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Polymer-based Nanogenerator for biomedical Applications

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Chemical Research in Chinese Universities 2020年第1期36卷 41-54页

作者： LI Jun LONG Yin WANG Xudong Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWisconsin 53706USA

Polymeric devices are the workhorses of modern *** one of the cutting-edge technology leveraging polymeric materials,nanogenerator that could convert micro-/nano-scale mechanical energy into electri-city based on the mechanism of piezoelectricity and triboelectricity exhibited great promise for biomedical applications,owning to the simple configuration,high efficiency,decent electrical output,biomimetic property as well as excellent *** this manuscript,the recent representative developments of NGs in biomedical applications are ***,such as working mechanisms underneath different NG prototypes are discussed,which is followed by innovative strategies endowing NG with biomimetic mechanical *** attempts to implement NG in specific biomedical fields(e.g.,power source for implantable medical devices,therapeutic electric stimulator,etc.)are introduced and *** manuscript ends up with subsection summarizing existed challenges while providing potential solutions for future NG developments in biomedical engineering.

关键词： Nanogenerator Polymeric material biomedical application

MXene‑Graphene Composites:A Perspective on biomedical Potentials

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Nano-Micro Letters 2022年第8期14卷 112-123页

作者： Ebrahim Mostafavi Siavash Iravani Stanford Cardiovascular institute Stanford University School of MedicineStanfordCA 94305USA Department of Medicine Stanford University School of MedicineStanfordCA 94305USA Faculty of Pharmacy and Pharmaceutical Sciences Isfahan University of Medical SciencesIsfahanIran

MXenes,transition metal carbides and nitrides with graphene-like structures,have received considerable attention since their first *** the other hand,Graphene has been extensively used in biomedical and medicinal *** and graphene,both as promising candidates of two-dimensional materials,have shown to possess high potential in future biomedical applications due to their unique physicochemical properties such as superior electrical conductivity,high biocompatibility,large surface area,optical and magnetic features,and extraordinary thermal and mechanical *** special structural,functional,and biological characteristics suggest that the hybrid/composite structure of MXene and graphene would be able to meet many unmet needs in different fields;particularly in medicine and biomedical engineering,where high-performance mechanical,electrical,thermal,magnetic,and optical requirements are ***,the hybridization and surface functionalization should be further explored to obtain biocompatible composites/platforms with unique physicochemical properties,high stability,and *** addition,toxicological and long-term biosafety assessments and clinical translation evaluations should be given high priority in *** very limited studies have revealed the excellent potentials of MXene/graphene in biomedicine,the next steps should be toward the extensive research and detailed analysis in optimizing the properties and improving their functionality with a clinical and industrial ***,different synthesis/fabrication methods and performances of MXene/graphene composites are discussed for potential biomedical *** potential toxicological effects of these composites on human cells and tissues are also covered,and future perspectives toward more successful translational applications are *** current state-of-the-art biotechnological advances in the use of MXene-Graphene composites,as wel

关键词： Graphene MXene Composites Hybrid structures Biocompatibility Cancer theranostics biomedical engineering

A Novel Vision of Reinforcing Nanofibrous Masks with Metal Nanoparticles:Antiviral Mechanisms Investigation

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Advanced Fiber Materials 2023年第4期5卷 1273-1317页

作者： Farinaz Hadinejad Hamed Morad Mohsen Jahanshahi Ali Zarrabi Hamidreza Pazoki‑Toroudi Ebrahim Mostafavi Nanotechnology Research institute Faculty of Chemical EngineeringBabol Noushirvani University of TechnologyBabol ***Iran Department of Pharmaceutics and Pharmaceutical Nanotechnology School of PharmacyIran University of Medical SciencesTehran ***Iran Ramsar Campus Mazandaran University of Medical SciencesRamsar ***Iran Department of biomedical Engineering Faculty of Engineering and Natural SciencesIstinye UniversityIstanbul 34396Turkey Physiology Research Center Faculty of MedicineIran University of Medical SciencesTehran ***Iran Department of Physiology Faculty of MedicineIran University of Medical SciencesTehran ***Iran Stanford Cardiovascular institute Stanford University School of MedicineStanfordCA 94305USA Department of Medicine Stanford University School of MedicineStanfordCA 94305USA

