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Elemene Antitumor Drugs Development Based on "Molecular Compatibility Theory" and Clinical Application: A Retrospective and Prospective Outlook

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Chinese Journal of Integrative Medicine 2024年第1期30卷 62-74页

作者： JIANG Xiao-ying SHI Li-ping ZHU Jun-long BAI Ren-ren XIE tian School of Pharmacy Hangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Good Clinical Practice Center Affliliated Hospital of Nanjing University of Chinese MedicineNanjing(210000)China

Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE tian introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles, specifically the "monarch, minister, assistant, and envoy" theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the "molecular compatibility theory", further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".

关键词： molecular compatibility theory Chinese integrative medicine elemene antitumor activity drug delivery structural modification

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World Journal of Emergency Medicine 2023年第3期14卷 253-254页

作者： Ya-qing An Yan-ling Dong Yi-jiao Men Liang Liu Yu Gong Jian-ling Su Heng-bo Gao ying-ping tian Emergency Department the Second Hospital of Hebei Medical UniversityShijiazhuang 050051China

Ritodrine hydrochloride(ritodrine)is a β2-adrenoceptor stimulant that has been effectively prescribed for the prevention of premature labor.[1]In clinical practice,one of the biggest drawbacks ofβ-mimetics is their adverse eff ects,including arrhythmias,myocardial ischemia,and pulmonary edema,due to theirβ-sympathomimetic effects.[2]Here,we report a rare pregnant case of spontaneous coronary artery dissection(SCAD)after intravenous infusion of ritodrine.

关键词： prevention artery ischemia

New method for multibody dynamics based on unknown constraint force

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Science China(Technological Sciences) 2024年第3期67卷 791-808页

作者： tian ying JIA yingHong ZHANG Jun School of Astronautics Beihang UniversityBeijing 100191China Beijing Institute of Control Engineering Beijing 100190China National Laboratory of Space Intelligent Control Beijing 100190China

This paper presents a new method for the dynamics of multibody systems based on unknown constraint force. The method can uniformly solve multibody systems with typical configurations, including the system with rigid-flexible coupling, the system in tree topology, and the system with loop constraints. Unlike common methods, the proposed method can model the loop system without “cutting off” loop constraints, leading to the exact same modelling process as the tree-like system performs. Based on graph theory, a topological record matrix M_(rec) is proposed to capture the arbitrary system configuration. Moreover, constraint forces are selected as the key variables in semi-recursive framework. With the recursive kinematics relationship between adjacent bodies, the constraint force equation is further assembled to achieve the full-state system solution. The numerical simulations demonstrate the accuracy of the proposed method.

关键词： multibody system dynamic modelling rigid-flexible coupling unknown constraint force graph theory semi-recursive algorithm

Achieving dynamic privacy measurement and protection based on reinforcement learning for mobile edge crowdsensing of IoT

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Digital Communications and Networks 2024年第2期10卷 380-388页

作者： Renwan Bi Mingfeng Zhao Zuobin ying Youliang tian Jinbo Xiong Fujian Provincial Key Laboratory of Network Security and Cryptology College of Computer and Cyber SecurityFujian Normal UniversityFuzhou350117China Guangxi Key Laboratory of Trusted Software Guilin University of Electronic TechnologyGuilin541004China Faculty of Data Science City University of Macao999078MacaoChina State Key Laboratory of Public Big Data College of Computer Science and TechnologyGuizhou UniversityGuiyang550025China

With the maturity and development of 5G field,Mobile Edge CrowdSensing(MECS),as an intelligent data collection paradigm,provides a broad prospect for various applications in ***,sensing users as data uploaders lack a balance between data benefits and privacy threats,leading to conservative data uploads and low revenue or excessive uploads and privacy *** solve this problem,a Dynamic Privacy Measurement and Protection(DPMP)framework is proposed based on differential privacy and reinforcement ***,a DPM model is designed to quantify the amount of data privacy,and a calculation method for personalized privacy threshold of different users is also ***,a Dynamic Private sensing data Selection(DPS)algorithm is proposed to help sensing users maximize data benefits within their privacy ***,theoretical analysis and ample experiment results show that DPMP framework is effective and efficient to achieve a balance between data benefits and sensing user privacy protection,in particular,the proposed DPMP framework has 63%and 23%higher training efficiency and data benefits,respectively,compared to the Monte Carlo algorithm.

