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Insights into the role of major bioactive dietary nutrients in lamb meat quality:a review

Journal of Animal Science and Biotechnology 2022年第4期13卷 951-966页

作者： JavierÁlvarez-Rodríguez Olaia Urrutia sandra lobón Guillermo Ripoll Juan Ramón Bertolín Margalida Joy Departament de Ciència Animal Universitat de Lleida25198 LleidaSpain Departamento de Agronomía Biotecnología y AlimentaciónIS-FOOD InstituteEscuela Técnica Superior de Ingeniería Agronómica y BiocienciasUniversidad Pública de NavarraPamplonaSpain Centro de Investigación y Tecnología Agroalimentaria de Aragón(CITA) Avda.Montañana 93050059 ZaragozaSpain Instituto Agroalimentario de Aragón–IA2(CITA-Universidad de Zaragoza) Avda.Miguel Servet17750013 ZaragozaSpain.

Feed supplementation withα-linolenic acid(ALA)and linoleic acid(LA)increases their content in muscle,ALA increases n-3 polyunsaturated fatty acids and decrease n-6/n-3 ratio in muscle,and LA increases rumenic ***,high LA supplementation may have negative effects on lambs’lipid oxidative stability of *** the sources of ALA and LA are fed as fresh forage,the negative effects are counterbalanced by the presence of other bioactive compounds,as vitamin E(mainlyα-tocopherol)and polyphenols,which delay the lipid oxidation in *** is a wide consensus on the capability of vitamin E delaying lipid oxidation on lamb meat,and its feed content should be adjusted to the length of supplementation.A high dietary inclusion of proanthocyanidins,phenolic compounds and terpenes reduce the lipid oxidation in muscle and may improve the shelf life of meat,probably as a result of a combined effect with dietary vitamin ***,the recommended dietary inclusion levels depend on the polyphenol type and concentration and antioxidant capacity of the feedstuffs,which cannot be compared easily because no routine analytical grading methods are yet *** phenolic compounds content in dietary ingredients/supplements for lambs are reported,no specific association with animal physiology responses may be established.

关键词： Fatty acid Forage Oilseed Polyphenol Vitamin E

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Influence of parameters on the microstructure of a duplex stainless steel joint welded by a GMAW welding process

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Progress in natural Science:Materials International 2022年第4期32卷 415-423页

作者： sandra Chacón-Fernández Antonio Portolés García Gerardo Romaní Labanda Universidad Politécnica de Madrid Escuela Técnica Superior de Ingenieros Industriales UPM

Duplex stainless steels（DSSs） are widely used in industry for their desirable properties. Any fusion welding technique modifies the microstructure and, consequently, the properties of the material. This paper presents a parametric study of the variables that determine the energy contribution（current, voltage and welding speed） and the structural modifications produced during gas metal arc welding. The analysis comprises metallographic study,phase balance, dimensioning of the weld beads and tensile and hardness tests. The influence of the variables studied on the thermal cycles obtained（temperatures reached and cooling rate） was determined by using a finite element model. The results showed that, in addition to the indicated parameters, the parameter power transfer per volume（W/m3） and the geometry in the bead must be controlled due to their influence on the heat flow distribution and phase balance.

关键词： Welding Heat input GMAW Duplex stainless steels (DSS) Finite element model (FEM)

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An optimized high quality male DnA extraction from spermatophores in open thelycum shrimp species

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Integrative Zoology 2017年第5期12卷 421-427页

作者： Laia PLAnELLA sandra HERAS Manuel VERA José-Luis GARCÍA-MARÍn María Inés ROLDÁn Laboratory of Genetic Ichthyology University of GironaGironaSpain

The crucial step of most of the current genetic studies is the extraction of DnA of sufficient quantity and *** genomic DnA isolation methods have been described to successfully obtain male DnA from shrimp ***,all current protocols require invasive handling methods with males for DnA *** Aristeus antennatus as a model we tested a reliable non-invasive differential DnA extraction method to male DnA isolation from spermatophores attached to female *** present protocol provides high quality and quantity DnA for polymerase chain reaction amplification and male *** new approach could be useful to experimental shrimp culture to select sires with relevant genetic patterns for selective breeding *** importantly,it can be applied to identify the mating pairs and male structure in wild populations of species as ***,where males are often difficult to *** method could be also valuable for biological studies on other spermatophore-using species,such as myriapods,arachnids and insects.

