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Correlation of neutrophil to lymphocyte ratio to severity of coronary artery disease and in-hospital clinical outcomes in patients with acute coronary syndrome: A prospective observational study

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Journal of Acute Disease 2024年第1期13卷 14-19页

作者： Vinodhkumar Kandibendla GThiruvikrama Prakash subash chandra Bose Prafull Dhewle Department of Cardiology Prakriya HospitalsNagasandraBangloreIndia Department of Cardiology E.S.HospitalVillupuramTamil NaduIndia Department of Cardiology Government Medical CollegeAnanthapuramuAndhra PradeshIndia Department of Cardiology Shrikrishna Hrudayalaya HospitalNagpurMaharashtraIndia

Objective:To explore correlation of neutrophil-to-lymphocyte ratio(NLR)to severity of coronary artery disease(CAD)and in-hospital clinical outcomes in patients with acute coronary syndrome(ACS).Methods:In this prospective and observational study,we recruited 500 patients with *** all the eligible patients,demographic details were collected,and laboratory parameters were *** CAD severity was evaluated in terms of the number of involved *** NLR was calculated based on neutrophils and lymphocytes and the correlation of various risk factors and severity and outcome of CAD was ***:77.2%of Patients was male,and 52%of the patients aged between 55-70 *** on the type of ACS,396 out of 500 patients had ST-elevation myocardial *** ascending trend in the white blood cell levels and NLR value was noted as the severity of the ACS increased and the highest white blood cell levels and NLR was noted among classⅣ*** mean NLR value among the non-survivors were higher compared to the survivors(9.52±5.72 vs.4.76±2.36;P<0.01).Receiver operating curve showed that the cut-off NLR value was 5.76 with a sensitivity of 75.0%and a specificity of 77.3%.Conclusions:The NLR can be used as an independent prognostic marker in *** elevated NLR value serves as a reliable predictor for short-term complications,notably in-hospital mortality.

关键词： Acute coronary syndrome Coronary artery disease Coronary vessels Hospital mortality Lymphocytes Neutrophils Prognosis Risk factors

Spatiotemporal dynamics of land use/land cover(LULC)changes and its impact on land surface temperature:A case study in New Town Kolkata,eastern India

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Regional Sustainability 2024年第2期5卷 26-48页

作者： Bubun MAHATA Siba Sankar sahu Archishman SARDAR Laxmikanta RANA Mukul MAITY Department of Geography Ravenshaw UniversityCuttack753003India Department of Geography Sri Krushna Chandra Gajapati(Autonomous)CollegeParalakhemundi761200India

Rapid urbanization creates complexity,results in dynamic changes in land and environment,and influences the land surface temperature(LST)in fast-developing *** this study,we examined the impact of land use/land cover(LULC)changes on LST and determined the intensity of urban heat island(UHI)in New Town Kolkata(a smart city),eastern India,from 1991 to 2021 at 10-a intervals using various series of Landsat multi-spectral and thermal *** study used the maximum likelihood algorithm for image classification and other methods like the correlation analysis and hotspot analysis(Getis–Ord Gi^(*) method)to examine the impact of LULC changes on urban thermal *** study noticed that the area percentage of built-up land increased rapidly from 21.91%to 45.63%during 1991–2021,with a maximum positive change in built-up land and a maximum negative change in sparse *** mean temperature significantly increased during the study period(1991–2021),from 16.31℃to 22.48℃in winter,29.18℃to 34.61℃in summer,and 19.18℃to 27.11℃in *** result showed that impervious surfaces contribute to higher LST,whereas vegetation helps decrease *** ecological status has been found in built-up land,and excellent ecological status has been found in vegetation and water *** hot spot and cold spot areas shifted their locations every decade due to random LULC *** after New Town Kolkata became a smart city,high LST has been ***,this study indicated that urbanization and changes in LULC patterns can influence the urban thermal environment,and appropriate planning is needed to reduce *** study can help policy-makers create sustainable smart cities.

