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胎盘植入孕妇子宫动脉血流动力学参数与血管新生的关系及其相关指标诊断价值

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血管与腔内血管外科杂志 2024年第2期10卷 219-223页

作者：樊春云杨明珠祝玉芳李争丹阳市人民医院超声诊断科江苏丹阳212300

目的探究胎盘植入孕妇子宫动脉血流动力学参数与血管新生的关系及其相关指标的诊断价值。方法收集2016年1月至2021年4月于丹阳市人民医院常规超声检查疑似胎盘植入的125例孕妇的临床资料,根据产后最终临床诊断及病理诊断结果分为观察... 详细信息

目的探究胎盘植入孕妇子宫动脉血流动力学参数与血管新生的关系及其相关指标的诊断价值。方法收集2016年1月至2021年4月于丹阳市人民医院常规超声检查疑似胎盘植入的125例孕妇的临床资料,根据产后最终临床诊断及病理诊断结果分为观察组(n=35,胎盘植入)与对照组(n=90,非胎盘植入)。比较两组孕妇的临床特征、子宫动脉血流动力学参数[子宫动脉搏动指数(PI)、阻力指数(RI)、收缩期峰值血流速度与舒张末期血流速度的比值(S/D)]及血管新生指标[可溶性血管内皮生长因子受体-1(sFlt-1)、血管内皮生长因子(VEGF)]。分析子宫动脉血流动力学参数、血管新生指标与胎盘植入的关系,子宫动脉血流动力学参数对胎盘植入的诊断价值,以及子宫动脉血流动力学参数与血管新生指标的相关性。结果观察组孕妇的流产次数、剖宫产次数均明显多于对照组孕妇,PI、RI及sFlt-1水平均明显低于对照组孕妇,S/D、VEGF水平均明显高于对照组孕妇,差异均有统计学意义(P<0.01)。多因素分析结果显示,调整混杂因素流产次数、剖宫产次数后,PI、RI、S/D、VEGF、sFlt-1均仍为胎盘植入的独立影响因素(P<0.05)。受试者工作特征(ROC)曲线分析结果显示,PI、RI、S/D、VEGF、sFlt-1诊断胎盘植入的曲线下面积(AUC)分别为0.716、0.717、0.626、0.797、0.793,各指标联合诊断胎盘植入的AUC为0.870。胎盘植入孕妇子宫动脉血流动力学参数PI、RI与VEGF呈负相关,与sFlt-1呈正相关(P<0.05);S/D与VEGF呈正相关,与sFlt-1呈负相关(P<0.05)。结论胎盘植入孕妇彩色多普勒超声下的子宫动脉血流动力学参数与血管新生具有明显相关性,且临床监测子宫动脉血流动力学参数、血管新生指标对胎盘植入的诊断具有积极意义。

关键词：胎盘植入子宫动脉血流动力学参数血管新生血管内皮生长因子可溶性血管内皮生长因子受体-1

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还原氧化石墨烯的可控制备及表征

材料导报 2024年第12期38卷 52-57页

作者：朱玉方张慧丽梁丰国杨新伟陈长科买买提江·依米提马俊红新疆大学化工学院乌鲁木齐830046 新疆众和股份有限公司新疆铝基电子电工材料重点实验室乌鲁木齐830013 新疆众和股份有限公司乌鲁木齐830013

化学氧化还原法是工业上较为成熟的一种制备还原氧化石墨烯(Reduced graphene oxide,RGO)的方法。本研究首先采用改进Hummers法氧化剥离石墨,在喷雾干燥条件下获得了片状氧化石墨烯(Graphene oxide,GO),然后分别采用维生素C(Vitamin C,... 详细信息

