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Tumor recurrence and survival prognosis in patients with advanced gastric cancer after radical resection with radiotherapy and chemotherapy

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1660-1669页

作者： Shuang-Fa Nie Chen-Yang Wang Lei Li Cheng Yang zi-ming zhu Jian-Dong Fei Department of General Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 75000Hebei ProvinceChina Department of Gastrointestinal Surgery Zhongshan Hospital of Fudan UniversityShanghai 200032China

BACKGROUND Advanced gastric cancer is a common malignancy that is often diagnosed at an advanced stage and is still at risk of recurrence after radical surgical ***,as one of the important treatment methods for gastric cancer,is of great significance for improving the survival rate of ***,the tumor recurrence and survival prognosis of gastric cancer patients after radio-therapy and chemotherapy are still *** To analyze the tumor recurrence after radical radiotherapy and chemotherapy for advanced gastric cancer and provide more in-depth guidance for *** A retrospective analysis was performed on 171 patients with gastric cancer who received postoperative adjuvant radiotherapy and chemotherapy in our hospital from 2021 to *** Kaplan-Meier method was used to calculate the recurrence rate and survival rate;the log-rank method was used to analyze the single-factor prognosis;and the Cox model was used to analyze the prognosis associated with multiple *** The median follow-up time of the whole group was 63 months,and the follow-up rate was 93.6%.Stage Ⅱ and Ⅲ patients accounted for 31.0%and 66.7%,*** incidences of Grade 3 and above acute gastrointestinal reactions and hematological adverse reactions were 8.8%and 9.9%,respectively.A total of 166 patients completed the entire chemoradiotherapy regimen,during which no adverse reaction-related deaths *** terms of the recurrence pattern,17 patients had local recurrence,29 patients had distant metastasis,and 12 patients had peritoneal implantation *** 1-year,3-year,and 5-year overall survival(OS)rates were 83.7%,66.3%,and 60.0%,*** 1-year,3-year,and 5-year disease-free survival rates were 75.5%,62.7%,and 56.5%,*** analysis revealed that T stage,peripheral nerve invasion,and the lymph node metastasis rate(LNR)were independent prognostic factors for *** Postoperative intensity-

关键词： Tumor recurrence Survival prognosis Advanced gastric cancer Radical resection Retrospective study

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Will the Next Century Be Green?

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Women of China 2000年第1期 38-40页

作者： ming zi zhu HONG

SINCE women and the environment have become today's world topics, a few women give their own ideas about environmental protection here.

关键词： Will the Next Century Be Green Be

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Implications for fault reactivation and seismicity induced by hydraulic fracturing

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Petroleum Science 2024年第2期21卷 1081-1098页

作者： zi-Han Sun ming-Guang Che Li-Hong zhu Shu-Juan Zhang Ji-Yuan Lu Chang-Yu Jin Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines School of Resources and Civil Engineering and Key Laboratory of Liaoning Province on Deep Engineering and Intelligent TechnologyNortheastern UniversityShenyang110819LiaoningChina Research Institute of Petroleum Exploration&Development PetroChina Company LimitedBeijing100084China The Exploration and Development Research Institute of Daqing Oilfield Limited Company Daqing163458HeilongjiangChina

Evaluating the physical mechanisms that link hydraulic fracturing(HF) operations to induced earthquakes and the anticipated form of the resulting events is significant in informing subsurface fluid injection operations. Current understanding supports the overriding role of the effective stress magnitude in triggering earthquakes, while the impact of change rate of effective stress has not been systematically addressed. In this work, a modified critical stiffness was brought up to investigate the likelihood, impact,and mitigation of induced seismicity during and after hydraulic fracturing by developing a poroelastic model based on rate-and-state fraction law and linear stability analysis. In the new criterion, the change rate of effective stress was considered a key variable to explore the evolution of this criterion and hence the likelihood of instability slip of fault. A coupled fluid flow-deformation model was used to represent the entire hydraulic fracturing process in COMSOL Multiphysics. The possibility of triggering an earthquake throughout the entire hydraulic fracturing process, from fracturing to cessation, was investigated considering different fault locations, orientations, and positions along the fault. The competition between the effects of the magnitude and change rate of effective stress was notable at each fracturing stage. The effective stress magnitude is a significant controlling factor during fracturing events, with the change rate dominating when fracturing is suddenly started or stopped. Instability dominates when the magnitude of the effective stress increases(constant injection at each fracturing stage) and the change rate of effective stress decreases(the injection process is suddenly stopped). Fracturing with a high injection rate, a fault adjacent to the hydraulic fracturing location and the position of the junction between the reservoir and fault are important to reduce the Coulomb failure stress(CFS) and enhance the critical stiffness as

