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Hunting of hunted:an ensemble modeling approach to evaluate suitable habitats for caracals in India

Ecological Processes 2022年第1期11卷 744-757页

作者： Ashish kumar Jangid Chandra Prakash Singh Jai Singh Parihar Jasbir Singh Chauhan Rajnish kumar Singh Prakash kumar verma Amritanshu Singh Shantanu Sharma Shekhar Kolipaka Wildlife Institute of India DehradunUttarakhand 248001India Space Applications Centre Indian Space Research OrganisationAhmedabadGujarat 380015India Madhya Pradesh State Forest Department Madhya Pradesh Tiger Foundation SocietyKuno National ParkBhopalMadhya Pradesh 462001India Leo Foundation WageningenThe Netherlands

Background:Large-scale hunting and various anthropogenic pressures in the recent past have pushed the Asiatic caracal(Caracal caracal schmitzi),an elusive medium-sized and locally threatened felid species towards local extinction in *** widely distributed historically,it has been sparsely reported from several regions of central and northern states in India till twentieth ***,the species distribution became confined only to the states of Rajasthan,Gujarat and Madhya Pradesh,which have had reported sightings in the twenty-first *** order to highlight the potentially suitable habitats for Asiatic caracals in India,we targeted forth-filtering of the spatial model ensemble by creating and utilizing the validated and spatially thinned species presence information(n=69)and related ecological variables(aridity,NDVI,precipitation seasonality,temperature seasonality,terrain ruggedness),filtered with anthropological variable(nightlight).Results:Out of eight spatial prediction models,the two most parsimonious models,Random Forest(AUC 0.91)and MaxEnt(AUC 0.89)were weighted and *** ensemble model indicated several clustered habitats,covering 1207.83 km^(2)areas in Kachchh(Gujarat),Aravalli mountains(Rajasthan),Malwa plateau(Rajasthan and Madhya Pradesh),and Bundelkhand region(Madhya Pradesh)as potentially suitable habitats for *** probabilities of pixels were further regressed with converted vegetation height data within selected highly potential habitats,i.e.,Ranthambore Kuno Landscape(RKL)(suitability~0.44+0.03(vegetation height)^(**),R^(2)=0.27).The regression model inferred a significant positive relation between vegetation height and habitat suitability,hence the lowest ordinal class out of three classes of converted vegetation height was masked out from the RKL,which yielded in an area of 567 km^(2) as potentially highly suitable habitats for caracals,which can be further proposed as survey areas and conservation priority are

关键词： Medium-sized cat Caracal caracal schmitzi Potentially suitable habitat Drylands Potential survey area

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Current understanding of the impact of COVID-19 on gastrointestinal disease:Challenges and openings

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World Journal of Gastroenterology 2021年第6期27卷 449-469页

作者： Tarun Sahu Arundhati Mehta Yashwant kumar Ratre Akriti Jaiswal Naveen kumar Vishvakarma Lakkakula Venkata Kameswara Subrahmanya Bhaskar Henu kumar verma Department of Physiology All India Institute of Medical ScienceRaipur 492001ChhattisgarhIndia Department of Biotechnology Guru Ghasidas VishwavidyalayaBilaspur 495001ChhattisgarhIndia Department of Zoology Guru Ghasidas VishwavidyalayaBilaspur 495001ChhattisgarhIndia Developmental and Stem Cell Biology Lab Institute of Experimental Endocrinology and Oncology CNRNaplesCampania 80131Italy

The novel coronavirus disease-2019(COVID-19)is caused by a positive-sense single-stranded RNA virus which belongs to the Coronaviridae *** March 2019 the World Health Organization declared that COVID-19 was a ***-19 patients typically have a fever,dry cough,dyspnea,fatigue,and *** patients also report gastrointestinal(GI)symptoms,including diarrhea,nausea,vomiting,and abdominal pain,as well as liver enzyme ***,many studies have found severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)viral RNA in rectal swabs and stool specimens of asymptomatic COVID-19 *** addition,viral receptor angiotensin-converting enzyme 2 and transmembrane protease serine-type 2,were also found to be highly expressed in gastrointestinal epithelial cells of the intestinal ***,SARS-CoV-2 can dynamically infect and replicate in both GI and liver *** together these results indicate that the GI tract is a potential target of ***,the present review summarizes the vital information available to date on COVID-19 and its impact on GI aspects.

