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Correlation of neutrophil to lymphocyte ratio to severity of coronary artery disease and in-hospital clinical outcomes in patients with acute coronary syndrome: A prospective observational study

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Journal of Acute Disease 2024年第1期13卷 14-19页

作者： Vinodhkumar Kandibendla GThiruvikrama Prakash subash chandra bose Prafull Dhewle Department of Cardiology Prakriya HospitalsNagasandraBangloreIndia Department of Cardiology E.S.HospitalVillupuramTamil NaduIndia Department of Cardiology Government Medical CollegeAnanthapuramuAndhra PradeshIndia Department of Cardiology Shrikrishna Hrudayalaya HospitalNagpurMaharashtraIndia

Objective:To explore correlation of neutrophil-to-lymphocyte ratio(NLR)to severity of coronary artery disease(CAD)and in-hospital clinical outcomes in patients with acute coronary syndrome(ACS).Methods:In this prospective and observational study,we recruited 500 patients with *** all the eligible patients,demographic details were collected,and laboratory parameters were *** CAD severity was evaluated in terms of the number of involved *** NLR was calculated based on neutrophils and lymphocytes and the correlation of various risk factors and severity and outcome of CAD was ***:77.2%of Patients was male,and 52%of the patients aged between 55-70 *** on the type of ACS,396 out of 500 patients had ST-elevation myocardial *** ascending trend in the white blood cell levels and NLR value was noted as the severity of the ACS increased and the highest white blood cell levels and NLR was noted among classⅣ*** mean NLR value among the non-survivors were higher compared to the survivors(9.52±5.72 vs.4.76±2.36;P<0.01).Receiver operating curve showed that the cut-off NLR value was 5.76 with a sensitivity of 75.0%and a specificity of 77.3%.Conclusions:The NLR can be used as an independent prognostic marker in *** elevated NLR value serves as a reliable predictor for short-term complications,notably in-hospital mortality.

关键词： Acute coronary syndrome Coronary artery disease Coronary vessels Hospital mortality Lymphocytes Neutrophils Prognosis Risk factors

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Influence of local stiffeners and cutout shapes on the vibration and stability characteristics of quasi-isotropic laminates under hygro-thermo-mechanical loadings

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Defence Technology（防务技术） 2022年第12期18卷 2107-2124页

作者： T.Rajanna K.S.subash chandra K.Venkata Rao Department of Civil Engineering B.M.S College of EngineeringBengaluru560019India Research Scholar B.M.S College of EngineeringBengaluru560019India Department of Mechanical Engineering B.M.S Evening College of EngineeringBengaluru560019India Department of Mechanical Engineering Government PolytechnicBagepalli561207India

The perforated stiffened panel is generally found as a sub-component of sophisticated *** fundamental purpose of this panel is to withstand against buckling under complicated loading and environmental ***,an accurate knowledge of critical buckling behaviour of stiffened panels is very much essential for a reliable and lightweight structural *** this paper,the focus is on quasi-laminated panels with different cutout shapes of various sizes and their responses to hygrothermal environments under nonlinearly varying edge loads and is compared with the locally stiffened *** this,the modelling of the panel and stiffener is done by adopting nine-noded heterosis plate elements and three noded beam elements *** stiffener formulation is suitably modified in order to take the torsional effect also into consideration along with the effect of shear ***,the plate and the stiffener elements are treated separately,and then the displacement compatibility is maintained between them by using the transformation *** a given loading and geometric discontinuity,the stress distribution within the perforated panel is highly non-uniform in nature and hence a dynamic approach has been used to calculate buckling loads by adopting two sets of boundary conditions,one set for pre-buckling stress analysis and the second set for buckling *** different quasi-isotropic stacking sequences are deliberated in this work by varying different ply-orientation in each *** study also addresses the effect of various parameters such as nonlinear loads,hygro-thermal loads,cutout size and shapes,position of cutout,stiffener parameters,stacking sequences,thickness of plate and boundary conditions.