关键词： Hydraulic fracturing Coulomb failure stress Rate-and-state fraction model Linear stability analysis Critical stiffness Seismically induced fault

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NUDT5 promotes the growth,metastasis,and Warburg effect of IDH wild-type glioblastoma multiforme cells by upregulating TRIM47

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 82-92页

作者： zi-Fa Zhang Shu-ming Liu Neurosurgery Department Shanxi Bethune HospitalTaiyuanShanxi Province030022China Shanxi Academy of Medical Sciences TaiyuanShanxi province030022China Emergency Department Taiyuan People’s HospitalTaiyuanShanxi Province030021China

Objective:To explore the regulatory mechanism of NUDT5 in glioblastoma multiforme(GBM).Methods:GEPIA database was used to predict the expressions of NUDT5 and tripartite motif family proteins 47(TRIM47)in GBM ***-qPCR and Western blot analyses were performed to examine NUDT5 expression in GBM ***-229 cell proliferation,migration as well as invasion were estimated by CCK-8,colony formation,wound healing,and Transwell assays following interference with *** assay,L-lactic acid kit,glucose detection kit,and ATP detection kit were applied for the detection of glycolysis-related ***-immunoprecipitation experiment was carried out to verify the relationship between NUDT5 and ***:GEPIA database showed that NUDT5 expression was significantly increased in GBM *** the expression of NUDT5 in GBM cells significantly suppressed the viability,proliferation,invasion,migration,and glycolysis of GBM ***,TRIM47 was highly expressed in GBM cells and interacted with *** of TRIM47 partially reversed the inhibitory effect of NUDT5 downregulation on the proliferation,metastasis,and glycolysis of GBM ***:NUDT5 promotes the growth,metastasis,and Warburg effect of GBM cells by upregulating *** NUDT5 and TRIM47 can be used as targets for GMB treatment.

关键词： Glioblastoma multiforme NUDT5 TRIM47 Growth Metastasis Warburg effect

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DNA hypermethylation of COL4A1 in ultraviolet-Binduced age-related cataract models in vitro and in vivo

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1791-1799页

作者： Li Wang Dan zhu Yang Yang Yuan He Jing Sun Yi-ming Li zi-Jing Wang Peng Li Department of Optometry Xi’an Medical UniversityXi’an 710021Shaanxi ProvinceChina Department of Ophthalmology the Second Affiliated Hospital of Xi’an Medical UniversityXi’an 710038Shaanxi ProvinceChina Department of Ophthalmology Xijing 986 HospitalFourth Military Medical UniversityXi’an 710054Shaanxi ProvinceChina

AIM:To explore the DNA methylation of COL4A1 in ultraviolet-B(UVB)-induced age-related cataract(ARC)models in vitro and in ***:Human lens epithelium B3(HLEB3)cells and Sprague Dawley rats were exposure to UVB *** MTT assay was utilized to evaluate cell *** cytometry was employed for analysis of cell apoptosis and cell ***4A1 expression in HLEB3 cells and anterior lens capsules were assessed using Western blot and reverse transcription-polymerase chain reaction(RTPCR).The localization of COL4A1 in HLEB3 cells was determined by *** methylation status of CpG islands located in COL4A1 promoter was verified using bisulfite-sequencing PCR(BSP).DNMTs and TETs mRNA levels was examined by ***:UVB exposure decreased HLEB3 cells proliferation,while increased the apoptosis rate and cells were arrested in G0/G1 ***4A1 expression was markedly inhibited in UVB treated cells compared to the *** status was detected in the CpG islands within COL4A1 promoter in HLEB3 cells subjected to UVB *** of DNMTs including DNMT1/2/3 were elevated in UVB treated HLEB3 cells compared to that in the controls,while expressions of TETs including TET1/2/3 showed the opposite *** from the UVB treated rat model further confirmed the decreased expression of COL4A1,hypermethylation status of the CpG islands at promoter of COL4A1 and abnormal expression of DNMT1/2/3 and TET1/2/in UVB exposure ***:DNA hypermethylation of COL4A1 promoter CpG islands is correlated with decreased COL4A1 expression in UVB induced HLEB3 cells and anterior lens capsules of rats.

