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Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients

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Journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca Correa Lysleine Alves deus Dahan da Cunha Nascimento Nicholas Rolnick rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araujo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinesio Silva Neto Claudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-Silva Fernando Honorato Souza Vitoria Marra da Motta Vilalva Mestrinho Rafael Lavarini dos Santos Rosangela Vieira andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hemodialysis(HD) per se is a risk factor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training *** aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this ***:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of ded concentric and eccentric lifting phases(each lasting 2 s) and were supervised by a strength and conditioning ***:Several variables were associated with elevated levels of D-dimer,including higher blood glucose,citrate use,recent cardiovascular events,recent intercurrents,higher inflammatory status,catheter as vascular access,older patients(>70 years old),and HD ***,RE+BFR significantly increases D-dimer after 4 *** with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.

关键词： Blood-flow restriction Chronic kidney disease Coagulation Hemodialysis Vascular occlusion exercises

Response to Commentary by Dr. Matthew J. Clarkson on

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Journal of Sport and Health Science 2024年第5期13卷 670-671页

作者： Hugo de Luca Corrêa Lysleine Alves deus Dahan da Cunha Nascimento Nicholas Rolnick rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araújo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinésio Silva Neto Cláudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-Silva Fernando Honorato Souza Vitória Marra da Motta Vilalva Mestrinho Rafael Lavarini dos Santos Rosangela Vieira andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil g Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

dear editor:We sincerely thank Matthew *** for his insightful commentary1 on our recent publication in the Journal of Sport and Health Science.2 Clarkson's pioneering work in the development and application of blood flow restriction (BFR) exercise protocols has undeniably laid the groundwork for subsequent investigations in this field,including our own.(3-6)His commentary not only highlights the relevance and timeliness of our study but also offers valuable perspectives on refining safety considerations for intradialytic BFR exercise among hemodialysis patients.

关键词： patients application flow

Effects of Imazethapyr-Based Herbicide Formulation in the Zebrafish (Danio rerio) Hepatocyte Cell Line (ZF-L): Cytotoxicity and Oxidative Stress

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Journal of Environmental Protection 2024年第6期15卷 747-765页

作者： Edila Maria Kickhöfel Ferrer Milena Mattes Cerveira Pedro Henrique Flores Da Cruz Cleiton Jesus andrade Pereira Lucas Moraes Berneira Claudio Martin Pereira de Pereira Nathalia Stark Pedra Roselia Maria Spanevello Jean Carlos Bauer Vieira Clarissa Piccinin Frizzo Mateus Tavares Kütter Janice Luehring Giongo rodrigo de Almeida Vaucher Center of Chemical Pharmaceutical and Food Sciences Microorganism Biochemistry and Molecular Biology Research Laboratory (LAPEBBIOM) Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Laboratory for Lipidomic and Bio-Organic Research Bioforensic Research Group Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Neurochemistry Inflammation and Cancer Laboratory Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil department of Chemistry Heterocycle Chemistry Center (NUQUIMHE) Federal University of Santa Maria (UFSM) Santa Maria Rio Grande do Sul Brazil department of Microbiology and Parasitology Biology Institute Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil

Seizures of agrochemical formulations have increased in Brazil and Rio Grande do Sul is among the Brazilian states with the highest number of seizures of these products obtained illicitly. The use of illicit formulations can cause significant harm to agricultural production, the environment, and non-target species. This study evaluated the cytotoxicity and oxidative stress of a seized formulation containing the herbicide imazethapyr (IMZT). Characterization of the herbicide included gas chromatography-mass spectrometry (GC-MS) and thermal analyses (thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC)). Hemolytic and cytotoxicity assays in ZF-L hepatic cells showed IC50 values of 12.75 µg/mL, 3.01 µg/mL, 2.67 µg/mL, and 1.61 µg/mL for erythrocytes, [3(4,5-dimethyl)-2 bromide-5 diphenyl tetrazolium] (MTT), neutral red (NR), and lactate dehydrogenase (LDH) assays, respectively. The median IC50 of 2.84 µg/mL was used in oxidative stress assays, revealing increased reactive oxygen species (ROS) production, reduced total sulfhydryl content, and decreased superoxide dismutase (SOD) and catalase (CAT) activity. This study is the first to report in vitro oxidative stress induced by IMZT in the ZF-L cell line, emphasizing the importance of in vitro assays for assessing the toxic effects of seized agrochemicals on human health and the environment.