关键词： Locally stiffened panels Buckling Vibration Cutouts Heterosis Hygrothermal environment

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Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第4期13卷 156-164页

作者： Gayatri Khuntia Jeevan Ranjan Dash Biswadeep Jena Uma Kanta Mishra subash chandra Parija Department of Pharmacology and Toxicology College of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia Department of Veterinary Surgery and Radiology College of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia Department of Veterinary Anatomy and Histology College of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia

Objective:To explore the cardioprotective effect of hesperidin against arsenic trioxide-induced cardiac toxicity in ***:Cardiac toxicity was induced by oral administration of 4 mg/kg arsenic trioxide for 30 ***,biochemical,electrocardiography,echocardiography,and histopathological examinations were ***:Hesperidin decreased the neutrophil-to-lymphocyte ratio,calcium,creatine kinase-myoglobin binding,lactate dehydrogenase,IL-6,and lipid peroxidation,as well as increased sodium and potassium concentration and superoxide dismutase and catalase activity in arsenic trioxide-intoxicated ***,it reduced peak systolic velocity and end-diastolic velocity while increasing heart *** trioxide-induced histopathological damage to cardiac tissue was prominently alleviated by hesperidin ***:Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in ***,it can be further explored as a cardioprotective agent.

关键词： Arsenic trioxide Hesperidin Cardiotoxicity ECG CK-MB LDH

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Development and characterization of ethylcellulose based microsphere for sustained release of nifedipine

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Journal of Pharmaceutical Analysis 2016年第5期6卷 341-344页

作者： Patitapabana Parida subash chandra Mishra Subhashree Sahoo Ajit Behera Bibhukalyan Prasad Nayak Department of Biotechnology and Medical Engineering NIT Rourkela Odisha 769008 India Department of Metallurgical and Materials Engineering NIT Rourkela Odisha 769008 India Department of Pharmaceutics Kanakmanjari Institute of Pharmaceutical Sciences Rourkela Odisha 769015 India Department of Metallurgical and Materials Engineering IIT Kharagpur West Bengal 721302 India

This article introduced the work of ethylcellulose based polymeric microsphere loaded with nifedipine for reduction in frequency of administration with low solubility in aqueous medium and high rate of absorption in the stomach. The non-aqueous polymeric suspension was put dropwise into an aqueous medium containing polyvinyl alcohol as a surfactant for the synthesis of microsphere by solvent evaporation. The microspheres were characterized by different techniques, namely, XRD, SEM, and NMR. The formation of microspheres was confirmed by SEM. XRD analysis revealed the semi-crystallinity nature of microspheres. The NMR study indicated the presence of hetero-aromatic nucleus in the microsphere.

关键词： Nifedipine Microsphere Solvent evaporation Sustained release

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Ulipristal Acetate (UPA): An Alternative Option to Surgery for Uterine Fibroids in Reproductive Age: A Review

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Yangtze Medicine 2022年第1期6卷 1-11页

作者： subash chandra Sharma Cunjian Yi Department of Gynecology and Obstetrics The First Affiliated Hospital of Yangtze University Jinzhou China

Uterine fibroids are common in females of reproductive age and substantially affecting fertility and quality of life. Current management strategies mainly involve surgical interventions. For treatment, options available are surgical and non-surgical, but the mode of management leans on several factors, such as severity of symptoms, patient’s age, myoma characteristics, desire to preserve uterus and fertility. Alternative approach to surgery for the treatment of symptomatic females with uterine myomas has been recognized. Ulipristal acetate (UPA) has been the first selective progesterone-receptor modulator (SPRM) approved for the pre-operative and long-term management of uterine fibroids. There are evidences promoting an important role for progesterone pathways in the pathophysiology of uterine fibroids which supports the use of ulipristal acetate. The availability of alternative choices to surgical intervention is very necessary especially for those willing to preserve uterus and fertility. One of the alternatives is with ulipristal acetate, which has been proven to treat fibroid symptoms effectively.

