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Energy & Environmental Materials 2024年第3期7卷 219-227页

作者： Sihang Cheng Cuimei Liu Yingqi Li Huaqiao Tan yonghui wang Yangguang Li Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Faculty of ChemistryNortheast Normal UniversityChangchun 130024China

Solar vapor generation(SVC)represents a promising technique for seawater desalination to alleviate the global water crisis and energy *** of its main bottleneck problems is that the evaporation efficiency and stability are limited by salt crystallization under high-salinity ***,we demonstrate that the 3D porous melamine-foam(MF)wrapped by a type of self-assembling composite materials based on reduced polyoxometalates(*** blue,HPB),oleic acid(OA),and polypyrrole(PPy)(labeled with MF@HPB-PPy_(n)-OA)can serve as efficient and stable SVC material at high *** characterizations of MF@HPB-PPy_(n)-OA indicate that both hydrophilic region of HPBs and hydrophobic region of OA co-exist on the surface of composite materials,optimizing the hydrophilic and hydrophobic interfaces of the SVC materials,and fully exerting its functionality for ultrahigh water-evaporation and anti-salt *** optimal MF@HPB-PPy_(10)-OA operates continuously and stably for over 100 h in 10wt%***,MF@HPB-PPy_(10)-OA accomplishes complete salt-water separation of 10wt%brine with 3.3kgm^(-2)h^(-1)under 1-sun irradiation,yielding salt harvesting efficiency of 96.5%,which belongs to the record high of high-salinity systems reported so far and is close to achieving zero liquid ***,the low cost of MF@HPB-PPy_(10)-OA(2.56$m^(-2))suggests its potential application in the practical SVC technique.

关键词： heteropoly blue(HPB) hydrophilic-hydrophobic interface polyoxometalates(POM) salt-water separation solar vapor generation(SVG)

Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A_(2)receptors

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Science China(Life Sciences) 2024年第5期67卷 986-995页

作者： Yuan Weng Xinyu Yang Qiansen Zhang Ying Chen Yueming Xu Chenyu Zhu Qiong Xie yonghui wang Huaiyu Yang Mingyao Liu Weiqiang Lu Gaojie Song Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China

The adenosine subfamily G protein-coupled receptors A_(2A)R and A_(2B)R have been identified as promising cancer immunotherapy *** of the A_(2A)R/A_(2B)R dual antagonists,AB928,has progressed to a phaseⅡclinical trial to treat rectal ***,the precise mechanism underlying its dual-antagonistic properties remains ***,we report crystal structures of the A_(2A)R complexed with AB928 and a selective A_(2A)R antagonist *** structures revealed a common binding mode on A_(2A)R,wherein the ligands established extensive interactions with residues from the orthosteric and secondary *** contrast,the cAMP assay and A_(2A)R and A_(2B)R molecular dynamics simulations indicated that the ligands adopted distinct binding modes on A_(2B)*** analysis of their chemical structures suggested that AB928 readily adapted to the A_(2B)R pocket,while 2-118 did not due to intrinsic *** disparity potentially accounted for the difference in inhibitory efficacy between A_(2B)R and A_(2A)*** study serves as a valuable structural template for the future development of selective or dual inhibitors targeting A_(2A)R/A_(2B)R for cancer therapy.

关键词： adenosine receptor A2AR A2BR inhibitor dual-antagonism drug discovery

Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

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Genes & Diseases 2024年第1期11卷 103-134页

作者： Kevin Qin Michael Yu Jiaming Fan Hongwei wang Piao Zhao Guozhi Zhaoo Wei Zeng Connie Chen yonghui wang Annie wang Zander Schwartz Jeffrey Hong Lily Song William Wagstaff Rex C.Haydon Hue H.Luu Sherwin H.Ho Jason Strelzow Russell R.Reid Tong-Chuan He Lewis L.Shi Chicago Medical School Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Departments of Orthopaedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China School of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37235USA Laboratory of Craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Wnt signaling plays a major role in regulating cell proliferation and *** Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical *** of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling *** crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ ***-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic *** complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic ***,both stimulatory and inhibitory treatments come with potential risks that need to be *** review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt *** thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/PCP,and the noncanonical Wnt/Ca2+*** description involved each of its components and their involvement in other cellular ***,this review explained the various other pathways and processes that crosstalk with Wnt signaling.