关键词： Mobile edge crowdsensing Dynamic privacy measurement Personalized privacy threshold Privacy protection Reinforcement learning

Stretchable and self-healing conductive fibers from hierarchical silver nanowires-assembled network

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Nano Research 2024年第2期17卷 763-770页

作者： ying-ying Wu Hong Chen Fan Zhang Pan Guo Haili Qin Huai-ping Cong Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering School of Chemistry and Chemical EngineeringHefei University of TechnologyHefei 230009China

Conductive fibers(CFs)with features of high conductivity,stretchability,self-healability,and electromechanical stability are key components of the increasingly popular wearable ***,since the lack of structural design of conductive network and interfacial interaction between soft polymer and conductive additives,it is still hard to enable CFs to meet above ***,we describe a facial drawing method from a hydrogel reservoir which is remolded into ultrathin and stretchable CFs with excellent multi-responsive *** hydrogel reservoir was fabricated in synergy of an ice-templating method and in situ polymerization using the assembled framework as a *** on the effective fabrication mechanism,the diameter of CFs could be well-tuned from 90 to 400μm by adjusting the dipping depth of the glass rod,accompanied with conductivity increased from 0.75 to 2.5 S/*** the hierarchical network structure was well maintained in the CFs,professional performances have been proved on the stretchability and electromechanical *** presence of massive hydrogen bonding and Ag–S bond enabled the CFs with excellent self-healability under the conditions of contact,electric field,and near infrared light,***,the CFs with high sensing property could be integrated into an advanced textile sensor through an effective healing-induced integration strategy,demonstrating its great potentials as superior two-dimensional(2D)electronic skins.

关键词： conductive fibers self-assembled silver nanowires Ag–S coordination self-healing flexible sensors

Associations between the use of red yeast rice preparations and adverse health outcomes:An umbrella review of meta-analyses of randomized controlled trials

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Journal of Integrative Medicine 2024年第2期22卷 126-136页

作者： Zhen-yu Ma Shu-ping Yang ying Li tian-tian Xu Ya-lin Yang Hui-yong Yang Heng-bing Li Le-jin Zhou Yong Diao Su-yun Li School of Medicine Huaqiao UniversityQuanzhou 362021Fujian ProvinceChina College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250355Shandong ProvinceChina Second Clinical Medical College Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina

Background:Red yeast rice(RYR),a natural lipid-lowering agent,is widely used in clinical ***,the existing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results,and the credibility of the evidence has not been ***:This study was designed to evaluate the existing evidence and offer a comprehensive understanding of the associations between the use of RYR preparations and various adverse health *** strategy:Seven literature databases were searched from inception to May 5,2023,using medical subject headings and free-text terms(e.g.,“red yeast rice,”“Xuezhikang,”and“Zhibitai”).Inclusion criteria:Meta-analyses that investigated and quantitatively estimated associations between the use of RYR preparations and adverse health outcomes were included in this *** extraction and analysis:Two researchers independently extracted data using a standardized data collection table;any disagreements were resolved by consulting a third *** on the participant,intervention,comparator and outcome(PICO)framework in each eligible meta-analysis,a series of unique associations between the use of RYR preparations and adverse health outcomes were *** associations’effect estimates were re-evaluated using random-effect ***:Fifteen meta-analyses,comprising 186(164 unique)randomized controlled trials,were *** on A Mea Surement Tool to Assess Systematic Reviews version 2,3(20%)and 12(80%)of these meta-analyses had low and critically low confidence,respectively.A total of 61 unique associations between the use of RYR preparations and adverse health outcomes were extracted from eligible *** on the random-effect models,10(16.4%)associations indicated a significant protective effect of RYR preparations against adverse health outcomes,while 5(8.2%)indicated an increased risk of adverse health outcomes related to uric acid,alanine transaminase and aspartate trans

关键词： Red yeast rice Safety Adverse health outcomes Umbrella review Meta-analysis Systematic review

Mechanical properties and microstructure of Mg-treated and Catreated industrial H13 steel after quenching and tempering

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Journal of Iron and Steel Research International 2024年第8期31卷 1987-2001页

作者： Jun-ying Yue Dong Hou De-yong Wang tian-peng Qu Xiang-long Li Jun tian School of Iron and Steel Soochow UniversitySuzhou 215021JiangsuChina

