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Aquaporins:Their role in cholestatic liver disease

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World Journal of Gastroenterology 2008年第46期14卷 7059-7067页

作者： Guillermo L Lehmann Maria C Larocca Leandro R Soria raúl A Marinelli Instituto de Fisiología Experimental Consejo Nacional de Investigaciones Científicas y TécnicasFacultad de Ciencias Bioquímicas y FarmacéuticasUniversidad Nacional de Rosario2000 RosarioSanta FeArgentina

This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and *** bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of *** question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of *** in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein *** combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water *** cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability.

关键词： Aquaporin Cholestasis Estrogen Hepatocyte Obstructive cholestasis, Sepsis Water transport

Perspective on Local Governance Reform in China

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China & World Economy 2006年第2期14卷 16-31页

作者： Mingxing Liu Binwen Song ra Tao associate professor School of Government Peking University Beijing China. assistant professor Zhejiang University of Finance ＆ EconomicsChina. associate professor Center for Chinese Agricultural PolicyBeijing China

This paper is an attempt to present an analysis of China＇s decentralization and local governance practices, the dilemmas rooted in the current institution. We argue that the misbehavior of local government officials is endogenous to China＇s central-local structure and that competition among localities has become distorted and constrained by various policy burdens and development mandates imposed from above. The information asymmetry for the enforcement cost of mandates that exists between central and local governments not only leads to difficulties and distortions in local performance evaluations, but also creates opportunities for local bureaucracy expansion and rent-seeking. Enhancingfiscal transfers, or strengthening political restraint, although necessary, would be far from enough to solve the local governance problems. The ultimate solution entails an in-depth deregulation reform on factor mobility and a furthest eradication of policy mandates for the local government.

关键词： political competition decentralization local governance policy mandate

Computation Analysis of Brand Experience Dimensions: Indian Online Food Delivery Platforms

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Computers, Materials & Continua 2021年第4期67卷 445-462页

作者： Sufyan Habib Nawaf N.Hamadneh SAl wadi ra’ed Masa’deh Department of Business Administration College of Administration and FinanceSaudi Electronic UniversityRiyadh11673Saudi Arabia Department of Basic Sciences College of Science and Theoretical StudiesSaudi Electronic UniversityRiyadh11673Saudi Arabia Department of Risk Management and Insurance The University of JordanAmmanJordan Management Information Systems Department School of BusinessThe University of JordanAmmanJordan

Online Food Delivery Platforms(OFDPs)has witnessed phenomenal growth in the past few years,especially this year due to the COVID-19 *** Pandemic has forced many governments across the world to give momentum to OFD services and make their presence among the *** Presence of several multinational and national companies in this sector has enhanced the competition and companies are trying to adapt various marketing strategies and exploring the brand experience(BEX)dimension that helps in enhancing the brand equity(BE)of *** are critical for building brand loyalty(BL)and making companies *** can experience different kinds of brand experiences through feeling,emotions,affection,behavior,and *** present research work is taken up to analyze the factors affecting BEX and its impact on BL and BE of the OFDPs and analyze the mediating role of BL in the relationship between BEX and BE of the OFDPs in the Indian context.A survey of 457 Indian customers was carried out.A questionnaire was used for data collection and a mediation study was used to test hypothesized *** computational analysis reveals that BEX influences the BL and BE of *** study further indicates that BL mediates the relationship between BEX and BE of *** effective marketing and relationship management practices will help company to enhance BEX that will enable in enhancing BL and raising BE of their *** therefore provides a more thorough analysis of BEX constructs and their consequences than previous *** of the managerial implication,limitations,and scope of future research are also presented in the study.

关键词： Hypothesis tests brand experience online food delivery platform statistical tests COVID-19

Antifungal activity of various essential oils against Saccharomyces cerevisiae depends on disruption of cell membrane integrity

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BIOCELL 2017年第1期41卷 13-18页

作者： HATİCE BÜŞra KONUK BENGÜERGÜDEN Department of Bioengineering Gebze Technical UniversityKocaeliTurkey

Antifungal activity and mode of action of nine essential oils(EOs)against *** cells were *** effects of commercial lemon peel,orange peel,tea tree,turpentine,rosemary,peppermint,thyme,oregano and clove oils were determined through Minimum Inhibitory Concentration(MIC),Minimum Fungicidal Concentration(MFC)and inhibition zone *** most effective oil was turpentine *** peel,thyme and oregano oils were also effective,according to MIC and *** zone measurements,also revealed oregano,orange peel,thyme,turpentine and clove oils as most efficient ***,membrane damage of yeast cells was studied by measuring the extracellular pH and conductivity in a concentration dependent *** peel,turpentine,thyme and oregano oils caused a clear increase in extracellular pH of glucose-induced yeast cells and induced an increase in extracellular *** results point to the deterioration of yeast cell membrane integrity upon exposure to *** these oils can be used as food preservatives and pharmaceutical agents,it is very important to understand their mode of action and their main target sites in the *** this research not only opens new perspectives to understand antifungal activity mechanisms of EOs,but also help widen their use.

