Glycosyltransferases and non-alcoholic fatty liver disease
Glycosyltransferases and non-alcoholic fatty liver disease作者机构：Department of Gastroenterology Beijing Tongren Hospital Capital Medical University Department of Obstetrics and Gynecology Shandong Jining First People’s Hospital Department of Cell Biology Municipal Laboratory for Liver Protection and Regulation of Regeneration Capital Medical University
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2016年第22卷第8期
页 面：2483-2493页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by The National Natural Science Foundation of China No.81041017 Beijing Municipal Natural Science Foundation No.7112032 Beijing Municipal Laboratory for Liver Protection and Regulation of Regeneration,and Scientific Research Common Program of Beijing Municipal Commission of Education No.KM201510025017
主 题：Non-alcoholic fatty liver disease Pathogenesis Glycosyltransferases Glycosylation
摘 要：Non-alcoholic fatty liver disease(NAFLD) is the most common form of chronic liver disease and its incidence is increasing worldwide. However, the underlying mechanisms leading to the development of NAFLD are still not fully understood. Glycosyltransferases(GTs) are a diverse class of enzymes involved in catalyzing the transfer of one or multiple sugar residues to a wide range of acceptor molecules. GTs mediate a wide range of functions from structure and storage to signaling, and play a key role in many fundamental biological processes. Therefore, it is anticipated that GTs have a role in the pathogenesis of NAFLD. In this article, we present an overview of the basic information on NAFLD, particularly GTs and glycosylation modification of certain molecules and their association with NAFLD pathogenesis. In addition, the effects and mechanisms of some GTs in the development of NAFLD are summarized.
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