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Research on the mechanism of the two-dimensional ultrasonic surface burnishing process to enhance the wear resistance for aluminum alloy

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Friction 2024年第3期12卷 490-509页

作者： zh.n-yu zh.U Qiu-Yang zh.NG yu LI Cong DING Guang-Jian PENG zh.ng-yu piao College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China Key Laboratory of Special Purpose Equipment and Advanced Processing Technology Ministry of Education and Zhejiang ProvinceZhejiang University of TechnologyHangzhou 310014China

The gradient nanostructure is machined on the aluminum(Al)alloy by the two-dimensional ultrasonic surface burnishing process(2D-USBP).The mechanism of why the gradient nanostructure enhances wear resistance is *** mechanical properties and microstructure characterization for the gradient nanostructure are performed by operating a nanoindenter,transmission electron microscopy(TEM),and electron backscattered diffraction(EBSD).Dry wear tests are performed on the samples before and after machining to evaluate the wear resistance and *** effect of the gradient nanostructure on the wear resistance is explored by developing the crystal plasticity(CP)finite element and molecular dynamics(MD)*** characterization results show that the 2D-USBP sample prepared a gradient structure of~600μm thick on the aluminum surface,increasing the surface hardness from 1.13 to 1.71 GPa and reducing the elastic modulus from 78.84 to 70.14 *** optimization of the surface microstructure and the increase of the mechanical properties effectively enhance the wear resistance of the sample,with 41.20%,39.07%,and 54.58% of the wear scar areas for the 2D-USBP treated samples to the original samples under 5,10,and 15 N loads,*** gradient nanostructure hinders the slip of dislocations inside the sample during the wear process and reduces the size and scope of plastic deformation;meanwhile,the resistance to deformation,adhesion,and crack initiation and propagation of the sample surface is improved,resulting in enhanced wear resistance.

关键词： structural superlubricity lattice registry elastic deformation strained solitons crystal plasticity molecular dynamics simulations

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Clinical characteristics and treatment of splenic infarction in children with systemic lupus erythematosus

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World Journal of Pediatrics 2024年第5期20卷 525-531页

作者： Yan Li yu-Rong piao Tong-Xin Han Hua-Wei Mao Department of Immunology Ministry of Education Key Laboratory of Major Diseases in ChildrenBeijing Key Laboratory for Genetics of Birth DefectsNational Center for Children’s HealthBeijing Children’s HospitalCapital Medical UniversityNo.56 Nan Li Shi LuBeijing100045China

Splenic infarction(SI)is a rare clinical phenomenon that occurs when the blood supply to the spleen is interrupted,resulting in tissue ischemia and necrosis[1].There are many causes of SI;in adult patients,cardioembolism,hematological malignancy,and infectious disease are the most common[2].Rheumatic diseases,especially systemic lupus erythematosus(SLE)and granulomatosis with polyangitis,can also lead to SI[3];however,only a few cases have been *** are currently no statistically meaningful data on the etiology of SI in *** most patients with SI can recover after conservative treatment,a small number of patients develop complications,such as splenic abscess,splenic rupture,splenic hemorrhage,and hemoperitoneum,and may even undergo splenectomy in severe cases.

关键词： erythematosus lupus treatment

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A Case of Brucellosis Concomitant with Severe Fever with Thrombocytopenia Syndrome—Weifang City,Shandong Province,China,2023

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China CDC weekly 2024年第27期6卷 677-680页

作者： Qingqing Xu Cuiping Wu Hui Liu Chao Geng Jinhui zh.ng Dongri piao Hongyan zh.o yu Fan Guozh.ng Tian Hai Jiang National Key Laboratory of Intelligent Tracing and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Department of Infectious Diseases Yidu Central Hospital of WeifangWeifang CityShandong ProvinceChina Institute of Bacterial Disease Jinan Center for Disease Control and PreventionJinan CityShandong ProvinceChina Tongliao Center for Disease Control and Prevention Tongliao CityInner Mongolia Autonomous RegionChina

Summary What is already known about this topic?Brucellosis and severe fever with thrombocytopenia syndrome(SFTS)are neglected zoonoses,attributable respectively to Brucella and the SFTS virus(SFTSV).While the incidence of these diseases has been rising,instances of co-infection remain *** is added by this report?This represents the first documented case of a rare coinfection involving Brucella and SFTSV.

