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Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2312-2323页

作者： Xian Li Mengxin Xu Jingyi yang Li Zhou Lin Liu Min Li Shasha Wang Mei-Qin Liu Zhixiang Huang Zhen Zhang Shuning Liu yunqi Hu Haofeng Lin Bowen Liu ying Sun Qingguo Wu Zheng-Li shi Ke Lan yu Chen Huimin yan yao-Qing Chen Wuhan Institute of Virology Chinese Academy of SciencesWuhanChina Vaccine and Immunology Research Center Translational Medical Research InstituteShanghai Public Health Clinical CenterFudan UniversityShanghaiChina University of Chinese Academy of Sciences BeijingChina School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdongChina State Key Laboratory of Virology Modern Virology Research CenterCollege of Life SciencesWuhan UniversityWuhanChina Aerosol Bio-Tech(Suzhou)Co. LTDSuzhouJiangsuChina National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products Sun Yat-sen UniversityGuanzhouChina

Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the ***,we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain(RBD)scaffold protein(3R-NC)adjuvanted with a flagellin protein(KFD)(3R-NC+KFDi.n).In mice,the vaccination elicited RBD-specific broad-neutralizing antibody responses in both serum and mucosal sites sustained at high level over a *** long-lasting humoral immunity was correlated with the presence of long-lived RBD-specific IgG-and IgA-producing plasma cells,alongside the Th17 and Tfh17-biased T-cell responses driven by the KFD *** upon these preclinical findings,an open labeled clinical trial was conducted in individuals who had been primed with the inactivated SARS-CoV-2(IAV)*** a favorable safety profile,the 3R-NC+KFDi.n boost elicited enduring broad-neutralizing IgG in plasma and IgA in salivary *** meet the challenge of frequently emerged variants,we further designed an updated triple-RBD scaffold protein with mutated RBD combinations,which can induce adaptable antibody responses to neutralize the newly emerging variants,including *** findings highlight the potential of the KFD-adjuvanted triple-RBD scaffold protein is a promising prototype for the development of a mucosal vaccine against SARS-CoV-2 infection.

关键词： vaccination vaccine sustained

The super-pangenome of Populus unveils genomic facets for its adaptation and diversification in widespread forest trees

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Molecular Plant 2024年第5期17卷 725-746页

作者： Tingting shi Xinxin Zhang yukang Hou Changfu Jia Xuming Dan yulin Zhang yuanzhong Jiang Qiang Lai Jiajun Feng Jianju Feng Tao Ma Jiali Wu Shuyu Liu Lei Zhang Zhiqin Long Liyang Chen Nathaniel R.Street Par K.Ingvarsson Jianquan Liu Tongming yin Jing Wang Key Laboratory for Bio-Resources and Eco-Environment of Ministry of Education College of Life SciencesSichuan UniversityChengduSichuanChina College of Horticulture and Forestry Tarim UniversityAlar 843300China Umea Plant Science Centre Department of Plant PhysiologyUmea UniversityUmeaVasterbottenSweden Linnean Centre for Plant Biology Department of Plant BiologyUppsala BioCenterSwedish University of Agricultural SciencesUppsalaSweden The Key Laboratory of Tree Genetics and Biotechnology of Jiangsu Province and Education Department of China Nanjing Forestry UniversityNanjingJiangsuChina

Understanding the underlying mechanisms and links between genome evolution and adaptive innovations stands as a key goal in evolutionary ***,among the world’s most widely distributed and cultivated trees,exhibit extensive phenotypic diversity and environmental *** this study,we present a genus-level super-pangenome comprising 19 Populus genomes,revealing the likely pivotal role of private genes in facilitating local environmental and climate *** the integration of pangenomes with transcriptomes,methylomes,and chromatin accessibility mapping,we unveil that the evolutionary trajectories of pangenes and duplicated genes are closely linked to local genomic landscapes of regulatory and epigenetic architectures,notably CG methylation in gene-body *** comparative genomic analyses have enabled the identification of 142202 structural variants across species that intersect with a significant number of genes and contribute substantially to both phenotypic and adaptive *** have experimentally validated a∼180-bp presence/absence variant affecting the expression of the CUC2 gene,crucial for leaf serration ***,we developed a user-friendly web-based tool encompassing the multi-omics resources associated with the Populus super-pangenome(http://***).Together,the present pioneering super-pangenome resource in forest trees not only aids in the advancement of breeding efforts of this globally important tree genus but also offers valuable insights into potential avenues for comprehending tree biology.

