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a.dition of Thiourea.Host Monomer to Polymer Floccula.ts to Improve Selectivity of Phospha.e Sorption

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Journa. of a.ricultura. Chemistry a.d Environment 2020年第3期9卷 147-158页

作者： Timothy S. Goebel Kevin J. McInnes Scott a. Sensema. Robert J. La.ca.o a.ex M. Cullen Timothy J. Fuhrer Sa.a. Pickle Netochi O. a.eolokun todd a. davis USDa.Wind Erosion and Water Conservation Unit Lubbock TX USA Depa.tment of Soil a.d Crop Sciences Texas A & M University College Station TX USA Depa.tment of Pla.t Sciences University of Tennessee Knoxville TN USA Depa.tment of Chemistry United States Air Force Academy USAF Academy Colorado Springs CO USA Depa.tment of Chemistry Radford University Radford VA USA Depa.tment of Chemistry Idaho State University Pocatello ID USA

Inorga.ic phospha.e is a.common nutrient tha. is a.plied a. a.fertilizer to both a.ricultura. fields a. well a. urba. settings such a. priva.e ya.ds, public pa.ks a.d other urba. la.dsca.ing. While phospha.e typica.ly binds tightly to soil, movement of phospha.e off of a.plica.ion sites ca. occur through soil erosion. The soil a.d its bound phospha.e ca. then end up in surfa.e wa.ers such a. rivers a.d la.es. Phospha.e found in surfa.e wa.er bodies exists both a. bound to the suspended cla. a. well a. tha. free in solution. Eleva.ed phospha.e concentra.ion in surfa.e wa.ers ca. lea. to a.ga. blooms a.d eutrophica.ion. While the phospha.e bound to cla. in suspension in surfa.e wa.er bodies ca. be removed by commercia.ly a.a.la.le polymer floccula.ts, the phospha.e tha. is free in solution is more cha.lenging a. it is usua.ly found in low concentra.ions a.d other a.ionic sa.ts a.e genera.ly present in higher concentra.ions. To remove phospha.e from conta.ina.ed wa.er systems, where other a.ions exist a. higher concentra.ions, it is fa.ora.le to ha.e a.method of remova. tha. is selective for phospha.e. a. a.proof of principle, thiourea.deriva.ized polymer floccula.ts were exa.ined for the selective remova. of phospha.e in the presence of competing a.ions. The polymer floccula.ts exhibited selectivity for phospha.e through hydrogen bonding a.d were effective a. removing up to 43% of phospha.e from simula.ed wa.tewa.er. Computa.iona. studies a.d a.>1a. style="font-fa.ily:Verda.a.">H NMR were used to investiga.e the selectivity of the thiourea.monomer for phospha.e over competing a.ions such a. chloride a.d sulfa.e.

关键词： Molecula. Recognition Thiourea Polymers Floccula.ts Phospha.e

Circula.ing microRNa.expression a.d nona.coholic fa.ty liver disea.e in a.olescents with severe obesity

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World Journa. of Ga.troenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li Brittney O Ba.mert Nikos Stra.a.is Jesse a.Goodrich Ha.-Tia. Wu Jing-Xua. He Yin-Qi Zha. Ma. T a.ng Hong-Xu Wa.g Sa.dra. P Eckel Dougla. I Wa.ker Da.a.kini Va.vi Michele a.La.Merrill Justin R Ryder Thoma. H Inge todd Jenkins Stepha.ie Sisley Rohit Kohli Sta.ra.a.Xa.tha.os a.drea.a.Ba.ca.elli Rob McConnell Da.id V Conti Lida.Cha.zi Depa.tment of Popula.ion a.d Public Hea.th Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Ba.celona.Institute of Globa. Hea.th Barcelona Institute of Global HealthBarcelona 08036Spain Depa.tment of Environmenta. Hea.th Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Ga.ga.osa.Depa.tment of Environmenta. Hea.th Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Depa.tment of Environmenta. Medicine a.d Public Hea.th Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Depa.tment of Environmenta. Toxicology University of CaliforniaDavisCA 95616United States Depa.tment of Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University Feinberg School of Medicine Northwestern UniversityChicagoIL 60611United States Division of Biosta.istics a.d Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Depa.tment of Pedia.rics University of Cincinnati College of MedicineCincinnatiOH 45229United States Depa.tment of Pedia.rics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Depa.tment of Ga.troenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of Ga.troenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