关键词： Urbanization Land use/land cover (LULC)changes Land surface temperature Urban heat island Hotspot analysis Smart city

Influence of local stiffeners and cutout shapes on the vibration and stability characteristics of quasi-isotropic laminates under hygro-thermo-mechanical loadings

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Defence Technology（防务技术） 2022年第12期18卷 2107-2124页

作者： T.Rajanna K.S.subash chandra K.Venkata Rao Department of Civil Engineering B.M.S College of EngineeringBengaluru560019India Research Scholar B.M.S College of EngineeringBengaluru560019India Department of Mechanical Engineering B.M.S Evening College of EngineeringBengaluru560019India Department of Mechanical Engineering Government PolytechnicBagepalli561207India

The perforated stiffened panel is generally found as a sub-component of sophisticated *** fundamental purpose of this panel is to withstand against buckling under complicated loading and environmental ***,an accurate knowledge of critical buckling behaviour of stiffened panels is very much essential for a reliable and lightweight structural *** this paper,the focus is on quasi-laminated panels with different cutout shapes of various sizes and their responses to hygrothermal environments under nonlinearly varying edge loads and is compared with the locally stiffened *** this,the modelling of the panel and stiffener is done by adopting nine-noded heterosis plate elements and three noded beam elements *** stiffener formulation is suitably modified in order to take the torsional effect also into consideration along with the effect of shear ***,the plate and the stiffener elements are treated separately,and then the displacement compatibility is maintained between them by using the transformation *** a given loading and geometric discontinuity,the stress distribution within the perforated panel is highly non-uniform in nature and hence a dynamic approach has been used to calculate buckling loads by adopting two sets of boundary conditions,one set for pre-buckling stress analysis and the second set for buckling *** different quasi-isotropic stacking sequences are deliberated in this work by varying different ply-orientation in each *** study also addresses the effect of various parameters such as nonlinear loads,hygro-thermal loads,cutout size and shapes,position of cutout,stiffener parameters,stacking sequences,thickness of plate and boundary conditions.

关键词： Locally stiffened panels Buckling Vibration Cutouts Heterosis Hygrothermal environment

Surveillance of antibiotic sensitivity pattern in chronic suppurative otitis media of an Indian teaching hospital

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第2期5卷 88-94页

作者： Mahesh chandra sahu Santosh Kumar Swain IMS and SUM Hospital Siksha'O'Anusandhan UniversityK8KalinganagarBhubaneswar751003OdishaIndia Department of Otorhinolaryngology IMS and SUM HospitalSiksha'O'Anusandhan UniversityK8KalinganagarBhubaneswar751003OdishaIndia

Introduction:Chronic suppurative otitis media (CSOM) is a common problem in worldwide and untreated CSOM leads to fatal complications like facial nerve paralysis,lateral sinus thrombosis,labyrinthitis,meningitis and brain abscess in developing country like ***:To isolate causative bacteria and antibiotic sensitivity pattern for CSOM and to know the prevalence of extended spectrum beta lactamases (ESBL) and Metallobetalactamases (MBL) in CSOM ***:A total of 500 ear swabs of clinical suspected CSOM patients were cultured on specific cultured medium and identified the bacteria with conventional *** all the identified bacteria were subjected with specific antibiotics by the Kirby-Bauer's method to know the resistance pattern of *** and MBL strains were detected by double disc diffusion ***:A total of 384 bacteria were isolated from 500 CSOM patients,among them 86 *** (22.40%),112 Staphylococcus aureus (29.17%),53 *** (13.80%),32 *** (18%),26 *** (6.77%),24 *** (6.25%),23 *** (5.99%),18 *** (4.69%) and 10 *** (2.60%) identified with conventional *** antibiotic disc diffusion methods 74.22% ESBL strains and 9.90%MBL strains were *** resistant strains of *** (86/384,22.40%) were more prevalent than those of *** (112/384,29.17%) and other bacteria in ear *** and vancomicin could control to gram negative bacteria and gram positive bacteria ***:Continuous and periodic evaluation of microbiological profile and antimicrobial sensitivity pattern of bacterial is essential for optimum management of CSOM patients.