关键词： Populus pangenomes whole-genome duplication structural variation genome evolution

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高应力扇形中深孔采场边帮控制爆破参数优化

黄金科学技术 2024年第3期32卷 511-522页

作者：李波温晨史秀志中南大学资源与安全工程学院湖南长沙410083 紫金(长沙)工程技术有限公司湖南长沙410017

针对扇形孔采场爆破边帮控制问题,提出了一种将靠近边帮的扇形炮孔施工成垂直平行孔用以控制边帮的构想。首先,通过理论计算得到4组平行炮孔不耦合系数与炮孔间距匹配下的模型参数,使用LS-DyNA对4组参数进行数值模拟;然后,通过对比分析... 详细信息

针对扇形孔采场爆破边帮控制问题,提出了一种将靠近边帮的扇形炮孔施工成垂直平行孔用以控制边帮的构想。首先,通过理论计算得到4组平行炮孔不耦合系数与炮孔间距匹配下的模型参数,使用LS-DyNA对4组参数进行数值模拟;然后,通过对比分析4组模型在无地应力作用和不同方向地应力作用时的爆破裂纹扩展情况,获得最优参数;最后基于优化参数开展工业试验。结果表明:高地应力会促进最大应力方向爆破裂纹扩展;4种模型中,不耦合系数为1.65,炮孔间距为1.1 m时开挖区域破岩效果最为合理;在试验采场开展工业试验,使用优化后的爆破参数进行爆破,采场回采后边帮平整,稳定性较好,验证了研究结论的正确性。

关键词：边帮控制爆破高地应力理论计算数值模拟扇形孔爆破裂纹扩展

低红外发射率控温热红外伪装材料的制备与性能

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纺织学报 2024年第6期45卷 32-38页

作者：时吉磊陈廷彬付少海张丽平江苏省纺织品数字喷墨印花工程技术研究中心江苏无锡214122 生态纺织教育部重点实验室(江南大学) 江苏无锡214122

目前,仅从阻隔目标热量散发或降低表面红外发射率单方面入手很难达到理想的热红外伪装效果。针对这一问题,通过在聚丙烯腈静电纺丝液中混合相变材料聚乙二醇和性价比较高的铁纳米粒子,采用静电纺丝技术制备了一种外表面具有低红外发射... 详细信息

目前,仅从阻隔目标热量散发或降低表面红外发射率单方面入手很难达到理想的热红外伪装效果。针对这一问题,通过在聚丙烯腈静电纺丝液中混合相变材料聚乙二醇和性价比较高的铁纳米粒子,采用静电纺丝技术制备了一种外表面具有低红外发射率、底层具有控温功能的复合纤维膜材料,分析了复合纤维膜的表观形貌、化学及物相结构、热学性能、红外发射率和控温性能,研究了复合材料的红外隐身性能。结果表明:当聚乙二醇4000和聚乙二醇1000投料比不同时,可得到相变温度在31.5~40.9℃之间的系列相变纤维膜;复合纤维膜的红外发射率最低为0.69,在55℃热台上能够产生12℃的表面温度差,最大可产生22.4℃的辐射温度差,与环境温度相比最低具有1.9℃的辐射温度差,使目标在红外热成像中与环境辐射颜色一致。

关键词：聚丙烯腈聚乙二醇铁纳米粒子红外隐身静电纺丝复合纤维膜相变温度红外发射率

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考虑关节间隙的多维隔振系统振动特性分析

振动工程学报 2024年第3期37卷 448-456页

作者：高翔石峰牛军川董瑞春山东理工大学机械工程学院山东淄博255000 中铝万成山东建设有限公司山东淄博255000 山东大学机械工程学院山东济南250061

为隔离车载精密仪器承受的多维振动,引入基于并联机构且考虑机构关节间隙的多维被动隔振系统。通过GF集(Generalized Function Set)型综合理论,得到一种具有三平移一转动运动特性的4-PUU(移动副-虎克副-虎克副)并联机构,在主动关节处添... 详细信息

为隔离车载精密仪器承受的多维振动,引入基于并联机构且考虑机构关节间隙的多维被动隔振系统。通过GF集(Generalized Function Set)型综合理论,得到一种具有三平移一转动运动特性的4-PUU(移动副-虎克副-虎克副)并联机构,在主动关节处添加弹簧和黏滞阻尼器,建立考虑关节间隙的多维隔振系统运动学和动力学方程,研究存在关节间隙的多维隔振系统在谐波、随机路面激励下的时域、频域隔振能力。研究结果表明:存在关节间隙的多维隔振系统能够实现多维振动在时域和频域中的有效衰减;随着关节间隙数值逐渐增大,隔振能力沿x轴方向变化最敏感,沿y轴方向变化最不敏感;系统第一阶共振峰对关节间隙变化敏感,向低频区域移动,隔振能力恶化。

关键词：多维隔振系统并联机构关节间隙隔振性能

MR弹性成像对慢性乙肝病人肝纤维化程度的评估:组织学坏死性炎症是否影响肝脏硬度的测定

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国际医学放射学杂志 2014年第6期 583-583页

作者： y.shi Q.Guo F.Xia B.Dzyubak K.J.Glaser Q.Li 罗为 Departments of Radiology Shengjing HospitalChina Medical University

摘要目的以组织病理学结果作为参考标准,探讨MR弹性成像对慢性乙型肝炎病毒(HBV)感染病人肝纤维化分级的诊断能力,并评估坏死性炎症对肝脏硬度的影响。材料

关键词：肝纤维化肝疾病弹性成像肝脏 MR 程度坏死性炎坏疽性炎病人炎症病理

Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation

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Protein & Cell 2024年第7期15卷 512-529页

