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Oscillations of elastically mounted cylinders in regular waves

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Applied Mathematics and Mechanics(English Edition) 2014年第6期35卷 767-782页

作者：苏炜詹杰民李毓湘 School of Engineering Sun Yat-sen University Department of Civil & Environmental Engineering The Hong Kong Polytechnic University

Under the assumption of potential flow and linear wave theory, a semi-analytic method based on eigenfunciton expansion is proposed to predict the hydrody-namic forces on an array of three bottom-mounted, surface-piercing circular cylinders. The responses of the cylinders induced by wave excitation are determined by the equa-tions of motion coupled with the solutions of the wave radiation and diffraction problems. Experiments for three-cylinder cases are then designed and performed in a wave flume to determine the accuracy of this method for regular waves.

关键词： wave diffraction wave force eigenfunciton method flexible vertical mounted cylinder array

Nuclear genome-derived circular RNA circPUMl localizes in mitochondria and regulates oxidative phosphorylation in esophageal squamous cell carcinoma

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Signal Transduction and Targeted Therapy 2022年第3期7卷 816-828页

作者： wei Gong Jiancheng Xu Yan Wang Qingjie min Xu Chen weimin zhang jie Chen Qimin zhan Key Laboratory of Carcinogenesis and Translational Research(ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital&Institute100142 BeijingChina institute of Systems Biomedicine School of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina Peking University International Cancer Institute 100191 BeijingChina Shenzhen Bay Laboratory Shenzhen 518132China Research Unit of Molecular Cancer Research Chinese Academy of Medical Sciences100021 BeijingChina

Circular RNAs(circRNAs)were shown to play an important role in the occurrence and progression of ***,the functions of nuclear genome-derived circRNAs localized in mitochondria of tumor cells remain largely ***,we report that circPUMl,a circular RNA derived from back-splicing of pre-mRNAs of nuclear genome PUM1,localizes in mitochondria.

关键词： esophageal circular squamous

Fluorescence polarization immunoassay for salinomycin based on monoclonal antibodies

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Science China Chemistry 2010年第3期53卷 552-554页

作者： Wang, zhan Hui Cheng, Lin Li Shi, wei min zhang, su Xia Shen, Jian Zhong National Reference Laboratories for Veterinary Drug Residue College of Veterinary Medicine China Agricultural University Beijing 100193 China

A fluorescence polarization immunoassay(FPIA) for the determination of salinomycin(SAL) was developed by using anti-SAL monoclonal antibodies(mAb).Fluorescein labeled SAL(tracer) was synthesized by the N-hydroxysuccinimide active ester method and purified using thin layer chromatography(TLC).The developed FPIA for SAL had a dynamic range from 0.60 to 2193 ng/mL with an IC50 value of 33.2 ng/mL and a detection limit(LOD) of 0.08 ng/*** significant cross-reactivities were observed with other drugs but 67.6% with narasin.

关键词： salinomycin tracer fluorescence polarization immunoassay monoclonal antibody

Glycosyltransferases and non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2016年第8期22卷 2483-2493页

作者： Yu-Tao zhan Hai-Ying su wei An Department of Gastroenterology Beijing Tongren Hospital Capital Medical University Department of Obstetrics and Gynecology Shandong Jining First People’s Hospital Department of Cell Biology Municipal Laboratory for Liver Protection and Regulation of Regeneration Capital Medical University

Non-alcoholic fatty liver disease(NAFLD) is the most common form of chronic liver disease and its incidence is increasing worldwide. However, the underlying mechanisms leading to the development of NAFLD are still not fully understood. Glycosyltransferases(GTs) are a diverse class of enzymes involved in catalyzing the transfer of one or multiple sugar residues to a wide range of acceptor molecules. GTs mediate a wide range of functions from structure and storage to signaling, and play a key role in many fundamental biological processes. Therefore, it is anticipated that GTs have a role in the pathogenesis of NAFLD. In this article, we present an overview of the basic information on NAFLD, particularly GTs and glycosylation modification of certain molecules and their association with NAFLD pathogenesis. In addition, the effects and mechanisms of some GTs in the development of NAFLD are summarized.