Prevention of spreading viral respiratory disease,especially in case of a pandemic such as coronavirus disease of 2019(COVID-19),has been proved impossible without considering obligatory face mask-wearing protocols for both healthy and contaminated *** widespread application of face masks for long hours and almost everywhere increases the risks of bacterial growth in the warm and humid environment inside the *** the other hand,in the absence of antiviral agents on the surface of the mask,the virus may have a chance to stay alive and be carried to different places or even put the wearers at risk of contamination when touching or disposing the *** this article,the antiviral activity and mechanism of action of some of the potent metal and metal oxide nanoparticles in the role of promising virucidal agents have been reviewed,and incorporation of them in an electrospun nanofibrous structure has been considered an applicable method for the fabrication of innovative respiratory protecting materials with upgraded safety levels.

关键词： Nanoshield Facemask Antiviral Metal nanoparticles Electrospinning Immunity booster

Surface hydrolysis-mediated PEGylation of poly(N-isopropyl acrylamide)based nanogels

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Regenerative Biomaterials 2017年第5期4卷 281-287页

作者： Jonathan T.Peters Stanley Verghese Deepak Subramanian Nicholas A.Peppas McKetta Department of Chemical Engineering The University of Texas at AustinAustinTXUSA institute for Biomaterials Drug Deliveryand Regenerative MedicineThe University of Texas at AustinAustinTXUSA Department of biomedical Engineering The University of Texas at AustinAustinTXUSA Department of Pediatrics and Department of Surgery and Perioperative CareDell Medical SchoolThe University of Texas at AustinAustinTXUSA Division of Pharmaceutics College of PharmacyThe University of Texas at AustinAustinTXUSA

In this work,poly(N-isopropyl acrylamide-co-acrylamide)[P(NIPAAm-co-AAm)]nanogels were modified by hydrolysis above the lower critical solution temperature(LCST)to localize carboxylic acid functional groups at the surface(surface hydrolysis).PNIPAAm copolymerized with 15%and 20%nominal AAm in the feed were prepared and compared to equivalent hydrogels with acrylic *** effect and extent of surface hydrolysis was confirmed by potentiometric titration and zeta *** surface modified nanogels were then modified with primary amine functionalized PEG *** hydrolysis-mediated PEGylation had little effect on the swelling response of the nanogels,while also preventing adsorption of model proteins in physiological relevant *** both 15%and 20%AAm gels both decreased protein adsorption,only the 20%AAm gels resulted in fully preventing protein *** results presented here point to surface hydrolysis as a new route to passivate nanogels for use in vivo.

关键词： PNIPMAAm hydrogels PEG passivation

Nanofiber matrix formulations for the delivery of Exendin-4 for tendon regeneration: In vitro and in vivo assessment

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Bioactive Materials 2023年第7期25卷 42-60页

作者： Sama Abdulmalik Jack Gallo Jonathan Nip Sara Katebifar Michael Arul Amir Lebaschi Lucas N.Munch Jenna M.Bartly Shilpa Choudhary Ivo Kalajzic Yeshavanth Kumar Banasavadi-Siddegowdae Syam P.Nukavarapu Sangamesh G.Kumbar Department of Orthopedic Surgery University of Connecticut HealthFarmingtonCTUSA Department of biomedical Engineering University of ConnecticutStorrsCTUSA Department of Materials Science and Engineering University of ConnecticutStorrsCTUSA Department of Physiology and Neurobiology University of ConnecticutStorrsCTUSA Department of Immunology Center on AgingUniversity of Connecticut HealthFarmingtonCTUSA Department of Reconstructive Sciences University of Connecticut HealthFarmingtonCTUSA Surgical Neurology Branch National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaMDUSA

Tendon and ligament injuries are the most common musculoskeletal injuries,which not only impact the quality of life but result in a massive economic *** interventions for tendon/ligament injuries utilize biological and/or engineered grafts to reconstruct damaged tissue,but these have *** matrices confer superior physicochemical properties over biological grafts but lack desirable bioactivity to promote tissue *** incorporating drugs can enhance bioactivity,large matrix surface areas and hydrophobicity can lead to uncontrolled burst release and/or incomplete release due to *** overcome these limitations,we evaluated the delivery of a peptide growth factor(exendin-4;Ex-4)using an enhanced nanofiber matrix in a tendon injury *** overcome drug surface binding due to matrix hydrophobicity of poly(caprolactone)(PCL)-which would be expected to enhance cell-material interactions-we blended PCL and cellulose acetate(CA)and electrospun nanofiber matrices with fiber diameters ranging from 600 to 1000 *** avoid burst release and protect the drug,we encapsulated Ex-4 in the open lumen of halloysite nanotubes(HNTs),sealed the HNT tube endings with a polymer blend,and mixed Ex-4-loaded HNTs into the polymer mixture before *** reduced burst release from~75%to~40%,but did not alter matrix morphology,fiber diameter,or tensile *** evaluated the bioactivity of the Ex-4 nanofiber formulation by culturing human mesenchymal stem cells(hMSCs)on matrix surfaces for 21 days and measuring tenogenic differentiation,compared with nanofiber matrices in basal media ***,we observed that Ex-4 nanofiber matrices accelerated the hMSC proliferation rate and elevated levels of sulfated glycosaminoglycan,tendon-related genes(Scx,Mkx,and Tnmd),and ECM-related genes(Col-Ⅰ,Col-Ⅲ,and Dcn),compared to *** then assessed the safety and efficacy of Ex-4 nanofiber matrices in a full-thickness rat Achilles tendon

关键词： Nanofiber matrix formulation Protein delivery Soft tissue regeneration Halloysite nanotubes

MEMS-in-the-lens architecture for a miniature high-NA laser scanning microscope

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Light(Science & Applications) 2019年第1期8卷 665-675页

作者： Tianbo Liu Milind Rajadhyaksha David L.Dickensheets Electrical and Computer Engineering Department Montana State UniversityBozemanMT 59715USA Dermatology Department Memorial Sloan Kettering Cancer CenterNew YorkNY 10022USA

Laser scanning microscopes can be miniaturized for in vivo imaging by substituting optical microelectromechanical system(MEMS)devices in place of larger *** emergence of multifunctional active optical devices can support further miniaturization beyond direct component replacement because those active devices enable diffraction-limited performance using simpler optical system *** this paper,we propose a catadioptric microscope objective lens that features an integrated MEMS device for performing biaxial scanning,axial focus adjustment,and control of spherical *** MEMS-in-the-lens architecture incorporates a reflective MEMS scanner between a low-numerical-aperture back lens group and an aplanatic hyperhemisphere front refractive element to support high-numerical-aperture *** implemented this new optical system using a recently developed hybrid polymer/silicon MEMS three-dimensional scan mirror that features an annular aperture that allows it to be coaxially aligned within the objective lens without the need for a beam *** optical performance of the active catadioptric system is simulated and imaging of hard targets and human cheek cells is demonstrated with a confocal microscope that is based on the new objective lens design.

关键词： scanning scanner mirror

To manage long COVID by selective SARS-CoV-2 infection biosensing

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The Innovation 2022年第5期3卷 9-10页

作者： Ajeet Kaushik Ebrahim Mostafavi NanoBiotech Laboratory Department of Environmental EngineeringFlorida Polytechnic UniversityLakelandFLUSA Stanford Cardiovascular institute Stanford University School of MedicineStanfordCA 94305USA Department of Medicine Stanford University School of MedicineStanfordCA 94305USA

