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Tumor biomarkers for diagnosis,prognosis and targeted therapy

Signal Transduction and Targeted Therapy 2024年第6期9卷 2391-2476页

作者： Yue Zhou Lei Tao Jiahao Qiu Jing Xu Xinyu Yang Yu Zhang Xinyu Tian Xinqi Guan xiaobo cen Yinglan Zhao Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China West China School of Pharmacy Sichuan UniversityChengdu 610041China School of Medicine Tibet UniversityLhasa 850000China National Chengdu center for Safety Evaluation of Drugs State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Tumor biomarkers,the substances which are produced by tumors or the body’s responses to tumors during tumorigenesis and progression,have been demonstrated to possess critical and encouraging value in screening and early diagnosis,prognosis prediction,recurrence detection,and therapeutic efficacy monitoring of *** the past decades,continuous progress has been made in exploring and discovering novel,sensitive,specific,and accurate tumor biomarkers,which has significantly promoted personalized medicine and improved the outcomes of cancer patients,especially advances in molecular biology technologies developed for the detection of tumor ***,we summarize the discovery and development of tumor biomarkers,including the history of tumor biomarkers,the conventional and innovative technologies used for biomarker discovery and detection,the classification of tumor biomarkers based on tissue origins,and the application of tumor biomarkers in clinical cancer *** particular,we highlight the recent advancements in biomarker-based anticancer-targeted therapies which are emerging as breakthroughs and promising cancer therapeutic *** also discuss limitations and challenges that need to be addressed and provide insights and perspectives to turn challenges into opportunities in this ***,the discovery and application of multiple tumor biomarkers emphasized in this review may provide guidance on improved precision medicine,broaden horizons in future research directions,and expedite the clinical classification of cancer patients according to their molecular biomarkers rather than organs of origin.

关键词： diagnosis breakthrough biomarkers

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Artificial Bear Bile:A Novel Approach to Balancing Medical Requirements and Animal Welfare

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Engineering 2024年第7期38卷 100-112页

作者： Yong Li Yuhong Huang Nan Feng Heping Zhang Jing Qu Shuanggang Ma Yunbao Liu Jiang Li Shaofeng Xu Ling Wang Mi Zhang Jie Cai Weiping Wang Ru Feng Hang Yu Bo Yu Dailiang Liang Heping Qin Suxiang Luo Yanfen Li Meifeng Li Ruihua Wang Chen Ma Yan Wang xiaobo cen Xiaoxian Xu Boli Zhang Xiaoliang Wang Shishan Yu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300250China Zhongshan Belling Biotechnology Co. Ltd.Zhongshan 528437China Zhongshan Anshi Biopharmaceutical Co. Ltd.Zhongshan 528437China WestChina-Frontier Pharma Tech Co. Ltd.Chengdu 610041China Tianjin University of Traditional Chinese Medicine Tianjin 301617China

Bear bile has been a valuable and effective medicinal material in traditional Chinese medicine(TCM)for over 13 ***,the current practice of obtaining it through bear farming is under scrutiny for its adverse impact on bear ***,we present a new approach for creating artificial bear bile(ABB)as a high-quality and sustainable alternative to natural bear *** study addresses the scientific challenges of creating bear bile alternatives through interdisciplinary collaborations across various fields,including resources,chemistry,biology,medicine,pharmacology,and TCM.A comprehensive efficacy assessment system that bridges the gap between TCM and modern medical terminology has been established,allowing for the systematic screening of therapeutic *** the utilization of chemical synthesis and enzyme engineering technologies,our research has achieved the environmentally friendly,large-scale production of bear bile therapeutic compounds,as well as the optimization and recomposition of ABB *** resulting ABB not only closely resembles natural bear bile in its composition but also offers advantages such as consistent product quality,availability of raw materials,and independence from threatened or wild *** preclinical efficacy evaluations have demonstrated the equivalence of the therapeutic effects from ABB and those from commercially available drained bear bile(DBB).Furthermore,preclinical toxicological assessment and phase I clinical trials show that the safety of ABB is on par with that of the currently used *** innovative strategy can serve as a new research paradigm for developing alternatives for other endangered TCMs,thereby strengthening the integrity and sustainability of TCM.