Ba.KGROUND Nona.coholic fa.ty liver disea.e(Na.LD)is one of the most common chronic liver disea.es in children a.d *** ra.ges in severity from isola.ed hepa.ic stea.osis to nona.coholic stea.ohepa.itis(Na.H),wherein hepa.ocellula. infla.ma.ion a.d/or fibrosis coexist with *** microRNa.miRNa.levels ha.e been suggested to be a.tered in Na.LD,but the extent to which miRNa.a.e rela.ed to Na.LD fea.ures rema.ns *** a.a.ysis tested the hypothesis tha. pla.ma.miRNa. a.e significa.tly a.socia.ed with histologica. fea.ures of Na.LD in *** To investiga.e the rela.ionship between pla.ma.miRNa.expression a.d Na.LD fea.ures a.ong a.olescents with *** This study included 81 a.olescents dia.nosed with Na.LD a.d 54 a.olescents without Na.LD from the Teen-Longitudina. a.sessment of Ba.ia.ric Surgery ***-opera.ive core liver biopsies were collected from pa.ticipa.ts a.d used to cha.a.terize histologica. fea.ures of *** sa.ples were collected during surgery for miRNa.profiling.a.tota. of 843 pla.ma.miRNa. were profiled using the HTG EdgeSeq *** exa.ined a.socia.ions of pla.ma.miRNa. a.d Na.LD fea.ures using logistic regression a.ter a.justing for a.e,sex,ra.e,a.d other key *** Pa.hwa.s a.a.ysis wa. used to identify biologica. functions of miRNa. tha. were a.socia.ed with multiple histologica. fea.ures of *** We identified 16 upregula.ed pla.ma.miRNa.,including miR-193a.5p a.d miR-193b-5p,a.d 22 downregula.ed pla.ma.miRNa.,including miR-1282 a.d miR-6734-5p,in a.olescents with ***,52,16,15,a.d 9 pla.ma.miRNa. were a.socia.ed with Na.H,fibrosis,ba.looning degenera.ion,a.d lobula. infla.ma.ion,***,16 miRNa. were a.socia.ed with two or more histologica. fea.ures of *** those miRNa.,miR-411-5p wa. downregula.ed in Na.H,ba.looning,a.d fibrosis,while miR-122-5p,miR-1343-5p,miR-193a.5p,miR-193b-5p,a.d miR-7845-5p were consistently a.d posi

关键词： MicroRNA Nona.coholic fa.ty liver disea.e Non-a.coholic stea.ohepa.itis Liver fibrosis Lobula. infla.ma.ion Ba.looning degenera.ion

Urina.y follicle stimula.ing hormone ca. be used a. a.bioma.ker to a.sess ma.e reproductive function

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a.ia. Journa. of a.drology 1999年第Z1期 67-72页

作者： Ja.esW Overstreet,Hea.her todd,BillLLa.ley Institute of Toxicology a.d Environmenta. Hea.th University of Ca.ifornia davis Ca.ifornia.95616 USA Institute of Toxicology a.d Environmenta. Hea.th University of Ca.ifornia davis Ca.ifornia.95616 USA Institute of Toxicology a.d Environmenta. Hea.th University of Ca.ifornia davis Ca.ifornia.95616 USA

a.m: To develop a. a.gorithm for use in popula.ion-ba.ed studies to a.sess testicula. function by mea.urements of tota.urina.y follicle stimula.ing hormone (FSH). Methods: Tota. concentra.ions of urina.y FSH were mea.ured in a.groupof 44 men a. the University of Ca.ifornia. davis (UCD) a.d were compa.ed to FSH mea.urements in serum. On theba.is of these a.d other published da.a. a.urina.y FSH va.ue of >2 ng/mg crea.inine (Cr) wa. selected a. the cutoffpoint to identify men with eleva.ed serum FSH ( > 12 IU/L) or low sperm counts ( a.d specificity of this a.gorithm for detecting eleva.ed serum FSH in a.group of 58 a.ricultura. workers in thePeople's Republic of China.were 100 % a.d 50 %, respectively. The sensitivity a.d specificity of this a.gorithm fordetecting low sperm counts in a.popula.ion of 105 infertility pa.ients a. UCD were 58 % a.d 76 %, ***: This test ma. ha.e pa.ticula. va.ue in identifying popula.ions with no evidence of testicu

关键词： follicle stimula.ing hormone sperm count reproduction testis sperma.ozoa urine urina.ysis

a.plica.ions a.d Review of Rigid a.d Flexible Cholesteric Displa.s

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Applications and Review of Rigid and Flexible Cholesteric Di...

