Insight into Crosstalk Between Mitophagy and Apoptosis/Necroptosis:Mechanisms and Clinical Applications in Ischemic Stroke
作者机构：Department of Anatomy and NeurobiologySchool of Basic Medical ScienceCentral South UniversityChangsha 410013China Clinical Medicine Eight-year Program03 Class18 GradeXiangya School of MedicineCentral South UniversityChangsha 410013China Clinical Medicine Eight-Year Program02 Class17 GradeXiangya School of MedicineCentral South UniversityChangsha 410013China Administrative Officethe Third Xiangya HospitalCentral South UniversityChangsha 410013China Hunan Key Laboratory of OphthalmologyChangsha 410008China Key Laboratory of Emergency and TraumaMinistry of EducationCollege of Emergency and TraumaHainan Medical UniversityHaikou 571199China
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2022年第42卷第2期
页 面：237-248页
核心收录：
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学]
基 金：This work was supported by grants from the National Natural Science Foundation of China(No.81971891,No.82172196,No.81772134 and No.81571939) Key Laboratory of Emergency and Trauma(Hainan Medical University)of Ministry of Education(No.KLET-202108) the College Students’Innovation and Entrepreneurship Project(No.S20210026020013).
主 题：mitophagy ischemic stroke apoptosis necroptosis clinical application crosstalk
摘 要：Ischemic stroke is a serious cerebrovascular disease with high morbidity and mortality.As a result of ischemia-reperfusion,a cascade of pathophysiological responses is triggered by the imbalance in metabolic supply and demand,resulting in cell loss.These cellular injuries follow various molecular mechanisms solely or in combination with this disorder.Mitochondria play a driving role in the pathophysiological processes of ischemic stroke.Once ischemic stroke occurs,damaged cells would respond to such stress through mitophagy.Mitophagy is known as a conservatively selective autophagy,contributing to the removal of excessive protein aggregates and damaged intracellular components,as well as aging mitochondria.Moderate mitophagy may exert neuroprotection against stroke.Several pathways associated with the mitochondrial network collectively contribute to recovering the homeostasis of the neurovascular unit.However,excessive mitophagy would also promote ischemia-reperfusion injury.Therefore,mitophagy is a double-edged sword,which suggests that maximizing the benefits of mitophagy is one of the direction of future efforts.This review emphasized the role of mitophagy in ischemic stroke,and highlighted the crosstalk between mitophagy and apoptosis/necroptosis.
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