关键词： differential spermatophore DnA extraction high quality DnA male genotyping non-invasive DnA extraction open thelycum shrimp

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Shaken not stirred: A molecular contribution to the systematics of genus Mugil (Teleostei, Mugilidae)

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Integrative Zoology 2016年第4期11卷 263-281页

作者： sandra HERAS Ferruccio MALTAGLIATI Maria Victoria FERnÁnDEZ María Inés ROLDÁn Laboratory of Genetic Ichthyology University of GironaGironaSpain Department of Biology University of PisaPisaItaly

With this work we addressed some molecular systematic issues within the Mugil cephalus species ***ticular attention was paid to the debated situations of:(i)Mugil liza,occurring in partial sympatry with Mugil cephalus in the northwestern Atlantic,and(ii)Mugil platanus,considered by some authors a synonymy of the former species and distributed in the southwestern *** sequenced 79 individuals of a 465-bp portion of the mitochondrial control region(CR)from 8 western Atlantic and 2 Mediterranean *** addition,all CR sequences available from GenBank for the studied taxa were added to our dataset,for a total of 323 indi***,229 haplotypes corresponding to 8 divergent monophyletic lineages were *** of phylogenetic analyses were consistent with the occurrence of past speciation events producing the observed lin*** these lineages,7 correspond to cryptic species and one is constituted by *** and *** a matter of fact,these 2 taxa constitute a single lineage within the *** species ***,individuals of ***/*** lineage analyzed by means of the 18 mitochondrial markers available in GenBank exhibited a degree of genetic diversity consistent with highly divergent *** the 8 lineages detected,the Mediterraean one(type locality)corresponds to ***;the lineage ***/*** should be named ***,under the priority principle,and the left 6 lineages need formal description.

关键词： cryptic species historical demography molecular phylogeny Mugil systematics

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Recent Advances in Single-Cell Metabolomics Based on Mass Spectrometry

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CCS Chemistry 2023年第2期5卷 310-324页

作者： Qinlei Liu sandra Martínez-Jarquín Renato Zenobi Department of Chemistry and Applied Biosciences ETH ZurichCH-8093 Zurich

Cellular heterogeneity is essential for the physiological functions of organisms,and precise interpretation of the relevant biological mechanisms involved requires accurate measurement of biomolecules,including DnA,RnA,proteins,and metabolites at the single-cell *** metabolites react most rapidly to environmental and biochemical changes such that their detection is a critical step in determining the physiological state of ***,their limited amounts,structural diversity,and significant content variation render single-cell metabolomics analysis technically *** spectrometry,with its high sensitivity,good selectivity,and wide dynamic range,has been widely used in the single-cell analysis in recent *** terms of ionization techniques,there are four main types of single-cell mass spectrometry methods:nano-electrospray ionization mass spectrometry,matrix-assisted laser desorption/ionization mass spectrometry,secondary ion mass spectrometry,and dielectric barrier discharge ionization mass *** this mini review,the progress of single-cellmass spectrometrymethodologies and data processing strategies are summarized,and the future trends in single-cell mass spectrometry are outlined.

关键词： single-cell analysis metabolomics mass spectrometry ionization techniques analytical methods

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MYC inhibitors in multiple myeloma

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Cancer Drug Resistance 2021年第4期4卷 842-865页

作者： sandra Martínez-Martín Laura Soucek Preclinical&Translational Research Program Vall d’Hebron Institute of Oncology(VHIO)Vall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Peptomyc S.L. Vall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Department of Biochemistry and Molecular Biology Universitat Autònoma de BarcelonaBellaterra 08193Spain InstitucióCatalana de Recerca i Estudis Avançats(ICREA) Barcelona 08010Spain

The importance of MYC function in cancer was discovered in the late 1970s when the sequence of the avian retrovirus that causes myelocytic leukemia was *** then,over 40 years of unceasing research have highlighted the significance of this protein in malignant transformation,especially in hematologic ***,some of the earliest connections among the higher expression of proto-oncogenes(such as MYC),genetic rearrangements and their relation to cancer development were made in Burkitt lymphoma,chronic myeloid leukemia and mouse *** myeloma(MM),in particular,is a plasma cell malignancy strictly associated with MYC deregulation,suggesting that therapeutic strategies against it would be beneficial in treating this ***,targeting MYC was-and,somehow,still is-challenging due to its unique properties:lack of defined three-dimensional structure,nuclear localization and absence of a targetable enzymatic *** these difficulties,however,many studies have shown the potential therapeutic impact of direct or indirect MYC *** molecules have been tested,in fact,in the context of *** this review,we summarize the current status of the different compounds,including the results of their clinical testing,and propose to continue with the efforts to identify,repurpose,redesign or improve drug candidates to combine them with standard of care therapies to overcome resistance and enable better management of myeloma treatment.