关键词： SARS-CoV-2 COVID-19 Gastrointestinal symptoms Recommendation Diagnosis Therapeutics

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Optics-based metaheuristic approach to assess critical failure surfaces in both circular and non-circular failure modes for slope stability analysis

Rock Mechanics Bulletin

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Rock Mechanics Bulletin 2024年第1期3卷 37-54页

作者： Jayraj Singh Amit kumar verma Haider Banka Ravishankar kumar Amit Jaiswal Department of Computer Science&Engineering NIIT UniversityRajasthanIndia Department of Civil&Environment Engineering Indian Institute of TechnologyPatnaBihar801106India Department of Computer Science&Engineering Indian Institute of Technology(ISM)DhanbadJharkhand826004India Department of Mining Bharat Coking Coal LimitedDhanbadJharkhand826005India

In many construction projects,a proactive slope stability evaluation is a *** many deterministic or non-deterministic approaches have been commonly used,metaheuristic approaches have resulted in high precision and significant outcomes for slope stability analysis *** current work focuses on the reliable assessment of critical failure surfaces associated with the least factor of safety value in both homogeneous and non-homogeneous slopes using a new simplified meta-heuristic approach called optics-inspired optimization(OIO).The algorithm utilizes six different LEM methods as a fitness function for deriving the factor of *** analysis over three benchmark studies has been performed to demonstrate the algorithm's robustness and *** implementation found more robust results as compared to previous ***,the algorithm's statistical implication is conducted using the ANOVA test,which inferred better *** this interpretation,the approach claims to be suitable and efficient for slope stability analysis.

关键词： OIO-Algorithm Metaheuristic algorithms Slope stability analysis Critical failure surface LEM'S procedure

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Novel targeting approaches and signaling pathways of colorectal cancer: An insight

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World Journal of Gastroenterology 2018年第39期24卷 4428-4435页

作者： Ankita Tiwari Shivani Saraf Amit verma Pritish kumar Panda Sanjay K Jain Pharmaceutics Research Projects Laboratory Department of Pharmaceutical SciencesDr. Hari Singh Gour Central University

Colorectal cancer(CRC) is the third most common cancer of mortality in the world. Chemotherapy based treatment leads to innumerable side effects as it delivers the anticancer drug to both normal cells besides cancer cells. Sonic Hedgehog(SHH), Wnt wingless-type mouse mammary tumor virus/β-catenin, transforming growth factor-β/SMAD, epidermal growth factor receptor and Notch are the main signaling pathways involved in the progression of CRC. Targeted therapies necessitate information regarding the particular aberrant pathways. Advancements in gene therapies have resulted in the recognition of novel therapeutic targets related with these signal-transduction cascades. CRC is a stepwise process where mutations occur over the time and activation of oncogenes and deactivation of tissue suppressor genes takes place. Genetic changes which are responsible for the induction of carcinogenesis include loss of heterozygosity in tumor suppressor genes such as adenomatous polyposis coli, mutation or deletion of genes like p53 and K-ras. Therefore, many gene-therapy approaches like gene correction, virusdirected enzyme-prodrug therapy, immunogenetic manipulation and virotherapy are currently being explored. Development of novel strategies for the safe and effective delivery of drugs to the cancerous site is the need of the hour. This editorial accentuates different novel strategies with emphasis on gene therapy and immunotherapy for the management of CRC.

关键词： Colorectal cancer Immunotherapy Gene therapy Signaling Targeted therapy

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Helicobacter pylori isolated from gastric juice have higher pathogenic potential than biopsy isolates

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Genes & Diseases 2024年第1期11卷 34-37页

作者： Budhadev Baral Dharmendra Kashyap Nidhi Varshney Tarun Prakash verma Ajay kumar Jain Debi Chatterji Vinod kumar Amit Mishra Awanish kumar Hem Chandra Jha Infection Bioengineering Group Department of Biosciences and Biomedical EngineeringIndian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Choithram Hospital and Research Center IndoreMadhya Pradesh452014India Department of Metallurgy Engineering and Materials Science Indian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Department of Bioscience&Bioengineering Indian Institute of Technology JodhpurNH 65 Nagaur RoadJodhpur DistrictKarwarRajasthan 342037India Department of Biotechnology National Institute of Technology RaipurGE RoadRaipurChhattisgarh 492010India

Persistent gastritis induced by Helicobacter pylori(***)is the strongest known risk factor for gastric cancer(GC).*** is prevalent in about 50%world's population,while it causes cancer in less than 2%of exposed individuals.1 Our studies found that *** infection can induce oncogenic properties in AGS cells by deregulating multiple factors associated with the cell cycle,apoptosis,and other important events associated with cancer progression.