关键词： Saccharomyces cerevisiae Essential oils Antifungal activity Cell membrane

Posterior reversible encephalopathy syndrome in a patient with metastatic breast cancer:A case report

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World Journal of Clinical Cases 2022年第7期10卷 2281-2285页

作者： Chae Hyun Song Seung Jun Lee Ha ra Jeon Department of Physical Medicine and Rehabilitation National Health Insurance Service Ilsan HospitalGoyang-si Gyeonggi-do 10444South Korea Department of Physical Medicine and Rehabilitation National Health Insurance Service Ilsan HospitalGoyang-si Gyeonggi-do ASI/KR/KS009/GoyangSouth Korea

BACKGROUND Posterior reversible encephalopathy syndrome(PRES)is a neurotoxic encephalopathic state with clinical symptoms such as headache,altered consciousness,visual disturbances,and *** edema occurs predominantly in the posterior occipital and parietal lobes of the *** is caused by various diseases,and its mechanism remains ***,it can be easily diagnosed based on characteristic lesions on magnetic resonance *** SUMMARY A 51-year-old woman with unremarkable past medical history presented with progressively worsening back pain since 2 *** examinations revealed paralumbar muscle tenderness,a large lesion on the right breast and several masslike lesions on both *** blood pressure(BP)was elevated(150/90 mmHg),and did not respond to antihypertensive *** the seventh day of hospitalization,she exhibited a confused mental status and generalized tonicclonic *** magnetic resonance imaging,bilateral cortical and subcortical edema of the occipital lobes,suggestive of PRES,was *** serum calcium was 15.8 mg/*** two days of treatment with nicardipine,elcatonin,and zolendronic acid,her BP was 130/91 mmHg and serum calcium was 10.1 mg/*** patient regained consciousness and her mental status ***-positron emission tomography revealed right breast cancer with extensive *** Although rare,hypercalcemia can lead to PRES by causing uncontrolled *** diagnosis can help prevent severe mental disturbances and even death.

关键词： Posterior reversible encephalopathy syndrome Breast cancer Hypercalcemia Hypertension Case report

Mental health of parents of children with autism spectrum disorder during COVID-19 pandemic: A systematic review

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World Journal of Psychiatry 2021年第7期11卷 388-402页

作者： Büşra Yılmaz Merve Azak NevinŞahin Department of Women's Health and Gynecologic Nursing Florence Nightingale Faculty of NursingIstanbul University-CerrahpasaIstanbul 34381Turkey Department of Pediatric Nursing Florence Nightingale Faculty of NursingIstanbul University-CerrahpasaIstanbul 34381Turkey

BACKGROUND Children diagnosed with autism spectrum disorder(ASD)may have great difficulties when their routines change,and this may affect the psychological wellbeing of their *** this reason,it is important to examine studies that address the mental health of parents in order to adapt to the coronavirus disease 2019(COVID-19)*** To determine the mental health status of parents with children diagnosed with ASD in the COVID-19 *** The study,which is a systematic review,was conducted between December 15,2020 and December 30,2020 by scanning articles in *** Scopus,Science Direct,PubMed,Cochrane,Web of Science,and Google Scholar databases were used for *** keywords COVID-19 AND(“autism”OR“autistic”OR“autism spectrum disorder”)AND parent AND(“mental health”OR“anxiety”OR“stress”)were used in the search *** inclusion criteria in the study were findings regarding the mental health of parents with children diagnosed with ASD in the COVID-19 pandemic,addressing their anxiety and stress situations,being a research article,and accessing the full text of the *** In the study,a total of 6389 articles were reached,and the full texts of 173 articles were evaluated for *** the articles excluded by the full-text search were eliminated,12 studies involving 7105 parents were included in the *** findings obtained from the articles containing data on mental health in the COVID-19 pandemic of parents with children with autism spectrum disorder were discussed in three *** were findings on the experiences of parents with children with ASD in the COVID-19 pandemic regarding the areas where parents with children with ASD need support in the COVID-19 pandemic and methods of coping with the COVID-19 pandemic for parents with children with *** the systematic review,it was determined that the anxiety and stress of the parents increased,they needed more support compared to the pre-pandemic period,

关键词： Autism spectrum disorder COVID-19 Mental health Pandemic Parents

Sex-specific life-history strategies among immature jumping spiders:Differences in body parameters and behavior

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Current Zoology 2023年第5期69卷 535-551页

作者： LászlóMezőfi Viktor Markó DóraÁgnes Taranyi Gábor Markó Institute of Plant Protection Hungarian University of Agriculture and Life SciencesBudapest 1118Hungary Institute of Viticulture and Enology Hungarian University of Agriculture and Life SciencesBudapest 1118Hungary

