Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation

作     者：Kai-Hui Zhang Fei-Fei Zhang Zhi-Ling Zhang Ke-Fei Fang Wen-Xing Sun Na Kong Min Wu Hai-Ou Liu Yan Liu Zhi Li Qing-Qing Cai Yang Wang Quan-Wei Wei Peng-Cheng Lin Yan Lin Wei Xu Cong-Jian Xu Yi-Yuan Yuan Shi-Min Zhao Kai-Hui Zhang;Fei-Fei Zhang;Zhi-Ling Zhang;Ke-Fei Fang;Wen-Xing Sun;Na Kong;Min Wu;Hai-Ou Liu;Yan Liu;Zhi Li;Qing-Qing Cai;Yang Wang;Quan-Wei Wei;Peng-Cheng Lin;Yan Lin;Wei Xu;Cong-Jian Xu;Yi-Yuan Yuan;Shi-Min Zhao

作者机构：The Obstetrics&Gynecology Hospital of Fudan UniversityState Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200090China Shanghai Key Laboratory of Metabolic Remodelingand Children’s Hospital of Fudan UniversityShanghai 200032China School of Life Sciences and Institutes of Biomedical SciencesFudan UniversityShanghai 200438China Department of Nutrition and Food HygieneSchool of Public HealthNantong UniversityNantong 226019China Reproductive Medicine CenterThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Shanghai Fifth People’s Hospital of Fudan UniversityFudan UniversityShanghai 200240China Department of Animal Science and TechnologyNanjing Agricultural UniversityNanjing 210014China Key Laboratory for Tibet Plateau Phytochemistry of Qinghai ProvinceCollege of PharmacyQinghai University for NationalitiesXining 810007China Pediatric Research InstituteChildren’s Hospital Affiliated to Shandong University(Jinan Children’s Hospital)Jinan 250022China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2024年第15卷第7期

页      面：512-529页

核心收录：

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：State Key Development Programs of China(Nos.2018YFA0800300)(S.M.Z),2018YFA0801300(W.X) National Natural Science Foundation of China(Nos.92253305)(S.M.Z),31821002(S.M.Z),32230054(S.M.Z),31930062(S.M.Z),91857000(S.M.Z),92157001(S.M.Z),32171298(W.X),81971449(Y.Y.Y),82171672(Y.Y.Y) Program of Shanghai Academic Research Leader(21XD1423000)(W.X) China postdoctoral science foundation(2022M721954)(K.H.Z) 

主　　题：ovulation glutamine granulosa cells PCOS FSH 

摘      要：Polycystic ovary syndrome(PCOS)is the leading cause of anovulatory *** understanding of the ovulation drivers hinders PCOS ***,we report that follicle stimulating hormone(FSH)controls follicular fluid(FF)glutamine levels to determine *** ovulation starts from FF-exposing granulosa cell(GC)*** glutamine,which decreases in pre-ovulation porcine FF,elevates in PCOS patients ***-glutamine chow to elevate FF glutamine inhibits mouse GC apoptosis and induces hormonal,metabolic,and morphologic PCOS ***,follicle-development-driving FSH promotes GC glutamine synthesis to elevate FF glutamine,which maintain follicle wall integrity by inhibiting GC apoptosis through inactivating ASK1-JNK apoptotic *** and glutamine inhibit the rapture of cultured murine *** removal or ASK1-JNK pathway activation with metformin or AT-101 reversed PCOS traits in PCOS models that are induced with either glutamine or *** suggest that glutamine,FSH,and ASK1-JNK pathway are targetable to alleviate PCOS.