关键词： Agrochemical Imidazolinone Zebrafish Cell Viability Oxidative Damage

Hydrological variability and long-term floristic-structural modifications in different habitats of a tropical semi-deciduous forest

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Journal of Forestry Research 2022年第3期33卷 801-811页

作者： Alisson Borges Miranda Santos Vinicius andrade Maia Cléber rodrigo de Souza Natália de Aguiar-Campos Aurélio de Jesus Rodrigues Pais Wilder Bento da Silva Nathalle Cristine Alencar Fagundes Jean Daniel Morel Rubens Manoel dos Santos department of Forestry Sciences Federal University of LavrasCampus UniversitárioC.P.3037LavrasBrazil Faculty of Environmental Engineering and Natural Resources Zambeze UniversityChimoioC.P.2400Mozambique Biological Sciences Universidade do Estado de Minas GeraisUnidade ItuiutabaAv.Antônio Carlos 6627Ituiutaba31270-901Brazil department of Biology Federal University of LavrasUniversity campusC.P.3037Lavras37200-000Brazil

Shifts in hydrological regimes alter river flow rates and flood pulses, decrease environmental heterogeneity and the floristic-structural complexity of associated plant communities. We tested the hypothesis that drought events affect plant community composition and structure at a small-scale within a riparian fragment towards a reduction in floristic-structural complexity. The tree community was sampled in three habitats (wet, transitional and dry) and monitored in seven inventories carried out between 1991 and 2018. Hydrological variations were evaluated through annual rainfalls, river flow rates and water level data. The species richness and the detrended correspondence analysis axes were used to characterise the temporal modifications in floristic composition. Community structure was described in terms of biomass: accumulated, growth of survivors, mortality and recruitment. Generalised linear mixed models were fitted to evaluate the effects of time and environment in community. It was concluded that the climate has become drier in recent years due to declining precipitation that has affected flow rates and water levels. The floristic-structural complexity of the study fragment was maintained during the monitoring period. However, prolonged and extreme drought events displayed the potential to impact floristic-structural patterns.

关键词： Forest dynamics Climate changes Semi-deciduous seasonal forest Temporal change Functioning communities

The burden of prolonged sedentary behavior imposed by uberization

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Sports Medicine and Health Science 2023年第2期5卷 159-163页

作者： Thalles Guilarducci Costa Vinnycius Nunes de Oliveira Douglas Assis Teles Santos Ricardo Borges Viana Marilia Santos andrade rodrigo Luiz Vancini Katja Weiss Beat Knechtle Claudio Andre Barbosa de Lira Laboratório de Avaliação do Movimento Humano Faculdade de Educação Física e DançaUniversidade Federal de GoiásGoiâniaBrazil Colegiado de Educação Física Universidade do Estado da BahiaCampus XTeixeira de FreitasBahiaBrazil Instituto de Educação Física e Esportes Universidade Federal do CearáFortalezaBrazil departamento de Fisiologia Universidade Federal de São PauloSão PauloBrazil Centro de Educação Física e desportos Universidade Federal do Espírito SantoVitóriaBrazil Institute of Primary Care University of Zurich8006ZurichSwitzerland Medbase St.Gallen Am Vadianplatz 9000St.GallenSwitzerland

Mobility applications are rapidly growing in cities worldwide due to their convenience and low *** applications drivers experience vast flexibility in work hours,often work longer than in fixed-hours jobs,and can constantly transport passengers in their vehicles for up to 12 h;after this,they must go offline for eight consecutive hours before driving ***,drivers have found an easy way around this limitation by switching to other apps and continuing *** burden of prolonged work can increase sedentary behavior among mobility applications *** behavior is any waking activity in which the individual expends 1.5 metabolic equivalents(METs)or less while sitting or *** behavior can increase the risk of detrimental effects on *** this opinion article,we aim to discuss the possible effects of the burden of prolonged work on the sedentary behavior of mobility applications drivers and propose possible strategies to face this concerning situation.

关键词： Mobility application Drivers Health outcomes Sedentary lifestyle Quality of life

Fluid flow simulation of industrial fixed bed mixed-flow grain dryer using k-ω SST turbulence model

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International Journal of Agricultural and Biological Engineering 2021年第2期14卷 226-230页

作者： Anderson rodrigo Visconcini Cid Marcos Gonçalves andrade Alexandre Marconi de Souza Costa Post-graduation department of Mechanical Engineering University of MaringáAv.Colombo3790-Bloco 14-Sala 2487020-900Maringá-PRBrazil

The fluid dynamics analysis on industrial,mixed-flow grain dryers with fixed bed using computational techniques is necessary to assist the design of such equipment contributing to cost reduction in the dryer projects and agricultural drying operations that involve the production of grains in the *** study presents a Computational Fluid Dynamic(CFD)solution for air flow analysis in an industrial *** air flow at the inlet and outlet of the dryer was investigated using the k-ωSST turbulence *** dryer region with soybean was considered as a laminar porous medium flow in the permanent and isothermal regime,having for the model a simplified geometry with the tower considered as a porous medium and the air inlet and outlet as a turbulent fluid *** flow was treated with a permanent and isothermal *** flow and pressures were used according to design *** validate the k-ωSST turbulence model,the velocity profile at the dryer inlet was obtained experimentally,which presented results with good agreement between the numerical and the experimental *** model obtained satisfactory results of the computational validation of the air flow in the dryer with good convergence requiring a minimum of computational effort,being suitable for the simulation of industrial-scale dryers,as to its air flow through a tower,operating with fixed bed soybean in the steady and isothermal regime.

关键词： computational methods fixed bed porous medium soybean dryer turbulent flow

Can small-scale altitudinal gradients predict spatial and temporal patterns in tropical forests?