关键词： Artificial bear bile Chemical profile Formula optimization Pharmacodynamic consistency Preclinical toxicological assessment

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Simvastatin Blocks Reinstatement of Cocaine-induced Conditioned Place Preference in Male Mice with Brain Lipidome Remodeling

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Neuroscience Bulletin 2021年第12期37卷 1683-1702页

作者： Wei Xu Yuman He Jiamei Zhang Hongchun Li Xuemei Wan Menglu Li Yonghai Wang Rui Xu Haoluo Zhang Yanping Dai Haxiaoyu Liu Linhong Jiang Ying Zhao xiaobo cen National Chengdu center for Safety Evaluation of Drugs State Key Laboratory of Biotherapy and Collaborative Innovation Center for BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Sichuan center for Disease Control and Prevention Chengdu 610041China Shenzhen Key Laboratory of Drug Addiction the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen 518055China School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug Evaluation(Yantai University)Ministry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of ShandongYantai UniversityYantai 264005China

Drug-associated reward memories are conducive to intense craving and often trigger *** has been shown to regulate lipids that are involved in memory formation but its influence on other cognitive processes is ***,we used a mass spectrometry-based lipidomic method to evaluate the impact of simvastatin on the mouse brain in a cocaine-induced reinstatement *** found that simvastatin blocked the reinstatement of cocaine-induced conditioned place preference(CPP)without affecting CPP ***,only simvastatin administered during extinction prevented cocaine-primed *** lipidome analysis showed that the nucleus accumbens was the region with the greatest degree of change caused by *** metabolism of fatty-acids,phospholipids,and triacylglycerol was profoundly *** reversed most of the effects on phospholipids induced by *** correlation matrix showed that cocaine and simvastatin significantly reshaped the lipid metabolic pathways in specific brain ***,simvastatin almost reversed all changes in the fatty acyl profile and unsaturation caused by *** summary,pre-extinction treatment with simvastatin facilitates cocaine extinction and prevents cocaine relapse with brain lipidome remodeling.

关键词： Simvastatin Cocaine relapse Extinction Lipidome Conditioned place preference

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Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neurons

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Genomics, Proteomics & Bioinformatics 2023年第3期21卷 551-572页

作者： Liang Wang Xiaojie Wang Chunqi Liu Wei Xu Weihong Kuang Qian Bu Hongchun Li Ying Zhao Linhong Jiang Yaxing Chen Feng Qin Shu Li Qinfan Wei Xiaocong Liu Bin Liu Yuanyuan Chen Yanping Dai Hongbo Wang Jingwei Tian Gang Cao Yinglan Zhao xiaobo cen National Chengdu center for Safety Evaluation of Drugs State Key Laboratory of Biotherapy/Collaborative Innovation Center for BiotherapyWest China Hospital of Sichuan UniversityChengdu 610041China Shenzhen Key Laboratory of Drug Addiction Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Psychiatry West China Hospital of Sichuan UniversityChengdu 610041China School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug Evaluation(Yantai University)Ministry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of ShandongYantai UniversityYantai 264005China State Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China

The expression of linear DNA sequence is precisely regulated by the three-dimensional(3D)architecture of ***-induced aberrant gene networks of neurons have been extensively investigated;however,how morphine impacts the 3D genomic architecture of neurons is still ***,we applied digestion-ligation-only high-throughput chromosome conformation capture(DLO Hi-C)technology to investigate the effects of morphine on the 3D chromatin architecture of primate cortical *** receiving continuous morphine administration for 90 days on rhesus monkeys,we discovered that morphine re-arranged chromosome territories,with a total of 391 segmented compartments being *** altered over half of the detected topologically associated domains(TADs),most of which exhibited a variety of shifts,followed by separating and fusing *** of the looping events at kilobase-scale resolution revealed that morphine increased not only the number but also the length of differential ***,all identified differentially expressed genes from the RNA sequencing data were mapped to the specific TAD boundaries or differential loops,and were further validated for changed ***,an altered 3D genomic architecture of cortical neurons may regulate the gene networks associated with morphine *** finding provides critical hubs connecting chromosome spatial organization and gene networks associated with the morphine effects in humans.