关键词： H.pylori pylori Helicobacter

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A review on valorization of different byproducts of mango(Mangifera indica L.)for functional food and human health

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Food Bioscience 2022年第4期48卷 665-692页

作者： Alok kumar Gupta Pawan Singh Gurjar Karma Beer Alemwati Pongener S.C.Ravi Smita Singh Anil verma Abha Singh Mamta Thakur Soubhagya Tripathy Deepak kumar verma Division of Post-harvest Management ICAR-Central Institute for Subtropical Horticulture(Ministry of Agriculture and Farmers WelfareGovernment.of India)LucknowUP226101India ICAR-Central Institute for Arid Horticulture BikanerRajasthanIndia ICAR-Indian Agricultural Research Institute AssamIndia Department of Nutrition and Dietetics University Institute of Applied Health SciencesChandigarh UniversityChandigarh140413PunjabIndia Department of Food Technology School of SciencesITM UniversityGwalior474001Madhya PradeshIndia Agricultural and Food Engineering Department Indian Institute of Technology KharagpurKharagpur721302West BengalIndia

Mango(Mangifera indica)is one of the most popular fruits in the *** processing,the byproducts such as peel,seed and kernel are produced,which are high in bioactive *** is a need to utilize them to formulate food products or extract the functional *** paper provides an overview about the nutritional composition of mango byproducts besides discussing the bioactive compounds(BACs).The manuscript also explores the existing evidences on the biological activity of BACs and the potential of mango peel and seed kernel to develop value-added foods and *** kernel is a great source of macronutrients and micronutrients with a relatively high antioxidant and polyphenolic content,whereas mango peels are rich in protocatechuic acids,mangiferin andβ-*** BACs demonstrate numerous biological activities including anti-oxidant antimicrobial,anti-diabetic,anti-cancer and anti-inflammatory *** of the promising strategies to utilize these byproducts is the development of different value-added food products such as bakery products,meat products,and dairy-based products for improving their phenolic compounds,fiber content,carotenoids,and antioxidant *** review thus illustrates the nutraceutical and pharmacological properties of mango byproducts and their appropriate use to enhance nutrition and health.

关键词： Mango peel and kernel Nutritional composition Bioactive compounds Flavonoids Mangiferin Carotenoids Food utilization Biological properties

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Study of morphologic variability of incudostapedial angle and its relation with temporal bone pneumatization

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Journal of Otology 2020年第2期15卷 50-53页

作者： Anup Singh David Victor kumar Irugu Rajeev kumar Hitesh verma Anandita Gupta Abha kumari Department of Otorhinolaryngology and Head and Neck Surgery All India Institute of Medical SciencesNew Delhi110029India Department of Otorhinolaryngology and Head and Neck Surgery Army College of Medical SciencesBase Hospital Delhi CantonmentKotwali RoadNew Delhi110010India Department of Otorhinolaryngology Command HospitalKolkata700027India

Introduction:Optimal sound transmission across the ossicular chain is dependent on the appropriate alignment of the middle ear *** joint(ISJ)is conventionally considered to be at right ***:We intended to study the ISJ anatomy and the impact of temporal bone pneumatization on the ***:In a cadaveric study comprising of 47 human temporal bones,canal wall down mastoidectomy was carried out under microscopic guidance keeping the ossicular chain *** morphology of ISJ was recorded and analysed with respect to the pneumatization status of the temporal *** data analysis was performed using statistical software Stata version ***:The mean ISJ angle for the 47 bones was 90.5^0(SD-15^0;range:54^0-122^0).The mean angle in well pneumatized bones was 93.7^0(SD-16.5;Range:54°-122^0)and in sclerotic mastoids was 88.7^0(SD-14;Range:68°-118^0).The difference in the ISJ angle in these two conditions was not statistically significant(p=0.27).The mean angle was found to be significantly more obtuse in the cases with partially eroded ISJ(111.4^0{SD-8.8;range:100.3^0-221.9^0};p=0.0001)and in the cases with an‘adherent/tilted morphology’of the stapes suprastructure with the promontory(mean-95.8^0(SD-13.8;range:70.7^0-120.4^0);p-<0.00001).Conclusion:The ISJ angle shows considerable *** variability needs to be taken into account when undertaking middle ear reconstructive procedures,specifically the ones involving the stapes *** mastoid pneumatization does not appear to have an impact on the ISJ angle.

关键词： Human Ear ossicles Anatomic variation Stapes surgery

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Secure Rotation Invariant Face Detection System for Authentication

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Computers, Materials & Continua 2022年第1期70卷 1955-1974页

作者： Amit verma Mohammed Baljon Shailendra Mishra Iqbaldeep Kaur Ritika Saini Sharad Saxena Sanjay kumar Sharma Department of Computer Science&Engineering Chandigarh Group of CollegesMohali140317India Department of Computer Engineering College of Computer&Information ScienceMajmaah University11952Saudi Arabia Department of Computer Science and Engineering Thapar Institute of Engineering&TechnologyPatiala147004India Department of Computer Centre&Campus Network Facility Science Complex PO Central UniversityGachibowliHyderabad500046TelanganaIndia

