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Theta Oscillations Support Prefrontal-hippocampal Interactions in Sequential Working Memory

Neuroscience Bulletin 2024年第2期40卷 147-156页

作者： Minghong Su Kejia Hu Wei Liu yunhao wu Tao Wang Chunyan Cao Bomin Sun Shikun Zhan Zheng ye Institute of Psychology Chinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China Department of Neurosurgery Center for Functional NeurosurgeryRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Institute of Neuroscience Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China

The prefrontal cortex and hippocampus may support sequential working memory beyond episodic memory and spatial *** stereoelectroencephalography(SEEG)study investigated how the dorsolateral prefrontal cortex(DLPFC)interacts with the hippocampus in the online processing of sequential *** patients with epilepsy(eight women,age 27.6±8.2 years)completed a line ordering task with SEEG recordings over the DLPFC and the *** showed longer thinking times and more recall errors when asked to arrange random lines clockwise(random trials)than to maintain ordered lines(ordered trials)before recalling the orientation of a particular ***,the ordering-related increase in thinking time and recall error was associated with a transient theta power increase in the hippocampus and a sustained theta power increase in the DLPFC(3–10 Hz).In particular,the hippocampal theta power increase correlated with the memory precision of line ***,theta phase coherences between the DLPFC and hippocampus were enhanced for ordering,especially for more precisely memorized ***,the theta band DLPFC→hippocampus influence was selectively enhanced for ordering,especially for more precisely memorized *** study suggests that theta oscillations may support DLPFC-hippocampal interactions in the online processing of sequential information.

关键词： Sequential working memory Hippocampus Dorsolateral prefrontal cortex Theta oscillations Stereoelectroencephalography(SEEG) Phase coherence Granger causality

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Poly(ferulic acid)nanocarrier enhances chemotherapy sensitivity of acute myeloid leukemia by selectively targeting inflammatory macrophages

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Chinese Chemical Letters 2024年第9期35卷 289-295页

作者： Weijian Zhang Xianyu Deng Liying Wang Jian Wang Xiuting Guo Lianggui Huang Xinyi Wang Jun wu Linjia Jiang Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Otolaryngology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Hematology The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China Department of Pediatrics Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)NanshaGuangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong Kong SAR 999077China

Macrophages,as a subset of innate immune cells,play a pivotal role in the initiation,maintenance,and resolution of inflammatory responses during tissue damage repair,defense against infections,and tumor ***,the mechanisms by which macrophages regulate inflammation in acute myeloid leukemia(AML)and their involvement in the chemotherapeutic effect remain *** this study,we have identified that AML cells stimulate macrophage expansion by activating the colony-stimulating factor 1 receptor(CSF1R)*** expanded macrophages activate nuclear factor kappa-B(NFκB)to induce the expression of inflammatory factors,thereby maintaining leukemic cell quiescence and promoting cell survival following ***,we have successfully utilized a poly(ferulic acid)nanocarrier to selectively target macrophages for inhibiting the NFκB-mediated inflammation,ultimately enhancing chemotherapy efficacy against *** together,our findings highlight the crucial role of macrophage-induced inflammation in conferring chemoresistance to AML,and demonstrate the potential of a targeted nanocarrier specifically designed for inflammatory macrophages to improve the AML chemotherapeutic outcomes.

关键词： Acute myeloid leukemia Chemoresistance Macrophage Inflammation NFκB

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A NOVEL STOCHASTIC HEPATITIS B VIRUS EPIDEMIC MODEL WITH SECOND-ORDER MULTIPLICATIVE α-STABLE NOISE AND REAL DATA

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Acta Mathematica Scientia 2024年第2期44卷 752-788页

作者： Anwarud DIN yassine SABBAR 吴鹏 Department of Mathematics Sun Yat-Sen UniversityGuangzhou510275China MAIS Laboratory MAMCS GroupFST ErrachidiaMoulay Ismail University of MeknesP.O.Box 509Errachidia52000Morocco School of Science Hangzhou Dianzi UniversityHangzhou310018China School of Data Sciences Zhejiang University of Finance and EconomicsHangzhou310018China