关键词： Myoma Females Uterine Fibroids Selective Progesterone Receptor Modulator (SPRM) Ulipristal Acetate (UPA)

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Graphene-induced Pd nanodendrites： A high performance hybrid nanoelectrocatalyst

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Nano Research 2013年第9期6卷 635-643页

作者： subash chandra Sahu Aneeya K. Samantarat Ajit Dash R. R. Juluri Ranjan K. Sahu B. K. Mishra Bikash Kumar Jena (1~3) Colloids & Materials Chemistry CSIR-Institute of Minerals and Materials Technology Bhubaneswar-7S I013 India Institute of Physics Bhubaneswar-751005 India Materials Science and Technology Division National Metallurgical Laboratory Jamshedpur-831007 India

A facile and green approach has been developed for the in situ synthesis of hybrid nanomaterials based on dendrite-shaped Pd nanostructures supported on graphene （RG）. The as-synthesized hybrid nanomaterials （RG-PdnDs） have been thoroughly characterized by high resolution transmission electron microscopy, X-ray photoelectron spectroscop）~ atomic force microscop）~ Raman spectroscopy and electrochemical techniques. The mechanism of formation of such dendrite- shaped Pd nanostructures on the graphene support has been elucidated using transmission electron microscopy （TEM） measurements. The RG induces the formation of, and plays a decisive role in shaping, the dendrite morphology of Pd nanostructures on its surface. Cyclic voltammetry and chronoamperometry techniques have been employed to evaluate the electrochemical performance of RG-PdnDs towards oxidation of methanol. The electrochemical （EC） activities of RG-PdnDs are compared with graphene-supported spherical-shaped Pd nanostructures, Pd nanodendrites alone and a commercial available Pd/C counterpart. The combined effect of the graphene support and the dendrite morphology of RG-PdnDs triggers the high electrocatalytic activity and results in robust tolerance to CO poisoning.

关键词： nanodendrites reduced graphene methanol oxidation surface poisoning

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Sliding Wear Performance Evaluation of Red Mud (RM), RM + Fly Ash (FA) and RM + FA + Al Coatings on Mild Steel

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Materials Sciences and Applications 2016年第3期7卷 171-179页

作者： Harekrushna Sutar Debashis Roy subash chandra Mishra Rabi Ranjan Murmu Chemical Engineering Department Indira Gandhi Institute of Technology Sarang India Chemical Engineering Department Jadavpur University Kolkata India Metallurgical and Materials Engineering Department National Institute of Technology Rourkela India

The research paper focuses on evaluating the dry sliding wear behaviour of plasma sprayed coatings like red mud (RM), RM + 5% Fly Ash (FA) and RM + 5% FA + 5% Al on mild steel cylindrical shape substrate. Spraying was done at 10 kW operating power level. A conventional pin on disc wear tester is adopted for wear analysis. The wear test was performed at track diameter of 50 mm and sliding speed of 60 rpm (0.157 m/s) with normal load of 10 N. The duration of sliding varies from 54 minutes for pure red mud coating to a maximum value of 102 minutes for RM + 5% FA + 5% Al composite coating. A significant decrease in wear rate (in terms of mass loss) is observed by reinforcement of fly ash and aluminium to red mud, which might be due to improved interfacial properties.

关键词： Red Mud Fly Ash Aluminium Plasma Coating Sliding Wear Frictional Force

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Comparative evaluation of effect of injectable platelet-rich fibrin with collagen membrane compared with collagen membrane alone for gingival recession coverage

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World Journal of Experimental Medicine 2022年第4期12卷 68-91页

作者： Laxmikanta Patra subash chandra Raj Neelima Katti Devapratim Mohanty Shib Shankar Pradhan Shaheda Tabassum Asit Kumar Mishra Kaushik Patnaik Annuroopa Mahapatra Department of Periodontics SCB Dental College and HospitalOdisha 753007India

BACKGROUND Collagen membrane and platelet-rich fibrin(PRF)have emerged as vital biomaterials in the field of periodontal *** invasive techniques are being preferred by most periodontists,as it is patient compliant with fewer post-surgical complications as compared to conventional surgical ***,in this study we have evaluated the effect of injectable PRF(i-PRF)with collagen membrane compared with collagen membrane alone using vestibular incision subperiosteal tunnel access(VISTA)technique for gingival recession *** To compare the efficacy of VISTA using collagen membrane with collagen membrane soaked in injectable PRF for gingival recession *** A split mouth randomized controlled clinical trial was designed;13 subjects having at least 2 teeth indicated for recession coverage were enrolled in this *** sites were randomly assigned to control group(VISTA using collagen membrane alone)and the test group(VISTA using collagen membrane with i-PRF).The clinical parameters assessed were pocket depth,recession depth(RD),recession width(RW),relative attachment level,keratinised tissue width(KTW),keratinised tissue thickness(KTT),and percentage root *** RD showed a statistically significant difference between the test group at 3 mo(0.5±0.513)and 6 mo(0.9±0.641)and the control group at 3 mo(0.95±0.51)and 6 mo(1.5±0.571),with P values of 0.008 and 0.04,*** also showed a statistically significant difference between the test group at 3 mo(1±1.026)and 6 mo(1.65±1.04)and the control group at 3 mo(1.85±0.875)and 6 mo(2.25±0.759),with P values of 0.008 and 0.001,*** for KTW showed statistically significant results between the test group at 1 mo(2.85±0.489),3 mo(3.5±0.513),and 6 mo(3.4±0.598)and the control group at 1 mo(2.45±0.605),3 mo(2.9±0.447),and 6 mo(2.75±0.444),with P values of 0.04,0.004,and 0.003,*** for KTT also showed statistically significant results between t

