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Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo wang Tingli Yuan Tianjie Lyu Ling Zhang meng wang Zhiying He Yongjun wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

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The Asymptotic Behavior of Chern-Simons Higgs Model on a Compact Riemann Surface with Boundary

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Acta Mathematica Sinica,English Series 2012年第1期28卷 145-170页

作者： meng wang Department of Mathematics Zhejiang UniversityHangzhou 310027P.R.China

We study the self-dual Chern-Simons Higgs equation on a compact Riemann surface with the Neumann boundary condition. In the previous paper, we show that the Chern-Simons Higgs equation with parameter A 〉 0 has at least two solutions （uλ^-, uλ^2） for A sufficiently large, which satisfy that uλ^1 - -u0 almost everywhere as λ →∞, and that uλ^2 →-∞ almost everywhere as λ→∞, where u0 is a （negative） Green function on M. In this paper, we study the asymptotic behavior of the solutions as λ →∞, and prove that uλ^2 - uλ^2- converges to a solution of the Kazdan-Warner equation if the geodesic curvature of the boundary OM is negative, or the geodesic curvature is nonpositive and the Gauss curvature is negative where the geodesic curvature is zero.

关键词： Riemann surface,. Neumann condition Chern-Simons Higgs model Green function Kazdan-Warner equation

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A ROBUST FINITE ELEMENT METHOD FOR A 3-D ELLIPTIC SINGULAR PERTURBATION PROBLEM

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Journal of Computational Mathematics 2007年第6期25卷 631-644页

作者： Ming wang Xiangrui meng LMAM School of Mathematical Science Peking University Beijing 100871 China

This paper proposes a robust finite element method for a three-dimensional fourth-order elliptic singular perturbation problem. The method uses the three-dimensional Morley element and replaces the finite element functions in the part of bilinear form corresponding to the second-order differential operator by a suitable approximation. To give such an approximation, a convergent nonconforming element for the second-order problem is constructed. It is shown that the method converges uniformly in the perturbation parameter.

关键词： Finite element Singular perturbation problem.

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Progressive learning with multi-scale attention network for cross-domain vehicle re-identification

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Science China(Information Sciences) 2022年第6期65卷 33-47页

作者： Yang wang Jinjia PENG Huibing wang meng wang School of Computer Science and Information Engineering Hefei University of Technology Intelligent Interconnected Systems Laboratory of Anhui Province Hefei University of Technology Information Science and Technology College Dalian Maritime University School of Cyber Security and Computer Hebei University

Vehicle re-identification(reID) aims to identify vehicles across different cameras that have nonoverlapping views. Most existing vehicle reID approaches train the reID model with well-labeled datasets via a supervised manner, which inevitably causes a severe drop in performance when tested in an unknown domain. Moreover, these supervised approaches require full annotations, which is limiting owing to the amount of unlabeled data. Therefore, with the aim of addressing the aforementioned problems, unsupervised vehicle reID models have attracted considerable attention. It always adopts domain adaptation to transfer discriminative information from supervised domains to unsupervised ones. In this paper, a novel progressive learning method with a multi-scale fusion network is proposed, named PLM, for vehicle reID in the unknown domain, which directly exploits inference from the available abundant data without any annotations. For PLM, a domain adaptation module is employed to smooth the domain bias, which generates images with similar data distribution to unlabeled target domain as “pseudo target samples”. Furthermore, to better exploit the distinct features of vehicle images in the unknown domain, a multi-scale attention network is proposed to train the reID model with the “pseudo target samples” and unlabeled samples; this network embeds low-layer texture features with high-level semantic features to train the reID model. Moreover, a weighted label smoothing(WLS) loss is proposed, which considers the distance between samples and different clusters to balance the confidence of pseudo labels in the feature learning module. Extensive experiments are carried out to verify that our proposed PLM achieves excellent performance on several benchmark datasets.

关键词： data adaptation module weighted label smoothing loss multi-scale attention network vehicle re-identification

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A mean field equation with symmetry on torus

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Science China Mathematics 2011年第10期54卷 2205-2211页

作者： wang meng Department of Mathematics ZheJiang University Hangzhou 310027 China

Let T^2 be a flat two-dimensional torus with fundamental cell domain [-1/2,1/2]×[-1/2,1/2],h（x） a positive smooth function satisfying the symmetric property （8） on T^*** this paper we give some sufficient conditi... 详细信息

关键词： mean field equation torus blow up

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期 369-376页

作者： Song-meng wang Hao Nian Yan-Fang wang Li-Shuo Zheng Yu-Tao Zheng Yi-Wei Dong Liping Huang Xiaoping wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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Porous organic polymer nanotubes as luminescent probe for highly selective and sensitive detection of Fe^(3+)

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Science China Chemistry 2017年第8期60卷 1090-1097页

作者： meng wang Lin Guo Dapeng Cao State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologBeLling 100029China

Two porous organic polymer nanotubes(PNT-2 and PNT-3) were synthesized via Ni-catalyzed Yamamoto reaction, using2,4,6-tris-(4-bromo-phenyl)-[1,3,5]-triazine(TBT) as one monomer, and 2,7-dibromopyrene(DBP) or 1,3,6,8-tetrabromopyrene(TBP) as another monomer. The scanning electron microscope(SEM) images show that both PNT-2 and PNT-3 possess clear hollow tube structures. Luminescent measurements indicate that both PNT-2 and PNT-3 can serve as luminescent probe for highly selective and sensitive detection of Fe^(3+) by luminescent quenching effect. Absorption competition quenching(ACQ) mechanism is also proposed to explain luminescent quenching behavior, i.e., the overlap of the UV-spectra between Fe^(3+) and PNTs causes the energy competition, and therefore leads to luminescent quenching. Moreover, both PNT-2 and PNT-3 still show high selectivity and sensitivity for sensing Fe^(3+) in 10% ethanol aqueous solution, which means that the two porous PNTs are promising candidates as luminescent probes for detecting Fe^(3+) in practical applications.