关键词： Antibiotics Chronic suppurative otitis media Gram negative bacteria ESBL MBL

A Review on the Evaporation Dynamics of Sessile Drops of Binary Mixtures:Challenges and Opportunities

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Fluid Dynamics & Materials Processing 2021年第2期17卷 253-284页

作者： Pradeep Gurrala Saravanan Balusamy Sayak Banerjee Kirti chandra sahu Department of Mechanical and Aerospace Engineering Indian Institute of Technology HyderabadSangareddyTelanganaIndia Department of Chemical Engineering Indian Institute of Technology HyderabadSangareddyTelanganaIndia

The wetting and evaporation dynamics of sessile droplets have gained considerable attention over the last few years due to their relevance to many practical applications,ranging from a variety of industrial problems to several biological *** made of binary mixtures typically undergo complex dynamics due to the differential volatility of the considered components and the ensuing presence of thermocapillary *** these reasons,many research groups have focused on the evaporation of binary droplets using a variegated set of experimental,numerical,and purely theoretical *** from reviewing the state-of-the-art about the existing experimental,analytical,and computational techniques used to study the evaporation dynamics of binary sessile droplets,we also provide some indications about possible future research directions in this specific area.

关键词： Wetting dynamics evaporation sessile droplet binary mixture thermocapillary flow

Differences in Tree Species Diversity and Soil Nutrient Status in a Tropical Sacred Forest Ecosystem on Niyamgiri Hill Range,Eastern Ghats,India

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Journal of Mountain Science 2012年第4期9卷 492-500页

作者： Sudam Charan sahu Nabin Kumar DHAL Brij LAL Rama chandra MOHANTY Environment and Sustainability Department CSIR-IMMTBhubaneswar-751013India Biodiversity Division CSIR-IHBTPalampurIndia Department of Botany Utkal UniversityBhubaneswar-751004India

We have quantitatively analyzed the tree species diversity with respect to soil nutrient status in three sites of a sacred forest ecosystem of Niyamgiri hill range, Eastern Ghats, India. Extensive field surveys and sampling were conducted in 3 sites of the hill range： Site 1 Pterocarpus dominated forest （PTF）（19°40＇02.2＇＇ N and 83°21＇23.1＇＇ E）, Site 2 Mangifera dominated forest （MAF）（19°40＇02.8＇＇ N and 83°21＇40.8＇＇ E） and Site 3 Mixed forest （MIF）（19°36＇47.1＂ N and 83°21＇02.7＇＇ E）. A total of 28 families, 42 genera, 46 tree species, and 286 individual trees were recorded on an area of0.6 ha. Tree density varied between 470 and 49o individuals ha and average basal area between 3.16 and l0.04 m2 ha-1. Shannon Index （H＇） ranged from 2.34 to 4.53, Simpson＇s Index ranged from 0.07 to o.09, and equitability Index ranged from 0.7 to 1.34. The number of individuals was highest in the girth at breast height （GBH） class of 50-7o cm. The soil nutrient status of the three forest types was related to tree species diversity. The soil pH value of the three sites reflected the slightly acidic nature of the area. Species diversity was positively correlated with organic carbon and phosphorus and negatively with nitrogen, EC and pH. The results of the current study may be helpful to further develop a conservation planfor tree species in tropical sacred forest ecosystems.

关键词： Tree species diversity Sacred forestecosystem Soil nutrient status Eastern Ghats

Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第4期13卷 156-164页

作者： Gayatri Khuntia Jeevan Ranjan Dash Biswadeep Jena Uma Kanta Mishra subash chandra Parija Department of Pharmacology and Toxicology College of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia Department of Veterinary Surgery and Radiology College of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia Department of Veterinary Anatomy and Histology College of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia

Objective:To explore the cardioprotective effect of hesperidin against arsenic trioxide-induced cardiac toxicity in ***:Cardiac toxicity was induced by oral administration of 4 mg/kg arsenic trioxide for 30 ***,biochemical,electrocardiography,echocardiography,and histopathological examinations were ***:Hesperidin decreased the neutrophil-to-lymphocyte ratio,calcium,creatine kinase-myoglobin binding,lactate dehydrogenase,IL-6,and lipid peroxidation,as well as increased sodium and potassium concentration and superoxide dismutase and catalase activity in arsenic trioxide-intoxicated ***,it reduced peak systolic velocity and end-diastolic velocity while increasing heart *** trioxide-induced histopathological damage to cardiac tissue was prominently alleviated by hesperidin ***:Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in ***,it can be further explored as a cardioprotective agent.