关键词： Vestibular incision subperiosteal tunnel access Injectable platelet-rich fibrin Collagen membrane Gingival recessions Treatment

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Effect of Red Mud (RM) Reinforcement on Physio-Chemical Characteristics of Ordinary Portland Slag Cement (OPSC) Mortar

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Advances in Materials Physics and Chemistry 2016年第8期6卷 231-238页

作者： Harekrushna Sutar Rabiranjan Murmu Debashis Roy subash chandra Mishra Asmita Mishra Chemical Engineering Department Indira Gandhi Institute of Technology Sarang India Chemical Engineering Department Jadavpur University Kolkata India Metallurgical and Materials Engineering Department National Institute of Technology Rourkela India

The investigation focuses on evaluating the effect of varying % of Red Mud (RM) reinforcement with Ordinary Portland Slag Cement (OPSC). Characterisation is done by adding 10%, 20%, 30%, 40% and 50% of RM by weight to OPSC. RM + OPSC composite mortars are made in an 8.5 × 5 × 4 cm3 cast iron mould with external vibration keeping water-binder ratio 0.4 by weight. The mortars are cured in water for 28 days and their physio-chemical characteristics are investigated. Mortar performances like compressive strength, hardness, XRD, FTIR, SEM are diagnosed. The composite mortars cementing properties are compared with original OPSC. The result reveals the augmentation of RM with OPSC increases the hydration capacity of OPSC with improved compressive strength. The experimental optimization shows a maximum value up to 10% - 20% OPSC can be replaced by RM as filling material.

关键词： Red Mud Cement Compressive Strength XRD FTIR SEM

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Wettability, Thermal and Sliding Behavior of Thermally Sprayed Fly Ash Premixed Red Mud Coatings on Mild Steel

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Materials Sciences and Applications 2020年第1期11卷 12-26页

作者： Harekrushna Sutar Birupakshya Mishra Rabiranjan Murmu Sangram Patra Sarat chandra Patra subash chandra Mishra Debashis Roy Chemical Engineering Department Jadavpur University Kolkata India Chemical Engineering Department Indira Gandhi Institute of Technology Sarang India Metallurgical and Materials Engineering Department National Institute of Technology Rourkela India

The present experimental work reveals the surface characteristics like wettability, thermal and sliding wear behaviour of plasma-sprayed red mud (RM) coatings premixed with fly ash (FA). Varying weight % of FA (10, 20, 30 and 40)—RM composite powder is used as precursor for coating. Atmospheric plasma-sprayed coatings are developed at different operating power like 5 kW, 10 kW, 15 kW and 20 kW separately on mild steel substrate. Tribological behaviour viz. sliding wear properties are studied at distinct operating load (10N, 15N, 20N, 25N), speed (40 rpm, 50 rpm, 60 rpm, 70 rpm) and track diameter of 100 mm using a pin on disc tribometer for duration of 30 minutes with 3 minute gap period for each experiment. The DSC and TGA experiments of the coatings are performed to understand the high temperature application areas. The contact angle result signifies the wettability of the prepared coatings is principally a function of composition. The reaction of surface roughness and spraying power is in-significant on water contact angle (WCA). In conclusion, the sliding wear experiments are optimized by Taguchi method to ascertain the influencing parameter on wear.

关键词： Red Mud Fly Ash Contact Angle DSC TGA Sliding Wear

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