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Journal of Forestry Research 2021年第5期32卷 1854-1865页

作者： Mariana Caroline Moreira Morelli Cléber rodrigo de Souza Jean Daniel Morel Vinícius andrade Maia Alisson Borges Miranda Santos Kaline Fernandes Miranda Rubens Manoel dos Santos Forest Sciences department Federal University of LavrasCampus UniversitárioCx.P.3037LavrasMGCEP 37200-000Brazil department of Biology Federal University of LavrasCampus UniversitárioLavrasMGCEP 37200-000Brazil

In tropical montane forests,compositional and structural changes are commonly driven by broad-scale altitudinal ***,given the lack of knowledge on small-scale vegetation changes and temporal dynamics,we address the effects of small-scale variations in soil and altitude on tree community structure,temporal dynamics and phylogenetic diversity in a semi-deciduous tropical forest of the Atlantic Forest Domain,southeastern *** 2010 and 2015 we sampled thirty plots of 400 m^(2),set up along an altitudinal gradient between 1000 and 1500 m a.s.I..In each plot,we collected soil samples for chemical and textural *** fitted linear models to test the effects of altitude and soil on community dynamics and phylogenetic *** and soil explained the spatial variation in number of individuals and phylogenetic diversity *** lower to higher altitudes,we found decreasing fertility,increasing tree density and decreasing phylogenetic *** significantly influenced the increases in total biomass(from 240.9 to 255.4 t ha^(-1))and individual biomass(from 0.15 to 0.17 t)recorded in the *** while community temporal dynamics had rates of 1.96%for mortality,1.02%for recruitment,1.61%for biomass loss and 2.81%for biomass gain,none of them were explained by altitude or *** species substitution averaged0.1 in the ***,these results suggest that the small-scale variations in altitude and soil likely determine the conditions and resources that drive community assembly and structure,which are expressed by spatial variations along the altitudinal *** the same time,temporal patterns were not influenced by altitude-related environmental variation,resulting in a similar dynamic behaviour across the gradient,suggesting that broad-scale factors may play a more important role than local ones.

关键词： Fine-scale Semideciduous forests Montane forests Dynamic patterns

Microengineering double layer hydrogel structures towards the recapitulation of the hematopoietic stem cell niche

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Science Bulletin 2018年第20期63卷 1319-1323页

作者： Pilar Carreras rodrigo Cortrim Chaves Miguel Gallardo Alejandra Ortiz Joaquin Martinez Lopez samuel K.Sia department of Biomedical Engineering Columbia UniversityNew YorkNY 10032USA Hematology department Research Institute i+12Hospital 12 OctubreMadrid 2804Spain Hematological Malignancies Clinical Research Unit H120 CNIOMadrid 28029Spain

Adult stem cells,especially from bone marrow,have a tremendous therapeutic potential,and its application in regenerative medicine has been increasingly studied [1,2].It is well known that three-dimensional (3D)cell culture matrix promotes many biological relevant functions not observed in two-dimensional (2D) monolayer cell culture [3]and therefore,engineering 3D cell culture platforms to mimic the native in vivo biological systems represents a realistic approach for studies of bone marrow stem cells. High-throughput microfluidics constitutes a promising technology to generate hydrogel three dimensional constructs [4,5],however, its application to host adult stem cells remains still a challenge.

关键词： hydrogel hematopoietic stem cell

Small-scale edaphic heterogeneity as a floristic-structural complexity driver in Seasonally Dry Tropical Forests tree communities

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Journal of Forestry Research 2020年第6期31卷 2347-2357页

作者： Cle´ber rodrigo de Souza Jean Daniel Morel Alisson Borges Miranda Santos Wilder Bento da Silva Vinı´cius andrade Maia Polyanne Aparecida Coelho Vanessa Leite Rezende Rubens Manoel dos Santos Forest Sciences departament Federal University of LavrasCx.P.3037Lavras 37200-000Brazil Biology department Federal University of LavrasCx.P.3037Lavras 37200-000Brazil

Our work aimed to test the hypothesis that soil microscale heterogeneity act as a community ecological driver,increasing diversity and promoting structural shifts on the Seasonally Dry Tropical Forest(SDTF)tree *** evaluated the relationship between microscale edaphic variations and floristic–structural patterns of tree communities in a SDTF fragment located in the southern end of the Brazilian Caatinga *** and soil data were obtained through 27 sample units of 400 m2(20 m 920 m),within each one we measured and identified at species level all arboreal individuals with Circumference at the Breast Height greater or equal to 10 cm,and also collected the soil *** the data we evaluated soil variation influence on the tree community structural and floristic patterns trough generalized linear *** explained the small-scale structural and floristic variations,contributing significantly to biomass,sprouting and to floristic relationships between sample *** was also observed a possible relation of the result with the Caatinga domain biogeographic history,due the presence of Sedimentary Caatinga species,which are not expected for the study *** plays an important role in driving small-scale complexity and diversity of SDTF,but we also suggest that Caatinga biogeographic events have influence on the high heterogeneity patterns.

关键词： Caatinga domain Edaphic variables Sprouting Sedimentary Caatinga