关键词： porous organic polymers polymer nanotubes luminescent sensors adsorption spectrum metal ions

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Moments of inertia of triaxial nuclei in covariant density functional theory

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Nuclear Science and Techniques 2024年第10期35卷 197-207页

作者： Yu-meng wang Qi-Bo Chen Department of Physics East China Normal UniversityShanghai 200241China

The covariant density functional theory(CDFT)and five-dimensional collective Hamiltonian(5DCH)are used to analyze the experimental deformation parameters and moments of inertia(MoIs)of 12 triaxial nuclei as extracted by Allmond and Wood[*** and ***,***.B 767,226(2017)].We find that the CDFT MoIs are generally smaller than the experimental values but exhibit qualitative consistency with the irrotational flow and experimental data for the relative MoIs,indicating that the intermediate axis exhibites the largest ***,it is found that the pairing interaction collapse could result in nuclei behaving as a rigid-body flow,as exhibited in the^(186-192)Os ***,by incorporating enhanced CDFT MoIs(factor of f≈1.55)into the 5DCH,the experimental low-lying energy spectra and deformation parameters are reproduced *** with both CDFT and the triaxial rotor model,the 5DCH demonstrates superior agreement with the experimental deformation parameters and low-lying energy spectra,respectively,emphasizing the importance of considering shape fluctuations.

关键词： Moment of inertia Trixial nucleus Covariant density functional theory Five-dimensional collective Hamiltonian Low-lying energy spectrum

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Optimizing air purification for household particulate matters using sensor-based and time-based intervention strategies

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Particuology 2023年第8期79卷 78-84页

作者： meng wang Tianjun Lu Yang Li Department of Epidemiology and Environmental Health School of Public and Health ProfessionsUniversity at BuffaloBuffalo14214USA Department of Earth Science and Geography California State UniversityDominguez HillsCarson90747USA Department of Environmental Science Baylor UniversityWaco76798USA

Filtration efficiency of portable air cleaner(PAC)is affected by resident perceptions and adherences to when and how to operate the *** PAC with smart control and sensor technology holds the promise to effectively reduce indoor air *** study aims to evaluate the efficiency of a PAC at removing indoor fine particulate matters(PM_(2.5))exposure under two automated operation settings:(1)a time-based mode in which the operation time is determined based on perceived time periods of indoor pollution by residents;(2)a sensor-based mode in which an air sensor monitor is used to determine the PAC based on the actual PM_(2.5) level against the indoor air quality *** study was conducted in a residential room for 55 days with a rolling setting on PAC(no filtration,sensor-based,time-based fil-trations)and a continuous measurement of PM_(2.5).We found that the PAC operated with sensor-based mode removed PM_(2.5) concentrations by 47%and prolonged clean air(<35 μg/m^(3))period by 23%compared to the purifications with time-based mode which reduced PM_(2.5) by 29%and increased clean air period by 13%.The sensor-based filtration identified indoor pollution episodes that are hardly detected by personal *** study findings support an automated sensor-based approach to optimize the use of PAC for effectively reducing indoor PM_(2.5) exposure.

关键词： Aircleaner Particulate matter Sensor-based filtration Time-based filtration Indoor pollution

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The Compressive and Shear Characteristics of Miura-ori Forms as Core Materials of Sandwich Structures

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Acta Mechanica Solida Sinica 2023年第4期36卷 531-540页

作者： Dora Karagiozova meng wang Guoxing Lu Institute of Mechanics Bulgarian Academy of SciencesAcad.G.Bonchev St.Block 4Sofia 1113Bulgaria School of Engineering Swinburne University of TechnologyHawthornVIC 3122Australia

The mechanical properties of Miura-ori foldcore metamaterials were studied using finite element *** responses of foldcores with various topological parameters to quasi-static out-of-plane compression and shear loading were analyzed using the relative density as a governing *** non-unique relationships between the core density and the materials'strength in the examined loading directions were revealed,pointing out the strong influence of the Miura-ori *** relationships were established between the elastic moduli and relative densities of the Miura-ori metamaterials while power-law functions of the relative density with different exponent constants were established for the strength in different loading *** was shown that the Miura-ori materials possess the highest strength under shear in the X1-X3 plane and it increases with the increase in the relative ***,this characteristic is strongly influenced by the sector angleα.In general,the difference between the two shear strengths increases when increasing the relative density by using thicker cell *** is noted that the strength of the Miura-ori materials as a function of the relative density is nearly constant with respect to the cell dimensions if the values of folding angleγ0 and sector angleαare *** mechanical characteristics of the Miura-ori material with equal relative density,which exhibits the highest strength among the analyzed origami models,are compared with the out-of-plane compression and shear responses of prismatic hexagonal *** is observed that compression and shear responses of the honeycomb outperform the Miura-ori foldcore in all loading directions when considering large deformations.

关键词： Miura-ori folded core Mechanical properties Relative density Finite element method

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