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Journal of Traditional Chinese medical Sciences 2024年第3期11卷 303-315页

作者： Jiayu Sheng Junyi Cheng Wenjie Chu Mengting Dong Ke Jiang Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese MedicineShanghai 200437China

Objective To investigate the mechanism underlying the effects exerted by the Qizhu prescription(QZP)in breast cancer(BC),and the respective *** Expression data from the ArrayExpress and The Cancer Genome Atlas(TCGA)were used to identify differentially expressed genes(DEGs)in *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses were performed on the DEGs to identify genes involved in protein–protein *** docking was used to explore the dynamic relationship between active molecules and *** function experiments and animal studies were conducted to evaluate the effects of hub genes and active QZP compounds on BC cell *** Among the 25 evaluated BC-related targets of QZP,matrix metalloproteinase-1(MMP1)and epidermal growth factor receptor(EGFR)exhibited the highest degrees of *** and KEGG enrichment analyses revealed that the anti-BC targets of QZP primarily affected drug responses and pathways in cancer *** docking analysis suggested potential interactions between EGFR and quercetin/luteolin,as well as between MMP1 and luteolin/kaempferol/*** significantly reduced BC cell proliferation,migration,invasion,and tumor development in *** of BC cells with quercetin decreased the expression or activation of several associated *** The findings of our study provide new insights into the therapeutic potential of traditional Chinese medicine against BC,with particular reference to QZP.

关键词： Traditional Chinese medicine Qizhu prescription Breast cancer Quercetin Network pharmacology

Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli Yuan Tianjie Lyu Ling Zhang Meng Wang Zhiying He Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research center of Stem Cells Translational Medicine ShanghaiChina National center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

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Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2024年

作者： Jinliang Wang Wenyong Zhou Yu Xu Jianchun Duan Qiaoxia Zhou Guoqiang Wang Leo Li Chunwei Xu Wenxian Wang Shangli Cai Zhijie Wang Jie Wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest Hospital School of Medicine Shanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular Oncology Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers, the non-squamous and squamous subtypes （nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology, and potential genomic correlates affecting responses to immune checkpoint inhibitor （ICI）-based treatments. In our inhouse training cohort （n=85）, the presence of the LRP1B deleterious mutation （LRP1B-del） was associated with longer and shorter progression-free survival （PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs, respectively (Pinteraction=0.008). These results were validated using a larger public ICI cohort (n=208, Pinteraction<0.001). Multiplex immunofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+T cells in nsqNSCLCs （P=0.040） and sqNSCLCs （P=0.014）, respectively. In the POPLAR/OAK cohort, nsqNSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel (hazard ratio （HR）=0.70, P=0.046), whereas this benefit was negligible in those without LRP1B-del （HR=1.05, P=0.64）. Conversely, sqNSCLCs without LRP1Bdel benefited more from atezolizumab （HR=0.60, P=0.002） than those with LRP1B-del （HR=1.30, P=0.31）. Consistent results were observed in the in-house CHOICE-01 cohort, in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone (Pinteraction=0.008). This multi-cohort study delineates the antithetical impacts of LRP1Bdel in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy alone. Our findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs, emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

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The compounds fromDerris laxiflora Benth suppresses lipopolysaccharideinduced inflammatory response in murine Raw264.7 cells

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中国药理学与毒理学杂志 2015年第S1期29卷 64-65页

作者： Ai-jen YANG Hsi-lin CHIU Ming-yu CHAO Jui-ching CHEN Department of Biotanicals Medical and Pharmaceutical Industry Technology and Development Center

