Surface hydrolysis-mediated PEGylation of poly(N-isopropyl acrylamide)based nanogels

作     者：Jonathan T.Peters Stanley Verghese Deepak Subramanian Nicholas A.Peppas 

作者机构：McKetta Department of Chemical EngineeringThe University of Texas at AustinAustinTXUSA Institute for BiomaterialsDrug Deliveryand Regenerative MedicineThe University of Texas at AustinAustinTXUSA Department of Biomedical EngineeringThe University of Texas at AustinAustinTXUSA Department of Pediatricsand Department of Surgery and Perioperative CareDell Medical SchoolThe University of Texas at AustinAustinTXUSA Division of PharmaceuticsCollege of PharmacyThe University of Texas at AustinAustinTXUSA 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2017年第4卷第5期

页      面：281-287页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：National Institute of Biomedical Imaging and Bioengineering(NIBIB) the National Institutes of Health(NIH)(R21 EB012726-03A1) 

主　　题：PNIPMAAm hydrogels PEG passivation 

摘      要：In this work,poly(N-isopropyl acrylamide-co-acrylamide)[P(NIPAAm-co-AAm)]nanogels were modified by hydrolysis above the lower critical solution temperature(LCST)to localize carboxylic acid functional groups at the surface(surface hydrolysis).PNIPAAm copolymerized with 15%and 20%nominal AAm in the feed were prepared and compared to equivalent hydrogels with acrylic *** effect and extent of surface hydrolysis was confirmed by potentiometric titration and zeta *** surface modified nanogels were then modified with primary amine functionalized PEG *** hydrolysis-mediated PEGylation had little effect on the swelling response of the nanogels,while also preventing adsorption of model proteins in physiological relevant *** both 15%and 20%AAm gels both decreased protein adsorption,only the 20%AAm gels resulted in fully preventing protein *** results presented here point to surface hydrolysis as a new route to passivate nanogels for use in vivo.