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Biocomposites:Their multifunctionality

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International Journal of Smart and Nano Materials 2010年第1期1卷 13-27页

作者： Kin-tak Lau Mei-po Ho Chi-ting Au-Yeung Hoi-yan Cheung Centre of Excellence in Engineered Fibre Composites Faculty of Engineering and SurveyingUniversity of Southern QueenslandQueenslandAustralia Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

During the last decade,tissue engineering has shown a considerable promise in providing more viable alternatives to surgical procedures for harvested tissues,implants and *** to the fast development on nano-and biomaterial technologies,it is now possible for doctors to use patients’cells to repair orthopaedic defects such as focal articular cartilage *** order to support the three-dimensional tissue formation,scaffolds made by biocompatible and bioresorbable polymers and composite materials,for providing temporary support of damaged body and cell structures,have been developed *** ceramic and metallic materials have been widely accepted for the development of implants,their non-resorbability and necessity of second surgical operation(like for bone repair),which induce extra pain for the patients,limit their wide *** development of different types of biocomposites for biomedical engineering applications is *** biocomposites include(i)basic biomaterials;(ii)natural fiber-reinforced biocomposites and(iii)nanoparticle-reinforced *** multifunctionality is discussed in terms of the control of mechanical properties,biodegradability and bioresorbability.

关键词： multifunctional materials biocomposite

ROAD+:Route Optimization with Additional Destination-Information and Its Mobility Management in Mobile Networks

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Journal of Computer Science & Technology 2010年第2期25卷 298-312页

作者： Moonseong Kim Matt W. Mutka Member, ACM Senior Member Jeonghoon Park Hyunseung Choo Department of Computer Science and Engineering Michigan State University East Lansing MI 48824 U.S.A. Digital Media and Communication Business Samsung Electronics Korea School of Information and Communication Engineering Sungkyunkwan University 440-746 Korea

In the NEtwork MObility （NEMO） environment, mobile networks can form a nested structure. In nested mobile networks that use the NEMO Basic Support （NBS） protocol, pinball routing problems occur because packets are routed to all the home agents of the mobile routers using nested tunneling. In addition, the nodes in the same mobile networks can communicate with each other regardless of Internet connectivity. However, the nodes in some mobile networks that are based on NBS cannot communicate when the network is disconnected from the Internet. In this paper, we propose a route optimization scheme to solve these problems. We introduce a new IPv6 routing header named ＂destination-information header＂（DH）, which uses DH instead of routing header type 2 to optimize the route in the nested mobile network. The proposed scheme shows at least 30% better performance than ROTIO and similar performance improvement as DBU in inter-route optimization. With respect to intra-route optimization, the proposed scheme always uses the optimal routing path. In addition, the handover mechanism in ROAD＋ outperforms existing schemes and is less sensitive to network size than other existing schemes.

关键词： NEtwork MObility (NEMO) route optimization (RO) NEMO basic support (NBS) pinball routing problem mobile network nested mobile network

Scalp electroacupuncture at the Baihui acupoint (DU 20) improves functional recovery in rats with cerebral ischemia Association with increased expression of vascular endothelial growth factors

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Neural Regeneration Research 2011年第36期6卷 2822-2828页

作者： Min-Wook Kim You Chul Chung Hee Chan Jung Moon-Seo Park Young-Min Han Yong-An Chung Lee-So Maeng Sang-In Park Jiyeon Lim Seung Chan Kim Woo-Seok Im Jin Young Chung Minky Kim Manho Kim Institute of Catholic Integrative Medicine (ICIM) Incheon St. Mary’s Hospital Catholic University of Korea Incheon Korea Department of Rehabilitation Medicine Catholic University of Korea Seoul Korea Department of Neurology Seoul National University Hospital SNUMRC Seoul Korea Department of Biotechnology Yonsei University Seoul Korea Department of Neurology Seoul Medical Center Seoul Korea

In this study, we induced cerebral infarction in rats by occluding the right middle cerebral artery, and tested the effects of electroacupuncture at the Baihui acupoint （DU 20）. Motor and sensory function was tested using Garcia’s scale and motor weakness grading, and the expression of vascular endothelial growth factor in the brain was quantified using immunoblotting and immunohistochemistry. We found that scalp electroacupuncture at DU 20 significantly improved motor performance and sensory function in rats with stroke, and this was accompanied by an increased expression of vascular endothelial growth factor in the ischemic brain tissue and peri-ischemic area. In addition, Pearson correlation analysis showed that the improvements in functional recovery were correlated with the increased expression of vascular endothelial growth factor.

