanoidal compound, was isolated from Pterocaryatonkinesis (Franch.) Dode. together with a known diarylheptanoid, myricatomentogenin (2), througha bioassay-guided fractionation procedure. The structure of 1 was elucidated as (+)-3 , 4 -epoxy-1-(4 -hydroxyphenyl)-7-(3 -hydroxyphenyl)-heptane-3-one by the spectroscopic *** (1) inhibited the proliferation of tsFT210, HCT-15 and K562 cells with the inhibitionrates of 20.2±2.4, 23.8±2.4 and 50.5±1.2% at 100 μg/mL, respectively. Flow cytometric analysisindicated that 1 could inhibit the cell cycle of tsFT210, HCT-15 and K562 cells at the G0/G1 phaseand could also induce apoptosis in HCT-15 (19%) and K562 (11%) cells.

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