Scalp electroacupuncture at the Baihui acupoint (DU 20) improves functional recovery in rats with cerebral ischemia Association with increased expression of vascular endothelial growth factors

作     者：Min-Wook Kim You Chul Chung Hee Chan Jung Moon-Seo Park Young-Min Han Yong-An Chung Lee-So Maeng Sang-In Park Jiyeon Lim Seung Chan Kim Woo-Seok Im Jin Young Chung Minky Kim Manho Kim 

作者机构：Institute of Catholic Integrative Medicine (ICIM) Incheon St. Mary’s Hospital Catholic University of Korea Incheon Korea Department of Rehabilitation Medicine Catholic University of Korea Seoul Korea Department of Neurology Seoul National University Hospital SNUMRC Seoul Korea Department of Biotechnology Yonsei University Seoul Korea Department of Neurology Seoul Medical Center Seoul Korea 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第36期

页      面：2822-2828页

核心收录：

学科分类：0710[理学-生物学] 1005[医学-中医学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100512[医学-针灸推拿学] 10[医学] 

基　　金：the Incheon St. Mary’s Hospital of the Catholic University of Korea  through the Clinical Research Laboratory Foundation Program  Korea Health 21 R&D Project  No. A092058  and WCU Neurocytomics 

主　　题：electroacupuncture cerebrovascular disorder vascular endothelial growth factor Baihui acupoint functional improvement 

摘      要：In this study, we induced cerebral infarction in rats by occluding the right middle cerebral artery, and tested the effects of electroacupuncture at the Baihui acupoint （DU 20）. Motor and sensory function was tested using Garcia’s scale and motor weakness grading, and the expression of vascular endothelial growth factor in the brain was quantified using immunoblotting and immunohistochemistry. We found that scalp electroacupuncture at DU 20 significantly improved motor performance and sensory function in rats with stroke, and this was accompanied by an increased expression of vascular endothelial growth factor in the ischemic brain tissue and peri-ischemic area. In addition, Pearson correlation analysis showed that the improvements in functional recovery were correlated with the increased expression of vascular endothelial growth factor.