The effect of magnesium treatment and calcium treatment on the microstructure and mechanical properties of industrial H13 steel after quenching and tempering was *** impact toughness and tensile tests were mainly carried out,and the microstructure was observed by scanning electron microscopy,electron backscattered diffraction,and X-ray *** results show that magnesium treatment is still feasible in industrial *** is mainly manifested in the refinement of lath martensite and *** with calcium treatment,the prior austenite grains and carbides size of industrial H13 steel treated with magnesium decreased by 3.17μm after *** quenching and tempering,the carbides(especially V-rich carbides)in Mg treatment obviously spheroidized and distributed uniformly and increased in quantity *** lath martensite size is reduced from 2.45 to 2.31μ*** suggests that magnesium treatment was able to yield smaller grains and more evenly distributed ***,the impact toughness,yield strength,and ultimate tensile strength of industrial H13 steel with magnesium treatment increased by 28%,65.5 MPa and 123.7 MPa,*** increment of strength mainly comes from dislocation strengthening,grain refinement strengthening,and precipitation strengthening,among which precipitation strengthening accounts for the largest proportion.

关键词： Industrial H13 steel Mg treatment Heat treatment Carbide-Mechanical property

Influence of friction-lubrication characteristics varying with rolling speed on instability of chatter and slip in cold tandem rolling process

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Journal of Iron and Steel Research International 2024年第4期31卷 894-908页

作者： Yan-li Xin Zhi-ying Gao Bo tian Qing-dong Zhang School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China

In the high-speed cold tandem rolling process of thin plate,chatter or slip instability gives rise to the deterioration of equipment and product *** instability behavior is closely related to interfacial friction-lubrication con-dition which is generally characterized by the friction ***,with higher and higher speed requirements,the commonly used model of friction coefficient is no longer applicable and accurate.A novel approach is suggested to calculate the speed-dependent friction coefficient,in which the viscosity-pressure-temperature effects of the lubricant,surface roughness states of work rolls and rolled piece are comprehensively involved and the mixed flm lubrication theory is ***,the influences of friction coefficient on the instability of slip and chatter are investigated for a five-stand cold tandem rolling *** one side,the critical friction coefficient for each stand is determined by calculating the corresponding slip factor;on the other hand,the friction coefficient varying with rolling speed is combined with the model of theoretical critical rolling speed presented under constant friction coefficient,so that the speed threshold is ***,the stable and unstable regions corresponding to the rear three stands are individually discussed,and the technical strategies are proposed to suppress both slip and chatter frequently occurring in the actual rolling process.

关键词： Cold tandem rolling:Oil film thickness Speed-dependent friction coefficient-Slip:Chatter

Resilience provides mediating effect of resilience between fear of progression and sleep quality in patients with hematological malignancies

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World Journal of Psychiatry 2024年第4期14卷 541-552页

作者： Yuan tian ying-Li Wang Department of Hematology The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou 121000Liaoning ProvinceChina Department of Cardiology The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou 121000Liaoning ProvinceChina

BACKGROUND Hematological tumors are common malignant tumors,with high morbidity and mortality *** patients with hematological malignancies develop sleep disorders that seriously affect their life and health because of acute onset of disease,rapid progression,high recurrence rates,complex treatment methods,and treatment *** To explore the mediating effect of resilience on fear of disease progression and sleep quality in patients with hematological *** A cross-sectional analysis of 100 patients with hematological malignancies,treated in the First Affiliated Hospital of Jinzhou Medical University between August 2022 and August 2023,was *** were assessed using a general data survey,a simplified scale for the fear of progression(FoP)of disease,a resilience scale,and the Pittsburgh Sleep Quality *** analysis was conducted to determine the relationship between various patient characteristics and FoP,resilience,and sleep ***’s correlation analysis was used to examine the correlations between mental resilience,FoP,and sleep *** The total FoP score mean value in patients with hematological malignancies was 38.09±5.16;the total resilience score mean value was 40.73±7.04;and the Pittsburgh Sleep Quality Index score mean value was 10.72±***,resilience,and sleep quality of the patients were associated with family per capita monthly income and patient education level(P<0.05).Spearman correlation analysis revealed that FoP was negatively correlated with resilience and sleep quality scores(r=-0.560,-0.537,P<0.01),respectively,and resilience was significantly associated with sleep quality scores(r=0.688,P<0.01).Mediation analysis showed that the mediating effect of resilience between FoP and sleep quality in patients with hematological malignancies was-0.100 and accounted for 50.51%of the total *** indicated that FoP directly and indirectly affected sleep quality through the mesomeric eff

关键词： Resilience Blood tumor Fear of progression Sleep quality Mediating effect