关键词： MYC inhibition multiple myeloma undruggable target targeted therapies transcription factor epigenetics MYC downregulation

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Assessment of food supplementation and surveillance as techniques to reduce damage caused by black capuchin monkeys Sapajus nigritus to forest plantations

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Current Zoology 2014年第5期60卷 581-590页

作者： sandra Bos MIKICH Laboratory of Ecology (Laborat6rio de Ecologia) Embrapa Florestas Caixa Postal 319 CEP 83411-000 Colombo PR Brazil Black Capuchin Monkey Program (Programa Macaco-prego) National Fund for the Control of Forest Pests (Fundo Nacional de Controle de Pragas Florestais) Dieter Liebsch Environmental Consulting (Dieter Liebsch Consultoria Ambiental) Curitiba PR Brazil dieterliebsch@yahoo.com.br

Black capuchin monkeys Sapajus nigritus are among several mammalian species that damage forest plantations, pri- marily plantations of pine trees （Pinus spp.） in South Brazil. Management practices to reduce these damages include supplemen- tary food offerings and plantation surveillance. To assess the efficiency of these techniques, four treatments were evaluated： feeding （F, with supplementary bananas and maize）, surveillance （S, in situ, wherein men patrolled the plantations, deterring the monkeys）, feeding ＋ surveillance （FS） and control （no procedures）（C）. The efficiency assessment of each treatment involved the number of recorded primate sightings in the treatments with the presence of guards （S and FS） and a damage inventory of the outskirts of the experimental points immediately before and after the experiment. These data were complemented by a simulta- neous study of the availability of fruit, the primary item in the diet of this primate species, in the remnant native forest in the study area. Most sightings of S. nigritus occurred early in the morning, and in general, sightings were inversely proportional to the availability of native fruits. This trend was most evident in treatment FS, most likely due to the presence of food. Treatments F and FS exhibited higher percentages of damage, indicating that these are inefficient management techniques. Treatment S exhi- bited the lowest damage rate, but at a high cost, making this technique difficult to apply over large expanses. The development of other management techniques, such as environmental enrichment and the use of deterrents, is recommended to minimize the damage caused by capuchins in forest plantations [Current Zoology 60 （5）： 581-590, 2014].

关键词： Cebus Damage control Wildlife management Pinus Food provisioning

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Antimicrobial properties of sea anemone Anthopleura nigrescens from Pacific coast of Costa Rica

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 418-421页

作者： Henry Borbn sandra Vldes Javier Alvarado-Mesn Roy Soto Ilena Vega Laboratory of Research and Development in Chemical Technology Department of ChemistryNational University Laboratory of Biochemistry and Biotechnology of Proteins Department of Biological ScienceNational University Laboratory of natural Products and Biological Essays Department of ChemistryNational University

Objective: To evaluate the antimicrobial and antifungal activities of the aqueous and partitioned extract of sea anemone Anthopleura nigrescens(A. nigrescens).Methods: The sea anemone A. nigrescens was collected, minced, homogenized,lyophilized and then further partitioned with diethyl ether, acetone, ethanol and *** fractions were evaluated for antimicrobial activity against bacterial and fungal ***: Acetone extract was found to produce a pronounced inhibition of 7.0 mm against Proteus vulgaris and diethyl ether extract inhibited Pseudomonas aeruginosa with an inhibition zone of 6.5 mm. In antifungal activity, ethanol extract showed good activity against Botrytis cinerea, Trichoderma harzianum and Rhizopus oryzae compared with other strains. Acetone and ethanol extract of A. nigrescens showed activity against all of pathogens tested. Slight activity was observed in the water extract with inhibition zone of 1.5 ***: The present study revealed that sea anemone A. nigrescens may also contain some biologically active agents which have potential activity against pathogenic microorganisms.

