Exosomes rewire the cartilage microenvironment in osteoarthritis:from intercellular communication to therapeutic strategies

作     者：Yuangang Wu Jiao Li Yi Zeng Wenchen Pu Xiaoyu Mu Kaibo Sun Yong Peng Bin Shen Yuangang Wu;Jiao Li;Yi Zeng;Wenchen Pu;Xiaoyu Mu;Kaibo Sun;Yong Peng;Bin Shen

作者机构：Orthopedic Research InstituteDepartment of OrthopedicsWest China HospitalSichuan UniversityChengduChina Laboratory of Molecular OncologyFrontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengduChina 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2022年第14卷第3期

页      面：259-274页

核心收录：

学科分类：1003[医学-口腔医学] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：funded by the National Natural Science Foundation of China(No.81974347) the Science and Technology Program of Sichuan Province(No.2021YJ0444) China Postdoctoral Science Foundation(No.2021M702351) Post-Doctor Research Project,West China Hospital,Sichuan University(No.2020HXBH081) 

主　　题：Exosomes rewire the cartilage microenvironment in osteoarthritis from intercellular communication to therapeutic strategies 

摘      要：Osteoarthritis(OA)is a prevalent degenerative joint disease characterized by cartilage loss and accounts for a major source of pain and disability ***,effective strategies for cartilage repair are lacking,and patients with advanced OA usually need joint *** comprehending OA pathogenesis may lead to transformative *** studies have reported that exosomes act as a new means of cell-to-cell communication by delivering multiple bioactive molecules to create a particular microenvironment that tunes cartilage ***,exosome cargos,such as noncoding RNAs(ncRNAs)and proteins,play a crucial role in OA progression by regulating the proliferation,apoptosis,autophagy,and inflammatory response of joint cells,rendering them promising candidates for OA monitoring and *** review systematically summarizes the current insight regarding the biogenesis and function of exosomes and their potential as therapeutic tools targeting cell-to-cell communication in OA,suggesting new realms to improve OA management.