Associations between the use of red yeast rice preparations and adverse health outcomes:An umbrella review of meta-analyses of randomized controlled trials

作     者：Zhen-yu Ma Shu-ping Yang Ying Li Tian-tian Xu Ya-lin Yang Hui-yong Yang Heng-bing Li Le-jin Zhou Yong Diao Su-yun Li Zhen-yu Ma;Shu-ping Yang;Ying Li;Tian-tian Xu;Ya-lin Yang;Hui-yong Yang;Heng-bing Li;Le-jin Zhou;Yong Diao;Su-yun Li

作者机构：School of MedicineHuaqiao UniversityQuanzhou 362021Fujian ProvinceChina College of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinan 250355Shandong ProvinceChina Second Clinical Medical CollegeNanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina 

出 版 物：《Journal of Integrative Medicine》 (结合医学学报（英文版）)

年 卷 期：2024年第22卷第2期

页      面：126-136页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the Natural Science Foundation of Fujian Province(Grant No.2022J05062) the Natural Science Foundation of Xiamen(Grant No.3502Z20227041) the Science and Technology Planning Project of Quanzhou(Grant No.2021N142S) the Scientific Research Funds of Huaqiao University(Grant No.21BS126) the Huaqiao University Young and Middleaged Teachers Science and Technology Innovation Funding Program(Grant No.ZQN-PY319) the Huaqiao University Research and Development Project(Grant No.20221HH273) 

主　　题：Red yeast rice Safety Adverse health outcomes Umbrella review Meta-analysis Systematic review 

摘      要：Background:Red yeast rice(RYR),a natural lipid-lowering agent,is widely used in clinical ***,the existing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results,and the credibility of the evidence has not been ***:This study was designed to evaluate the existing evidence and offer a comprehensive understanding of the associations between the use of RYR preparations and various adverse health *** strategy:Seven literature databases were searched from inception to May 5,2023,using medical subject headings and free-text terms(e.g.,“red yeast rice,“Xuezhikang,and“Zhibitai).Inclusion criteria:Meta-analyses that investigated and quantitatively estimated associations between the use of RYR preparations and adverse health outcomes were included in this *** extraction and analysis:Two researchers independently extracted data using a standardized data collection table;any disagreements were resolved by consulting a third *** on the participant,intervention,comparator and outcome(PICO)framework in each eligible meta-analysis,a series of unique associations between the use of RYR preparations and adverse health outcomes were *** associations’effect estimates were re-evaluated using random-effect ***:Fifteen meta-analyses,comprising 186(164 unique)randomized controlled trials,were *** on A Mea Surement Tool to Assess Systematic Reviews version 2,3(20%)and 12(80%)of these meta-analyses had low and critically low confidence,respectively.A total of 61 unique associations between the use of RYR preparations and adverse health outcomes were extracted from eligible *** on the random-effect models,10(16.4%)associations indicated a significant protective effect of RYR preparations against adverse health outcomes,while 5(8.2%)indicated an increased risk of adverse health outcomes related to uric acid,alanine transaminase and aspartate trans