作者： Kai-Hui Zhang Fei-Fei Zhang Zhi-Ling Zhang Ke-Fei Fang Wen-Xing Sun Na Kong Min Wu Hai-Ou Liu yan Liu Zhi Li Qing-Qing Cai yang Wang Quan-Wei Wei Peng-Cheng Lin yan Lin Wei Xu Cong-Jian Xu yi-yuan yuan shi-Min Zhao The Obstetrics&Gynecology Hospital of Fudan University State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200090China Shanghai Key Laboratory of Metabolic Remodeling and Children’s Hospital of Fudan UniversityShanghai 200032China School of Life Sciences and Institutes of Biomedical Sciences Fudan UniversityShanghai 200438China Department of Nutrition and Food Hygiene School of Public HealthNantong UniversityNantong 226019China Reproductive Medicine Center The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Shanghai Fifth People’s Hospital of Fudan University Fudan UniversityShanghai 200240China Department of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210014China Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province College of PharmacyQinghai University for NationalitiesXining 810007China Pediatric Research Institute Children’s Hospital Affiliated to Shandong University(Jinan Children’s Hospital)Jinan 250022China

Polycystic ovary syndrome(PCOS)is the leading cause of anovulatory *** understanding of the ovulation drivers hinders PCOS ***,we report that follicle stimulating hormone(FSH)controls follicular fluid(FF)glutamine levels to determine *** ovulation starts from FF-exposing granulosa cell(GC)*** glutamine,which decreases in pre-ovulation porcine FF,elevates in PCOS patients ***-glutamine chow to elevate FF glutamine inhibits mouse GC apoptosis and induces hormonal,metabolic,and morphologic PCOS ***,follicle-development-driving FSH promotes GC glutamine synthesis to elevate FF glutamine,which maintain follicle wall integrity by inhibiting GC apoptosis through inactivating ASK1-JNK apoptotic *** and glutamine inhibit the rapture of cultured murine *** removal or ASK1-JNK pathway activation with metformin or AT-101 reversed PCOS traits in PCOS models that are induced with either glutamine or *** suggest that glutamine,FSH,and ASK1-JNK pathway are targetable to alleviate PCOS.

关键词： ovulation glutamine granulosa cells PCOS FSH

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蜂巢组织的三维结构模拟

纺织学报 2024年第8期45卷 158-164页

作者：徐辉朱昊史红艳绍兴文理学院纺织服装学院浙江绍兴312000 浙江省清洁染整技术研究重点实验室浙江绍兴312000

为解决蜂巢织物模拟时仿真度不高、经纬纱空间轨迹不准确等问题,提出一种蜂巢织物的模拟方法。将浮长线的拉拢作用与邻近组织点偏移倾向等因素相结合,分析了浮长线内组织点的偏移;在此基础上,建立了组织点偏移的数学模型,提出纱线偏移... 详细信息

为解决蜂巢织物模拟时仿真度不高、经纬纱空间轨迹不准确等问题,提出一种蜂巢织物的模拟方法。将浮长线的拉拢作用与邻近组织点偏移倾向等因素相结合,分析了浮长线内组织点的偏移;在此基础上,建立了组织点偏移的数学模型,提出纱线偏移的算法。为避免偏移后不同纱线间的渗透与穿刺,依照机织物的织造规律设计了纱线的碰撞检测与处理算法;考虑蜂巢织物的凹凸外观,将织物的平纹组织划分为凸起和凹下二部分。研究结果表明:采取偏移算法后的织物模拟效果逼真,更接近实际织物中纱线的空间轨迹;经碰撞检测处理后的纱线一方面减少了渗透,另一方面也突出了织物的凹凸效果;对蜂巢织物平纹部分的划分处理使模拟织物表观的倒金字塔凹槽清晰可见,取得了预期效果。

关键词：蜂巢组织浮长线原理偏移算法碰撞处理凹凸表观织物模拟

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壁厚分布对金属隔膜翻转偏心行为的影响研究

载人航天 2024年第3期30卷 291-299页

作者：范凯施华赵和明上海空间推进研究所上海201112 上海空间发动机工程技术研究中心上海201112

为确保金属隔膜的有序翻转,实现贮箱质心规则变化和推进剂均衡排放,研究分析了壁厚分布对金属隔膜翻转偏心行为的影响。结果表明:对于等壁厚隔膜,锥壳和球冠具有一定的纠偏能力,过渡球壳不具有纠偏能力。采用过渡球壳均匀变壁厚方案,通... 详细信息

为确保金属隔膜的有序翻转,实现贮箱质心规则变化和推进剂均衡排放,研究分析了壁厚分布对金属隔膜翻转偏心行为的影响。结果表明:对于等壁厚隔膜,锥壳和球冠具有一定的纠偏能力,过渡球壳不具有纠偏能力。采用过渡球壳均匀变壁厚方案,通过增大偏向段和偏离段翻转启动压力差ΔP_(r),促使偏离段较小的轴向分力P_(y)优先达到翻转启动压力P_(r),进而提升过渡球壳纠偏能力,以更小的壁厚梯度和更低的重量代价实现隔膜翻转不偏心。

关键词：壁厚分布翻转偏心金属隔膜