关键词： neglected instance Shandong

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语序与半虚功能词对汉语零动词存在句成句的制约作用

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汉语学习 2024年第5期 36-44页

作者：朴珍玉延边大学文学院吉林延吉133002

存在句一直是汉语语法研究的重点问题,一百年来产生了很多重要的研究成果,但对于句法上缺省B段动词的零动词存在句较少专文论述。文章提出,只有A段和C段的“NPL+NP2”既是名词谓语句的次类,也是存在句的次类。A段和C段分别表示处所和存... 详细信息

存在句一直是汉语语法研究的重点问题,一百年来产生了很多重要的研究成果,但对于句法上缺省B段动词的零动词存在句较少专文论述。文章提出,只有A段和C段的“NPL+NP2”既是名词谓语句的次类,也是存在句的次类。A段和C段分别表示处所和存在物,高层语义表存在,其述谓功能体现在半虚功能词必须确保句首名词表处所,句末名词表非特定事物的有无及多少。语序要求严格:一方面要满足表义上从整体到部分、从背景到图像的语序,另一方面要满足信息结构上从话题到说明的自然顺序。零动词存在句焦点结构与一般的有动词句不同,其焦点不是论元焦点,而是宽焦点,因此NP2不具有独立性,不能回指。

关键词：述谓关系实现半虚功能词信息结构话题—说明结构

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“冷山不冷”:论查尔斯·弗雷泽《冷山》中的家园共同体

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东北大学学报（社会科学版） 2024年第1期26卷 135-142页

作者：张端朴玉吉林大学公共外语教育学院吉林长春130012

美国作家查尔斯·弗雷泽以《冷山》对美国南方阿巴拉契亚山区冷山住民的家园书写闻名遐迩,而“共同体”理论内涵则成为理解冷山这一家园本质的关键。该作以人物对“共同体”理念的感知与实践为主线,真切描绘出一幅鲜活的家园共同体图景... 详细信息

美国作家查尔斯·弗雷泽以《冷山》对美国南方阿巴拉契亚山区冷山住民的家园书写闻名遐迩,而“共同体”理论内涵则成为理解冷山这一家园本质的关键。该作以人物对“共同体”理念的感知与实践为主线,真切描绘出一幅鲜活的家园共同体图景。在弗雷泽刻画的冷山家园中,有八口之家的“跨种族共同体”形塑,有作为姐妹情谊的“女性共同体”责任彰显,还有基于全球意识的“区域共同体”愿景表达,三者共同铸就了冷山中美好的家园共同体生活。《冷山》围绕美国南方冷山深处的家园生活展开叙述,探讨种族情谊、女性联结及区域生活等议题,表现出弗雷泽在21世纪对美国南方文学题材的再关注,以及对全球化时代喧嚣之下的家园生活的思考。

关键词：查尔斯·弗雷泽《冷山》家园家园共同体

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The role and research progress of MDSC in immune aging-related diseases

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Biomedical Engineering Communications 2024年第2期3卷 4-9页

作者： Xi-Xing Fang Han-zh.u Li Xue-Mei piao yu-Ming Wang yu-Hong Bian Medical School Hubei Minzu UniversityEnshi 445099China College of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Nursing Department People's Hospital of Longjing CityLongjing 133499China

Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous immature cells with a strong immunosuppressive function in myeloid cells,which are impeded in the differentiation of myeloid cells under the pathological conditions of hypoxia,inflammation,infection,and *** individuals age,there is a significant increase in myeloid-derived suppressor cells(MDSCs),which subsequently enhance the immunosuppressive functions of Tregs(regulatory T cells)and Bregs(regulatory B cells).Therefore,MDSC may be related to immune system remodeling,thereby preventing excessive lesions caused by *** indicates that MDSC could serve as a potent inducer of immune *** senescence,characterized by immune dysfunction with aging,is closely linked to the onset of diseases like infections,pulmonary fibrosis,and *** achieve the purpose of anti-aging by intervening in immune aging and slow down the occurrence and development of related ***,understanding the biological characteristics of MDSC and its role in immune aging is crucial for immunotherapy targeting *** article reviews the different roles of MDSC in immune aging and its relationship with pulmonary fibrosis,tumor and other related diseases to provide theoretical basis for more comprehensive targeted MDSC immunotherapy.