关键词： Non-alcoholic fatty liver disease Pathogenesis Glycosyltransferases Glycosylation

3D direct writing and micro detonation of CL-20 based explosive ink containing O/W emulsion binder

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Defence Technology（防务技术） 2022年第8期18卷 1340-1348页

作者： zhan-xiong Xie Chong-wei An Bao-yun Ye Jia-qing Mu Chun-yan Li min-jie Li Song-jin Liu School of Environment and Safety Engineering North University of ChinaTaiyuanShanxi030051China Shanxi Engineering Technology Research Center for Ultrafine Powder North University of China030051TaiyuanChina No.55 Research Institute of China North Industries Group CorporationChangchun130012China

The booming development of DIW technology present an unprecedented prospect in energetic materials field and has attracted great interest due to its relative simplicity and high flexibility of ***,a novel CL-20 based explosive ink formulation have been developed successfully for MEMS initiation systems via DIW *** designed PVA/GAP into an oil-in-water(O/W)emulsion,in the way that the aqueous solution of PVA as water phase,the ethyl acetate solution of GAP as oil phase,the combination of Tween 80 and SDS as emulsifier,BPS as a curing agent of *** ideal formulation with good shear-thinning rheology properties and clear gel point was prepared using only 10 wt%*** dual-cured network formed during the curing process made the printed sample have good mechanical *** printed samples had satisfactory molding effect without cracks or fractures,the crystal form of CL-20 not changed and the thermal stability have *** of explosive inks via DIW in micro-scale grooves had excellent detonation performances,which critical detonation size was 1×0.045 mm,detonation velocity was 7129 m/s and when the corner reaching 150°can still detonated *** study may open new avenues for developing binder systems in explosive ink formulations.

关键词： Direct writing Explosive ink Emulsion binder system CL-20 based energetic composites Micron detonation

A highly reduced Mo_(74) polyoxometalate featuring high proton conductivity accessed by building block strategy

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Science China Chemistry 2024年第3期67卷 862-868页

作者： Shi-Yi Liu Xue-Xin Li wei-Chao Chen Kui-zhan Shao Xin-Long Wang Chao Qin Zhong-min su Key Laboratory of Polyoxometalate and Reticular Material Chemistry of ministry of Education Department of ChemistryNortheast Normal UniversityChangchun 130024China State Key Laboratory of supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun 130021China

Highly reduced polyoxometalates(POMs) are predicted to be used as rather high energy density materials;however,it still suffers from the limited cluster species and reduction *** we demonstrate that it is possible to employ the building block strategy to generate a highly reduced polyoxomolybdate(C_(2)H_(8)N)_(14)(NH_(4))_(4)H_(14)[Mo_(48)-ⅤMo_(26)ⅥO_(202)(OH)_(12)(SO_(4))_(6)]·46H_(2)O(Mo_(74)).The fundamental Mo-based{Mo_x}(x=4,5,and 6) building blocks,which are templated by tetra-coordinated anions{MoO_(4)}or{SO_(4)},not only lay foundation for the formation of Mo_(74) featuring an unprecedented reduction ratio of 65%,but also give rise to SBBs-mediated(secondary building blocks) supramolecular dense packing interactions among the isolated Mo_(74) clusters that are favorable for proton ***,high proton conductivity(2.04×10^(-2)S cm^(-1)) had been realized at 50℃ and 90% relative humidity,revealing one of the well-known POMs-based crystalline proton conducting *** result highlights that this building block approach possesses great potential in producing highly reduced POM systems that can achieve controllable reduced ratio and desirable properties.

关键词： polyoxometalate building block molybdenum highly reduced state proton conduction

Theoretical predict structure and property of the novel CL-20/2,4-DNI cocrystal by systematic search approach

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Defence Technology（防务技术） 2022年第6期18卷 907-917页

作者： Hao-jie Li Jian-chao Liu Li Yang Zhen-zhan Yan Yue-wen Lu Ji-min Han Xiao-ting Ren wei Li State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Science and Technology on Aerospace Chemical Power Laboratory Hubei Institute of Aerospace ChemotechnologyXiangyang441003HubeiChina

Cocrystallization integrates the merits of high energy and insensitivity between energetic molecules to obtain energetics with satisfying ***,how to obtain supramolecular synthons accurately and rapidly for predicting the structure and property of cocrystal remains a challenging *** this research,an efficient systematic search approach to predict CL-20/2,4-DNI cocrystal has been proposed that 2,4-DNI revolves around CL-20 with a stoichiometric ratio of 1:1 in accordance with the specified rules(hydrogen bond length:2.2-3.0 Å;search radius:6.5 Å;the number of hydrogen bond:1-3).Eight possible supramolecular synthons were obtained by combining quantum chemistry with molecular *** structure prediction indicated that there are four structures in cocrystal,namely P21/c,P212121,Pbca and Pna21,and CL-20/2,4-DNI cocrystal is likely to be P21/c and the corresponding cell parameters are Z=4,a=8.28 Å,b=12.17 Å,c=20.42 Å,α=90°,β=96.94°,γ=90°,and ρ=1.9353 g/cm^(3).To further study the intermolecular interaction of CL-20/2,4-DNI cocrystal,a series of theoretical analyses were employed including intermolecular interaction energy,electrostatic potential(ESP),Density of State(DOS),Hirshfeld surface *** C-H…O hydrogen bonds are demonstrated as the predominant driving forces in the cocrystal *** mechanical properties and detonation properties of CL-20/2,4-DNI cocrystal implies that the cocrystal shows better ductility and excellent detonation performances(9257 m/s,39.27 GPa)and can serve as a promising energetic *** structure predicted was compared with the experimental one to verify the accuracy of systematic search *** is a less than 8.8%error between experiment and predict results,indicating the systematic search approach has extremely high reliability and *** systematic search approach can be a new strategy to search supramolecular synthons and identify structures effectively and does have t

