Nano-calcium silicate mineralized fish scale scaffolds for enhancing tendon-bone healing

作     者：Fei Han Tian Li Mengmeng Li Bingjun Zhang Yufeng Wang Yufang Zhu Chengtie Wu 

作者机构：State Key Laboratory of High-Performance Ceramics and Superfine MicrostructureShanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing100049PR China Department of Orthopaedic SurgeryNanjing First HospitalNanjing Medical UniversityNanjing210006PR China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第20卷第2期

页      面：29-40页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported by the National Basic Research Program of China(grant No.2021YFA0715700) the Natural Science Foundation of China(32130062) Innovation Cross Team of Chinese Academy of Sciences(JCTD-2018-13) Science and Technology Commission of Shanghai Municipality(20442420300,21DZ1205600) 

主　　题：Fish scales Tendon repair High strength Bioactivities Tendon-bone healing enhancement 

摘      要：Tendon-bone healing is essential for an effective rotator cuff tendon repair surgery,however,this remains a significant challenge due to the lack of biomaterials with high strength and *** by the high-performance exoskeleton of natural organisms,we set out to apply natural fish scale(FS)modified by calcium silicate nanoparticles(CS NPs)as a new biomaterial(CS-FS)to overcome the *** from its“Bouligandmicrostructure,such FS-based scaffold maintained excellent tensile strength(125.05 MPa)and toughness(14.16 MJ/m^(3)),which are 1.93 and 2.72 times that of natural tendon respectively,allowing it to well meet the requirements for rotator cuff tendon ***,CS-FS showed diverse bioactivities by stimulating the differentiation and phenotypic maintenance of multiple types of cells participated into the composition of tendon-bone junction,(*** marrow mesenchymal stem cells(BMSCs),chondrocyte,and tendon stem/progenitor cells(TSPCs)).In both rat and rabbit rotator cuff tear(RCT)models,CS-FS played a key role in the tendon-bone interface regeneration and biomechanical function,which may be achieved by activating BMP-2/Smad/Runx2 pathway in ***,natural fish scale-based biomaterials are the promising candidate for clinical tendon repair due to their outstanding strength and bioactivity.