“Astragali Radix−Salviae Miltiorrhizae Radix Et Rhizoma”herb pair in the treatment of liver cirrhosis and its pharmacological mechanisms
作者机构：School of Integrative MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China Department of OncologyFirst Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300380China Pharmaceutical DepartmentTianjin Second People’s HospitalTianjin 300192China
出 版 物：《Drug Combination Therapy》 (药物联合治疗)
年 卷 期：2023年第5卷第2期
页 面：21-29页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported by the National Key R&D Program of China (2018YFC1706506) the National Natural Science Foundation of China Youth Program (81703921) the Tianjin Key Medical Discipline (Specialty)Construction Project
主 题：liver cirrhosis herb pair China National Intellectual Property Administration Data mining network pharmacology
摘 要：Objective:Liver cirrhosis is a disease that seriously damages human *** Chinese Medicine(TCM)formulae have a good therapeutic effect on cirrhosis,and the herb pair is the smallest unit in formula compatibility,which is important for improving the therapeutic ***,identifying core herb pairs among TCM formulae is ***:We mined the data of TCM formulae for the treatment of cirrhosis in the China National Intellectual Property Administration for the first time and analyzed their herb characteristics and association *** screened 405 patented TCM formulae,including 953 *** on frequency statistics and association rules,we determined“Astragali Radix-Salviae Miltiorrhizae Radix Et Rhizomaas the core herb ***:Six active compounds,Isorhamnetin,Formononetin,Calycosin,Cryptotanshinone,Dihydrotanshinone I,and Tanshinone II A,were screened out based on previous studies and network *** found that SRC,TP53,HSP90AA1,MAPK3,MAPK1,and STAT3 played pivotal roles in treating ***,molecular docking indicated that MAPK3 might be a potential pharmacological target for ***:We preliminarily predicted and verified the pharmacological and molecular mechanism of“Astragali Radix-Salviae Miltiorrhizae Radix Et Rhizomain treating *** can expand the scope of TCM in the treatment of cirrhosis,guide people to use clinical formulae,and provide valuable insights for further drug discovery studies.
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