化学氧化还原法是工业上较为成熟的一种制备还原氧化石墨烯(Reduced graphene oxide,RGO)的方法。本研究首先采用改进Hummers法氧化剥离石墨,在喷雾干燥条件下获得了片状氧化石墨烯(Graphene oxide,GO),然后分别采用维生素C(Vitamin C,VC)化学还原、快速升温热还原、慢速升温热还原、VC还原结合快速升温热还原法对GO样品进行还原,得到了四种RGO样品,并对其进行了全面的物理化学表征。结果表明,还原方法对RGO形貌结构及导电性有显著影响:采用VC化学还原可得到比表面积较大且具有微/介多级孔道的球状RGO,其还原程度低,导电性差;采用热还原可得到还原程度较高、导电性良好的片状RGO,并且较快的升温速率有利于发生膨胀剥离,可有效提高相应RGO样品的比表面积;VC还原与快速升温热还原相结合则可以得到比表面积和还原程度都较高的多孔球状RGO,但由于RGO颗粒之间较大的接触电阻,其导电性不及热还原得到的片状RGO。

关键词：还原氧化石墨烯还原方法化学还原热还原维生素C

Nano-calcium silicate mineralized fish scale scaffolds for enhancing tendon-bone healing

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Bioactive Materials 2023年第2期20卷 29-40页

作者： Fei Han Tian Li Mengmeng Li Bingjun Zhang Yufeng Wang yufang zhu Chengtie Wu State Key Laboratory of High-Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049PR China Department of Orthopaedic Surgery Nanjing First HospitalNanjing Medical UniversityNanjing210006PR China

Tendon-bone healing is essential for an effective rotator cuff tendon repair surgery,however,this remains a significant challenge due to the lack of biomaterials with high strength and *** by the high-performance exoskeleton of natural organisms,we set out to apply natural fish scale(FS)modified by calcium silicate nanoparticles(CS NPs)as a new biomaterial(CS-FS)to overcome the *** from its“Bouligand”microstructure,such FS-based scaffold maintained excellent tensile strength(125.05 MPa)and toughness(14.16 MJ/m^(3)),which are 1.93 and 2.72 times that of natural tendon respectively,allowing it to well meet the requirements for rotator cuff tendon ***,CS-FS showed diverse bioactivities by stimulating the differentiation and phenotypic maintenance of multiple types of cells participated into the composition of tendon-bone junction,(*** marrow mesenchymal stem cells(BMSCs),chondrocyte,and tendon stem/progenitor cells(TSPCs)).In both rat and rabbit rotator cuff tear(RCT)models,CS-FS played a key role in the tendon-bone interface regeneration and biomechanical function,which may be achieved by activating BMP-2/Smad/Runx2 pathway in ***,natural fish scale-based biomaterials are the promising candidate for clinical tendon repair due to their outstanding strength and bioactivity.

关键词： Fish scales Tendon repair High strength Bioactivities Tendon-bone healing enhancement

甜橙精油芳香疗法在抑郁焦虑情绪干预中的研究进展

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香料香精化妆品 2024年第2期 21-26页

作者：张紫钰朱玉芳王新玲陈海英河北医科大学研究生学院河北石家庄050017 河北医科大学护理学院河北石家庄050031 河北省人民医院护理部河北石家庄050051

芳香疗法作为一种天然的非药物疗法,具有操作简便、安全经济等优势,逐渐被应用于舒缓和改善情绪。其中,甜橙精油气味清新、香甜,具有广泛的生物活性,得到研究人员的青睐。从甜橙精油的生物活性及安全性、甜橙芳香疗法对抑郁焦虑情绪影... 详细信息

芳香疗法作为一种天然的非药物疗法,具有操作简便、安全经济等优势,逐渐被应用于舒缓和改善情绪。其中,甜橙精油气味清新、香甜,具有广泛的生物活性,得到研究人员的青睐。从甜橙精油的生物活性及安全性、甜橙芳香疗法对抑郁焦虑情绪影响的作用机制和干预效果方面进行梳理、分析和综述,以期为甜橙芳香疗法在临床实践中应用提供理论依据。