OBJECTIVE The emerging role of chronic inflammation is the major degenerative diseases of modern society such as periodontitis,atherosclerosis,rheumatoid arthritis,Parkinson′s disease and even *** components were isolated from Derris laxiflora Benth.,In this study,we found these compounds from Derris laxiflora Benth suppress lipopolysaccharide-induced inflammatory response in murine macrophage(RAW 264.7)*** RAW 264.7cells were cultured in DMEM media supplemented with 10%(V/V)heated-inactivated FBS,penicillin 100U·mL-1 and streptomycin 100μg·*** cells were incubated at 37℃in a humidified atmosphere of 5%CO2in ***264.7cells were seeded in a 24-well plate at a density of 2×105 mL-1 and then incubated with or without LPS(100ng·mL-1)in the absence or presence of compounds for 24 *** of these isolates on NO production were measured indirectly by analysis of nitrite levels using the Griess *** was used as a positive *** ight components were isolated from Derris laxiflora Benth.,including three new pterocarpans 7,6′-dihydroxy-3′-methoxypterocarpan(1),derrispisatin(2),derriscoumaronochromone(3)and three new flavonoids cis-3,4′-dihydroxy-5,7-dimethoxyflavan(4),derriflavanone B(5),iso-lupinenol(6)as well as two known ones,lonchocarpol A(7)and lonchocarpol D(8).The structures of these new compounds were determined by analysis of their spectroscopic ***264.7 cells were treated with the compounds from Derris laxiflora Benth for 24 *** them,compounds 5,7 and 8 significantly suppressed the NO production in LPS-treated RAW264.7 cells with IC50 values<10μg·*** In this study,we found that compounds from Derris laxiflora Benth suppresses lipopolysaccharide-induced inflammatory response in murine Raw264.7 cells.

关键词： lipopolysaccharide RAW264.7cells Derris laxiflora

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网络药理学与验证性实验分析阐释芪术方治疗乳腺癌的药理机制（英文）

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Journal of Traditional Chinese medical Sciences 2024年第3期 303-315页

作者：盛佳钰陈珺怡褚雯婕董梦婷江科上海中医药大学附属岳阳中西医结合医院乳腺病科

目的：芪术方(QZP)化裁自经验方“乳癌术后方”，临床使用具有提高患者生活质量、降低复发转移风险的等特点，但是其作用机制尚待完善，本研究旨在探索芪术方在乳腺癌中的具体机制与作用靶点。方法：利用Array Express和癌症基因组图谱(... 详细信息

目的：芪术方(QZP)化裁自经验方“乳癌术后方”，临床使用具有提高患者生活质量、降低复发转移风险的等特点，但是其作用机制尚待完善，本研究旨在探索芪术方在乳腺癌中的具体机制与作用靶点。方法：利用Array Express和癌症基因组图谱(TCGA)的表达数据，鉴定乳腺癌中的差异表达基因(DEGs)。对这些DEGs进行基因本体(GO)和京都基因与基因组百科全书(KEGG)富集分析，以达到识别参与蛋白质-蛋白质相互作用的基因的目的。采用分子对接技术探索活性分子与靶点之间的动态关系。通过细胞功能实验和动物研究评估关键基因和活性，探讨QZP化合物对乳腺癌肿瘤细胞生物学行为的影响。结果：在评估的25个与乳腺癌相关的QZP靶点后，基质金属蛋白酶-1(MMP1)和表皮生长因子受体(EGFR)表现的失调强度最高。GO和KEGG富集分析表明，QZP的抗乳腺癌靶点主要影响药物敏感性和肿瘤细胞通路。分子对接分析表明，EGFR与槲皮素/木犀草素、MMP1与木犀草素/山奈酚/槲皮素之间分别存在潜在的相互作用。槲皮素能够显著减少乳腺癌细胞的增殖、迁移、侵袭，抑制体内肿瘤的发生发展。利用QZP活性成分槲皮素处理乳腺癌细胞后，多种乳腺癌相关蛋白的表达活性降低。结论：本研究筛选分析了QZP治疗乳腺癌潜在的靶点与通路，验证了槲皮素作为QZP中的活性成分，可以通过降低乳腺癌细胞的增殖、迁移和侵袭，为中医癌症治疗的进一步研究奠定了基础。