关键词： human lens epithelium cells age-related cataract COL4A1 hypermethylation ultraviolet-B rat

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Mechanical performance of 22SiMn2TiB steel welded with lowtransformation- temperature filler wire and stainless steel filler wire

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Journal of Iron and Steel Research International 2024年第4期31卷 967-981页

作者： zi-dong Lin Kai-jie Song Zhen Sun zi-qian zhu Xue-feng Zhao Constantinos Goulas Wei Ya Xing-hua Yu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China Department of Design Production and Management Faculty of Engineering Technology.University of TwenteEnschede 7500 AETheNetherlands Rotterdam Additive Manufacture Fieldlab(RAMLAB) Rotterdam 3089 JWTheNetherlands

TX-80 low-transformation-temperature(LTT)welding wire was used to replace the traditional ER 307Si welding wire to realize the connection of 22SiMn2TiB armor steel in manual overlay *** previously existing issues,such as welding cracks,large welding deformation,and severe welding residual stress,were solved to ensure good strength and ductility *** particular,with the same welding conditions,TX-80 LTT wire eliminates welding *** reduces the welding deformation no matter the base pretreatment of pre-setting angle or no pre-setting *** comparison,it was found that the microstructure at the TX-80 weld is mainly composed of martensite and a small amount of retained *** contrast,the microstructure of the ER 307Si weld consists of a large amount of austenite and a small amount of skeleton-like *** variation trend of residual stress and microhardness from the weld to the base were investigated and compared with the mechanical properties of base *** TX-80 and the ER 307Si tensile samples elongation is 6.76%and 6.01%,while the ultimate tensile strengths are 877 and 667 MPa,*** average impact toughness at room temperature of the ER 307Si weld is 143.9 J/cm^(2),much higher than that of the TX-80 weld,which is only 36.7 J/cm^(2).The relationship between impact and tensile properties with microstructure species and distribution was *** addition,the fracture surface of the tensile and the impact samples was observed and *** dimples,fewer pores,larger radiation zone,and shear lips of TX-80 samples indicate better tensile ductility and worse impact toughness than those of ER 307Si weld.

关键词： Low-transformation-temperature material 22SiMn2TiB steel Welding deformation Residual stress Martensitic transformation Mechanical property

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Sequence structure controllable polymerization-induced self-assembly

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Science China Chemistry 2024年第1期67卷 390-397页

作者： zi-Xuan Chang Ren-Man zhu Chun-Yan Hong Wen-Jian Zhang Department of Polymer Science and Engineering University of Science and Technology of ChinaHefei 230026China Institute of Physical Science and Information Technology Anhui UniversityHefei 230601China Key Laboratory of Environment-Friendly Polymeric Materials of Anhui Province Anhui UniversityHefei 230601China

Polymerization-induced self-assembly(PISA)combines synthesis and self-assembly of artificial polymers in one-pot,which brings us one step closer to emulating ***,the reported PISA formulations primarily focus on developing nano-objects with new chemical compositions and rarely on structural regulation of polymers with specific ***,sequence structure controllable polymerization-induced self-assembly(SCPISA)is reported by using 7-(2-methacryloyloxyethoxy)-4-methylcoumarin(CMA)as a *** the copolymerization of 2-hydroxyethyl methacrylate(HEMA)and CMA,controlled incorporation of CMA units into the polymer chains can be realized by programmable light/heat ***-based P(HEMA-co-CMA)copolymers with the same composition but different sequence structures generate a range of ***,the morphologies of the resultant nano-objects can also be controlled by regulating the feed molar ratio of CMA and HEMA,which is similar to the conventional PISA,but the synthesis procedure is obviously simplified in *** versatility of the methodology is further demonstrated by the fabrication of different functional nano-objects with sequence structure-dependent morphologies in SCPISA systems with different functional monomers.

关键词： polymerization-induced self-assembly sequence-controlled polymers PET-RAFT polymerization

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Enhanced carbon capture with motif-rich amino acid loaded defective robust metal-organic frameworks

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Nano Research 2024年第3期17卷 2004-2010页

作者： Qi-Ye Ju Jia-Jia Zheng Li Xu Hai-Yan Jiang zi-Qian Xue Lu Bai Yang-Yang Guo ming-Shui Yao Ting-Yu zhu State Key Laboratory of Multi-phase Complex Systems CAS Key Laboratory of Green Process and EngineeringBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Laboratory of Theoretical and Computational Nanoscience National Center for Nanoscience and TechnologyChinese Academy of SciencesBeijing 100190China School of Rare Earths University of Science and Technology of ChinaHefei 230026China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341000China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institute for Integrated Cell-Material Sciences Kyoto UniversityInstitute for Advanced StudyKyoto UniversityYoshidaUshinomiya-choSakyokuKyoto 606-8501Japan