关键词： Biological activity Antibacterial Antifungal Bioactive Sea anemone

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Sarcoma stratification by combined pH2AX and MAP17(PDZK1IP1)levels for a better outcome on doxorubicin plus olaparib treatment

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Signal Transduction and Targeted Therapy 2020年第1期5卷 697-709页

作者： Marco Perez JoséManuel García-Heredia Blanca Felipe-Abrio sandra Muñoz-Galván Javier Martín-Broto Amancio Carnero Instituto de Biomedicina de Sevilla(IBIS) Hospital Universitario Virgen del RocíoUniversidad de SevillaConsejo Superior de Investigaciones CientíficasSevillaSpain Ciber de Cancer IS Carlos IIIMadridSpain Departamento de Bioquímica Vegetal y Biología Molecular Universidad de SevillaSevillaSpain Departamento de Anatomía Patológica Hospital Universitario Virgen del RocíoSevillaSpain

Sarcomas constitute a rare heterogeneous group of tumors,including a wide variety of histological *** advances in our understanding of the pathophysiology of the disease,first-line sarcoma treatment options are still limited and new treatment approaches are *** H2AX phosphorylation is a sensitive marker for double strand breaks and has recently emerged as biomarker of DnA damage for new drug *** this study,we explored the role of H2AX phosphorylation at Ser139 alone or in combination with MAP17 protein,an inducer of DnA damage through ROS increase,as prognostic biomarkers in sarcoma ***,we proposed doxorubicin and olaparib combination as potential therapeutic strategies against sarcomas displaying high level of both *** evaluate retrospectively the levels of pH2AX(Ser139)and MAP17 in a cohort of 69 patients with different sarcoma types and its relationship with clinical and pathological *** found that the levels of pH2AX and MAP17 were related to clinical features and poor ***,we pursued PARP1 inhibition with olaparib to potentiate the antitumor effect of DnA damaging effect of the DnA damaging agent doxorubicin to achieve an optimal synergy in *** demonstrated that the combination of olaparib and doxorubicin was synergistic in vitro,inhibiting cell proliferation and enhancing pH2AX intranuclear accumulation,as a result of DnA *** synergism was corroborated in patient-derived xenografts(PDX)where the combination was effective in tumors with high levels of pH2AX and MAP17,suggesting that both biomarkers might potentially identify patients who better benefit from this combined therapy.

关键词： H2AX doxorubicin treatment

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Pork Meat Quality of Preto Alentejano and Commercial Largewhite Landrace Cross

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Journal of Integrative Agriculture 2013年第11期12卷 1961-1971页

作者： Alfredo Teixeira sandra Rodrigues Veterinary and Animal Reserch Centre (CECAV) Agrarian School of Polytechnic Institute of BraganaCampus Sta Apolónia Apt.1172Bragan a 5301-855Portugal Mountain Research Centre(CIMO) Agrarian School of Polytechnic Institute of BraganaCampus Sta Apolónia Apt.1172Bragan a 5301-855Portugal

This work aimed to evaluate the physical-chemical characteristics of pork from a local breed （Portuguese black pork called Preto Alentejano） and a commercial breed. Sixteen animals were used, 4 females and 4 males from each breed. Animals had 80-100 kg of live weight. The longissimus muscle between the 5th thoracic vertebra and the 10th lumbar vertebra was used in the analysis. Samples were analysed for protein, fat, pigments, ashes, dry mater, water-holding capacity, and texture. Results of fat and pigments contents indicate signiifcant （P〈0.05 and P〈0.01） differences for all treatments. For protein, ashes, dry mater, water-holding capacity and texture, no signiifcant differences were found for sex. In the analysis of fatty acids composition, ten were detected, being the main ones C16：0, C18：0, C16：1, C18：1, C18：2. There was a predominance of monounsaturated fatty acids （MUFA）, followed by saturated （SFA） and polyunsaturated （PUFA）. Differences were signiifcant for sex （P〈0.01） and breed （P〈0.01）. Preto Alentejano breed and females presented the higher percentages of SFA （P〈0.01） and MUFA （P〈0.001） fatty acids. Differences between breeds might be due to breed production system and feed differences.

关键词： breed sex pork meat quality

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