Use of hydroxychloroquine and azithromycin combination to treat the COVID-19 infection

作     者：Jyoti Bajpai Akshyaya Pradhan Ajay Kumar Verma Surya Kant 

作者机构：Department of Respiratory MedicineKing George's Medical UniversityLukcnowLucknow 226003Uttar PradeshIndia Department of CardiologyKing George's Medical UniversityLukcnowLucknow 226003Uttar PradeshIndia Department of Respiratory MedicineKing George Medical UniversityLucknow 226003Uttar PradeshIndia 

出 版 物：《World Journal of Experimental Medicine》 (世界实验医学杂志)

年 卷 期：2022年第12卷第3期

页      面：44-52页

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

主　　题：Hydroxychloroquine Azithromycin Antiviral effects QT interval Randomized controlled trial 

摘      要：Coronavirus disease 2019(COVID-19)infection is unequivocally the worst crisis in recent decades,which is caused by a severe acute respiratory virus 2.Currently,there is no effective therapy for the COVID-19 infection.Different countries have different guidelines for treating COVID-19 in the absence of an approved therapy for COVID-19.Therefore,there is an imminent need to identify effective treatments,and several clinical trials have been conducted worldwide.Both hydroxychloroquine[HCQS],chloroquine,and azithromycin(AZ)have been widely used for management based on in vitro studies favoring antiviral effects against the COVID-19 virus.However,there is evidence both in favor and against the use of hydroxychloroquine and azithromycin(HCQS+AZ)combination therapy to manage the COVID-19 infection.The combination of hydroxychloroquine and azithromycin was significantly associated with increased adverse events.However,the inference of these findings was from observational studies.Therefore,large randomized trials are imperative to show the future path for the use of HCQS+AZ combination therapy.However,owing to the ban on HCQS use in COVID-19,this may no longer be essential.This review is on the pharmacology,trials,regimens,and side effects of hydroxychloroquine and azithromycin combination therapy.