Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats

作     者：Gayatri Khuntia Jeevan Ranjan Dash Biswadeep Jena Uma Kanta Mishra Subash Chandra Parija Gayatri Khuntia;Jeevan Ranjan Dash;Biswadeep Jena;Uma Kanta Mishra;Subash Chandra Parija

作者机构：Department of Pharmacology and ToxicologyCollege of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia Department of Veterinary Surgery and RadiologyCollege of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia Department of Veterinary Anatomy and HistologyCollege of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2023年第13卷第4期

页      面：156-164页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Arsenic trioxide Hesperidin Cardiotoxicity ECG CK-MB LDH 

摘      要：Objective:To explore the cardioprotective effect of hesperidin against arsenic trioxide-induced cardiac toxicity in ***:Cardiac toxicity was induced by oral administration of 4 mg/kg arsenic trioxide for 30 ***,biochemical,electrocardiography,echocardiography,and histopathological examinations were ***:Hesperidin decreased the neutrophil-to-lymphocyte ratio,calcium,creatine kinase-myoglobin binding,lactate dehydrogenase,IL-6,and lipid peroxidation,as well as increased sodium and potassium concentration and superoxide dismutase and catalase activity in arsenic trioxide-intoxicated ***,it reduced peak systolic velocity and end-diastolic velocity while increasing heart *** trioxide-induced histopathological damage to cardiac tissue was prominently alleviated by hesperidin ***:Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in ***,it can be further explored as a cardioprotective agent.