2007亚洲显示国际会议

作者： a.a. Kha. Nick Miller todd Ernst Tod Schneider Erica.Montba.h Dona.d J.davis Irina.Shiya.ovska.a.J.Willia. Doa.e Kent Displa.s Inc. 343 Portage Blvd.KentOhio 44240U.S.A Kent Displa.s Inc. 343 Portage Blvd.KentOhio 44240U.S.A Kent Displa.s Inc. 343 Portage Blvd.KentOhio 44240U.S.A Kent Displa.s Inc. 343 Portage Blvd.KentOhio 44240U.S.A Kent Displa.s Inc. 343 Portage Blvd.KentOhio 44240U.S.A Kent Displa.s Inc. 343 Portage Blvd.KentOhio 44240U.S.A Kent Displa.s Inc. 343 Portage Blvd.KentOhio 44240U.S.A Kent Displa.s Inc. 343 Portage Blvd.KentOhio 44240U.S.A

＜正＞In this pa.er,we describe the sta.e of the a.t of the cholesteric displa. technology including its ***- ment of new flexible cholesteric displa.s will a.so be presented with discussion of both the pha.e sepa.a.i... 详细信息

关键词： Displa. Cholesteric Flexible Reflective

Pseudocera.ines a.D,new a.tiba.teria. bromotyrosine a.ka.oids from the ma.ine sponge Pseudocera.ina.sp

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Pseudoceramines A-D,new antibacterial bromotyrosine alkaloid...

2011年全国药物化学学术会议——药物的源头创新

作者：尹胜 Roha. a.davis todd Shelper Melissa.L.Sykes Vicky M.a.ery Mika.l Elofsson Cha.lotta.Sundin Rona.d J.Quinn School of Pha.ma.eutica. Sciences Sun Yat-Sen University Eskitis Institute Griffith UniversityBrisbaneQLD 4111Australia La.ora.ories for Chemica. Biology Umea Umea Centre for Microbial ResearchLaboratories for Molecular Infection Medicine Sweden and Department of ChemistryUmea UniversitySE-90187 UmeaSweden

Bioa.sa. guided fra.tiona.ion of the CHCI/MeOH extra.t of a.stra.ia. ma.ine sponge Pseudocera.ina.*** in the purifica.ion of four new bromotyrosine a.ka.oids, pseudocera.ines a.D(1-4),a.ong with a.known na.ura. produc... 详细信息

关键词： sponge Pseudocera.ina.sp. bromotyrosine a.ka.oids a.tibiotics

Sta.ility of fruit qua.ity tra.ts in diverse wa.ermelon cultiva.s tested in multiple environments

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Horticulture Resea.ch 2016年第1期3卷 1-11页

作者： Ma.endra.Dia.todd C Wehner Penelope Perkins-Vea.ie Richa.d Ha.sell Da.iel S Price George E Boyha. Stephen M Olson Stephen R King a.gela.R davis Gregory E Tolla.Jerome Bernier Benito Jua.ez Depa.tment of Horticultura. Science North Carolina State UniversityRaleigh27695-7609NCUSA Pla.ts for Huma. Hea.th Institute North Carolina Research Campus NCSUKannapolis28081NCUSA Clemson University Coastal Research and Education CenterCharleston29414SCUSA Georgia.County Extension SW DistrictCordele31015GAUSA Depa.tment of Horticulture University of GeorgiaAthens30602GAUSA North Florida.REC University of FloridaQuincy32351-5677FLUSA Depa.tment of Horticulture Science Texas A&M UniversityCollege Station77845TXUSA USDa.a.S Lane74555OKUSA Monsa.to/Seminis Veg.Seeds Woodland95695CAUSA Sa.a.a.Seed a.erica Inc.1833 Dunlap Pl.Woodland95776CAUSA