关键词： Morphine Rhesus monkey Chromatin spatial architecture Topologically associated domain Loop

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升阳益胃汤联合双岐杆菌治疗食管贲门癌术后腹泻的临床疗效观察

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西南军医 2016年第1期18卷 24-26页

作者：李亮岑小波泸州医学院附属中医医院心胸外科四川泸州646000

目的观察中西医结合治疗食管贲门癌术后腹泻患者的临床疗效。方法选取2014年1月—2014年10月就诊于我院的食管贲门癌术后腹泻患者60例,随机分为治疗组和对照组各30例。对照组:口服或管喂双岐杆菌四联活菌片;治疗组:在对照组的基础上加... 详细信息

目的观察中西医结合治疗食管贲门癌术后腹泻患者的临床疗效。方法选取2014年1月—2014年10月就诊于我院的食管贲门癌术后腹泻患者60例,随机分为治疗组和对照组各30例。对照组:口服或管喂双岐杆菌四联活菌片;治疗组:在对照组的基础上加用升阳益胃汤。结果治疗组总有效率为90.0%,对照组有效率为66.7%,两组患者临床疗效比较有显著差异(P<0.05)。结论升阳益胃汤联合双岐杆菌能有效促进肠道功能的恢复,对食管贲门癌术后腹泻有较好的疗效。

关键词：升阳益胃汤双岐杆菌食管癌,贲门癌腹泻

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应用全切片图像进行毒性病理学同行评议的研究进展

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药物评价研究 2023年第10期46卷 2284-2288页

作者：周围邱爽陈珂岑小波胡春燕国家药品监督管理局药品审评中心北京100022 成都华西海圻医药科技有限公司(国家成都新药安全性评价中心) 四川成都610000

全切片图像是通过数字切片扫描仪将整个组织切片扫描生成的二维图像,近年来已广泛应用于病理学教学、组织切片讨论、科研等领域。参照美国毒性病理学会(STP)对全切片图像在诊断中的应用建议、经济合作与发展组织(OECD)和美国食品药品管... 详细信息

全切片图像是通过数字切片扫描仪将整个组织切片扫描生成的二维图像,近年来已广泛应用于病理学教学、组织切片讨论、科研等领域。参照美国毒性病理学会(STP)对全切片图像在诊断中的应用建议、经济合作与发展组织(OECD)和美国食品药品管理局(FDA)关于使用全切片图像进行病理学同行评议的指导原则,对药物非临床研究质量管理规范(GLP)条件下应用全切片图像进行毒性病理学同行评议的工作流程、内容和要求进行相关总结。同时结合中国合同研究组织(CRO)采用全切片图像开展毒性病理学评价进行概述,以期提升我国毒性病理学评价和病理学同行评议工作的规范性与专业水平。

关键词：毒性病理学评价全切片图像同行评议病理学药物非临床研究

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锌对大鼠成骨细胞膜Ca^(2+)-ATP酶活性的调节

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卫生研究 2000年第1期29卷 52-54页

作者：岑小波王瑞淑王航华西医科大学附属第一医院医学实验中心成都610041 华西医科大学公共卫生学院华西医科大学口腔医学院

为了研究锌对大鼠成骨细胞膜Ca2+ -ATP酶和Na+ 、K+ -ATP酶活性的影响及其机制,实验设对照组和3个补锌组。采用孔雀绿比色法同步测定膜Ca2+ -ATP酶和Na+ ,K+ -ATP酶活性,以研究Zn2+ 对酶活性的影响以及蛋白激酶C或钙调素特异性抑制剂对Z... 详细信息

为了研究锌对大鼠成骨细胞膜Ca2+ -ATP酶和Na+ 、K+ -ATP酶活性的影响及其机制,实验设对照组和3个补锌组。采用孔雀绿比色法同步测定膜Ca2+ -ATP酶和Na+ ,K+ -ATP酶活性,以研究Zn2+ 对酶活性的影响以及蛋白激酶C或钙调素特异性抑制剂对Zn2+ 诱导的成骨细胞膜Ca2+ -ATP酶活性的影响。结果表明,Zn2+ 可以显著提高成骨细胞膜Ca2+ -ATP酶活性,但对Na+ ,K+ -ATPase活性无影响;钙调素特异性抑制剂R24571对Zn2+ 诱导的Ca2+ -ATPase活性无影响,钙调素对膜Ca2+ -ATP酶基础活性也无激活作用;蛋白激酶C特异性抑制剂三氟拉嗪可使Zn2+ 诱导的Ca2+ -ATP酶的活性显著降低。因此,锌可能通过蛋白激酶C介导调节成骨细胞膜Ca2+