关键词： β-catenin Canonical Wnt Noncanonical Wnt Signal transduction Signaling crosstalk

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

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Genes & Diseases 2024年第3期11卷 155-187页

作者： Michael Yu Kevin Qin Jiaming Fan Guozhi Zhao Piao Zhao Wei Zeng Connie Chen Annie wang yonghui wang jiamin Zhong Yi Zhu William Wagstaff Rex C.Haydon Hue H.Luu Sherwin Ho Michael J.Lee Jason Strelzow Russell R.Reid Tong-Chuan He School of Medicine Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedic Surgery The First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China Department of Orthopaedic Surgery Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Department of Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China

The evolutionarily conserved Wnt signaling pathway plays a central role in develop-ment and adult tissue homeostasis across *** proteins are secreted,lipid-modified signaling molecules that activate the canonical(β-catenin dependent)and non-canonical(β-catenin independent)Wnt signaling *** behaviors such as proliferation,differ-entiation,maturation,and proper body-axis specification are carried out by the canonical pathway,which is the best characterized of the known Wnt signaling *** signaling has emerged as an important factor in stem cell biology and is known to affect the self-renewal of stem cells in various *** includes but is not limited to embryonic,hematopoietic,mesenchymal,gut,neural,and epidermal stem *** signaling has also been implicated in tumor cells that exhibit stem cell-like *** signaling is crucial for bone formation and presents a potential target for the development of therapeutics for bone *** surprisingly,aberrant Wnt signaling is also associated with a wide variety of diseases,including *** of Wnt pathway members in cancer can lead to unchecked cell proliferation,epithelial-mesenchymal transition,and ***,advances in the understand-ing of dysregulated Wnt signaling in disease have paved the way for the development of novel therapeutics that target components of the Wnt *** with a brief overview of the mechanisms of canonical and non-canonical Wnt,this review aims to summarize the cur-rent knowledge of Wnt signaling in stem cells,aberrations to the Wnt pathway associated with diseases,and novel therapeutics targeting the Wnt pathway in preclinical and clinical studies.

关键词： β-Catenin Cancer Canonical Wnt Disease Non-canonical Wnt Stem cells Targeted therapy Wnt signaling

RORγt反向激动剂用于自身免疫性疾病治疗的研究进展

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中国药科大学学报 2024年第1期55卷 87-102页

作者：鲁丽雪王永辉复旦大学药学院药物化学系

视黄酸受体相关孤儿受体RORγt作为Th17细胞特异性转录因子可诱导Th17细胞的分化以及炎性因子IL-17等的产生，在炎症和自身免疫性疾病等病症的发生和发展过程中发挥着重要作用。近年来RORγt反向激动剂已成为学术界乃至国际制药公司研... 详细信息

视黄酸受体相关孤儿受体RORγt作为Th17细胞特异性转录因子可诱导Th17细胞的分化以及炎性因子IL-17等的产生，在炎症和自身免疫性疾病等病症的发生和发展过程中发挥着重要作用。近年来RORγt反向激动剂已成为学术界乃至国际制药公司研究的热点领域。目前已报道多种骨架结构类型，包括正构位点反向激动剂和变构位点反向激动剂。本文通过介绍RORγt的结构与功能，并对处于临床和临床前研究中的一些RORγt反向激动剂进行综述，以期为RORγt反向激动剂的进一步研究与开发提供参考。

关键词：自身免疫性疾病 Th17细胞 RORγt反向激动剂

优势物种对内蒙古典型草原营养物质生产的决定性影响

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草业科学 2024年第9期41卷 2012-2024页

作者：王若冰王永慧赵宏宇张斌内蒙古大学生态与环境学院内蒙古呼和浩特010021

草地通过提供粗蛋白、粗脂肪、中性洗涤纤维和酸性洗涤纤维等营养物质而支撑畜牧业发展,但也受到干旱化的气候及日益增强的放牧和刈割活动的威胁。基于为期3年的内蒙古典型草原草地管理模式和降水量改变控制试验,本研究发现其营养物质... 详细信息