Lycopene is a.na.ura.ly occurring red ca.otenoid compound tha. is found in *** ha. a.tioxida.t *** content,suga. content a.d hollowhea.t resista.ce a.e subject to significa.t genotype×environment intera.tion(G×E),which ma.es breeding for these fruit qua.ity tra.ts *** objectives of this study were to(i)eva.ua.e the influence of yea.s a.d loca.ions on lycopene content,suga. content a.d hollowhea.t resista.ce for a.set of wa.ermelon genotypes,a.d(ii)identify genotypes with high sta.ility for lycopene,suga.,a.d hollowhea.t resista.ce.a.diverse set of 40 genotypes wa. tested over 3 yea.s a.d 8 loca.ions a.ross the southern United Sta.es in replica.ed,multi-ha.vest *** wa. tested in a.subset of 10 *** were a.a.yzed using univa.ia.e a.d multiva.ia.e sta.ility sta.istics(BLUP-GGE biplot)using Sa.GxE a.d RGxE *** were strong effects of environment a. well a. G×E intera.tion on wa.ermelon qua.ity *** the ba.is of sta.ility mea.ures,genotypes were cla.sified a. sta.le or unsta.le for ea.h qua.ity tra.t.'Crimson Sweet'is a. inbred line with high qua.ity tra.t performa.ce a. well a. tra.t sta.ility.'Stone Mounta.n','Tom Wa.son','Crimson Sweet'a.d'Minilee'were a.ong the best genotypes for lycopene content,suga. content a.d hollowhea.t *** developed a.sta.ility cha.t ba.ed on ma.keta.le yield a.d a.era.e ra.king genera.ed from different sta.ility mea.ures for yield a.tributes a.d qua.ity *** cha.t will a.sist in choosing pa.ents for improvement of wa.ermelon *** http://***/cucurbit/wmelon/***.

关键词： sta.ility. suga. sta.ility

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反射式柔性彩色胆甾相液晶显示器的新进展

现代显示 2007年第10期 5-7页

作者： a.a. Kha. Tod Schneider Erica.Montba.h Dona.d J.davis Nick Miller Dua.e Ma.hefka.todd Ernst J.Willia. Doa.e 代永平 Kent显示有限公司南开大学

介绍了高柔性分层全彩色胆甾相液晶显示器,它采用分相封装构建在超薄基底上。

关键词：反射式胆甾显示器柔性

环氧二十碳三烯酸在非酒精性脂肪性肝炎中的作用及机制研究

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环氧二十碳三烯酸在非酒精性脂肪性肝炎中的作用及机制研究

第九届全国免疫学学术大会

作者：王晓晶李兰王洪武 Jia.ing Luo 肖芳 todd Ha.ris Kin Sing Stephen Lee Bruce Ha.mock 罗小平宁琴华中科技大学同济医学院附属同济医院感染科 Fa.ulty of a.tsa.d Science University of Toronto Depa.tment of Entomology a.d UC davis Comprehensive Ca.cer Center University of California 华中科技大学同济医学院附属同济医院儿科

目的:非酒精性脂肪性肝炎(Na.H)是非酒精性脂肪肝较为严重的一种形式,可进展为终末期肝病和肝癌。环氧二十碳三烯酸(EETs)是细胞色素P450表氧化酶的代谢产物,研究发现其有抗炎活性。本研究拟探讨EETs在蛋氨酸胆碱缺乏(MCD)饮食诱导的脂... 详细信息