关键词：中医药治疗芪术方乳腺癌槲皮素网络药理学

Gene editing particle system as a therapeutic approach for drug-resistant colorectal cancer

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Nano Research 2020年第6期13卷 1576-1585页

作者： Jee-Yeon Ryu You Jung Choi Eun-Jeong Won Emmanuel Hui Ho-Shik Kim Young-Seok Cho Tae-Jong Yoon Laboratory of Nanopharmacy College of PharmacyResearch Institute of Pharmaceutical Science and Technology(RIPST)Ajou UniversitySuwon16499Republic of Korea Division of Gastroenterology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul06591Republic of Korea Moogene Medi Co. Ltd.Seongnam13488Republic of Korea

The epidermal growth factor receptor(EGFR)pathway plays an important role in the progression of colorectal cancer(CRC).Anti-EGFR drugs based on antibodies have been widely used for treating CRC through inducing the cell death ***,the majority of CRC patients will inevitably develop drug-resistance during anti-EGFR drug treatment,which is mainly caused by a point mutation in the KRAS *** developed a nanoliposomal(NL)particle containing the Cas9 protein and a single-guide RNA(sgRNA)complex(Cas9-RNP),for genomic editing of the KRAS *** NL particle is composed of bio-compatible lipid compounds that can effectively encapsulate *** modifying the NL particle to include the appropriate antibody,it can specifically recognize EGFR expressing CRC and effectively deliver the gene-editing *** conditions of NL treatment were optimized using a KRAS mutated CRC in vivo mouse *** with KRAS-mutated CRC showed drug resistance against cetuximab,a therapeutic antibody *** treating the mice with the KRAS gene-editing NL particles,the implanted tumors showed a dramatic decrease in *** results demonstrated that this genomic editing complex has great potential as a therapeutic carrier system for the treatment of drug-resistant cancer caused by a point mutation.

关键词： nanoliposome clustered regularly interspaced short palindromic repeat and associated Cas9 nuclease(CRISPR/Cas9) KRAS mutation drug-resistance colorectal cancer

Surgical failure after colonic stenting as a bridge to surgery

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World Journal of Gastroenterology 2014年第33期20卷 11826-11834页

作者： Jung Ho Kim Kwang An Kwon Jong Joon Lee Won-Suk Lee Jeong-Heum Baek Yoon Jae Kim Jun-Won Chung Kyoung Oh Kim Dong Kyun Park Ju Hyun Kim Department of Internal Medicine Gachon University Gil Medical Center Incheon 405760 South Korea Department of Surgery Gachon University Gil Medical Center Incheon 405760 South Korea

AIM: To identify risk factors for surgical failure after colonic stenting as a bridge to surgery in left-sided malignant colonic obstruction.

关键词： Colorectal neoplasms Endoscopy Intesti-nal obstruction Risk factors Stents

Endoscopic stenting for recurrence-related colorectal anastomotic site obstruction:Preliminary experience

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World Journal of Gastroenterology 2014年第38期20卷 13936-13941页

作者： Jung Ho Kim Jong Joon Lee Jae Hee Cho Kyoung Oh Kim Jun-Won Chung Yoon Jae Kim Kwang An Kwon Dong Kyun Park Ju Hyun Kim Department of Internal Medicine Gachon University Gil Medical Center

AIM: To evaluate the efficacy of stents in treating patients with anastomotic site obstructions due to cancer recurrence following colorectal surgery.

关键词： Colorectal neoplasms Endoscopy Intestinal obstruction Stents Surgical anastomosis

Exploring the Mechanism of Tripterygium wilfordii Against Cancer Using Network Pharmacology and Molecular Docking

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World Journal of Traditional Chinese Medicine 2022年第3期8卷 417-425页

作者： Shui-Xiu Xiao Shao-Jin Li Wan-Xian Fang Jv Chen Hai-Jian Li Yong-Li Situ Obstetrics and Gynecology Shenzhen Longhua District Central HospitalShenzhen 518110GuangdongChina medical Laboratory Shenzhen Longhua District Central HospitalShenzhen 518110GuangdongChina Research Department Guangzhou Darui Biotechnology Co.Ltd.Guangzhou 510670GuangdongChina Department of Pharmacy Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524023GuangdongChina Department of Clinical Laboratory Medicine Guangdong Second Provincial Central HospitalGuangzhou 510317GuangdongChina College of Pharmacy Jinan UniversityGuangzhou 510632GuangdongChina

Background: The root of Tripterygium wilfordii(Tripterygii radix), a natural powerful traditional Chinese medicine(TCM) for various diseases treatment, has been used for centuries in the Asian countries as anti-rheumatoid arthritis(RA) agent, antioxidant agent, and anti-inflammatory agent. Its combination with other herbs in treating RA has been explored. The anti-RA effect of T. wilfordii for cancer treatment has been supported by some evidence. Aims and Objectives: To investigate the anticancer mechanism of T. wilfordii, bioinformatics databases were used to identify its active ingredients. Materials and Methods: Target proteins associated with cancer were determined using a network pharmacology analysis platform, and 25 key active compounds and 55 key targets of T. wilfordii were identified in our study. A common potential mechanism of T. wilfordii involvement in cancer was disclosed by in-depth network analysis of diseases, functions, and ***, the analysis results of the TCM-disease target protein interaction network revealed 5 potential targets;subsequently, a total of 30targets(these 5 targets, as well as 25 previously identified compounds) were subjected to molecular docking. Results: Our results showed that the therapeutic effect of T. wilfordii in cancer is characterized by multiple components, targets, and pathways. The regulation of signaling pathways such as Kaposi sarcoma-associated herpes virus infection, colorectal cancer, small-cell lung cancer, and prostate cancer may be the important pharmacodynamic basis of anticancer therapy. Conclusion: Triptonoditerpenic acid inhibited proliferation and induced apoptosis in SW480 cells. The mechanism may be related to the downregulation of Bcl-2 expression, upregulation of Bax mRNA expression, and expression inhibition of PTGS2.

关键词： Tripterygium wilfordii cancer network pharmacology molecular docking

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Recent advances in electronic devices for monitoring and modulation of brain

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Nano Research 2021年第9期14卷 3070-3095页

作者： Yong Won Kwon Yoon Sun Jun Young-Geun Park Jiuk Jang Jang-Ung Park Nano Science technology Institute Department of Materials Science and EngineeringYonsei UniversitySeoul 03722Republic of Korea center for Nanomedicine Institute for Basic Science(IBS)Seoul 03722Republic of Korea Graduate Program of Nano Biomedical Engineering(NanoBME) Advanced Science InstituteYonsei UniversitySeoul 03722Republic of Korea

The brain is actuated by billions of neurons with trillions of interconnections that regulate human *** the mechanisms of these systems that induce sensory reactions and respond to disease remains one of the greatest challenges in science,engineering,and *** advances in nanomaterials and nanotechnologies have led to the extensive research of electronic devices for brain interfaces to better understand the neural activities of the brains complex nervous *** development of sensor devices for monitoring the physiological signals of the brain related to traumatic injury status has accompanied by the progress of electronic neural probes in *** addition,these neurological and stereotactic surgical revolutions hold immense potential for clinical analysis of pharmacological systems within cerebral ***,we review the progress of electronic devices interfacing with brain in terms of the materials,fabrication technologies,and device *** activity can be measured and modulated by brain probes based on newly developed nanofabrication ***,in vivo pathological monitoring of the brain and pharmacological assessment has been developed in miniaturized and wireless *** also consider the key challenges and prospects for further development,and explore the future directions emerging in the latest research.

关键词： neural interfaces neural recording neuromodulation intracranial pressure monitoring microfluidic drug delivery