According to the national institutes of Health(NIH),the initiative of The Rapid Acceleration of Diagnostics Tech and Advanced Technology Platforms(RADxTech/ATP)program was established to promote research and development(R&D)in the field of investigating selective,sensitive,and affordable sensing technologies for coronavirus disease 2019(COVID-19)*** is a goaloriented approach toward point-of-care testing(POCT)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection management *** May 2022,RADxTech/ATP has been involved in 1.9 billion tests production,44 FDA authorized tests,first over-the-counter test for POCT and home-based testing,and>100 companies dedicated to smart sensor development(https://***/covid-19/radx-tech-program/radx-tech-dashboard).Despite such outstanding growth,COVID-19 management is far from in control due to SARS-CoV-2 mutations,virus presence in life systems(including human-to-human transmission,water,food,animal,and air[mainly indoor premises])。

关键词： POCT infection acute

Activatable nanoscale metal-organic framework for ratiometric photoacoustic imaging of hydrogen sulfide and orthotopic colorectal cancer in vivo

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Science China Chemistry 2020年第9期63卷 1315-1322页

作者： Wenmin Zhang Jun Wang Lichao Su Hui Chen Lan Zhang Lisen Lin Xiaoyuan Chen Jibin Song Huanghao Yang College of Chemical Engineering Fuzhou UniversityFuzhou 350116China Key Laboratory for Analytical Science of Food Safety and Biology Ministry of EducationCollege of ChemistryFuzhou UniversityFuzhou 350116China Laboratory of Molecular imaging and Nanomedicine National Institute of Biomedical Imaging and BioengineeringNational Institutes of HealthBethesdaMD 20892USA

Nanoscale metal-organic frameworks(nano MOFs)have emerged as a promising biomedical nanoplatform because of their unique ***,the exploration of nano MOFs in photoacoustic(PA)imaging is still ***,a novel hydrogen sulfide(H2 S)-activated nano copper-based MOF(Cu-MOF)was developed as a near-infrared(NIR)ratiometric PA probe for in vivo monitoring of endogenous H2 S level and orthotopic colorectal cancer imaging via in situ reaction of nano Cu-MOFs with endogenous H2 S that is closely associated with tumor growth and proliferation in colon *** synthesized nano Cu-MOFs displayed excellent PA responsiveness towards tumor H2 S level with high selectivity and rapid *** result suggests the developed probe may provide a unique opportunity to investigate the malignant behaviors of H2 S-associated events in vivo.

关键词： PA imaging MOFs ratiometric probe H2S orthotopic colorectal cancer

Machine learning in neurological disorders:A multivariate LSTM and AdaBoost approach to Alzheimer's disease time series analysis

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Health Care Science

Health Care Science 2024年第1期3卷 41-52页

作者： Muhammad Irfan Seyed Shahrestani Mahmoud Elkhodr School of Computer Data and Mathematical SciencesWestern Sydney UniversitySydneyAustralia School of Engineering and Technology Central Queensland UniversitySydneyAustralia

Introduction:Alzheimer's disease(AD)is a progressive brain disorder that impairs cognitive functions,behavior,and *** detection is crucial as it can slow down the progression of ***,early diagnosis and monitoring of AD's advancement pose significant challenges due to the necessity for complex cognitive assessments and medical ***:This study introduces a data acquisition technique and a preprocessing pipeline,combined with multivariate long short-term memory(M-LSTM)and AdaBoost *** models utilize biomarkers from cognitive assessments and neuroimaging scans to detect the progression of AD in patients,using The AD Prediction of Longitudinal Evolution challenge cohort from the Alzheimer's Disease Neuroimaging Initiative ***:The methodology proposed in this study significantly improved performance *** testing accuracy reached 80%with the AdaBoost model,while the M-LSTM model achieved an accuracy of 82%.This represents a 20%increase in accuracy compared to a recent similar ***:The findings indicate that the multivariate model,specifically the M-LSTM,is more effective in identifying the progression of AD compared to the AdaBoost model and methodologies used in recent research.

关键词： Alzheimer's disease AdaBoost cognitive data multivariate LSTM neuroimaging data