关键词：甜橙精油芳香疗法抑郁焦虑

Organosilicon polymer-derived ceramics: An overview

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Journal of Advanced Ceramics 2019年第4期8卷 457-478页

作者： Shengyang FU Min zhu yufang zhu School of Materials Science and Engineering University of Shanghai for Science and Technology

Polymer-derived ceramics(PDCs) strategy shows a great deal of advantages for the fabrication of advanced ceramics. Organosilicon polymers facilitate the shaping process and different silicon-based ceramics with controllable components can be fabricated by modifying organosilicon polymers or adding fillers. It is worth noting that silicate ceramics can also be fabricated from organosilicon polymers by the introduction of active fillers, which could react with the produced silica during pyrolysis. The organosilicon polymer-derived ceramics show many unique properties, which have attracted many attentions in various fields. This review summarizes the typical organosilicon polymers and the processing of organosilicon polymers to fabricate silicon-based ceramics, especially highlights the three-dimensional(3 D) printing technique for shaping the organosilicon polymerderived ceramics, which makes the possibility to fabricate silicon-based ceramics with complex structure. More importantly, the recent studies on fabricating typical non-oxide and silicate ceramics derived from organosilicon polymers and their biomedical applications are highlighted.

关键词： polymer-derived ceramics(PDCs) organosilicon polymers 3D printing silicon-based ceramics

3D printing of conch-like scaffolds for guiding cell migration and directional bone growth

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生物活性材料(英文) 2023年第4期22卷 127-140页

作者： Boshi Feng Meng Zhang Chen Qin Dong Zhai Yufeng Wang Yanling Zhou Jiang Chang yufang zhu Chengtie Wu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai200050People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049People’s Republic of China

Regeneration of severe bone defects remains an enormous challenge in *** regenerative scaffolds to directionally guide bone growth is a potential strategy to overcome this ***,an interesting creature widely spreading in ocean,has tough spiral shell that can continuously grow along the spiral ***,inspired by the physiological features of conches,a conch-like(CL)scaffold based onβ-TCP bioceramic material was successfully prepared for guiding directional bone growth via digital light processing(DLP)-based 3D *** from the spiral structure,the CL scaffolds significantly improved cell adhesion,proliferation and osteogenic differentiation in vitro compared to the conventional 3D ***,the spiral structure in the scaffolds could efficiently induce cells to migrate from the bottom to the top of the scaffolds,which was like“cells climbing stairs”.Furthermore,the capability of guiding directional bone growth for the CL scaffolds was demonstrated by a special half-embedded femoral defects model in *** new bone tissue could consecutively grow into the protruded part of the scaffolds along the spiral *** work provides a promising strategy to construct biomimetic biomaterials for guiding directional bone tissue growth,which offers a new treatment concept for severe bone defects,and even limb regeneration.

关键词： 3D printing Spiral structure Conch-like scaffolds Cell migration Tissue regeneration Severe bone defects

改进Sakai法合成1H-1,2,3-三氮唑

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化工科技 2024年第2期32卷 18-21页

作者：毛学兵常丽霞朱玉芳曹广双姚伟禹城市应急指挥中心山东禹城251200 山东省思威安全生产技术中心山东济南250014 济南大学水利与环境学院山东济南250022

对Sakai法合成1H-1,2,3-三氮唑进行改进,以2,2-二甲氧基乙醛、对甲苯磺酰肼、氨为原料一锅法合成目标产品。优化了环合反应工艺条件,在最佳反应条件下,1H-1,2,3-三氮唑收率为92.7%,纯度为99.4%,产品质量符合市场需求。通过工艺改进,减... 详细信息

对Sakai法合成1H-1,2,3-三氮唑进行改进,以2,2-二甲氧基乙醛、对甲苯磺酰肼、氨为原料一锅法合成目标产品。优化了环合反应工艺条件,在最佳反应条件下,1H-1,2,3-三氮唑收率为92.7%,纯度为99.4%,产品质量符合市场需求。通过工艺改进,减少反应步骤,提高收率,后处理更加简单,利于工业化生产。