关键词： Arsenic trioxide Hesperidin Cardiotoxicity ECG CK-MB LDH

Recent advances on pathogenesis,diagnosis,prevention,immunological aspects,and vectors of dengue:A review

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Asian Pacific Journal of Tropical Biomedicine 2023年第8期13卷 325-338页

作者： Mahesh chandra sahu Rakesh Kumar Samantaray Aditi Pal Sanghamitra Pati Division of Medical Entomology ICMR-Regional Medical Research CentreChandrasekharpurBhubaneswar-751023OdishaIndia ICMR-Regional Medical Research Centre ChandrasekharpurBhubaneswar-751023OdishaIndia

Dengue is a vector-borne disease caused by the dengue virus(DENV)of family *** fever is common in both developed and developing ***,approximately 400 million cases of dengue fever are reported annually,resulting in approximately 22000 *** cases in India have progressively increased in the last *** recent years,substantial progress has been made in understanding various aspects of dengue,including its pathogenesis,diagnosis,prevention strategies,immunological responses,and the role of vectors in its *** transmission of a positive RNA virus occurs through Aedes mosquitoes,specifically Aedes aegypti and Aedes *** virus is associated with a wide spectrum of symptoms,ranging from mild undifferentiated fever to severe hemorrhagic fever and shock,posing a potential threat to human *** are 4 types of antigenically distinct dengue serotypes(DENV-1 to DENV-4)and among them,DENV-2 is more lethal and extremely *** overcome the severity of dengue,Dengvaxia is administered to children 9 to 16 years old with evidence of previous dengue *** diagnosis of dengue is carried out by ELISA-based non-structural protein(NS1)and immunoglobulin ***,there are no specific biomarkers to identify severe disease *** factors and temperature play an important role in complex interaction among host,vector,and virus to manifest the severity of *** is a need for the refinement of climate-based disease forecasting models in India to effectively control the spread of *** mosquito repellent should be used periodically to kill or repel the Aedes mosquito to prevent the spread of dengue in humans.

关键词： Dengue Aedes mosquitoes Insecticide NS1 Immunoglobulin

Development and characterization of ethylcellulose based microsphere for sustained release of nifedipine

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Journal of Pharmaceutical Analysis 2016年第5期6卷 341-344页

作者： Patitapabana Parida subash chandra Mishra Subhashree Sahoo Ajit Behera Bibhukalyan Prasad Nayak Department of Biotechnology and Medical Engineering NIT Rourkela Odisha 769008 India Department of Metallurgical and Materials Engineering NIT Rourkela Odisha 769008 India Department of Pharmaceutics Kanakmanjari Institute of Pharmaceutical Sciences Rourkela Odisha 769015 India Department of Metallurgical and Materials Engineering IIT Kharagpur West Bengal 721302 India

This article introduced the work of ethylcellulose based polymeric microsphere loaded with nifedipine for reduction in frequency of administration with low solubility in aqueous medium and high rate of absorption in the stomach. The non-aqueous polymeric suspension was put dropwise into an aqueous medium containing polyvinyl alcohol as a surfactant for the synthesis of microsphere by solvent evaporation. The microspheres were characterized by different techniques, namely, XRD, SEM, and NMR. The formation of microspheres was confirmed by SEM. XRD analysis revealed the semi-crystallinity nature of microspheres. The NMR study indicated the presence of hetero-aromatic nucleus in the microsphere.

关键词： Nifedipine Microsphere Solvent evaporation Sustained release