Current understanding of the impact of COVID-19 on gastrointestinal disease:Challenges and openings

作     者：Tarun Sahu Arundhati Mehta Yashwant Kumar Ratre Akriti Jaiswal Naveen Kumar Vishvakarma Lakkakula Venkata Kameswara Subrahmanya Bhaskar Henu Kumar Verma 

作者机构：Department of PhysiologyAll India Institute of Medical ScienceRaipur 492001ChhattisgarhIndia Department of BiotechnologyGuru Ghasidas VishwavidyalayaBilaspur 495001ChhattisgarhIndia Department of ZoologyGuru Ghasidas VishwavidyalayaBilaspur 495001ChhattisgarhIndia Developmental and Stem Cell Biology LabInstitute of Experimental Endocrinology and Oncology CNRNaplesCampania 80131Italy 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2021年第27卷第6期

页      面：449-469页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：SARS-CoV-2 COVID-19 Gastrointestinal symptoms Recommendation Diagnosis Therapeutics 

摘      要：The novel coronavirus disease-2019(COVID-19)is caused by a positive-sense single-stranded RNA virus which belongs to the Coronaviridae *** March 2019 the World Health Organization declared that COVID-19 was a ***-19 patients typically have a fever,dry cough,dyspnea,fatigue,and *** patients also report gastrointestinal(GI)symptoms,including diarrhea,nausea,vomiting,and abdominal pain,as well as liver enzyme ***,many studies have found severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)viral RNA in rectal swabs and stool specimens of asymptomatic COVID-19 *** addition,viral receptor angiotensin-converting enzyme 2 and transmembrane protease serine-type 2,were also found to be highly expressed in gastrointestinal epithelial cells of the intestinal ***,SARS-CoV-2 can dynamically infect and replicate in both GI and liver *** together these results indicate that the GI tract is a potential target of ***,the present review summarizes the vital information available to date on COVID-19 and its impact on GI aspects.