草地通过提供粗蛋白、粗脂肪、中性洗涤纤维和酸性洗涤纤维等营养物质而支撑畜牧业发展,但也受到干旱化的气候及日益增强的放牧和刈割活动的威胁。基于为期3年的内蒙古典型草原草地管理模式和降水量改变控制试验,本研究发现其营养物质生产能力随降水量减少而降低。尽管放牧和刈割的影响弱于降水量,但仍可通过降低群落生产力而降低其营养物质生产能力。此外,羊草(Leymus chinensis)和克氏针茅(Stipa krylovii)等优势物种的营养物质含量和群落生产力贡献调控群落营养物质生产能力对降水量和草地管理模式变化的响应。这意味着,干旱化的气候会降低内蒙古典型草原优势物种营养物质供给能力,从而降低群落营养物质生产,威胁畜牧业的可持续发展,而日益增强的放牧和刈割活动会使其进一步恶化。

关键词：内蒙古典型草原气候变化草地管理模式变化补偿效应选择效应

军事权力、大乘佛教与室利佛逝海上贸易模式构建

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东南亚纵横 2024年第4期 25-34页

作者：王勇辉华中师范大学政治与国际关系学院/中印尼人文交流研究中心湖北武汉430079

7-14世纪,作为印度尼西亚巽他群岛海上强国的室利佛逝,地理位置优越,控制着马六甲海峡和巽他海峡,联通着东西方的贸易往来。作为第一个势力范围涵盖整个马来半岛的古国,室利佛逝大力发展海上贸易,并将大乘佛教确立为国教,将在印度衰落... 详细信息

7-14世纪,作为印度尼西亚巽他群岛海上强国的室利佛逝,地理位置优越,控制着马六甲海峡和巽他海峡,联通着东西方的贸易往来。作为第一个势力范围涵盖整个马来半岛的古国,室利佛逝大力发展海上贸易,并将大乘佛教确立为国教,将在印度衰落的佛教又一次在室利佛逝发扬光大,室利佛逝成为世界性的佛教中心。大乘佛教深深地影响着印度尼西亚海岛地区政治、经济和宗教等方面的发展。赛代斯将这种现象称之为“印度化”。作为东南亚最强大的古国之一,室利佛逝宗教文化和海上贸易模式具有鲜明的特点,通过加强王权的控制力,以军队为后盾,通过征服领地、扩张商品生产地,建立起强大的海上贸易网络,为控制马六甲海峡和巽他海峡的黄金水道提供保障。同时,以大乘佛教作为强化政权的精神动力,大乘佛教成为统治者加强权力的工具,也给统治者带来了变革的动力,并影响着室利佛逝海上贸易模式的构建。从宗教和海上贸易模式来看,室利佛逝是东南亚古代文明发展过程中的特色符号。室利佛逝政权持续了约7个半世纪,在印度尼西亚诸多古国中存在时间之长是罕见的,通过构建东南亚海岛地区霸权和将大乘佛教定为国教,实现其统治的海岛地区的“印度化”。在对外关系上,室利佛逝与印度和中国的唐朝都保持着较为密切的联系,为研究印度尼西亚古代史上的“印度化”及中国的古代丝绸之路提供了重要参考价值。

关键词：印度尼西亚室利佛逝海上贸易模式军事权力大乘佛教

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智能技术在电力系统运维与管理中的应用

电力设备管理 2024年第15期 146-148页

作者：王桐王雍会国网物资有限公司国网河北省电力有限公司超高压分公司

本文探讨了智能技术在电力系统运维与管理中的关键应用案例。通过分析真实数据,揭示了智能技术在提高电力系统效率、降低运维成本、优化设备维护等方面的突出作用。研究重点集中于基于大数据分析、人工智能算法和物联网技术的应用,这些... 详细信息

本文探讨了智能技术在电力系统运维与管理中的关键应用案例。通过分析真实数据,揭示了智能技术在提高电力系统效率、降低运维成本、优化设备维护等方面的突出作用。研究重点集中于基于大数据分析、人工智能算法和物联网技术的应用,这些技术为电力系统管理者提供了更精准的数据支持,帮助其进行智能决策和实时监控。本文旨在深入探讨智能技术的具体应用,为电力系统运维与管理领域相关人员提供有价值的参考。

