Poly(ferulic acid)nanocarrier enhances chemotherapy sensitivity of acute myeloid leukemia by selectively targeting inflammatory macrophages

作     者：Weijian Zhang Xianyu Deng Liying Wang Jian Wang Xiuting Guo Lianggui Huang Xinyi Wang Jun Wu Linjia Jiang Weijian Zhang;Xianyu Deng;Liying Wang;Jian Wang;Xiuting Guo;Lianggui Huang;Xinyi Wang;Jun Wu;Linjia Jiang

作者机构：Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene RegulationSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of OtolaryngologySun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of HematologyThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China Department of PediatricsSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Bioscience and Biomedical Engineering ThrustThe Hong Kong University of Science and Technology(Guangzhou)NanshaGuangzhou 511400China Division of Life ScienceThe Hong Kong University of Science and TechnologyHong Kong SAR 999077China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第9期

页      面：289-295页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学] 

基　　金：the National Key Research and Development Program of China(No.2022YFA1103302) the National Natural Science Foundation of China(Nos.92268205,52173150,51973243,82204287) Guangdong Innovative and Entrepreneurial Research Team Program(No.2019ZT08Y485) Guangdong Basic and Applied Basic Research Foundation(No.2021B1515020012) Guangzhou Science and Technology Program City-University Joint Funding Project(No.2023A03J0001) 

主　　题：Acute myeloid leukemia Chemoresistance Macrophage Inflammation NFκB 

摘      要：Macrophages,as a subset of innate immune cells,play a pivotal role in the initiation,maintenance,and resolution of inflammatory responses during tissue damage repair,defense against infections,and tumor ***,the mechanisms by which macrophages regulate inflammation in acute myeloid leukemia(AML)and their involvement in the chemotherapeutic effect remain *** this study,we have identified that AML cells stimulate macrophage expansion by activating the colony-stimulating factor 1 receptor(CSF1R)*** expanded macrophages activate nuclear factor kappa-B(NFκB)to induce the expression of inflammatory factors,thereby maintaining leukemic cell quiescence and promoting cell survival following ***,we have successfully utilized a poly(ferulic acid)nanocarrier to selectively target macrophages for inhibiting the NFκB-mediated inflammation,ultimately enhancing chemotherapy efficacy against *** together,our findings highlight the crucial role of macrophage-induced inflammation in conferring chemoresistance to AML,and demonstrate the potential of a targeted nanocarrier specifically designed for inflammatory macrophages to improve the AML chemotherapeutic outcomes.