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Chinese Journal of Cancer Research 2014年第1期26卷 4-11页

作者： Guochang Chen Boneng Mao Qi Pan Qian Liu Xinfang Xu yueji ning Department of Gastroenterology Affiliated Hospital of Jiangsu University

Objective：The aim of this study was to establish the risk scoring system towards the advanced colorectal neoplasm （CN） risk in the average-risk populations in the southern Jiangsu Province,and to evaluate the screening ***：Totally 905 cases of the average-risk populations who received the colonoscopy were selected as the *** multivariate logistic regression analysis method was used to establish the scoring system towards the occurrence risk of the advanced tumor,and its screening efficacy was evaluated through the prediction consistency,distinguishing ability and screening ***：The scoring system consisted of five variables,namely age,gender,coronary heart disease,egg intake and stool *** results revealed that it had good prediction consistency （P=0.205） and distinguishing ability [the area under the receiver operating characteristic （ROC） curve was 0.75,with 95％ confidence interval （95％ CI） of 0.69-0.82].Thus,2.5 points was set as the screening cutoff value,and its sensitivity,specificity,accuracy,positive predictive value,negative predictive value,positive likelihood ratio and negative likelihood ratio were 93.8 ％,47.6％,50.1％,9.1％,99.3％,1.79 and 0.13,***：The established scoring system had good screening efficacy,and can be used as the screening tool applying to the CN screening within the average-risk populations in the southern Jiangsu Province.

关键词： Colorectal neoplasm (CN) colonoscopy cross-sectional studies screening risk factor

外周血血脂及尿酸水平与结直肠息肉的相关性分析

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中国现代医生 2018年第34期56卷 43-45页

作者：宁月季江苏省宜兴市人民医院消化内科江苏宜兴214200

目的探讨外周血内血脂指标和尿酸水平对结直肠息肉发生情况的影响。方法选取2016年3月～2017年12月在我院住院行结肠镜检查的患者362例,经肠镜及病理确诊为结直肠息肉患者185例为研究组;经肠镜检查未见明显异常者177例为对照组。所有患... 详细信息

目的探讨外周血内血脂指标和尿酸水平对结直肠息肉发生情况的影响。方法选取2016年3月～2017年12月在我院住院行结肠镜检查的患者362例,经肠镜及病理确诊为结直肠息肉患者185例为研究组;经肠镜检查未见明显异常者177例为对照组。所有患者均行肠镜检查,检测血清尿酸(UA)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)以及低密度脂蛋白胆固醇(LDL-C)。结果研究组TC、TG和LDL-C水平高于对照组,且差异具有统计学意义(P0.05);研究组UA水平明显高于对照组,且差异具有统计学意义(P<0.05)。Pearson相关性分析结果显示,结直肠息肉患者的UA水平与HDL-C水平呈负相关(r=-0.223,P<0.05),与TC、TG、LDL-C呈正相关(r=0.322,r=0.178,r=0.215,全部P<0.05)。结论外周血TC、TG、LDL-C以及UA升高与结直肠息肉发生相关,同时结直肠息肉患者UA水平与血脂指标具有相关性。在诊疗结直肠息肉疾病时,需注重患者的健康教育,培养患者健康的饮食习惯及生活方式,以减少结直肠息肉的发生率。

关键词：结直肠息肉尿酸血脂肠镜

Prevention of colonic fibrosis by taurine in rats with colitis induced by 2,4,6-trinitrobenzene sulphonic acid

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Prevention of colonic fibrosis by taurine in rats with colit...

第二十二届全国中西医结合消化系统疾病学术会议暨消化疾病诊治进展学习班

作者： Lin lin,Cheng jiafei,ning yueji,Zhang wei,Zhang hongjie Department of Gastroenterology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,P.R.China

Background:Over one-third of patients with Crohn’ s disease(CD) would develop intestinal stricture,with no effective medical intervention,though much adventage has been made during the past several *** has an antifibrotic effect on a number of organs,however, its role in colonic fibrosis remains ***:To investigate the efficacy of taurine on

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Cajal间质细胞与糖尿病胃轻瘫的关系

胃肠病学和肝病学杂志 2011年第1期20卷 90-92页

作者：宁月季张蔚林琳南京医科大学第一附属医院消化科南京210029

Cajal间质细胞(ICC)是胃肠道中与肠神经细胞和平滑肌密切相关的间质细胞,网络状分布于整个胃肠组织,对胃肠慢波的产生及胃肠动力的维持起关键作用。研究表明,糖尿病胃轻瘫(DGP)患者及其动物模型均存在ICC数目明显减少、结构破坏、且与... 详细信息

Cajal间质细胞(ICC)是胃肠道中与肠神经细胞和平滑肌密切相关的间质细胞,网络状分布于整个胃肠组织,对胃肠慢波的产生及胃肠动力的维持起关键作用。研究表明,糖尿病胃轻瘫(DGP)患者及其动物模型均存在ICC数目明显减少、结构破坏、且与神经末梢及平滑肌之间的连接减少。因此,ICC的异常可能是DGP的重要原因之一。本文就ICC与DGP的研究现状进行探讨。

关键词： Cajal间质细胞糖尿病胃轻瘫平滑肌细胞胰岛素干细胞因子

Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 12-17页

作者： Song Jiang Congwen Zhu ning Jiang State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of *** on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual *** magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity *** reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.