Selection forces often generate sex-specific differences in various traits closely related to *** in adult spiders(Araneae),sexes often differ in coloration,body size,antipredator,or foraging behavior,such sex-related differences are less pronounced among ***,sex-specific life-history strategies may also be adaptive for ***,we hypothesized that among spiders,immature individuals show different life-history strategies that are expressed as sex-specific differences in body parameters and behavioral features,and also in their *** used immature individuals of a protandrous jumping spider,Carrhotus xanthogramma,and examined sex-related *** results showed that males have higher mass and larger prosoma than *** were more active and more risk tolerant than *** activity increased with time,and larger males tended to capture the prey faster than small ones,while females showed no such ***,females reacted to the threatening abiotic stimuli more with the increasing number of test *** both males and females,individuals with better body conditions tended to be more risk *** showed no sex-specific differences in interindividual behavioral consistency and in intraindividual behavioral variation in the measured behavioral ***,we also found evidence for behavioral syndromes(i.e.,correlation between different behaviors),where in males,only the activity correlated with the risk-taking behavior,but in females,all the measured behavioral traits were *** present study demonstrates that *** sexes follow different life-history strategies even before attaining maturity.

关键词： activity behavioral syndrome boldness intraindividual variability repeatability sexual dimorphism

Role of seed size, phenology, oogenesis and host distribution in the specificity and genetic structure of seed weevils (Curculio spp.) in mixed forests

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Integrative Zoology 2018年第3期13卷 267-279页

作者： Harold ARIAS-LECLAIRE raúl BONAL Daniel GARCÍA-LÓPEZ Josep Maria ESPELTA CREAF Centre for Ecological Research and Forestry ApplicationsCerdanyola del Vallès08193Spain Exact and Natural Sciences School State Distance University of Costa RicaUNEDMercedes de Montes de OcaSan JoséCosta Rica Forest Research Group INDEHESAUniversity of ExtremaduraPlasenciaSpain DITEG Research Group University of Castilla-La ManchaToledoSpain Zoology Department Autonomous University of BarcelonaCerdanyola del VallèsSpain

Synchrony between seed growth and oogenesis is suggested to largely shape trophic breadth of seed-feeding insects and ultimately to contribute to their co-existence by means of resource partitioning or in the time when infestation *** we investigated:(i)the role of seed phenology and sexual maturation of females in the host specificity of seed-feeding weevils(Curculio spp.)predating in hazel and oak mixed forests;and(ii)the consequences that trophic breadth and host distribution have in the genetic structure of the weevil *** analyses were used to establish unequivocally host specificity and to determine the population genetic *** identified 4 species with different specificity,namely Curculio nucum females matured earlier and infested a unique host(hazelnuts,Corylus avellana)while 3 species(Curculio venosus,Curculio glandium and Curculio elephas)predated upon the acorns of the 2 oaks(Quercus ilex and Quercus pubescens).The high specificity of *** coupled with a more discontinuous distribution of hazel trees resulted in a significant genetic structure among *** addition,the presence of an excess of local rare haplotypes indicated that *** populations went through genetic expansion after recent ***,these effects were not observed in the more generalist Curculio glandium predating upon ***,co-existence of weevil species in this multi-host-parasite system is influenced by both resource and time *** what extent the restriction in gene flow among *** populations may have negative consequences for their persistence in a time of increasing disturbances(*** in Mediterranean areas)deserves further research.

关键词： Corylus avellana Curculio spp. genetic structure Quercus spp. trophic breadth

The nucleoside antiviral prodrug remdesivir in treating COVID-19 and beyond with interspecies significance

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Animal Diseases 2022年第1期2卷 1-15页

作者： Daisy Yan One Hyuk ra Bingfang Yan Sidney Kimmel Medical College Thomas Jefferson University1025 Walnut StPhiladelphiaPA 19107USA Department of Anesthesiology Brigham and Women's Hospital75 Francis StBostonMA 02115USA Division of Pharmaceutical Sciences James L Winkle College of PharmacyUniversity of CincinnatiCincinnatiOH 45229USA

Infectious pandemics result in hundreds and millions of deaths,notable examples of the Spanish Flu,the Black Death and *** current pandemic,caused by SARS-CoV-2(severe acute respiratory syndrome coronavirus 2),is unprecedented even in the historical term of *** unprecedentedness is featured by multiple surges,rapid identification of therapeutic options and accelerated development of ***,originally developed for Ebola viral disease,is the first treatment of COVID-19(Coronavirus disease 2019)approved by the United States Food and Drug *** demonstrated by in vitro and preclinical studies,this therapeutic agent is highly potent with a broad spectrum activity against viruses from as many as seven families even cross ***,randomized controlled trials have failed to confirm the efficacy and *** improves some clinical signs but not critical parameters such as *** antiviral agent is an ester/phosphorylation prodrug and excessive hydrolysis which increases cellular *** is given intravenously,leading to concentration spikes and likely increasing the potential of hydrolysis-based *** review has proposed a conceptual framework for improving its efficacy and minimizing toxicity not only for the COVID-19 pandemic but also for future ones caused by remdesivir-sensitive viruses.

关键词： Animal model Carboxylesterases COVID-19 Coronavirus Drug-drug interactions interspecies difference Pandemic Remdesivir SARS-CoV-2