关键词： electroacupuncture cerebrovascular disorder vascular endothelial growth factor Baihui acupoint functional improvement

Springback behavior of tailor rolled blank in U-shape forming

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Journal of Iron and Steel Research(International) 2017年第8期24卷 787-794页

作者： Ri-huan Lu Xiang-hua Liu Shou-dong Chen Lu Feng Xian-lei Hu Li-zhong Liu State Key Laboratory of Rolling&Automation Northeastern UniversityShenyang 110819LiaoningChina School of Materials Science and Engineering Northeastern UniversityShenyang 110819LiaoningChina

The springback of tailor rolled blanks with quenching and partitioning steels was *** order to find out the springback behavior and related influence factors for the novel sheets,both experimental and simulation methods have been used to compare and analyze the springback characteristics of equal thickness blanks and tailor rolled blanks in U-channel *** the results,the overall springback angles of tailor rolled blanks at thin and thick sides are respectively 106.79° and 99.705°,which are both lower than those of the corresponding equal thickness *** to the existence of the thickness transition zone,the stress distribution in thin and thick sides of blanks is *** location of dangerous region in thin side of tailor rolled blanks is closer to the end of side,and the thick side moved to the middle of straight wall,which are different with the equal thickness ***,the released quantitles of tangential stress and strain per unit section of blank are adopted to calculate relative springback angles and give novel evaluation criteria for qualitatively analyzing the amount of springback *** comparing the results,it shows that the tangential strain method is more suitable for the actual situation.

关键词： Tailor rolled blank Springback angle Elastic recovery Tangential stress Tangential strain

Control and Nash Games with Mean Field Effect

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Chinese Annals of Mathematics,Series B 2013年第2期34卷 161-192页

作者： Alain BENSOUSSAN Jens FREHSE International Center for Decision and Risk Analysis School of Management University of Texas-DallasFrance School of Business the Hong Kong Polytechnic University Graduate Department of Financial Engineering Ajou University Institute for Applied Mathematics University of Bonn

Mean field theory has raised a lot of interest in the recent years (see in particular the results of Lasry-Lions in 2006 and 2007,of Gueant-Lasry-Lions in 2011,of HuangCaines-Malham in 2007 and many others).There are a lot of *** general,the applications concern approximating an infinite number of players with common behavior by a representative *** agent has to solve a control problem perturbed by a field equation,representing in some way the behavior of the average infinite number of *** approach does not lead easily to the problems of Nash equilibrium for a finite number of players,perturbed by field equations,unless one considers averaging within different groups,which has not been done in the literature,and seems quite *** this paper,the authors approach similar problems with a different motivation which makes sense for control and also for differential *** the systems of nonlinear partial differential equations with mean field terms,which have not been addressed in the literature so far,are considered here.

关键词：平均场理论控制问题纳什均衡游戏场效应非线性偏微分方程应用程序场方程

Overcoming oral insulin delivery barriers： application of cell penetrating peptide and silica-based nanoporous composites

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Frontiers of Chemical Science and Engineering 2013年第1期7卷 9-19页

作者： Huining HE Junxiao YE Jianyong SHENG Jianxin WANG Yongzhuo HUANG Guanyi CHEN Jingkang WANG Victor C YANG School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China Department of Pharmaceutics School of Pharmacy Fudan University Key Laboratory of Smart Drug Delivery Ministry of Education & PLA Shanghai 201203 China Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China School of Environmental Science and Engineering State Key Laboratory of Engines Tianjin University Tianjin 300072 China Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of Pharmacy Tianjin Medical University Tianjin 300070 China Department of Pharmaceutical Sciences College of Pharmacy University of Michigan Michigan 48109-1065 USA

Oral insulin delivery has received the most attention in insulin formulations due to its high patient compliance and, more importantly, to its potential to mimic the physiologic insulin secretion seen in non-diabetic individuals. However, oral insulin delivery has two major limitations： the enzymatic barrier that leads to rapid insulin degradation, and the mucosal barrier that limits insulin＇s bioavailability. Several approaches have been actively pursued to circumvent the enzyme barrier, with some of them receiving promising results. Yet, thus far there has been no major success in overcoming the mucosal barrier, which is the main cause in undercutting insulin＇s oral bioavailability. In this review of our group＇s research, an innovative silica-based, mucoadhesive oral insulin formulation with encapsulated-insulin/cell penetrating peptide （CPP） to overcome both enzyme and mucosal barriers is discussed, and the preliminary and convincing results to confirm the plausibility of this oral insulin delivery system are reviewed. In vitro studies demonstrated that the CPPinsulin conjugates could facilitate cellular uptake of insulin while keeping insulin＇s biologic functions intact. It was also confirmed that low molecular weight protamine （LMWP） behaves like a CPP peptide, with a cell translocation potency equivalent to that of the widely studied TAT. The mucoadhesive properties of the produced silica-chitosan composites could be controlled by varying both the pH and composition; the composite consisting of chitosan （25wt-%） and silica （75 wt-%） exhibited the greatest mucoadhesion at gastric pH. Furthermore, drugrelease from the composite network could also be regulated by altering the chitosan content. Overall, the universal applicability of those technologies could lead to development of a generic platform for oral delivery of many other bioactive compounds, especially for peptide or protein drugs which inevitably encounter the poor bioavailability issues.