Biometric applications widely use the face as a component for recognition and automatic *** rotation is a variable component and makes face detection a complex and challenging task with varied angles and *** problem has been investigated,and a novice algorithm,namely RIFDS(Rotation Invariant Face Detection System),has been *** objective of the paper is to implement a robust method for face detection taken at various *** to achieve better results than known algorithms for face *** RIFDS Polar Harmonic Transforms(PHT)technique is combined with Multi-Block Local Binary Pattern(MBLBP)in a hybrid *** MBLBP is used to extract texture patterns from the digital image,and the PHT is used to manage invariant rotation *** this manner,RIFDS can detect human faces at different rotations and with different facial *** RIFDS performance is validated on different face databases like LFW,ORL,CMU,MIT-CBCL,JAFFF Face Databases,and Lena *** results show that the RIFDS algorithm can detect faces at varying angles and at different image resolutions and with an accuracy of 99.9%.The RIFDS algorithm outperforms previous methods like Viola-Jones,Multi-blockLocal Binary Pattern(MBLBP),and Polar HarmonicTransforms(PHTs).The RIFDS approach has a further scope with a genetic algorithm to detect faces(approximation)even from shadows.

关键词： Pose variations face detection frontal faces facial expressions emotions

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Targeting biosignatures of hyperglycemia and oxidative stress in diabetes comorbid depressive rats: effectiveness of hydroethanolic extract of the whole plant of Ludwigia octovalvis

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Traditional Medicine Research 2023年第2期8卷 13-20页

作者： Stuti Pandey Pawan kumar Pandey Alakh Niranjan Sahu Himanshu verma Manmath kumar Nandi Department of Medicinal Chemistry Faculty of AyurvedaInstitute of Medical SciencesBanaras Hindu UniversityVaranasi 221005Uttar PradeshIndia Department of Pharmaceutical Engineering&Technology Indian Institute of Technology Banaras Hindu UniversityVaranasi 221005Uttar PradeshIndia

Background:The prime objective of the current research was to evaluate the whole plant hydroalcoholic extract of Ludwigia octovalvis(HLO)against hyperglycemia,and oxidative stress biomarkers in rats induced with diabetes comorbid depression,diabetes comorbid depression(streptozotocin-nicotinamide+electric footshocks).Methods:2,2-Diphenyl-1-picrylhydrazyl assay of HLO versus ascorbic acid was *** of 200 and 400 mg/kg body weight/day HLO doses versus 25 mg/kg body weight/day metformin was studied through insulin,glucose,superoxide dismutase,lipid peroxidation,catalase,and behavioral assessment(forced swim and open field tests).Results:IC50 values of HLO and ascorbic acid were 33.52 and 27.86μg/mL *** the HLO doses showed intended results with respect to oxidative stress biomarkers in diabetes comorbid depression rats in comparison to *** field test showed better results for HLO in diabetes comorbid depression ***,hypoglycemic effects,and forced swim test performance of metformin was slightly higher than the 400 mg dose,followed by the 200 mg dose of *** gallate,gallic acid,β-sitosterol,and quercetin in HLO might resulted in attenuating diabetic as well as depression ***:Inhibition of glucosidase and lipase activity,and AMP-activated protein kinase phosphorylation might be the possible biochemical changes occurred in HLO treated rats.

关键词： 2,2-diphenyl-1-picrylhydrazyl assay brain homogenate insulin superoxide dismutase content catalase activity lipid peroxidation

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Use of hydroxychloroquine and azithromycin combination to treat the COVID-19 infection

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World Journal of Experimental Medicine 2022年第3期12卷 44-52页

作者： Jyoti Bajpai Akshyaya Pradhan Ajay kumar verma Surya Kant Department of Respiratory Medicine King George's Medical UniversityLukcnowLucknow 226003Uttar PradeshIndia Department of Cardiology King George's Medical UniversityLukcnowLucknow 226003Uttar PradeshIndia Department of Respiratory Medicine King George Medical UniversityLucknow 226003Uttar PradeshIndia

Coronavirus disease 2019(COVID-19)infection is unequivocally the worst crisis in recent decades,which is caused by a severe acute respiratory virus ***,there is no effective therapy for the COVID-19 *** countries have different guidelines for treating COVID-19 in the absence of an approved therapy for ***,there is an imminent need to identify effective treatments,and several clinical trials have been conducted *** hydroxychloroquine[HCQS],chloroquine,and azithromycin(AZ)have been widely used for management based on in vitro studies favoring antiviral effects against the COVID-19 ***,there is evidence both in favor and against the use of hydroxychloroquine and azithromycin(HCQS+AZ)combination therapy to manage the COVID-19 *** combination of hydroxychloroquine and azithromycin was significantly associated with increased adverse ***,the inference of these findings was from observational ***,large randomized trials are imperative to show the future path for the use of HCQS+AZ combination ***,owing to the ban on HCQS use in COVID-19,this may no longer be *** review is on the pharmacology,trials,regimens,and side effects of hydroxychloroquine and azithromycin combination therapy.

关键词： Hydroxychloroquine Azithromycin Antiviral effects QT interval Randomized controlled trial

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