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Transcriptome Analysis Identifies SenZfp536,a Sense LncRNA that Suppresses Self-renewal of Cortical Neural Progenitors

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Neuroscience Bulletin 2021年第2期37卷 183-200页

作者： Kuan Tian Andi Wang Junbao Wang Wei Li wenchen shen Yamu Li Zhiyuan Luo Ying Liu Yan Zhou College of Life Sciences Renmin Hospital of Wuhan UniversityWuhan UniversityWuhan430072China Frontier Science Center for Immunology and Metabolism Medical Research InstituteSchool of MedicineWuhan UniversityWuhan430071China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China

Long non-coding RNAs(lncRNAs)regulate transcription to control development and homeostasis in a variety of tissues and ***,their roles in the development of the cerebral cortex have not been well ***,a bioinformatics pipeline was applied to delineate the dynamic expression and potential cis-regulating effects of mouse lncRNAs using transcriptome data from 8 embryonic time points and sub-regions of the developing cerebral *** further characterized a sense lncRNA,SenZfp536,which is transcribed downstream of and partially overlaps with the protein-coding gene *** SenZfp536 and Zfp536 were predominantly expressed in the proliferative zone of the developing ***536 was cis-regulated by SenZfp536,which facilitates looping between the promoter of Zfp536 and the genomic region that transcribes ***,knocking down or activating the expression of SenZfp536 increased or compromised the proliferation of cortical neural progenitor cells(NPCs),***,overexpressing Zfp536 in cortical NPCs reversed the enhanced proliferation of cortical NPCs caused by SenZfp536 *** study deepens our understanding of how lncRNAs regulate the propagation of cortical NPCs through cis-regulatory mechanisms.

关键词： Zfp536 Sense lncRNA Self-renewal Cortical development Neural progenitor

NUMB enhances Notch signaling by repressing ubiquitination of NOTCH1 intracellular domain

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Journal of Molecular Cell Biology 2020年第5期12卷 345-358页

作者： Zhiyuan Luo Lili Mu Yue Zheng wenchen shen Jiali Li Lichao Xu Bo Zhong Ying Liu Yan Zhou College of Life Sciences Renmin Hospital of Wuhan UniversityMedical Research Institute at School of MedicineWuhan UniversityWuhan 430072China

The release and nuclear translocation of the intracellular domain of Notch receptor(NICD)is the prerequisite for Notch signaling-mediated transcriptional *** is subjected to various posttranslational modifications including ***,we surprisingly found that NUMB proteins stabilize the intracellular domain of NOTCH1 receptor(N1ICD)by regulating the ubiquitin–proteasome machinery,which is independent of NUMB’s role in modulating ***1,a deubiquitinating enzyme(DUB),was further identified as a positive N1ICD regulator,and NUMB facilitates the association between N1ICD and BAP1 to stabilize ***,BAP1 stabilizes N1ICD independent of its DUB activity but relying on the BRCA1-inhibiting ***1 strengthens Notch signaling and maintains stem-like properties of cortical neural progenitor ***,NUMB enhances Notch signaling by regulating the ubiquitinating activity of the BAP1–BRCA1 complex.

关键词： NUMB Notch intracellular domain BAP1 ubiquitination neural progenitor cells

Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b

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Protein & Cell 2020年第3期11卷 161-186页

作者： Wei Li wenchen shen Bo Zhang Kuan Tian Yamu Li Lili Mu Zhiyuan Luo Xiaoling Zhong Xudong Wu Ying Liu Yan Zhou College of Life Sciences Renmin Hospital of Wuhan UniversityMedical Research Institute at School of MedicineWuhan UniversityWuhan 430072China Department of Cell Biology Tianjin Medical UniversityQixiangtai Road 22Tianjin 300070China

The mechanisms underlying spatial and temporal control of cortical neurogenesis of the brain are largely *** non-coding RNAs(lncRNAs)have emerged as essential cell fate *** we found LncKdm2b(also known as Kancr),a lncRNA divergently transcribed from a bidirectional promoter of Kdm2b,is transiently expressed during early differentiation of cortical projection ***,Kdm2b’s transcription is positively regulated in cis by LncKdm2b,which has intrinsic-activating function and facilitates a permissive chromatin environment at the Kdm2b’s promoter by associating with *** tracing experiments and phenotypic analyses indicated LncKdm2b and Kdm2b are crucial in proper differentiation and migration of cortical projection *** observations unveiled a lncRNA-dependent machinery in regulating cortical neuronal differentiation.