关键词： CL-20 2,4-DNI Cocrystal Intermolecular interaction Systematic search

Global Epidemic of Ebola Virus Disease and the Importation Risk into China: An Assessment Based on the Risk Matrix Method

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Biomedical and Environmental Sciences 2023年第1期36卷 86-93页

作者： SHANG wei Jing JING Wen zhan LIU Jue LIU min School of Public Health Peking UniversityBeijing 100191China

Objective To analyze the global epidemic status of the Ebola virus disease(EVD) and assess the importation risk into *** Data from World Health Organization reports were used. We described the global epidemic status of EVD from 1976–2021, and assessed and ranked the importation risk of EVD from the diseaseoutbreaking countries into China using the risk matrix and Borda count methods, *** From 1976–2021, EVD mainly occurred in western and central Africa, with the highest cumulative number of cases(14,124 cases) in Sierra Leone, and the highest cumulative fatality rate(85%) in the Congo. Outbreaks of EVD have occurred in the Democratic Republic of the Congo and Guinea since 2018. The importation risk into China varies across countries with outbreaks of *** Democratic Republic of the Congo had an extremely high risk(23 Borda points), followed by Guinea and Liberia. Countries with a moderate importation risk were Nigeria, Uganda, Congo, Sierra Leone,Mali, and Gabon, while countries with a low importation risk included sudan, Senegal, and Co te d’*** China is under the risk of EVD importation with the globalization and severe epidemic status of EVD. Key attention need to be paid to the Democratic Republic of the Congo, Guinea, and Liberia. Therefore, it is necessary to prevent and prepare in advance for importation risk in China.

关键词： Ebola virus disease Infectious disease Importation risk Risk matrix method

Proteomic analysis of primary colon cancer-associated fibroblasts using the SELDI-ProteinChip platform

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第3期13卷 159-167页

作者： zhan-huai WANG Ke-feng DING jie-kai YU Xiao-hui ZHAI Shu-qin RUAN Shan-wei WANG Yong-liang ZHU Shu ZHENG su-zhan zhanG Cancer Institute （Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education Key Laboratory of Molecular Biology in Medical Sciences Zhejiang Province China） the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China 2Department of Oncology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Gastroenterology the Second Aff~liated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Objective： Cancer-associated fibroblasts （CAFs） are one of the hallmarks of the cancer microenvironment. Recent evidence has indicated that CAFs are more competent in enhancing cancer cell growth and migration than normal fibroblasts. However, the unique protein expression of CAFs has not been fully elucidated. This study aims to investigate the characterizations of colon CAFs by comparing the differential protein expression between CAFs and normal fibroblasts. Methods： Primary fibroblasts were isolated from surgical specimen of human colon cancer and matched normal colonic tissue. Purity of the cell population was verified through immunostain analysis. Total cell lysates and conditioned media from each group of cells were extracted, and protein expression analysis was con- ducted using the surface-enhanced laser desorption/ionization time-of-flight mass spectrometry （SELDI-TOF-MS） ProteinChip platform. Results： Most primary cells showed typical fibroblast-like features after two weeks. Increased proportion of a-smooth muscle actin-positive myofibroblasts was detected within the CAFs in four of the six pairs of primary cells. Fibroblast activation protein was weakly expressed in most cells without differences. Using SELDI-TOF-MS ProteinChip platform, four protein peaks mass over charge ratio （m/z） 1142, 3011, 4035, and 4945 were detected in the total cell lysates, and two protein peaks m/z 1368 and 1389 were detected in the conditioned media. The potential candidate proteins found in the Swiss-Prot database include morphogenetic neuropeptides, FMRFamide-related peptides, insulin-like growth factor II, thymosin 13-4-like protein 3, and tight junction-associated protein 1. Conclusions： Using the SELDI-ProteinChip platform, differential protein expressions were identified in colon CAFs compared with normal colonic stromal fibroblasts. The complex proteomic alternations in colon CAFs may play important roles related to the colon cancer microenvironment.

关键词： Colon cancer Cancer microenvironment Cancer-associated fibroblasts Proteomics surface-enhancedlaser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS)