3D printing of conch-like scaffolds for guiding cell migration and directional bone growth

作     者：Boshi Feng Meng Zhang Chen Qin Dong Zhai Yufeng Wang Yanling Zhou Jiang Chang Yufang Zhu Chengtie Wu 

作者机构：State Key Laboratory of High Performance Ceramics and Superfine MicrostructureShanghai Institute of Ceramics Chinese Academy of SciencesShanghai200050People’s Republic of China Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing100049People’s Republic of China 

出 版 物：《生物活性材料(英文)》 (Bioactive Materials)

年 卷 期：2023年第22卷第4期

页      面：127-140页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0836[工学-生物工程] 

基　　金：This work was supported by the National Key Research and Development Program of China(grant number 2021YFB3800800) the Natural Science Foundation of China(grant numbers 32225028,32130062) Science and Technology Commission of Shanghai Municipality(grant number 21DZ1205600) Shanghai Pilot Program for Basic Research-Chinese Academy of Science,Shanghai Branch(grant number JCYJ-SHFY-2022-003) 

主　　题：3D printing Spiral structure Conch-like scaffolds Cell migration Tissue regeneration Severe bone defects 

摘      要：Regeneration of severe bone defects remains an enormous challenge in *** regenerative scaffolds to directionally guide bone growth is a potential strategy to overcome this ***,an interesting creature widely spreading in ocean,has tough spiral shell that can continuously grow along the spiral ***,inspired by the physiological features of conches,a conch-like(CL)scaffold based onβ-TCP bioceramic material was successfully prepared for guiding directional bone growth via digital light processing(DLP)-based 3D *** from the spiral structure,the CL scaffolds significantly improved cell adhesion,proliferation and osteogenic differentiation in vitro compared to the conventional 3D ***,the spiral structure in the scaffolds could efficiently induce cells to migrate from the bottom to the top of the scaffolds,which was like“cells climbing stairs.Furthermore,the capability of guiding directional bone growth for the CL scaffolds was demonstrated by a special half-embedded femoral defects model in *** new bone tissue could consecutively grow into the protruded part of the scaffolds along the spiral *** work provides a promising strategy to construct biomimetic biomaterials for guiding directional bone tissue growth,which offers a new treatment concept for severe bone defects,and even limb regeneration.