关键词： long non-coding RNA neuronal differentiation cerebral cortex KDM2B divergent lncRNA

增温对青藏高原高寒草甸3种植物氮磷化学计量与重吸收的影响

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Journal of Plant Ecology 2024年第3期17卷 73-83页

作者： Lang Zheng Xuan Cao Zhiyong Yang Hui Wang Qiqi Zang wenchen Song Miaogen shen Chunwang Xiao College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing 100101China Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China

全球气候变化将对生态系统造成重要影响,尤其是那些对气候变化极为敏感的高寒草甸生态系统。然而,全球变暖对高寒草甸植物氮磷化学计量特征和重吸收作用的影响仍不清楚。为了研究青藏高原高寒草甸植物的氮磷化学计量特征和重吸收作用,... 详细信息

全球气候变化将对生态系统造成重要影响,尤其是那些对气候变化极为敏感的高寒草甸生态系统。然而,全球变暖对高寒草甸植物氮磷化学计量特征和重吸收作用的影响仍不清楚。为了研究青藏高原高寒草甸植物的氮磷化学计量特征和重吸收作用,本研究采用开顶箱(OTCs)进行了3年的人工增温实验。选择3种优势物种和4种不同高度的OTC(0.4、0.6、0.8、1 m),设置4种增温处理(全年增温、冬季增温、夏秋冬季增温和春夏秋季增温)。结果表明,在不同增温方法下,土壤温度随OTC高度的增加而显著升高。随着温度的上升,高山嵩草(Kobresia pygmaea)的氮限制增加,矮生嵩草(***)的磷限制增加,而钉柱委陵菜(Potentilla saundersiana)的氮磷限制对温度的增加不敏感。在温度升高的情况下,氮磷重吸收效率比(NRE:PRE)与氮磷比(N:P)都表现出相同的变化趋势。3种物种的化学计量特征对温度升高的响应存在差异,显示出氮、磷限制对温度变化的反应是多方面的,而且草地生态系统可能具备一定程度的自我调节能力。上述结果表明,全球气候变暖情景下,仅依赖单一优势物种的化学计量指标来代表整个生态系统的氮、磷限制并不准确,使用N:P比值来反映营养限制可能会产生误导。

关键词：增温氮磷重吸收养分限制高寒草甸

A retrospective analysis of mature T-and NK-cell lymphomas

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Cancer Biology & Medicine 2024年第3期21卷 223-229页

作者： Junlei Jia Xiaohui Wang Zheng Song shen Meng Yue Fei Jingwei Yu Xia Liu Xue Han Lanfang Li Lihua Qiu Zhengzi Qian Shiyong Zhou wenchen Gong Bin Meng Xiubao Ren Xianhuo Wang Huilai Zhang National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine and Department of LymphomaTianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinThe Sino-US Center for Lymphoma and Leukemia ResearchTianjin 300060China Department of Radiation Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinan 250117China Department of Pathology Department of Immunology/Biotherapy Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin 300060China

Mature T-and natural killer(NK)-cell lymphomas are heterogeneous groups of malignant lymphoid neoplasms arising from T and NK cells. The incidence of mature T-and NK-cell lymphomas is 2.1 per 100,000 people, according... 详细信息

关键词： lymphoma neoplasms killer

混合动力车辆自动机械变速器换挡过程分析与控制

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汽车工程 2016年第3期38卷 337-343页

作者：沈文臣胡宇辉席军强陈慧岩北京理工大学机械与车辆学院北京100081 北京理工大学智能车辆研究所北京100081

基于"虚拟离合器"技术的自动机械变速器换挡过程的关键是动力中断过程中电机的主动同步与执行机构的挂挡控制。通过对自动机械变速器中同步器的接合机理分析,提出一种基于电机转矩控制的变速器输入端主动同步方法,即通过电机的转矩输出... 详细信息

基于"虚拟离合器"技术的自动机械变速器换挡过程的关键是动力中断过程中电机的主动同步与执行机构的挂挡控制。通过对自动机械变速器中同步器的接合机理分析,提出一种基于电机转矩控制的变速器输入端主动同步方法,即通过电机的转矩输出取代传统同步器依靠换挡力产生的同步摩擦力矩来消除进挡过程中同步器主从动部分的转速差。试验验证的结果表明,基于电机转矩控制的自动机械变速器换挡过程控制方法可以降低同步器的磨损,缩短动力中断的时间,提高进挡成功率与可靠性。

关键词：混合动力车辆机械自动变速器换挡过程转矩控制

Transcriptome analysis of mouse cortical development and haracterization of long non-coding RNAs

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Transcriptome analysis of mouse cortical development and har...

