Elemene Antitumor Drugs Development Based on "Molecular Compatibility Theory" and Clinical Application: A Retrospective and Prospective Outlook

作     者：JIANG Xiao-ying SHI Li-ping ZHU Jun-long BAI Ren-ren XIE Tian JIANG Xiao-ying;SHI Li-ping;ZHU Jun-long;BAI Ren-ren;XIE Tian

作者机构：School of PharmacyHangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-cancer Chinese MedicinesEngineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Good Clinical Practice CenterAffliliated Hospital of Nanjing University of Chinese MedicineNanjing(210000)China 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2024年第30卷第1期

页      面：62-74页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：molecular compatibility theory Chinese integrative medicine elemene antitumor activity drug delivery structural modification 

摘      要：Elemene, derived from Curcuma wenyujin, one of the 8 famous genuine medicinal materials of Zhejiang province, exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE Tian introduced the innovative concept of molecular compatibility theory by combining Chinese medicine principles, specifically the monarch, minister, assistant, and envoy theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the molecular compatibility theory, further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene s potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of molecular compatibility theory.