关键词： Annual cycle SST anomaly Antisymmetric mode ENSO

连续性静脉-静脉血液滤过治疗重症急性胰腺炎的疗效

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江苏医药 2015年第18期41卷 2170-2171页

作者：屠继军陈国昌宁月季江苏大学附属宜兴医院消化病科 214200

目的观察连续性静脉-静脉血液滤过(CVVH)治疗重症急性胰腺炎(SAP)的疗效。方法回顾性分析21例SAP患者的临床资料,比较采用CVVH法治疗前后的生化指标变化、急性生理与慢性健康评分(APACHEⅡ)及并发症。结果治愈18例,治愈率为85.7%。治疗... 详细信息

目的观察连续性静脉-静脉血液滤过(CVVH)治疗重症急性胰腺炎(SAP)的疗效。方法回顾性分析21例SAP患者的临床资料,比较采用CVVH法治疗前后的生化指标变化、急性生理与慢性健康评分(APACHEⅡ)及并发症。结果治愈18例,治愈率为85.7%。治疗后,血尿素氮、血清肌酐和ALT均较治疗前降低,APACHEⅡ评分改善(P<0.05或P<0.01)。未出现与CVVH相关的严重并发症。结论早期行CVVH治疗能有效改善SAP患者病情,减少并发症。

关键词：连续性静脉-静脉血液滤过重症急性胰腺炎

超早期和早期肠内营养对老年肥胖重度急性胰腺炎疗效的对比研究

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胃肠病学 2017年第12期22卷 744-747页

作者：宁月季潘琦毛伯能陈国昌刘芊许新芳江苏省宜兴市人民医院消化内科 214200

背景:早期给予肠内营养可改善重度急性胰腺炎(SAP)患者肠黏膜屏障、减少感染和并发症;但何时开始肠内营养目前仍存在争议。目的:探讨不同肠内营养开始时间对老年肥胖SAP患者的治疗效果。方法:回顾性分析接受超早期肠内营养(A组)和早期... 详细信息

背景:早期给予肠内营养可改善重度急性胰腺炎(SAP)患者肠黏膜屏障、减少感染和并发症;但何时开始肠内营养目前仍存在争议。目的:探讨不同肠内营养开始时间对老年肥胖SAP患者的治疗效果。方法:回顾性分析接受超早期肠内营养(A组)和早期肠内营养(B组)患者的临床疗效、住院时间、住院费用和并发症发生率以及治疗前后血清炎症因子水平。结果:A组总有效率高于B组,但差异无统计学意义(90.9%对79.2%,χ~2=1.227,P>0.05)。与B组相比,A组治疗后血、尿淀粉酶恢复正常时间以及住院时间显著缩短,住院费用明显降低(P<0.05);腹痛、腹胀、呕吐和发热症状消失时间显著缩短(P<0.05);血清炎症因子IL-6、TNF-α和CRP水平显著降低(P<0.05);感染率发生率显著降低(P<0.05)。结论:与早期肠内营养组相比,超早期肠内营养对于老年肥胖SAP患者疗效更佳,且具有住院时间较短、费用更低的优点。

关键词：重度急性胰腺炎老年人肥胖超早期肠内营养治疗

2型糖尿病与非2型糖尿病患者发生细菌性肝脓肿临床特征分析

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实用肝脏病杂志 2023年第5期26卷 730-733页

作者：宁月季成家飞钱佶朱瑞农江苏省宜兴市人民医院消化内科 214200 南京中医药大学附属江苏省中医院消化内科

目的分析2型糖尿病(T2DM)与非2型糖尿病患者发生细菌性肝脓肿(PLA)的临床特征差异。方法 2016年1月~2021年12月我院收治的T2DM合并PLA患者54例,未合并T2DM的PLA患者72例,采用单用抗生素、脓肿穿刺抽脓联合抗生素或经皮肝脓肿穿刺置管... 详细信息

目的分析2型糖尿病(T2DM)与非2型糖尿病患者发生细菌性肝脓肿(PLA)的临床特征差异。方法 2016年1月~2021年12月我院收治的T2DM合并PLA患者54例,未合并T2DM的PLA患者72例,采用单用抗生素、脓肿穿刺抽脓联合抗生素或经皮肝脓肿穿刺置管引流联合抗生素治疗,观察临床特征的差异。结果合并T2DM组年龄为(58.6±8.4)岁,显著大于非T2DM组【(54.2±9.7)岁,P<0.05】,病程为(27.5±8.1)d,显著长于非T2DM组【(17.1±4.9),P<0.05】,合并心血管疾病的比率为24.1%,显著高于非T2DM组的9.7%(P<0.05);合并T2DM组腹痛、腹胀、黄疸和体质量下降发生率分别为63.0%、64.8%、25.9%和92.6%,显著高于非T2DM组(分别为19.4%、11.1%、12.5%和62.5%,P<0.05);入院时,T2DM组外周血WBC、NEUT和血清白蛋白水平分别为(17.8±5.2)×10^(9)/L、(74.6±7.5)%和(28.4±4.8)g/L,显著低于非T2DM组【分别为(22.2±4.6)×10^(9)/L、(85.2±9.3)%和(35.6±6.3)g/L,P<0.05】,而血清总胆红素水平为(30.8±4.8)μmol/L,显著高于非T2DM组【(16.5±3.4)μmol/L,P<0.05】;T2DM组单纯接受抗生素治疗的比率为22.2%,显著低于非T2DM组的38.9%,而接受抗生素联合脓肿置管引流的比率为48.1%,显著高于非T2DM组的33.3%,差异具有统计学意义(P<0.05);在治疗1个月末,T2DM组治愈率为74.1%,转为慢性脓肿比率为24.1%,而非T2DM组分别为87.5%和12.5%,两组差异具体统计学意义(P<0.05)。结论合并T2DM的PLA患者临床表现重,治疗大多需要置管引流,预后稍差,需要临床认真对待,以改善预后。

关键词：细菌性肝脓肿 2型糖尿病临床特征转归

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The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing ning Shi Lv Qian Wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En ning Chang Liu Yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina