Identification of 3-ketocapnine reductase activity within the human microbiota
作者机构：School of Biology and Biological EngineeringSouth China University of TechnologyGuangzhouChina Institute of Chemical BiologyShenzhen Bay LaboratoryShenzhenChina College of Chemistry and PharmacyNorthwest A&F UniversityYanglingChina
出 版 物：《mLife》 (微生物（英文）)
年 卷 期：2024年第3卷第2期
页 面：307-316页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the Shenzhen Bay Laboratory Startup Funds(21230051 to X.T.) Guangdong Province's Pearl River Recruitment Program of Talents(2021QN02Y855 to X.T.) GuangDong Basic and Applied Basic Research Foundation(2021A1515110334 to M.C.) the Natural Science Basic Research Plan in Shaanxi Province of China(2023-JC-QN-0160 to L.H.) the Scientific Research Foundation of Northwest A&F University(Z1090122052 to L.H.)
主 题：3-ketocapnine reductase capnines human microbiota sulfonolipids
摘 要：The microbial synthesis of sulfonolipids within the human body is likely involved in maintaining human health or causing ***,the enzymes responsible for their biosynthesis remain largely *** this study,we identified and verified the role of 3-ketocapnine reductase,the third-step enzyme,in the four-step conversion of L-phosphoserine into sulfobacin B both in vivo and in *** finding builds upon our previous research into sulfonolipid biosynthesis,which focused on the vaginal bacterium Chryseobacterium gleum DSM 16776 and the gut bacterium Alistipes finegoldii DSM *** comprehensive gene mapping,we demonstrate the widespread presence of potential sulfonolipid biosynthetic genes across diverse bacterial species inhabiting various regions of the human *** findings shed light on the prevalence of sulfonolipid-like metabolites within the human microbiota,suggesting a potential role for these lipid molecules in influencing the intricate biointeractions within the complex microbial ecosystem of the human body.
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