Correlation of neutrophil to lymphocyte ratio to severity of coronary artery disease and in-hospital clinical outcomes in patients with acute coronary syndrome: A prospective observational study

作     者：Vinodhkumar Kandibendla GThiruvikrama Prakash Subash Chandra Bose Prafull Dhewle Vinodhkumar Kandibendla;G.Thiruvikrama Prakash;Subash Chandra Bose;Prafull Dhewle

作者机构：Department of CardiologyPrakriya HospitalsNagasandraBangloreIndia Department of CardiologyE.S.HospitalVillupuramTamil NaduIndia Department of CardiologyGovernment Medical CollegeAnanthapuramuAndhra PradeshIndia Department of CardiologyShrikrishna Hrudayalaya HospitalNagpurMaharashtraIndia 

出 版 物：《Journal of Acute Disease》 (急性病杂志（英文版）)

年 卷 期：2024年第13卷第1期

页      面：14-19页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Acute coronary syndrome Coronary artery disease Coronary vessels Hospital mortality Lymphocytes Neutrophils Prognosis Risk factors 

摘      要：Objective:To explore correlation of neutrophil-to-lymphocyte ratio(NLR)to severity of coronary artery disease(CAD)and in-hospital clinical outcomes in patients with acute coronary syndrome(ACS).Methods:In this prospective and observational study,we recruited 500 patients with *** all the eligible patients,demographic details were collected,and laboratory parameters were *** CAD severity was evaluated in terms of the number of involved *** NLR was calculated based on neutrophils and lymphocytes and the correlation of various risk factors and severity and outcome of CAD was ***:77.2%of Patients was male,and 52%of the patients aged between 55-70 *** on the type of ACS,396 out of 500 patients had ST-elevation myocardial *** ascending trend in the white blood cell levels and NLR value was noted as the severity of the ACS increased and the highest white blood cell levels and NLR was noted among classⅣ*** mean NLR value among the non-survivors were higher compared to the survivors(9.52±5.72 vs.4.76±2.36;P0.01).Receiver operating curve showed that the cut-off NLR value was 5.76 with a sensitivity of 75.0%and a specificity of 77.3%.Conclusions:The NLR can be used as an independent prognostic marker in *** elevated NLR value serves as a reliable predictor for short-term complications,notably in-hospital mortality.