The use of metal-organic frameworks(MOFs)as solid adsorption materials for carbon capture is promising,but achieving efficient and reversible adsorption with a balance of capacity and selectivity for carbon dioxide(CO_(2))over N_(2) remains a *** take full advantage of the strong channel traffic and robustness of MOFs with relatively small pores,it is highly necessary to employ a defect-engineering strategy to construct a broader channel structure that can facilitate the loading of functional motif-rich amino acids(AAs).This strategy can greatly enhance the CO_(2) adsorption performance of *** this study,motif-rich amino acids are loaded into the defective and robust porous frameworks via combined defect-engineering and post-synthetic *** defective Zr/Hf-MOF-808s modified with AAs,especially for the 18 mol%4-nitroisophthalic acid,generated defective products allowing for the loading of L-serine(L-Ser).This modification resulted in a significant improvement in both the adsorption capacity(248%improvement at 298 K,100 kPa)and the selectivity of CO_(2)/N_(2) using the ideal adsorbed solution theory(IAST),with the selectivity increasing to 120.55 and 38.27 at 15 and 100 kPa,respectively,while maintaining good cycling *** functional theory(DFT)simulation,CO_(2) temperature-programmed desorption(CO_(2)-TPD),and in situ Fourier transform infrared spectroscopy(FTIR)were further employed to have a better understanding of the enhanced CO_(2) adsorption ***,unlike the AAs loaded pristine MOF-808s that showed the best CO_(2) adsorption capacity with the loading of short and small glycine(Gly),the broadened channel size in our work enables the loading of functional motif-rich L-serine,which brings more active binding sites,improving CO_(2) adsorption.

关键词： carbon capture and storage metal-organic framework(MOF) amino acids(AAs) defect-engineering motif-rich

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Supramolecular polymer network constructed by a functionalized polyimidazolium salt derived from metal-carbene template approach

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Science China Chemistry 2024年第4期67卷 1224-1228页

作者： ming-ming Gan zi-En Zhang Yi-Fan Zhang Heng Zhang Li-Ying Sun Ying-Feng Han Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry and Materials ScienceNorthwest UniversityXi’an 710127China

In this study,we present a supramolecular templating approach for constructing polyimidazolium salt containing crown ether and cyclobutane *** strategy involves the formation of metal-carbene templates,photochemical cycloaddition,and subsequent demetallation of metal *** by the host-guest chemistry between crown ether units and ammonium salts,we successfully fabricated a supramolecular polymer SPN1,which features imidazolium receptors and cyclobutane *** obtained SPN1 demonstrates outstanding reversible stimulus-response,antibacterial behavior and conductivity.

关键词： metal-carbene template crown ether polyimidazolium salt host-guest chemistry

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Comparison of engineering failures and seismic responses of 500 kV transformer-bushing systems in the 2022 Luding earthquake

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Earthquake Engineering and Engineering Vibration 2024年第4期23卷 1029-1041页

作者： zhu Wang Wu ming’er Xie Qiang Department of Structural Engineering Tongji UniversityShanghai 200092China Key Laboratory of Performance Evolution and Control for Engineering Structures(Tongji University) Shanghai 200092China

Cemented and mechanically clamped types of end fittings(fitting-C and fitting-M)are commonly used in transformer *** the Luding Ms 6.8 earthquake that occurred in China on September 5,2022,all transformer bushings with the two types of end fittings in a 500 kV substation were ***-earthquake field investigations were conducted,and the failures of the two types of bushings were *** elementary simulation models of the transformer-bushing systems were developed to simulate the engineering failures,and further compute their seismic responses for *** results indicate that the hitch lugs of the connection flange are structurally harmful to seismic ***-M can decrease the bending stiffness of the bushing due to the flexible sealing rubber *** it provides a more flexible connection that dissipates energy,the peak accelerations and relative displacements at the top of the bushing are significantly lower than those of the bushing with *** with fitting-C,fitting-M transfers the high-stress areas from the connection flange to the root of the porcelain,so the latter becomes the most vulnerable ***-M increases the failure risk of the low-strength porcelain,indicating the unsuitability of applying it in high-intensity fortification regions.

关键词： transformer bushing end fitting Luding earthquake,engineering failure seismic responses

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