Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b

作     者：Wei Li Wenchen Shen Bo Zhang Kuan Tian Yamu Li Lili Mu Zhiyuan Luo Xiaoling Zhong Xudong Wu Ying Liu Yan Zhou Wei Li;Wenchen Shen;Bo Zhang;Kuan Tian;Yamu Li;Lili Mu;Zhiyuan Luo;Xiaoling Zhong;Xudong Wu;Ying Liu;Yan Zhou

作者机构：College of Life SciencesRenmin Hospital of Wuhan UniversityMedical Research Institute at School of MedicineWuhan UniversityWuhan 430072China Department of Cell BiologyTianjin Medical UniversityQixiangtai Road 22Tianjin 300070China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2020年第11卷第3期

页      面：161-186页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

基　　金：supported by grants from National Key R&D Program of China(2018YFA0800700) National Natural Science Foundation of China(Grant Nos.31671418 and 31471361) National Natural Science Foundation of Hubei Province(2018CFA016) Fundamental Research Funds for the Central Universities(2042017kf0242) Wuhan University Experiment Technology Project Funding(WHU-2018-SYJS-01) 

主　　题：long non-coding RNA neuronal differentiation cerebral cortex KDM2B divergent lncRNA 

摘      要：The mechanisms underlying spatial and temporal control of cortical neurogenesis of the brain are largely *** non-coding RNAs(lncRNAs)have emerged as essential cell fate *** we found LncKdm2b(also known as Kancr),a lncRNA divergently transcribed from a bidirectional promoter of Kdm2b,is transiently expressed during early differentiation of cortical projection ***,Kdm2b’s transcription is positively regulated in cis by LncKdm2b,which has intrinsic-activating function and facilitates a permissive chromatin environment at the Kdm2b’s promoter by associating with *** tracing experiments and phenotypic analyses indicated LncKdm2b and Kdm2b are crucial in proper differentiation and migration of cortical projection *** observations unveiled a lncRNA-dependent machinery in regulating cortical neuronal differentiation.