This work presents an advanced and detailed analysis of the mechanisms of hepatitis B virus(HBV)propagation in an environment characterized by variability and *** on some biological features of the virus and the assumptions,the corresponding deterministic model is formulated,which takes into consideration the effect of *** deterministic model is extended to a stochastic framework by considering a new form of disturbance which makes it possible to simulate strong and significant *** long-term behaviors of the virus are predicted by using stochastic differential equations with second-order multiplicative α-stable *** developing the assumptions and employing the novel theoretical tools,the threshold parameter responsible for ergodicity(persistence)and extinction is *** theoretical results of the current study are validated by numerical simulations and parameters estimation is also ***,we obtain the following new interesting findings:(a)in each class,the average time depends on the value ofα;(b)the second-order noise has an inverse effect on the spread of the virus;(c)the shapes of population densities at stationary level quickly changes at certain values of α.The last three conclusions can provide a solid research base for further investigation in the field of biological and ecological modeling.

关键词： HBV model nonlinear perturbation probabilistic bifurcation long-run forecast numerical simulation

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NCAPD2 serves as a potential prognostic biomarker for lung adenocarcinoma and promotes cell proliferation,migration,invasion and cell cycle in vitro

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Oncology Research 2024年第9期32卷 1439-1452页

作者： PEILING wu LIFANG ZHAO HONGyAN ZHANG yUEyAN LOU DONGFANG CHEN SHAN XUE XUEQING LIU HANDONG JIANG Department of Respiratory and Critical Care Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai200127China

Objectives:The pro-oncogenic effects of NCAPD2 have been extensively studied across various tumor types;however,its precise role within the context of lung adenocarcinoma(LUAD)remains *** study aims to elucidate the biological functions of NCAPD2 in LUAD and unravel the underlying mechanistic ***:Utilizing bioinformatics methodologies,we explored the differential expression of NCAPD2 between normal and tumor samples,along with its correlations with clinical-pathological characteristics,survival prognosis,and immune ***:In the TCGA-LUAD dataset,tumor samples demonstrated significantly elevated levels of NCAPD2 expression compared to normal samples(py,higher NCAPD2 expression was notably associated with advanced T,N,and M stages,pathologic stage,gender,smoking status,and diminished overall survival(OS).Moreover,differentially expressed genes(DEGs)associated with NCAPD2 were predominantly enriched in pathways related to cell *** infiltration analysis revealed that NCAPD2 expression levels were linked to the infiltration of memory B cells,naïve CD4+T cells,activated memory CD4+T cells,and M1 *** vitro experiments demonstrated that silencing NCAPD2 suppressed LUAD cell proliferation,migration,invasion,epithelial-mesenchymal transition(EMT),and cell cycle ***:In summary,NCAPD2 may represent a promising prognostic biomarker and novel therapeutic target for LUAD.

关键词： NCAPD2 LUAD Prognosis Immune infiltration Cell cycle

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Identification of 3-ketocapnine reductase activity within the human microbiota

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mLife 2024年第2期3卷 307-316页

作者： Xiaotong wu Lukuan Hou Haili Zhang yi Ma Jufang Wang Mingwei Cai Xiaoyu Tang School of Biology and Biological Engineering South China University of TechnologyGuangzhouChina Institute of Chemical Biology Shenzhen Bay LaboratoryShenzhenChina College of Chemistry and Pharmacy Northwest A&F UniversityYanglingChina

The microbial synthesis of sulfonolipids within the human body is likely involved in maintaining human health or causing ***,the enzymes responsible for their biosynthesis remain largely *** this study,we identified and verified the role of 3-ketocapnine reductase,the third-step enzyme,in the four-step conversion of L-phosphoserine into sulfobacin B both in vivo and in *** finding builds upon our previous research into sulfonolipid biosynthesis,which focused on the vaginal bacterium Chryseobacterium gleum DSM 16776 and the gut bacterium Alistipes finegoldii DSM *** comprehensive gene mapping,we demonstrate the widespread presence of potential sulfonolipid biosynthetic genes across diverse bacterial species inhabiting various regions of the human *** findings shed light on the prevalence of sulfonolipid-like metabolites within the human microbiota,suggesting a potential role for these lipid molecules in influencing the intricate biointeractions within the complex microbial ecosystem of the human body.