关键词：锌 Ca^2+-ATP酶成骨细胞蛋白激酶C

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从药品技术审评的角度看GLP实施的必要性

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中国药事 2005年第7期19卷 390-392页

作者：岑小波赵瀛兰王莉朱家谷韩玲四川大学华西医院国家成都中药安全性评价中心 610041 国家食品药品监督管理局药品审评中心

临床前安全性研究的不规范性会影响药品的科学评价。GLP有利于增进药品技术审评的科学化与规范化,而药品技术审评有助于促进GLP的实施与完善。二者应协调发展、与时俱进,相得益彰,提高我国的新药研发水平,促进医药产业的发展,保障人民... 详细信息

临床前安全性研究的不规范性会影响药品的科学评价。GLP有利于增进药品技术审评的科学化与规范化,而药品技术审评有助于促进GLP的实施与完善。二者应协调发展、与时俱进,相得益彰,提高我国的新药研发水平,促进医药产业的发展,保障人民健康。

关键词： GLP 药品技术审评

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升阳益胃汤加减治疗食管贲门癌术后腹泻的临床对比分析

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泸州医学院学报 2013年第1期36卷 49-51页

作者：刘浩黄娟岑小波陈光明廖代祥泸州医学院附属中医院胸外科四川泸州646000 泸州医学院病理学教研室四川泸州646000

目的:评价升阳益胃汤加减水煎服与西药对照治疗食管贲门癌术后出现腹泻的治疗作用,观察该药的毒副作用和不良反应,对其安全性作出评价。方法:88例食管贲门癌术后腹泻患者随机分成2组。治疗组44例用升阳益胃汤,对照组44例采用传统止泻西... 详细信息

目的:评价升阳益胃汤加减水煎服与西药对照治疗食管贲门癌术后出现腹泻的治疗作用,观察该药的毒副作用和不良反应,对其安全性作出评价。方法:88例食管贲门癌术后腹泻患者随机分成2组。治疗组44例用升阳益胃汤,对照组44例采用传统止泻西药思密达(蒙脱石散)、多酶片疗程均为4周。治疗效果以包宗昭"临床诊断及疗效判断的四级加权评分法介绍"进行综合分析评价。结果:治疗组的痊愈率及总有效率均优于对照组,差异有统计学意义(P<0.05)。结论:升阳益胃汤加减水煎服治疗食道癌术后腹泻可以明显减轻腹泻症状,且能改善病人腹泻的伴随症状,不易复发,无西药长期服用所带来的毒副作用,安全有效。

关键词：升阳益胃汤食管贲门癌腹泻

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AP对正常和内毒素化大鼠脾细胞体外分泌细胞因子的影响

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华西药学杂志 1999年第5期14卷 346-348页

作者：王莉杜俊蓉蔡绍晖朱玲岑小波陈淑杰唐琼包定元长谷川高明华西医科大学附一院

从分子免疫水平探讨了巴巴多斯芦荟多糖提取物（ＡＰ）对免疫系统的作用。结果表明巴巴多斯芦荟多糖提取物对体外正常大鼠脾细胞分泌ＩＬ－１、ＩＬ－６、ＴＮＦα等细胞因子均有一定的促进作用，而对内毒素诱导脾细胞分泌的细胞因子Ｉ... 详细信息

从分子免疫水平探讨了巴巴多斯芦荟多糖提取物（ＡＰ）对免疫系统的作用。结果表明巴巴多斯芦荟多糖提取物对体外正常大鼠脾细胞分泌ＩＬ－１、ＩＬ－６、ＴＮＦα等细胞因子均有一定的促进作用，而对内毒素诱导脾细胞分泌的细胞因子ＩＬ－１、ＩＬ－６、ＴＮＦα有显著抑制作用。对ＩＬ－２的分泌在以上两种情况下均表现促进作用。显示巴巴多斯芦荟多糖提取物对细胞因子的分泌可产生双向调控作用。

关键词：巴巴多斯芦荟多糖提取物细胞因子免疫调节

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