第三届“模式生物与人类健康”发育遗传学全国学术研讨会

作者： Kuan Tian Wei Li wenchen shen Lili Mu Zhiyuan Luo Jing Liu Xiaoling Zhong Yamu Li Kuanwei sheng Ying Liu 周严 College of Life Sciences at Wuhan University

Cortical neural progenitor cells(NPCs)change their competency over time during development,giving rise to distinct cell types *** genes that govern cortical development are now known,but it remains elusive how their temporal expression is ***,long non-coding RNAs are found to be essential for cell-fate specification and precise gene regulation in many developmental *** this study,strand-specific RNA sequencing studies unveil

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气动换挡执行机构压力特性仿真与试验

农业机械学报 2016年第2期47卷 338-348页

作者：沈文臣胡宇辉余天啸席军强陈慧岩北京理工大学机械与车辆学院北京100081 北京理工大学智能车辆研究所北京100081

气动换挡执行机构的响应高度滞后与强非线性特点,给机械自动变速器换挡机构的选型和设计带来难点,常规的稳态分析存在较大误差。针对开关阀控制的气动选换挡执行机构气腔中压力形成特点,建立了综合考虑电、磁、机械和流体传动原理的数... 详细信息

气动换挡执行机构的响应高度滞后与强非线性特点,给机械自动变速器换挡机构的选型和设计带来难点,常规的稳态分析存在较大误差。针对开关阀控制的气动选换挡执行机构气腔中压力形成特点,建立了综合考虑电、磁、机械和流体传动原理的数学模型来描述气动执行机构的动态耦合特性。通过仿真,对阀控压力腔容积、电磁阀进排气口的有效面积等影响气腔中压力形成特性的因素进行了分析,并通过试验验证了模型的准确性。该模型可直接用于换挡执行机构的参数优化或者自动控制,为解决气动换挡过程中的换挡力控制问题提供基础。

关键词：气动执行机构动态特性压力特性开关阀

基于“虚拟离合器”的混合动力车辆AMT换挡过程控制

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机械工程学报 2014年第18期50卷 108-117页

作者：沈文臣胡宇辉于会龙席军强陈慧岩北京理工大学机械与车辆学院北京100081

自动机械变速器(Automatic mechanical transmission,AMT)是单轴并联混合动力系统中的核心部件,对其换挡过程的快速、精确控制直接决定着混合动力系统的加速性、经济性、使用寿命以及可靠性。一种基于'虚拟离合器'技术的混合动力系统AM... 详细信息

自动机械变速器(Automatic mechanical transmission,AMT)是单轴并联混合动力系统中的核心部件,对其换挡过程的快速、精确控制直接决定着混合动力系统的加速性、经济性、使用寿命以及可靠性。一种基于'虚拟离合器'技术的混合动力系统AMT换挡过程控制方法可以充分保证其性能。该方法的五个时序进行详细论述,并分别提出各个阶段的核心控制问题。基于该单轴并联混合动力系统的结构特点,建立以考虑传动系统中驱动轴扭转振动特性的动力学模型,在此基础上,推导出可用于换挡过程控制的机械自动变速器中传递转矩的近似数学模型;通过试验验证该模型可以有效控制变速器传递的转矩,降低摘空挡后变速器输出轴转速的振荡。实车试验表明以变速器传递零转矩为目标的'虚拟离合器'技术可以有效应用于AMT的换挡过程控制。该技术的应用可以实现AMT无离合器操控的换挡过程,能够有效缩短换挡过程动力中断的时间,降低换挡过程车速的振荡,提高AMT系统的换挡品质。

关键词：虚拟离合器混合动力传动系统换挡过程自动机械变速器变速器传递转矩