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Insight into Crosstalk Between Mitophagy and Apoptosis/Necroptosis:Mechanisms and Clinical Applications in Ischemic Stroke

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Current Medical Science 2022年第2期42卷 237-248页

作者： Yan-di YANG zi-xin li Xi-min HU Hao WAN Qi ZHANG Rui XIAO Kun XIONG Department of Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangsha 410013China Clinical Medicine Eight-year Program 03 Class18 GradeXiangya School of MedicineCentral South UniversityChangsha 410013China Clinical Medicine Eight-Year Program 02 Class17 GradeXiangya School of MedicineCentral South UniversityChangsha 410013China Administrative Office the Third Xiangya HospitalCentral South UniversityChangsha 410013China Hunan Key Laboratory of Ophthalmology Changsha 410008China Key Laboratory of Emergency and Trauma Ministry of EducationCollege of Emergency and TraumaHainan Medical UniversityHaikou 571199China

Ischemic stroke is a serious cerebrovascular disease with high morbidity and *** a result of ischemia-reperfusion,a cascade of pathophysiological responses is triggered by the imbalance in metabolic supply and demand,resulting in cell *** cellular injuries follow various molecular mechanisms solely or in combination with this *** play a driving role in the pathophysiological processes of ischemic *** ischemic stroke occurs,damaged cells would respond to such stress through *** is known as a conservatively selective autophagy,contributing to the removal of excessive protein aggregates and damaged intracellular components,as well as aging *** mitophagy may exert neuroprotection against *** pathways associated with the mitochondrial network collectively contribute to recovering the homeostasis of the neurovascular ***,excessive mitophagy would also promote ischemia-reperfusion ***,mitophagy is a double-edged sword,which suggests that maximizing the benefits of mitophagy is one of the direction of future *** review emphasized the role of mitophagy in ischemic stroke,and highlighted the crosstalk between mitophagy and apoptosis/necroptosis.

关键词： mitophagy ischemic stroke apoptosis necroptosis clinical application crosstalk

The basic core traditional C hinese medicine for the prevention and treatment of COVID-19 and its active mechanisms

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Pharmacology Discovery 2024年第1期4卷 21-30页

作者： Zhe Xu zi-xin li zi-Yao Geng Rong-li Shu Hui-Fang Zhou Yu-Hong Bian School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Oncology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300380China

Background:COVID-19 has had a dramatic impact on human health,economies,societies,and livelihoods around the *** Chinese medicine(TCM)formulae have played an important role in the prevention and treatment of *** evaluated the role of TCM in treating of COVID-19 and encouraged other countries to promote the use of TCM ***,the key is to find the basic core traditional Chinese medicine(BC-TCM)among those ***:For the first time,we mined the data of TCM formulae in CNIPA and analyzed herb characteristics and association *** then determined the BC-TCM and screened main compounds and therapeutic ***,the potential molecular mechanisms were explored by using enrichment analyses and molecular ***:This study screened 123 patented TCM formulae,including 312 *** to frequency statistics and association rules,nine herbs(Gan Cao,Jin Yinhua,Guang Huoxiang,Fu ling,Huang Qi,Jie Geng,lian Qiao,Cang Zhu,Ku xingren)were selected as the *** BC-TCM involved 166 main compounds and 48 therapeutic *** active compounds Hederagenin,Spinasterol,Beta-sitosterol,and liquiritin had high binding activity to the COVID-19 targets 3CL,ACE2,and core targets RELA,HSP90AA1,STAT3,MAPK3,and TP53 according to molecular docking ***,Hederagenin might be a potential compound for the prevention and treatment of ***:Our research predicted and confirmed the preventive therapeutic effect of BC-TCM on *** has the potential to broaden the scope of TCM,guide people in using clinical formulae,and provide valuable insights for future TCM discovery research.

关键词： COVID-19 traditional Chinese medicine China national intellectual property administration data mining network pharmacology

Synthesis and Characterization of a Novel β-cyclodextrin Fluorescent Probe

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复旦学报（自然科学版） 2007年第5期46卷 780-781页

作者： Sheng-mei Song1, Dai-zi Zhou, Du-xin li, Chuan Dong, Pei-hua lin(Department of Chemistry, Shanxi University, Taiyuan 030006, China) Department of Chemistry Shanxi University Taiyuan 030006

1 Introduction In recent years, new development for the fluorescent chemical sensor has made the method and application of fluorescent probes been greatly enhanced and extended fully. Fluorescent probes has important value not only in research of pharmacology and physiology, but also has made great contribution in environmental science, information science *** modified by fluorescence group as a spectral probe in supramolecular chemistry has important applications, and Japan's Ueno researc...