关键词： MDSC immunosenescence tumor progression pulmonary fibrosis immunosenescence therapy

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Effects of postoperative treatment with chemotherapy and cellular immunotherapy on patients with colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3202-3210页

作者： zh.n-yu Ding Ying piao Tong Jiang Juan Chen Yi-Nuo Wang Hui-Ying yu zh.n-Dong zh.ng Department of Oncology General Hospital of Northern Theater CommandShenyang 110016Liaoning ProvinceChina Laboratory of Military Health in Cold Region Center for Disease Control and Prevention of Northern Theater CommandShenyang 110034Liaoning ProvinceChina Department of Clinical Medicine Shenyang Pharmaceutical UniversityShenyang 110016Liaoning ProvinceChina Basic Medicine Laboratory General Hospital of Northern Theater CommandShenyang 110016Liaoning ProvinceChina

BACKGROUND The outcome of surgical treatment for colorectal cancer(CRC)remains unsatis-factory and warrants further exploration and *** To clarify the impact of chemotherapy plus cellular immunotherapy[dendritic cell-cytokine-induced killer(DC-CIK)cell immunotherapy]on patients after CRC surgery and to explore the mediating *** A total cohort of 121 patients who underwent CRC surgery between January 2019 and April 2022 were *** sample comprised a control group of 55 pa-tients who received the XELOX chemotherapy regimen and a research group of 66 patients who received XELOX+DC-CIK *** performed compa-rative analyses of the clinical and pathological data of the two groups,including efficacy(2-year disease-free survival[DFS]rate),the incidence of adverse events(diarrhea,myelosuppression,gastrointestinal reactions,and peripheral neuritis),serum levels of tumor markers[carcinoembryonic antigens and carbohydrate an-tigens(CA)19-9 and CA242],and T-cell subsets[cluster of differentiation(CD)3+,CD3+CD4+,CD3+CD8+,natural killer(NK),and NK T cells].We also conducted preliminary univariate and mul-tivariate analyses of the variables that affected the efficacy of the *** We found a significantly higher 2-year DFS rate of treatment efficacy in the research group than in the control group,with a statistically lower incidence of adverse *** groups showed a reduction in serum tumor markers after treatment but there was no marked intergroup *** treatment,the various T-cell subgroup indicators in the control group were significantly lower than those in the research *** indices of T-cell subsets in the research group showed no significant change from preoperative *** analysis revealed a significant correlation between TNM staging,tumor differentiation,and the rates of nonresponse to treatment in CRC patients after *** results indicated that the treatment approach si

关键词： Analysis of variables affecting outcomes Cellular immunotherapy Chemotherapy Colorectal cancer Clinical effects

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贵州罗甸玉“麻点”和“草花”的物质组成及成因研究

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光谱学与光谱分析 2024年第11期44卷 3236-3243页

作者：张可轩于海燕柏鹤张予烨桂林理工大学地球科学学院广西隐伏金属矿产勘查重点实验室

选取带有“麻点”和“草花”花纹的贵州罗甸透闪石玉（罗甸玉）为研究对象，利用扫描电镜、电子探针和激光拉曼光谱仪测试技术，探讨罗甸玉中“麻点”和“草花”的物质组成和成因。测试结果表明：大的团块状“麻点”分布在部分方解石和... 详细信息

