The basic core traditional C hinese medicine for the prevention and treatment of COVID-19 and its active mechanisms
作者机构：School of Integrative MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China Department of OncologyFirst Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300380China
出 版 物：《Pharmacology Discovery》
年 卷 期：2024年第4卷第1期
页 面：21-30页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the National Key R&D Program of China(2018YFC1706506 and 2021YFE0200300) the Tianjin Municipal Education Commission Science and Technology Plan Project(2021KJ137)
主 题：COVID-19 traditional Chinese medicine China national intellectual property administration data mining network pharmacology
摘 要：Background:COVID-19 has had a dramatic impact on human health,economies,societies,and livelihoods around the *** Chinese medicine(TCM)formulae have played an important role in the prevention and treatment of *** evaluated the role of TCM in treating of COVID-19 and encouraged other countries to promote the use of TCM ***,the key is to find the basic core traditional Chinese medicine(BC-TCM)among those ***:For the first time,we mined the data of TCM formulae in CNIPA and analyzed herb characteristics and association *** then determined the BC-TCM and screened main compounds and therapeutic ***,the potential molecular mechanisms were explored by using enrichment analyses and molecular ***:This study screened 123 patented TCM formulae,including 312 *** to frequency statistics and association rules,nine herbs(Gan Cao,Jin Yinhua,Guang Huoxiang,Fu Ling,Huang Qi,Jie Geng,Lian Qiao,Cang Zhu,Ku Xingren)were selected as the *** BC-TCM involved 166 main compounds and 48 therapeutic *** active compounds Hederagenin,Spinasterol,Beta-sitosterol,and Liquiritin had high binding activity to the COVID-19 targets 3CL,ACE2,and core targets RELA,HSP90AA1,STAT3,MAPK3,and TP53 according to molecular docking ***,Hederagenin might be a potential compound for the prevention and treatment of ***:Our research predicted and confirmed the preventive therapeutic effect of BC-TCM on *** has the potential to broaden the scope of TCM,guide people in using clinical formulae,and provide valuable insights for future TCM discovery research.
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