Nuclear genome-derived circular RNA circPUMl localizes in mitochondria and regulates oxidative phosphorylation in esophageal squamous cell carcinoma

作     者：Wei Gong Jiancheng Xu Yan Wang Qingjie Min Xu Chen Weimin Zhang Jie Chen Qimin Zhan 

作者机构：Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Laboratory of Molecular OncologyPeking University Cancer Hospital&Institute100142 BeijingChina institute of Systems BiomedicineSchool of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina Peking University International Cancer Institute100191 BeijingChina Shenzhen Bay LaboratoryShenzhen 518132China Research Unit of Molecular Cancer ResearchChinese Academy of Medical Sciences100021 BeijingChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第3期

页      面：816-828页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the National Natural Science Foundation of China(81988101,81830086) Guangdong Basic and Applied Basic Research Foundation(2019B030302012) CAMS Innovation Fund for Medical Sciences(2019-I2M-5-081) Major Program of Shenzhen Bay Laboratory(S201101004) PKU-Baidu Fund(Project 2019BD012) 

主　　题：esophageal circular squamous 

摘      要：Circular RNAs(circRNAs)were shown to play an important role in the occurrence and progression of ***,the functions of nuclear genome-derived circRNAs localized in mitochondria of tumor cells remain largely ***,we report that circPUMl,a circular RNA derived from back-splicing of pre-mRNAs of nuclear genome PUM1,localizes in mitochondria.