关键词： β-CD carbazole fluorescent probe synthesis

Nitrido-osmium（Ⅵ） bidentate pyrazolate complexes induces apoptosis in HepG2 cells via mitochondrial pathway

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Nitrido-osmium（Ⅵ） bidentate pyrazolate complexes induces ...

Salvage radical prostatectomy for radiorecurrent prostate cancer： the Chinese experience

第十一届全国化学生物学学术会议

作者： Chuang-Xian Wang Peng-Chao-Ji zi-xin li Wen-Xiu Ni Department of Chemistry Shantou University Medical College

Osmium complexes are potential anticancer candidates which act through different mechanisms from cisplatin-based chemotherapy regimens. Some research suggests that osmium complexes have shown promising anti-tumor effects in vitro and in vivo[1, 2]. Here, three Nitrido-osmium（VI） bidentate pyrazolate complexes are synthesized and characterized. The cytotoxicity of these Os（VI） complexes is correlated with different the ester group on ligands. Further studies show that complex OsN-Propyl induce caspase-dependent apoptosis through cellular ATP depletion, reactive oxygen species elevation, mitochondrial membrane potential reduction in HepG2 cells. Studies on its mechanism of action have shown that the complex OsN-Propyl can induce programmed apoptosis through endogenous and exogenous action pathways. Moreover, the complex OsN-Propyl showed good inhibition tumor growth in a mouse xenograft tumor model.

关键词： Nitrido-osmium Ester base Cell apoptosis Antitumor activity

来源： cnki会议评论

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Chinese Medical Journal 2013年第23期126卷 4592-4593页

作者： GAO Xu WANG Hai-feng FANG zi-yu LU xin li Yao-ming WANG Yan SUN Ying-hao Department of Urology Changhai Hospital Second Military University Shanghai 200433 China

For localized prostate cancer, radiation therapy （RT） is commonly used. However, in the first five years of RT, 10%-20% of localized prostate cancer patients, ano 30%-50% of the locally advanced prostate cancer patients will progress to biochemical recurrence. In the past, only few these patients considered salvage radical prostatectomy （SRP） as their primary selection due to the significant morbidity.

关键词： radiorecurrent prostate cancer salvage radical prostatectomy biochemical recurrence

“Astragali Radix−Salviae Miltiorrhizae Radix Et Rhizoma”herb pair in the treatment of liver cirrhosis and its pharmacological mechanisms

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Drug Combination Therapy 2023年第2期5卷 21-29页

作者： Zhe Xu Hui-Fang Zhou Bo-Yang Gong Zhao-Dong li zi-xin li li Wang Yu-Hong Bian School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Oncology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300380China Pharmaceutical Department Tianjin Second People’s HospitalTianjin 300192China

Objective:liver cirrhosis is a disease that seriously damages human *** Chinese Medicine(TCM)formulae have a good therapeutic effect on cirrhosis,and the herb pair is the smallest unit in formula compatibility,which is important for improving the therapeutic ***,identifying core herb pairs among TCM formulae is ***:We mined the data of TCM formulae for the treatment of cirrhosis in the China National Intellectual Property Administration for the first time and analyzed their herb characteristics and association *** screened 405 patented TCM formulae,including 953 *** on frequency statistics and association rules,we determined“Astragali Radix-Salviae Miltiorrhizae Radix Et Rhizoma”as the core herb ***:Six active compounds,Isorhamnetin,Formononetin,Calycosin,Cryptotanshinone,Dihydrotanshinone I,and Tanshinone II A,were screened out based on previous studies and network *** found that SRC,TP53,HSP90AA1,MAPK3,MAPK1,and STAT3 played pivotal roles in treating ***,molecular docking indicated that MAPK3 might be a potential pharmacological target for ***:We preliminarily predicted and verified the pharmacological and molecular mechanism of“Astragali Radix-Salviae Miltiorrhizae Radix Et Rhizoma”in treating *** can expand the scope of TCM in the treatment of cirrhosis,guide people to use clinical formulae,and provide valuable insights for further drug discovery studies.

关键词： liver cirrhosis herb pair China National Intellectual Property Administration Data mining network pharmacology

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风电并网对电力系统电压稳定性的影响

科技视界 2017年第4期 32-33页

作者：辛自立河南大学河南开封475000

风电作为一种绿色低碳的可再生能源,最近几年时间内发展非常迅速。风电场向电网中提供有功功率的同时,还从电力系统中吸收了相当一部分的无功功率,因此大量的风电机组并网运行造成了电力系统电压质量下降。本文简要介绍了风力发电的现状... 详细信息

风电作为一种绿色低碳的可再生能源,最近几年时间内发展非常迅速。风电场向电网中提供有功功率的同时,还从电力系统中吸收了相当一部分的无功功率,因此大量的风电机组并网运行造成了电力系统电压质量下降。本文简要介绍了风力发电的现状,分析了风电并网对电力系统电压稳定性影响的原因,并提出了一种抑制电压波动的方法。

关键词：电力系统风力发电电压稳定风电并网

Tuning the porosity of {Co12IICo8III（μ3-OH）24（X）}11+ supramolecular frameworks by reaction time for D2/H2 separation

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Science China Chemistry 2025年

作者： Zhuozhou Xie Zhu Zhuo zi-Ang Nan Qing li Xiufang li zi-Xiu Lu linzhe Lü Jin liu Luyao liu Wenjing Wang Wei Wang Daqiang Yuan You-Gui Huang State Key Laboratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of Sciences State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical EngineeringXiamen University

Systematicly tuning the porosities of porous materials is crucial for targeted gas mixture separation,yet it remains a longstanding *** a common strategy,altering the phenylene ring count in the organic building units has been exploited to adjust pore apertures in metal organic frameworks （MOFs） and covalent organic frameworks （COFs）,resulting in only a stepwise pore size variation of approximately 2.8?.Unlike MOFs and COFs,the porosities for supramolecular assembly frameworks are highly dependent on the packings of the molecular building units in the *** above strategy cannot be applied to supramolecular assembly frameworks and other strategies are required to adjust pore apertures in supramolecular frameworks,especially to achieve porous materials with the optimal pore size for D2/H2separation （～3?）.Here,we successfully modulate the porosity of supramolecular frameworks of[CoII1+12CoIII8L12（μ3-OH）24（X）]1clusters （L=mono-deprotonated 1-iminoisoindole-3-amine,X=ClO?4or Cl?） by controlling the duration of self-assembly *** simply adjusting the reaction time,we obtain three[CoII12CoIII8L12（μ3-OH）24（X）]11+supramolecular frameworks:[CoII12CoIII8（μ3-OH）24（ClO4）L12)]·（Cl）4·（HCO2）7（1）,[CoII12CoIII8L12（μ3-OH）24（Cl）]·（ClOI4）4·（Cl）6·（HCO2）·（H2O）10（2）,and[CoI12CoIII8L12（μ3-OH）24（Cl）]·（Cl）11·（H2O）12（3）.The different stacking patterns of the[CoII12CoIII8L12（μ3-OH）24（X）]11+clusters in these frameworks lead to significantly varied stabilities and *** 1 exhibits permanent porosity with interconnected channels and maintains stability under harsh *** contrast,compound 2 is nearly nonporous,and compound 3 becomes unstable upon *** pores of compound 1 show higher affinity to D2than H2,and the pore aperture diameter of compound 1 （～3.06?） meets the optimal porosity for D2/***,compound 1 demonstrates moderate D2/H2separation at 77 K (retention time:～7 min/g for D2/H2/Ne （10/10/80 vol%） in a flow of 5 mL

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对氨基苯甲酸生物合成基因pabAB的缺失对抗生素FR-008生物合成的影响

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上海交通大学学报 2009年第12期43卷 1837-1841页

作者：章亦荣白林泉邓子新李敏上海交通大学微生物代谢教育部重点实验室上海200030

抗生素FR-008是由链霉菌FR-008产生的一种七烯大环内酯类抗真菌抗生素,它以对氨基苯甲酸(PABA)为起始单位,在I型聚酮合酶(PKS)的催化下合成聚酮内酯环.前期生物合成基因簇序列测定发现了可能的对氨基苯甲酸生物合成基因(pabAB),编码4-氨... 详细信息

抗生素FR-008是由链霉菌FR-008产生的一种七烯大环内酯类抗真菌抗生素,它以对氨基苯甲酸(PABA)为起始单位,在I型聚酮合酶(PKS)的催化下合成聚酮内酯环.前期生物合成基因簇序列测定发现了可能的对氨基苯甲酸生物合成基因(pabAB),编码4-氨基-4-脱氧-分支酸(ADC)合成酶.通过同框缺失实验获得pabAB发生缺失的基因置换突变株BLQ-1并通过聚合酶链式反应(PCR)扩增进行了验证.高效液相色谱(HPLC)分析和生物测定证实突变菌株BLQ-1丧失了合成抗生素FR-008的能力.这种产量的丧失可以通过回补克隆的pabAB基因或喂养外源PABA得到回复.实验证明,pabAB负责对氨基苯甲酸的合成,是抗生素FR-008生物合成的必需基因.

关键词：抗生素FR-008 链霉菌对氨基苯甲酸起始单位