关键词： 3-ketocapnine reductase capnines human microbiota sulfonolipids

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Heyingwuzi formulation alleviates diabetic retinopathy by promoting mitophagy via the HIF-1α/BNIP3/NIX axis

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World Journal of Diabetes 2024年第6期15卷 1317-1339页

作者： Jia-Jun wu Shu-yan Zhang Lin Mu Zhi-Guo Dong yin-Jian Zhang Department of Ophthalmology Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Ophthalmology Eye and ENT HospitalFudan UniversityShanghai 200031China

BACKGROUND Diabetic retinopathy(DR)is the primary cause of visual problems in patients with *** Heyingwuzi formulation(HyWZF)is effective against *** To determine the HyWZF prevention mechanisms,especially those underlying *** Human retinal capillary endothelial cells(HRCECs)were treated with high glucose(hg),HyWZF serum,PX-478,or Mdivi-1 in ***,cell counting kit-8,transwell,and tube formation assays were used to evaluate HRCEC proliferation,invasion,and tube formation,*** electron microscopy was used to assess mitochondrial morphology,and Western blotting was used to determine the protein *** cytometry was used to assess cell apoptosis,reactive oxygen species(ROS)production,and mitochondrial membrane ***,C57BL/6 mice were established in vivo using streptozotocin and treated with HyWZF for four *** glucose levels and body weight were monitored *** in retinal characteristics were evaluated using hematoxylin and eosin,tar violet,and periodic acid-Schiff *** levels in retinal tissues were determined via Western blotting,immunohistochemistry,and *** HyWZF inhibited excessive ROS production,apoptosis,tube formation,and invasion in hg-induced HRCECs via mitochondrial autophagy in *** increased the mRNA expression levels of BCL2-interacting protein 3(BNIP3),FUN14 domain-containing 1,BNIP3-like(BNIP3L,also known as NIX),PARKIN,PTEN-induced kinase 1,and hypoxia-inducible factor(HIF)-1α.Moreover,it downregulated the protein levels of vascular endothelial cell growth factor and increased the light chain 3-II/I ***,PX-478 and Mdivi-1 reversed these ***,PX-478 and Mdivi-1 rescued the effects of HyWZF by decreasing oxidative stress and apoptosis and increasing *** intervention improved the symptoms of diabetes,tissue damage,number of acellular capillaries,and oxidative stress in ***,in vivo

关键词： Diabetic retinopathy HIF-1α/BNIP3/NIX axis Mitophagy Heyingwuzi formulation Traditional Chinese medicine

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Petrogenesis and Tectonic Implications of the Paleoproterozoic A-Type Granites in the Xiong’ershan Area along the Southern Margin of the North China Craton

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Journal of Earth Science 2024年第2期35卷 416-429页

作者： Jinhong Xu yuping Jiang Shuli Hu Zhengwei Zhang Chengquan wu Chaofei Zheng Xiyao Li Ziru Jin Sensen Zhang yatao Zhou State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang550081China University of Chinese Academy of Sciences Beijing100049China Henan Province Non-ferrous Metals Geological Mineral Resources Bureau Zhengzhou450053China Jiangmen Land Market Monitoring Center Jiangmen 529000China