关键词： insulin cell penetrating peptide mucoadhesive composites oral delivery

EXPLICIT ERROR ESTIMATES FOR COURANT, CROUZEIX-RAVIART AND RAVIART-THOMAS FINITE ELEMENT METHODS

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Journal of Computational Mathematics 2012年第4期30卷 337-353页

作者： Carsten Carstensen Joscha Gedicke Donsub Rim Institut fur Mathematik Humboldt-Universitiit zu Berlin Unter den Linden 6 10099 Berlin Germany Department of Computational Science and Engineering Yonsei University 120-749 Seoul Korea Institut fur Mathematik Humboldt-Universitat zu Berlin Unter den Linden 6 10099 Berlin Germany Yonsei School of Business and Department of Computational Science and Engineering Yonsei University 120-749 Seoul Korea

The elementary analysis of this paper presents explicit expressions of the constants in the a priori error estimates for the lowest-order Courant, Crouzeix-Raviart nonconforming and P^viart-Thomas mixed finite element methods in the Poisson model problem. The three constants and their dependences on some maximal angle in the triangulation are indeed all comparable and allow accurate a priori error control.

关键词： Error estimates Conforming Nonconforming Mixed Finite element method.

Large deviation principle for diffusion processes under a sublinear expectation

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Science China Mathematics 2012年第11期55卷 2205-2216页

作者： CHEN ZengJing 1,2 & XIONG Jie 3,4,1 School of Mathematics,Shandong University,Jinan 250100,China 2 Department of Financial Engineering,Ajou University,Suwon 443749,Korea 3 Department of Mathematics,University of Macao,PO Box 3001,Macao,China 4 Department of Mathematics,University of Tennessee,Knoxville,TN 37996-1300,USA School of Mathematics Shandong University Jinan China Department of Financial Engineering Ajou University Suwon Korea Department of Mathematics University of Macau Macau China Department of Mathematics University of Tennessee Knoxville USA

We represent the exponential moment of the Brownian functionals under a nonlinear expectation according to the solution to a backward stochastic differential *** an application,we establish a large deviation principle of the Freidlin and Wentzell type under the corresponding nonlinear probability for diffusion processes with a small diffusion coefficient.

关键词：大偏差原理扩散过程期望次线性倒向随机微分方程扩散系数非线性概率

Ultrasound-mediated targeted microbubbles： a new vehicle for cancer therapy

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Frontiers of Chemical Science and Engineering 2013年第1期7卷 20-28页

作者： Junxiao YE Huining HE Junbo GONG Weibing DONG Yongzhuo HUANG Jianxin WANG Guanyi CHEN Victor C YANG School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China Department of Pharmaceutics School of Pharmacy Fudan University Key Laboratory of Smart Drug Delivery Ministry of Education & PLA Shanghai 201203 China School of Environmental Science and Engineering State Key Laboratory of Engines Tianjin University Tianjin 300072 China Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of Pharmacy Tianjin Medical University Tianjin 300070 China Department of Pharmaceutical Sciences College of Pharmacy University of Michigan Ann Arbor MI 48109-1065 USA

With the hope of overcoming the serious side effects, great endeavor has been made in tumor-targeted chemotherapy, and various drug delivery modalities and drug carriers have been made to decrease systemic toxicity caused by chemotherapeutic agents. Scientists from home and abroad focus on the research of targeted microbubbles contrast agent, and the use of the targeted ultrasound microbubble contrast agent can carry gene drugs and so on to the target tissue, as well as mediated tumor cell apoptosis and tumor microvascular thrombosis block, etc., thus plays the role of targeted therapy. Recent studies have elucidated the mechanisms of drug release and absorption, however, much work remains to be done in order to develop a successful and optimal system. In this review, we summarized the continuing efforts in under-standing the usage of the ultrasound triggered target microbubbles in cancer therapy, from release mechanism to preparation methods. The latest applications of ultra-sound-triggered targeted microbubbles in cancer therapy, especially in gene therapy and antiangiogenic cancer therapy were discussed. Moreover, we concluded that as a new technology, ultrasound-triggered targeted microbubbles used as drug carriers and imaging agents are still energetic and are very likely to be translated into clinic in the near future.

关键词： ultrasound-mediated targeted microbubbles cancer