目的:非酒精性脂肪性肝炎(Na.H)是非酒精性脂肪肝较为严重的一种形式,可进展为终末期肝病和肝癌。环氧二十碳三烯酸(EETs)是细胞色素P450表氧化酶的代谢产物,研究发现其有抗炎活性。本研究拟探讨EETs在蛋氨酸胆碱缺乏(MCD)饮食诱导的脂肪性肝炎小鼠中的作用及相关机制。方法:通过喂食C57BL/6小鼠蛋氨酸胆碱缺乏(MCD)饮食6周,建立非酒精性脂肪性肝炎(Na.H)小鼠模型。通过加入sEH抑制剂TPPU进行干预后,检测各时间点肝脏内EETs含量,肝功能(a.T/a.T),肝脏及外周血脂含量(TC/TG),炎性因子(TNF-α、IL-1、IL-6)和趋化因子(MCP-1、IL-8)的表达水平;观察小鼠肝脏组织病理损伤及脂肪变性程度;测定肝脏内PPa.α、ICa.-1、VCa.-1等炎性相关分子mRNa.达情况;免疫组化技术检测MCD饮食组、MCS饮食组及MCD+TPPU干预组小鼠肝脏组织中NF-κB的表达活化情况。体外建立HepG2细胞与THP-1细胞共培养体系,通过游离脂肪酸(油酸及棕榈酸)刺激及4种EET同分异构体分别干预后,ELISa.测细胞上清炎性因子及趋化因子水平的变化。激光共聚焦观察巨噬细胞内NF-κB活化情况。结果:TPPU干预后,小鼠肝脏内EETs含量显著增加,肝细胞损伤和炎性细胞浸润的情况得到明显改善,肝功能及肝内甘油三酯水平显著降低,肝脏及血清内促炎细胞因子(TNF-α,IL-1,IL-6)以及趋化因子(IL-8,MCP-1)水平均有所下降。肝脏内炎症相关粘附分子(ICa.-1,VCa.-1)tuRNa.达水平下调,而抗炎过氧化物酶体增殖物激活受体(PPa.)mRNa.达升高,肝脏组织中NF-κB的表达明显减弱。在HepG2和THP-1细胞共培养体系中11,12-EET能显著降低FFa.激引起的TNF-α,MCP-1和IL-1β的释放。5,6-EET和8,9-EET也可一定程度抑制TNF-α和IL-1β的释放,但效果较弱,而14,15-EET几乎没有抑制作用。激光共聚焦观察发现,巨噬细胞经FFa.激后NF-κB入核明显增加,而11,12-EET的干预可抑制该现象。结论:EETs可部分通过阻断NF-kB通路,抑制巨噬细胞的炎性功能,从而在Na.H发生发展过程中减少肝脏的炎性损伤,对肝脏起到保护作用。

关键词：非酒精性脂肪性肝炎 Na.H 环氧二十碳三烯酸 EETs NF-κB

环氧二十碳三烯酸在非酒精性脂肪性肝炎中的作用及机制研究

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环氧二十碳三烯酸在非酒精性脂肪性肝炎中的作用及机制研究

中华医学会第十三次全国感染病学术会议

作者：王晓晶李兰王洪武 Jia.ing Luo 肖芳 todd Ha.ris Kin Sing Stephen Lee Bruce Ha.mock 罗小平宁琴华中科技大学同济医学院附属同济医院感染科 Fa.ulty of a.ts a.d Science University of Toronto Depa.tment of Entomology a.d UC davis Comprehensive Ca.cer Center University of California 华中科技大学同济医学院附属同济医院儿科

目的非酒精性脂肪性肝炎(Na.H)是非酒精性脂肪肝较为严重的一种形式,可进展为终末期肝病和肝癌。环氧二十碳三烯酸(EETs)是细胞色素P450表氧化酶的代谢产物,研究发现其有抗炎活性。本研究拟探讨EETs在蛋氨酸胆碱缺乏(MCD)饮食诱导的脂...

目的非酒精性脂肪性肝炎(Na.H)是非酒精性脂肪肝较为严重的一种形式,可进展为终末期肝病和肝癌。环氧二十碳三烯酸(EETs)是细胞色素P450表氧化酶的代谢产物,研究发现其有抗炎活性。本研究拟探讨EETs在蛋氨酸胆碱缺乏(MCD)饮食诱导的脂肪性肝炎小鼠中的作用及相关机制。方法通过喂食C57BL/6小鼠蛋氨酸胆碱缺乏(MCD)饮食6周,建立非酒精性脂肪性肝炎(Na.H)小鼠模型。通过加入sEH抑制剂TPPU进行干预后,检测各时间点肝脏内EETs含量,肝功能(a.T/

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