关键词： Sakai反应对甲苯磺酰肼 2,2-二甲氧基乙醛 1H-1,2,3-三氮唑合成

Spin engineering of single-site metal catalysts

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The Innovation 2022年第4期3卷 96-103页

作者： Zichuang Li Ruguang Ma Qiangjian Ju Qian Liu Lijia Liu yufang zhu Minghui Yang Jiacheng Wang State Key Laboratory of High-Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of Sciences1295 Dingxi RoadShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China School of Materials Science and Engineering Suzhou University of Science and Technology99 Xuefu RoadSuzhou 215009China Department of Chemistry Western University1151 Richmond StreetLondonON N6A 5B7Canada Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences1219 Zhongguan West RoadNingbo 315201China Hebei Provincial Key Laboratory of Inorganic Nonmetallic Materials College of Materials Science and EngineeringNorth China University of Science and TechnologyTangshan 063210China

Single-site metal atoms(SMAs)on supports are attracting extensive interest as new catalytic systems because of maximized atom utilization and superior ***,rational design of configuration-optimized SMAs with high activity from the perspectives of fundamental electron spin is highly ***,N-coordinated Fe single atoms are successfully distributed over axial carbon micropores to form dangling-FeN4 centers(d-FeN4).This unique d-FeN4 demonstrates much higher intrinsic activity toward oxygen reduction reaction(ORR)in HClO4 than FeN4 without micropore underneath and commercial Pt/*** theoretical calculation and electronic structure characterization imply that d-FeN4 endows central Fe with medium spin(t2g 4 eg 1),which provides a spin channel for electron transition compared with FeN4 with low *** leads to the facile formation of the singlet state of oxygen-containing species from triplet oxygen during the ORR,thus showing faster kinetics than *** work provides an in-depth understanding of spin tuning on SMAs for advanced energy catalysis.

关键词： kinetics attracting faster

不同前处理方法对5种中药农药残留量检测的影响

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中国药品标准 2024年第3期25卷 251-256页

作者：张万青刘芫汐陈高翩朱慧茹朱玉芳刘潇潇广东省药品检验所广州510663 中国食品药品检定研究院北京100050

目的:研究分析不同前处理方法对当归、菊花、枸杞子、黄芪、金银花中农药残留测定结果的影响。方法:样品分别经QuEChERS法和高速匀浆结合亲水亲油平衡(HLB)材料固相萃取法处理,采用超高效液相色谱-串联质谱法(UHPLC-MS/MS)同时测定克百... 详细信息

目的:研究分析不同前处理方法对当归、菊花、枸杞子、黄芪、金银花中农药残留测定结果的影响。方法:样品分别经QuEChERS法和高速匀浆结合亲水亲油平衡(HLB)材料固相萃取法处理,采用超高效液相色谱-串联质谱法(UHPLC-MS/MS)同时测定克百威、3-羧基克百威、甲拌磷、甲拌磷砜、甲拌磷亚砜、甲基异柳磷等5种农药残留量。采用超高效液相色谱柱Agilent Poroshell 120 SB-C_(18)(2.1 mm×100 mm,2.7μm);采用梯度洗脱方式,水相为含5 mmol·L^(-1)甲酸铵的0.1%甲酸溶液,有机相为含5 mmol·L^(-1)甲酸铵的0.1%甲酸溶液-乙腈(体积比5∶95);柱温为35℃;质谱分析中以电喷雾离子源正离子模式扫描,多反应监测模式检测。结果:QuEChERS法和HLB固相萃取法测得结果偏差在9.09%~55.56%之间。结论:中药农药残留量检测前处理方法的选定,建议以阳性样本的测定数据为评价指标与依据,选择测定值较高、提取效率高的方法。

关键词：农药残留 QuEChERS 亲水亲油平衡材料当归菊花枸杞子黄芪金银花