选取带有“麻点”和“草花”花纹的贵州罗甸透闪石玉（罗甸玉）为研究对象，利用扫描电镜、电子探针和激光拉曼光谱仪测试技术，探讨罗甸玉中“麻点”和“草花”的物质组成和成因。测试结果表明：大的团块状“麻点”分布在部分方解石和透闪石的交界处或透闪石晶界处，小的片状“麻点”分布在方解石或透闪石的小的孔洞中。“麻点”的扫描电镜能谱和电子探针成分分析结果表明其由铁氧化物组成，拉曼光谱特征峰显示为赤铁矿。“草花”呈“沙漠玫瑰”的团球状或无定形状存在于两种结构透闪石交界处或柱状、片状透闪石的边缘。“草花”的扫描电镜能谱和电子探针成分分析结果表明其为锰氧化物，拉曼光谱特征峰显示为钙锰矿(640、 356和287 cm-1)或水钠锰矿(636、 582和506cm-1)。依据带有“麻点”和“草花”花纹的罗甸玉的成分和结构特征可以推测：罗甸玉中大的团块状“麻点”是后期富含Fe的热液与透闪石玉成矿热液混染成矿，而小的片状“麻点”则由富Fe热液充填形成。“草花”周围呈浸染状的叶片状或柱状透闪石是由富Mn热液与透闪石玉成矿热液混合结晶形成Mn含量比较高的透闪石，后期富Mn热液运移到柱状或片状透闪石的边缘或裂隙处析出形成钙锰矿或水钠锰矿。

关键词：罗甸玉麻点草花成分微形貌

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The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

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Genes & Diseases 2024年第3期11卷 155-187页

作者： Michael yu Kevin Qin Jiaming Fan Guozh. zh.o piao zh.o Wei Zeng Connie Chen Annie Wang Yonghui Wang jiamin zh.ng Yi zh. William Wagstaff Rex C.Haydon Hue H.Luu Sherwin Ho Michael J.Lee Jason Strelzow Russell R.Reid Tong-Chuan He School of Medicine Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedic Surgery The First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China Department of Orthopaedic Surgery Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Department of Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China

The evolutionarily conserved Wnt signaling pathway plays a central role in develop-ment and adult tissue homeostasis across *** proteins are secreted,lipid-modified signaling molecules that activate the canonical(β-catenin dependent)and non-canonical(β-catenin independent)Wnt signaling *** behaviors such as proliferation,differ-entiation,maturation,and proper body-axis specification are carried out by the canonical pathway,which is the best characterized of the known Wnt signaling *** signaling has emerged as an important factor in stem cell biology and is known to affect the self-renewal of stem cells in various *** includes but is not limited to embryonic,hematopoietic,mesenchymal,gut,neural,and epidermal stem *** signaling has also been implicated in tumor cells that exhibit stem cell-like *** signaling is crucial for bone formation and presents a potential target for the development of therapeutics for bone *** surprisingly,aberrant Wnt signaling is also associated with a wide variety of diseases,including *** of Wnt pathway members in cancer can lead to unchecked cell proliferation,epithelial-mesenchymal transition,and ***,advances in the understand-ing of dysregulated Wnt signaling in disease have paved the way for the development of novel therapeutics that target components of the Wnt *** with a brief overview of the mechanisms of canonical and non-canonical Wnt,this review aims to summarize the cur-rent knowledge of Wnt signaling in stem cells,aberrations to the Wnt pathway associated with diseases,and novel therapeutics targeting the Wnt pathway in preclinical and clinical studies.

关键词： β-Catenin Cancer Canonical Wnt Disease Non-canonical Wnt Stem cells Targeted therapy Wnt signaling

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Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

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Genes & Diseases 2024年第1期11卷 103-134页

作者： Kevin Qin Michael yu Jiaming Fan Hongwei Wang piao zh.o Guozh. zh.oo Wei Zeng Connie Chen Yonghui Wang Annie Wang Zander Schwartz Jeffrey Hong Lily Song William Wagstaff Rex C.Haydon Hue H.Luu Sherwin H.Ho Jason Strelzow Russell R.Reid Tong-Chuan He Lewis L.Shi Chicago Medical School Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Departments of Orthopaedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China School of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37235USA Laboratory of Craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Wnt signaling plays a major role in regulating cell proliferation and *** Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical *** of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling *** crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ ***-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic *** complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic ***,both stimulatory and inhibitory treatments come with potential risks that need to be *** review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt *** thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/PCP,and the noncanonical Wnt/Ca2+*** description involved each of its components and their involvement in other cellular ***,this review explained the various other pathways and processes that crosstalk with Wnt signaling.

关键词： β-catenin Canonical Wnt Noncanonical Wnt Signal transduction Signaling crosstalk

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