关键词：电力系统运维与管理大数据分析人工智能算法物联网技术

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基于响应面法的矿粉复合固化盐渍土试验研究

硅酸盐通报 2024年第5期43卷 1917-1927页

作者：王永辉朱连勇王成王超彭永倩塔里木大学水利与建筑工程学院阿拉尔843300

采用矿粉加固盐渍土可有效提高盐渍土强度,降低盐渍土路基溶陷性,但矿粉常温条件表现稳定,潜在活性需要被激发,针对上述问题,采用矿粉作为前驱体,研究不同掺量脱硫石膏-氢氧化钠-电石渣(DG-NaOH-CS,DNC)固化剂对矿粉复合固化盐渍土力学... 详细信息

采用矿粉加固盐渍土可有效提高盐渍土强度,降低盐渍土路基溶陷性,但矿粉常温条件表现稳定,潜在活性需要被激发,针对上述问题,采用矿粉作为前驱体,研究不同掺量脱硫石膏-氢氧化钠-电石渣(DG-NaOH-CS,DNC)固化剂对矿粉复合固化盐渍土力学性能、耐久性和微观机理的影响。结果表明,脱硫石膏、氢氧化钠、电石渣最优配合比为6.03∶0.63∶4.24(质量比)。基于最优配合比,DNC改性土28 d无侧限抗压强度均值为14.16 MPa,响应面模型预测值为14.08 MPa,说明预测值与试验值具有良好的相关性;相较于同掺量水泥固化土,DNC改性土呈现出更好的抗压强度、抗冻融循环和抗干湿循环性能。扫描电子显微镜(SEM)、X射线衍射(XRD)和傅里叶红外光谱(FTIR)分析显示,DNC固化剂在试块内水化产生大量水化硅酸钙(C-S-H)、水化铝酸钙(C-A-H)和钙矾石(AFt)胶凝材料,填补土体内部孔隙,从而进一步提高固化土强度。

关键词：盐渍土固化剂响应面法力学性能耐久性微观结构

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天然皂皮皂苷与大豆分离蛋白协同构建高蛋白减脂植物基蛋黄酱及其特性

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食品科学 2024年第9期45卷 22-28页

作者：尹文俊朱蒙蒙陈小威孙尚德王永辉河南工业大学粮油食品学院河南郑州450001 河南工业大学国家工程实验室/省重点实验室河南郑州450001 许昌学院食品与药学院河南许昌461000

本研究利用天然皂皮皂苷(Quillaja saponin,QS)与大豆分离蛋白(soybean protein isolate,SPI)稳定乳液凝胶的协同效应构建高蛋白、减脂的植物基蛋黄酱(plant-based mayonnaise,PM)。利用静态光散射、激光共聚焦、低形变流变学和质构特... 详细信息

本研究利用天然皂皮皂苷(Quillaja saponin,QS)与大豆分离蛋白(soybean protein isolate,SPI)稳定乳液凝胶的协同效应构建高蛋白、减脂的植物基蛋黄酱(plant-based mayonnaise,PM)。利用静态光散射、激光共聚焦、低形变流变学和质构特性对比分析PM与两种市售蛋黄酱在外观、乳滴粒径大小与分布、硬度、涂抹性、热稳定性和冻融稳定性等方面的特性。结果表明,以10%SPI和0.18%QS或10%SPI、0.18%QS和1%SPI凝胶颗粒(soy protein isolate gel particles,SGPs)为蛋白配料可构建出与商品蛋黄酱在外观、涂抹状态、质构以及流变特性上相媲美的高蛋白减脂PM(10%蛋白质与50%脂肪、11%蛋白质与40%脂肪,以质量分数计)。在该体系中,QS不仅赋予了高蛋白乳化制品黏度稀化的质构调节性,还赋予了SPI基乳液凝胶优越的热稳定性和冻融稳定性。本研究可为“高蛋白”“减脂”PM的开发与应用提供理论与技术指导。

关键词：植物基食品大豆分离蛋白高蛋白食品减脂食品素蛋黄酱