Paleoproterozoic A-type granites are widely distributed in the southern margin of the North China Craton(SNCC),providing important information for understanding the Paleoproterozoic tectonic regimes in this *** paper reports newly obtained whole-rock compositions and zircon U-Pb ages for the Tieluping syenogranite porphyry(TLP)and Huoshenmiao alkali granite porphyry(HSM)in the *** from the TLP and HSM have U-Pb ages of 1805±12 and 1792±14 Ma,*** ages are taken to date the emplacement of these *** had high total alkali contents(K_(2)O+Na_(2)O>7.13 wt.%),with high 10000×Ga/Al ratios(3.06–3.41)and Zr+y+Nb+Ce values(709 ppm–910 ppm)as well as high zircon saturation temperatures(864–970℃),indicative of A-type granite *** y/Nb(1.75–3.32),Ce/Nb(7.72–9.72),and yb/Ta(2.89–5.60)ratios suggested that TLP and HSM belonged to the A2-type *** negative whole rockε_(Nd)(t)values(−8.4 to−6.6)and negative zirconε_(Hf)(t)values(−15.9 to−6.3)confirmed that TLP and HSM were likely generated by the partial melting of an ancient continental ***εHf(t)(−7.4 to+4.0)values of inherited zircons in the TLP suggested that they were derived from the partial melting of Archean basement *** the geochemical similarity of the 1.80 Ga A-type granitoids in the SNCC,we propose that the TLP and HSM were formed in a post-collisional regime that was likely associated with the break-off of the Paleoproterozoic subducted *** of the asthenosphere provided huge heat to generate the regional 1.80 Ga A-type granite in the SNCC.

关键词： Paleoproterozoic A-type granite Post-collisional North China Craton tectonic geochemistry

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A Novel Two-dimensional Low-redundancy Array Design for Solar Radio Imaging

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Research in Astronomy and Astrophysics 2024年第9期24卷 178-189页

作者： Weidan Zhang Bing Wang Zhao wu Guang Lu yao Chen yan Fabao Laboratory for Electromagnetic Detection Institute of Space SciencesShandong UniversityWeihai 264209China Center for Integrated Research on Space Science Astronomyand PhysicsInstitute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China School of Mechanical Electrical&Information EngineeringShandong UniversityWeihai 264209China

The radioheliograph is an extensive array of antennas operating on the principle of aperture synthesis to produce images of the *** image acquired by the telescope results from convoluting the Sun’s true brightness distribution with the antenna array’s directional *** imaging quality of the radioheliograph is affected by a multitude of factors,with the performance of the“dirty beam”being simply one *** factors such as imaging methods,calibration techniques,clean algorithms,and more also play a significant influence on the resulting image *** the layout of the antenna array directly affects the performance of the dirty beam,the design of an appropriate antenna configuration is critical to improving the imaging quality of the *** on the actual needs of observing the Sun,this work optimized the antenna array design and proposed a twodimensional low-redundancy *** proposed array was compared with common T-shaped arrays,y-shaped arrays,uniformly spaced circular arrays,and three-arm spiral *** simulations and experiments,their performance in terms of sampling point numbers,UV coverage area,beam-half width,sidelobe level,and performance in the absence of antennas are compared and *** was found that each of these arrays has its advantages,but the two-dimensional low-redundancy array proposed in this paper performs best in overall *** has the shortest imaging calculation time among the array types and is highly robust when antennas are missing,making it the most suitable choice.

关键词： interferometers methods:observational techniques:interferometric

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Synthesis of Long-Chain Oligomeric Donor and Acceptors via Direct Arylation for Organic Solar Cells

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Chinese Journal of Chemistry 2024年第5期42卷 523-532页

作者： yu wu Xin-yu He Xu-Min Huang Ling-Jun yang Peng Liu Na Chen Chang-Zhi Li Shi-yong Liu Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry College of MaterialsMetallurgical and ChemistryJiangxi University of Science and TechnologyGanzhouJiangxi341000 China Department of Polymer Science and Engineering Zhejiang UniversityHangzhouZhejiang310027 China

The rapid synthesis of structurally complicated electron donors&acceptors still remains a major challenge in organic solar cells(OSC).In this work,we developed a highly efficient strategy to access long-chain oligomeric donor and acceptors for OSC applications.A series of cyclopentadithiophene(CPDT)and benzothiadiazole(BT)-basedπ-conjugated oligomers,i.e.,three oligomeric acceptors(BTDT)n-IC(n=1—3)and one long-chain oligomeric donor(BTDT)4-RD,are facilely synthesized by an atom-and step-economical,and labor-saving direct C—H arylation(DACH)reaction(i.e.,C—H/C—Br cross coupling).Note that(BTDT)4-RD involving five CPDT,four BT and two rhodamine(RD)building blocks is the longest oligomeric donor in the fullerene-free OSC devices ever *** dependence of the structure-property-performance correlation of(BTDT)n-IC(n=1—3)and(BTDT)4-RD on theπ-conjugation lengths is thoroughly investigated by opto-electrochemical measurements,bulk heterojunction(BHJ)OSC devices and ***(BTDT)1-IC:PBDB-T and(BTDT)4-RD:y6 BHJs achieve power conversion efficiencies of 9.14%and 4.51%,*** findings demonstrate that DACH reaction is a powerful tool to tune the opto-electronic properties and device performances by regulating the lengths ofπ-conjugated oligomers with varied numbers of repeating units.

关键词： Long-chainπ-conjugated oligomer Organic solar cells Direct arylation Atom-economical synthesis Cyclopentadithiophene Benzothiadiazole C—H activation Conjugation Oligomers

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Spin transport of half-metal Mn_(2)X_(3) with high Curie temperature:An ideal giant magnetoresistance device from electrical and thermal drives

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Frontiers of physics 2024年第4期19卷 125-135页

作者： Bin Liu Xiaolin Zhang Jingxian Xiong Xiuyang Pang Sheng Liu Zixin yang Qiang yu Honggen Li Sicong Zhu Jian wu Hubei Province Key Laboratory of Systems Science in Metallurgical Process The State Key Laboratory for Refractories and MetallurgyCollaborative Innovation Center for Advanced SteelsInternational Research Institute for Steel TechnologyWuhan University of Science and TechnologyWuhan 430081China Key Laboratory of Artificial Micro-and Nano-structures of Ministry of Education and School of Physical and Technology Wuhan UniversityWuhan 430072China College of Advanced Interdisciplinary Studies Nanhu Laser LaboratoryNational University of Defense TechnologyChangsha 410073China Department of Mechanical Engineering National University of SingaporeSingapore 117575Singapore i-Lab&Key Laboratory of Nanodevices and Applications&Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and NanoBionicsChinese Academy of SciencesSuzhou 215123China Institute of Optical Science and Technology School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China

Currently,magnetic storage devices are encountering the problem of achieving lightweight and high integration in mobile computing devices during the information *** a result,there is a growing urgency for twodimensional half-metallic materials with a high Curie temperature(TC).This study presents a theoretical investigation of the fundamental electromagnetic properties of the monolayer hexagonal lattice of Mn_(2)X_(3)(X=S,Se,Te).Additionally,the potential application of Mn_(2)X_(3) as magneto-resistive components is *** three of them fall into the category of ferromagnetic *** particular,the Monte Carlo simulations indicate that the TC of Mn2S3 reachs 381 K,noticeably greater than room *** findings present notable advantages for the application of Mn2S3 in spintronic ***,a prominent spin filtering effect is apparent when employing non-equilibrium Green’s function simulations to examine the transport *** resulting current magnitude is approximately 2×10^(4) nA,while the peak gigantic magnetoresistance exhibits a substantial value of 8.36×10^(16)%.It is noteworthy that the device demonstrates a substantial spin Seebeck effect when the temperature differential between the electrodes is *** brief,Mn_(2)X_(3) exhibits outstanding features as a highTC half-metal,exhibiting exceptional capabilities in electrical and thermal drives spin ***,it holds great potential for usage in spintronics applications.

关键词： half-metals Mn_(2)X_(3) high Curie temperature electrical and thermal GMR

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